Mutagenetix > Incidental Mutations

Incidental Mutation 'IGL02944:Vmn1r175'

364647

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn1r175

Ensembl Gene

ENSMUSG00000095632

Gene Name

vomeronasal 1 receptor 175

Synonyms

Gm6299

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.081) question?

Stock #

IGL02944

Quality Score

Status

Chromosome

Chromosomal Location

23807182-23810643 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 23809166 bp

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 12 (E12G)

Ref Sequence

ENSEMBL: ENSMUSP00000154170 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000166141] [ENSMUST00000228383]

Predicted Effect

probably damaging
Transcript: ENSMUST00000166141
AA Change: E12G

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)

SMART Domains

Protein: ENSMUSP00000126357
Gene: ENSMUSG00000095632
AA Change: E12G

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	296	8.8e-15	PFAM
Pfam:7tm_1	13	285	2.5e-6	PFAM
Pfam:V1R	41	295	4.4e-22	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000228383
AA Change: E12G

PolyPhen 2 Score 0.972 (Sensitivity: 0.77; Specificity: 0.96)

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 34 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akap13	A	G	7: 75,608,657	Q343R	probably benign	Het
Antxr1	T	A	6: 87,188,159	N432I	possibly damaging	Het
Arhgap15	T	C	2: 44,142,350		probably null	Het
Atp6v1h	T	A	1: 5,093,355		probably benign	Het
Cav2	T	C	6: 17,281,457	Y33H	probably damaging	Het
Ccdc175	T	A	12: 72,117,893	D585V	probably benign	Het
Coro7	T	C	16: 4,635,412	D271G	probably benign	Het
Cylc1	T	A	X: 111,123,604	D551E	possibly damaging	Het
Dnah1	A	T	14: 31,300,871	I1103N	possibly damaging	Het
Gm44	A	G	X: 90,892,262	K41E	probably benign	Het
Gmds	T	A	13: 32,338,452	Y11F	probably benign	Het
Igkv13-54-1	C	T	6: 69,617,390		noncoding transcript	Het
Irf8	A	G	8: 120,755,125	T318A	probably benign	Het
Lrrc40	G	A	3: 158,041,665		probably benign	Het
Mbd1	G	A	18: 74,277,410	G428E	probably damaging	Het
Myom2	A	T	8: 15,104,065		probably null	Het
Nav2	C	T	7: 49,420,256	R287W	probably damaging	Het
Nfs1	C	T	2: 156,127,768	D320N	probably damaging	Het
Nlrp9a	A	T	7: 26,558,651	T565S	probably benign	Het
Nod1	A	T	6: 54,924,947	I951N	possibly damaging	Het
Olfr353	T	G	2: 36,890,788	E20A	possibly damaging	Het
Olfr675	A	G	7: 105,024,923	L19P	probably damaging	Het
Olfr694	A	G	7: 106,689,269	L154P	probably damaging	Het
Olfr924	A	T	9: 38,848,752	I213F	possibly damaging	Het
Pkhd1l1	T	C	15: 44,501,531	Y689H	probably damaging	Het
Ppp2r5c	A	G	12: 110,567,800	I366V	probably benign	Het
Ppp3cb	T	C	14: 20,528,235	Y149C	probably damaging	Het
Prdm1	T	C	10: 44,441,811	S354G	probably benign	Het
Ralgapa1	T	A	12: 55,757,951	Q520L	probably benign	Het
Slc25a54	A	T	3: 109,080,615	Y24F	probably benign	Het
Slfn3	T	A	11: 83,213,011	V236E	probably damaging	Het
Syt6	A	G	3: 103,575,549		probably benign	Het
Trim30a	G	T	7: 104,435,777	N75K	probably benign	Het
Xylt1	A	T	7: 117,634,757	T504S	probably benign	Het

Other mutations in Vmn1r175

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1163:Vmn1r175	UTSW	7	23808512	missense	probably benign	0.30
R1901:Vmn1r175	UTSW	7	23808793	missense	probably benign	0.00
R1926:Vmn1r175	UTSW	7	23809041	missense	possibly damaging	0.81
R1957:Vmn1r175	UTSW	7	23808383	missense	probably benign	0.21
R2163:Vmn1r175	UTSW	7	23808927	missense	probably benign	0.29
R2381:Vmn1r175	UTSW	7	23808668	missense	probably benign	0.31
R3109:Vmn1r175	UTSW	7	23808968	missense	probably benign	0.00
R3419:Vmn1r175	UTSW	7	23808650	missense	probably damaging	0.96
R3941:Vmn1r175	UTSW	7	23808968	missense	probably benign	0.00
R4982:Vmn1r175	UTSW	7	23809069	missense	possibly damaging	0.61
R5191:Vmn1r175	UTSW	7	23809022	missense	possibly damaging	0.91
R5326:Vmn1r175	UTSW	7	23809106	missense	possibly damaging	0.88
R5333:Vmn1r175	UTSW	7	23808579	missense	possibly damaging	0.69
R5476:Vmn1r175	UTSW	7	23809131	missense	possibly damaging	0.82
R5542:Vmn1r175	UTSW	7	23809106	missense	possibly damaging	0.88
R5761:Vmn1r175	UTSW	7	23808480	missense	probably benign	0.01
R5918:Vmn1r175	UTSW	7	23808947	missense	probably damaging	1.00
R6163:Vmn1r175	UTSW	7	23809166	missense	possibly damaging	0.71
R6563:Vmn1r175	UTSW	7	23808605	missense	possibly damaging	0.61

Posted On

2015-12-18