Incidental Mutation 'IGL02945:Lingo3'
ID 364690
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lingo3
Ensembl Gene ENSMUSG00000051067
Gene Name leucine rich repeat and Ig domain containing 3
Synonyms LERN2
Accession Numbers
Essential gene? Probably non essential (E-score: 0.072) question?
Stock # IGL02945
Quality Score
Status
Chromosome 10
Chromosomal Location 80668635-80679873 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 80670532 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 466 (I466T)
Ref Sequence ENSEMBL: ENSMUSP00000054960 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053986] [ENSMUST00000219924]
AlphaFold Q6GQU6
Predicted Effect probably damaging
Transcript: ENSMUST00000053986
AA Change: I466T

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000054960
Gene: ENSMUSG00000051067
AA Change: I466T

DomainStartEndE-ValueType
LRRNT 23 57 1.54e-5 SMART
LRR_TYP 76 99 1.38e-3 SMART
LRR_TYP 100 123 4.94e-5 SMART
LRR 124 147 3.86e0 SMART
LRR 148 171 4.98e-1 SMART
LRR 172 195 1.62e1 SMART
LRR 246 267 3.46e2 SMART
LRR 269 291 3.86e0 SMART
LRR 292 315 3.24e0 SMART
LRR 316 339 4.34e-1 SMART
LRRCT 351 404 7.18e-3 SMART
IGc2 419 486 3.12e-14 SMART
transmembrane domain 526 548 N/A INTRINSIC
low complexity region 571 581 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000219924
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933411G06Rik A T 10: 51,633,095 (GRCm39) noncoding transcript Het
Adgrf4 T C 17: 42,978,257 (GRCm39) Q362R probably benign Het
Akap6 A G 12: 52,927,620 (GRCm39) N177D probably damaging Het
Alms1 A G 6: 85,597,915 (GRCm39) I914V probably damaging Het
Arhgap11a A T 2: 113,667,818 (GRCm39) S394R possibly damaging Het
Cacna1h C T 17: 25,607,033 (GRCm39) V962I probably damaging Het
Calr3 A T 8: 73,192,401 (GRCm39) L91Q probably damaging Het
Ccnf T C 17: 24,443,890 (GRCm39) E626G probably damaging Het
Clec10a A T 11: 70,061,368 (GRCm39) I295F possibly damaging Het
Cop1 A T 1: 159,134,259 (GRCm39) N167I probably benign Het
Csmd1 G T 8: 16,321,584 (GRCm39) Q505K possibly damaging Het
Ctrc A C 4: 141,573,563 (GRCm39) V6G possibly damaging Het
Cyp2c69 T C 19: 39,875,091 (GRCm39) R21G possibly damaging Het
Dnah5 A G 15: 28,270,572 (GRCm39) H958R probably benign Het
Egfr T A 11: 16,702,514 (GRCm39) L11Q probably damaging Het
Erich2 A G 2: 70,364,738 (GRCm39) T371A probably damaging Het
Fbxl21 T A 13: 56,674,983 (GRCm39) F111L probably damaging Het
Grik4 G T 9: 42,509,175 (GRCm39) T416N possibly damaging Het
Grin3a A G 4: 49,792,971 (GRCm39) V254A possibly damaging Het
Hat1 G A 2: 71,251,037 (GRCm39) R195K probably benign Het
Hmgb4 A C 4: 128,154,387 (GRCm39) Y60* probably null Het
Ighv12-3 A G 12: 114,330,337 (GRCm39) W53R probably damaging Het
Irs2 C A 8: 11,057,781 (GRCm39) C217F probably damaging Het
Kcnb1 T C 2: 167,030,308 (GRCm39) E79G probably benign Het
Lyst T C 13: 13,935,783 (GRCm39) S3665P possibly damaging Het
Myh9 A T 15: 77,646,205 (GRCm39) L1926Q probably benign Het
Myom1 A G 17: 71,399,088 (GRCm39) probably benign Het
Nbeal1 T C 1: 60,245,569 (GRCm39) F198L probably damaging Het
Nktr A G 9: 121,557,697 (GRCm39) T63A probably damaging Het
Nle1 A T 11: 82,794,910 (GRCm39) probably benign Het
Nr3c2 A T 8: 77,636,288 (GRCm39) D463V probably damaging Het
Or5k17 A T 16: 58,746,703 (GRCm39) I77N probably damaging Het
Or8b43 A G 9: 38,360,812 (GRCm39) I215V probably benign Het
