Incidental Mutation 'R0378:Tcerg1l'
ID 36468
Institutional Source Beutler Lab
Gene Symbol Tcerg1l
Ensembl Gene ENSMUSG00000091002
Gene Name transcription elongation regulator 1-like
Synonyms 5730476P14Rik
MMRRC Submission 038584-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R0378 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 137810703-137999459 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 137878384 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Alanine at position 326 (V326A)
Ref Sequence ENSEMBL: ENSMUSP00000124476 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000160436]
AlphaFold Q3B807
Predicted Effect probably benign
Transcript: ENSMUST00000160436
AA Change: V326A

PolyPhen 2 Score 0.010 (Sensitivity: 0.96; Specificity: 0.77)
SMART Domains Protein: ENSMUSP00000124476
Gene: ENSMUSG00000091002
AA Change: V326A

DomainStartEndE-ValueType
low complexity region 6 44 N/A INTRINSIC
low complexity region 52 97 N/A INTRINSIC
WW 146 178 2.11e1 SMART
low complexity region 235 249 N/A INTRINSIC
WW 344 376 3.29e-4 SMART
low complexity region 402 415 N/A INTRINSIC
FF 454 507 4.57e-12 SMART
FF 520 574 1.53e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000162222
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.4%
  • 3x: 98.7%
  • 10x: 97.0%
  • 20x: 94.8%
Validation Efficiency 95% (40/42)
Allele List at MGI
Other mutations in this stock
Total: 41 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts18 C A 8: 114,469,749 (GRCm39) R651L probably damaging Het
Amd1 T C 10: 40,165,380 (GRCm39) D317G possibly damaging Het
Artn A G 4: 117,784,815 (GRCm39) probably benign Het
Bub1b T A 2: 118,471,604 (GRCm39) V988E probably benign Het
Cyp2c65 G T 19: 39,061,662 (GRCm39) C216F probably benign Het
Cyp3a11 T C 5: 145,805,417 (GRCm39) E200G probably benign Het
Cyp3a25 T A 5: 145,923,652 (GRCm39) K330N probably damaging Het
Duox2 C A 2: 122,115,064 (GRCm39) V1138L probably benign Het
Erc2 A G 14: 27,733,651 (GRCm39) D567G probably damaging Het
Eri2 A G 7: 119,393,139 (GRCm39) probably null Het
Foxa3 A G 7: 18,757,294 (GRCm39) Y17H probably damaging Het
Fto T C 8: 92,200,940 (GRCm39) S324P probably damaging Het
Get3 A T 8: 85,751,893 (GRCm39) M1K probably null Het
Gls2 T G 10: 128,043,180 (GRCm39) L457R probably benign Het
Gstcd A T 3: 132,692,169 (GRCm39) L582H probably damaging Het
Gtf3c1 G A 7: 125,246,786 (GRCm39) R1508* probably null Het
Kif21a T C 15: 90,853,977 (GRCm39) probably null Het
Klra5 A T 6: 129,883,577 (GRCm39) D93E possibly damaging Het
Lgr5 T C 10: 115,290,404 (GRCm39) D456G probably damaging Het
Mau2 A G 8: 70,483,305 (GRCm39) S186P probably damaging Het
Msr1 T C 8: 40,042,423 (GRCm39) D384G possibly damaging Het
Ncf4 T C 15: 78,137,503 (GRCm39) V93A probably damaging Het
Oas1f T G 5: 120,994,489 (GRCm39) C337G probably damaging Het
Or10al3 A G 17: 38,011,932 (GRCm39) M124V probably damaging Het
Or5p58 A T 7: 107,694,429 (GRCm39) F116Y probably benign Het
Or6c33 T A 10: 129,853,872 (GRCm39) L214H probably damaging Het
Pwwp3a C A 10: 80,074,713 (GRCm39) probably null Het
Rasl10b T C 11: 83,309,519 (GRCm39) S159P probably damaging Het
Sephs1 A G 2: 4,904,371 (GRCm39) T250A probably benign Het
Smg8 C A 11: 86,971,249 (GRCm39) D841Y probably damaging Het
Sox7 T C 14: 64,181,398 (GRCm39) V65A probably damaging Het
Sp140 C T 1: 85,547,772 (GRCm39) probably benign Het
Srsf10 A G 4: 135,590,501 (GRCm39) Y142C possibly damaging Het
Tcam1 G A 11: 106,174,904 (GRCm39) E120K probably benign Het