Pcdhb18 T C 18: 37,623,048 (GRCm39) I126T probably benign Het
Pgm1 A G 4: 99,818,731 (GRCm39) I127V probably benign Het
Rai14 A G 15: 10,574,795 (GRCm39) I721T probably benign Het
Rps6ka1 A G 4: 133,594,510 (GRCm39) Y57H probably damaging Het
Scara3 T A 14: 66,168,660 (GRCm39) D319V probably damaging Het
Selp G A 1: 163,961,498 (GRCm39) G404S probably damaging Het
Serinc3 A G 2: 163,472,836 (GRCm39) probably benign Het
Slc4a8 A G 15: 100,705,080 (GRCm39) probably null Het
Spen G T 4: 141,221,624 (GRCm39) L325I unknown Het
Sphkap A T 1: 83,254,552 (GRCm39) S779T probably damaging Het
Stxbp2 A T 8: 3,691,971 (GRCm39) I538F probably benign Het
Thumpd1 A T 7: 119,315,970 (GRCm39) S326R possibly damaging Het
Tmem255b T C 8: 13,505,141 (GRCm39) S149P probably damaging Het
Tnni3k A T 3: 154,743,075 (GRCm39) S95T possibly damaging Het
Trim66 G A 7: 109,059,383 (GRCm39) Q954* probably null Het
Ttn A T 2: 76,582,316 (GRCm39) I22859N probably damaging Het
Zfp319 A T 8: 96,050,446 (GRCm39) probably benign Het
Other mutations in Lingo3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01141:Lingo3 APN 10 80,671,147 (GRCm39) missense probably damaging 1.00
IGL02120:Lingo3 APN 10 80,671,693 (GRCm39) missense probably damaging 1.00
IGL02755:Lingo3 APN 10 80,671,843 (GRCm39) missense possibly damaging 0.49
IGL02938:Lingo3 APN 10 80,670,988 (GRCm39) missense probably benign 0.00
IGL03167:Lingo3 APN 10 80,671,178 (GRCm39) missense probably damaging 1.00
R0639:Lingo3 UTSW 10 80,671,618 (GRCm39) missense probably benign 0.11
R0645:Lingo3 UTSW 10 80,671,169 (GRCm39) missense probably benign 0.00
R0673:Lingo3 UTSW 10 80,671,618 (GRCm39) missense probably benign 0.11
R1250:Lingo3 UTSW 10 80,670,605 (GRCm39) missense probably benign 0.05
R1521:Lingo3 UTSW 10 80,671,555 (GRCm39) missense probably benign
R1794:Lingo3 UTSW 10 80,671,432 (GRCm39) missense probably benign 0.19
R4665:Lingo3 UTSW 10 80,671,372 (GRCm39) missense probably damaging 1.00
R5587:Lingo3 UTSW 10 80,671,364 (GRCm39) missense probably damaging 0.98
R6458:Lingo3 UTSW 10 80,671,150 (GRCm39) missense probably damaging 1.00
R7082:Lingo3 UTSW 10 80,671,625 (GRCm39) missense probably benign
R7231:Lingo3 UTSW 10 80,670,938 (GRCm39) missense possibly damaging 0.86
R7314:Lingo3 UTSW 10 80,670,707 (GRCm39) missense possibly damaging 0.92
R7390:Lingo3 UTSW 10 80,670,463 (GRCm39) missense probably damaging 1.00
R7450:Lingo3 UTSW 10 80,670,671 (GRCm39) nonsense probably null
R7650:Lingo3 UTSW 10 80,671,597 (GRCm39) missense probably damaging 1.00
R7894:Lingo3 UTSW 10 80,670,610 (GRCm39) nonsense probably null
R7920:Lingo3 UTSW 10 80,670,382 (GRCm39) missense probably benign 0.09
R8070:Lingo3 UTSW 10 80,671,955 (GRCm39) start gained probably benign
R8095:Lingo3 UTSW 10 80,671,255 (GRCm39) missense probably benign 0.01
R8171:Lingo3 UTSW 10 80,670,595 (GRCm39) missense probably benign
R8178:Lingo3 UTSW 10 80,670,464 (GRCm39) missense possibly damaging 0.80
R8425:Lingo3 UTSW 10 80,670,816 (GRCm39) missense probably benign 0.04
R9053:Lingo3 UTSW 10 80,670,821 (GRCm39) missense probably benign 0.00
R9059:Lingo3 UTSW 10 80,670,523 (GRCm39) missense probably benign 0.12
R9706:Lingo3 UTSW 10 80,670,288 (GRCm39) missense probably damaging 0.99
R9794:Lingo3 UTSW 10 80,670,707 (GRCm39) missense possibly damaging 0.92
Z1176:Lingo3 UTSW 10 80,670,689 (GRCm39) missense possibly damaging 0.95
Posted On 2015-12-18