Tcl1b5 T A 12: 105,145,326 (GRCm39) W97R probably damaging Het
Tmem108 T C 9: 103,376,856 (GRCm39) R198G possibly damaging Het
Ube2ql1 T A 13: 69,887,017 (GRCm39) Q148L possibly damaging Het
Vmn1r5 A T 6: 56,962,570 (GRCm39) I82L probably benign Het
Wdr6 A T 9: 108,453,063 (GRCm39) S273R probably damaging Het
Ylpm1 C T 12: 85,043,850 (GRCm39) probably benign Het
Zfp90 G A 8: 107,152,138 (GRCm39) R617Q possibly damaging Het
Other mutations in Tcerg1l
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00504:Tcerg1l APN 7 137,811,533 (GRCm39) missense probably damaging 0.99
IGL01402:Tcerg1l APN 7 137,861,568 (GRCm39) missense probably damaging 0.98
IGL01510:Tcerg1l APN 7 137,996,034 (GRCm39) splice site probably benign
IGL01638:Tcerg1l APN 7 137,881,805 (GRCm39) missense probably damaging 1.00
IGL01710:Tcerg1l APN 7 137,996,789 (GRCm39) missense possibly damaging 0.81
IGL02547:Tcerg1l APN 7 137,850,100 (GRCm39) critical splice donor site probably null
IGL02887:Tcerg1l APN 7 137,831,619 (GRCm39) missense probably damaging 1.00
IGL03105:Tcerg1l APN 7 137,850,173 (GRCm39) splice site probably benign
IGL03348:Tcerg1l APN 7 137,815,100 (GRCm39) missense probably damaging 0.97
R1474:Tcerg1l UTSW 7 137,881,804 (GRCm39) missense probably damaging 0.99
R1589:Tcerg1l UTSW 7 137,963,496 (GRCm39) missense probably damaging 0.99
R1658:Tcerg1l UTSW 7 137,995,909 (GRCm39) missense probably damaging 0.98
R1792:Tcerg1l UTSW 7 137,963,595 (GRCm39) missense probably benign 0.07
R1807:Tcerg1l UTSW 7 137,996,826 (GRCm39) missense probably benign 0.34
R2920:Tcerg1l UTSW 7 137,850,108 (GRCm39) missense probably damaging 0.99
R3148:Tcerg1l UTSW 7 137,861,596 (GRCm39) missense probably benign
R4106:Tcerg1l UTSW 7 137,861,673 (GRCm39) missense probably damaging 0.99
R4180:Tcerg1l UTSW 7 137,878,405 (GRCm39) critical splice acceptor site probably null
R4241:Tcerg1l UTSW 7 137,999,361 (GRCm39) missense unknown
R4898:Tcerg1l UTSW 7 137,819,786 (GRCm39) missense probably damaging 0.99
R5652:Tcerg1l UTSW 7 137,881,775 (GRCm39) missense probably damaging 0.97
R6646:Tcerg1l UTSW 7 137,996,912 (GRCm39) splice site probably null
R6824:Tcerg1l UTSW 7 137,995,844 (GRCm39) critical splice donor site probably null
R7414:Tcerg1l UTSW 7 137,819,786 (GRCm39) missense probably damaging 0.97
R7490:Tcerg1l UTSW 7 137,861,557 (GRCm39) missense probably damaging 1.00
R8810:Tcerg1l UTSW 7 137,811,526 (GRCm39) missense possibly damaging 0.79
R8889:Tcerg1l UTSW 7 137,999,260 (GRCm39) nonsense probably null
R8892:Tcerg1l UTSW 7 137,999,260 (GRCm39) nonsense probably null
R9146:Tcerg1l UTSW 7 137,831,588 (GRCm39) missense probably damaging 1.00
R9374:Tcerg1l UTSW 7 137,995,998 (GRCm39) missense possibly damaging 0.95
R9392:Tcerg1l UTSW 7 137,815,164 (GRCm39) missense probably damaging 0.98
R9402:Tcerg1l UTSW 7 137,811,551 (GRCm39) missense probably damaging 0.99
R9428:Tcerg1l UTSW 7 137,811,490 (GRCm39) missense probably damaging 0.99
R9551:Tcerg1l UTSW 7 137,995,998 (GRCm39) missense possibly damaging 0.95
R9552:Tcerg1l UTSW 7 137,995,998 (GRCm39) missense possibly damaging 0.95
R9572:Tcerg1l UTSW 7 137,881,787 (GRCm39) missense probably benign 0.07
R9624:Tcerg1l UTSW 7 137,995,923 (GRCm39) missense possibly damaging 0.71
Predicted Primers PCR Primer
(F):5'- AGAACGCGCTTTCTCTCTGATGAC -3'
(R):5'- GAGACTGCTTCTTGTGGATCACCC -3'

Sequencing Primer
(F):5'- CTGATGACATTAAGCAGACTCTGG -3'
(R):5'- AGTGTAGGCCATTGTCAACC -3'
Posted On 2013-05-09