Incidental Mutation 'IGL02946:Sgta'
ID 364759
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Sgta
Ensembl Gene ENSMUSG00000004937
Gene Name small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha
Synonyms 5330427H01Rik, Sgt, D10Ertd190e
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02946
Quality Score
Status
Chromosome 10
Chromosomal Location 80879909-80896015 bp(-) (GRCm39)
Type of Mutation splice site
DNA Base Change (assembly) A to G at 80885612 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000151678 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000005067] [ENSMUST00000218208] [ENSMUST00000219401] [ENSMUST00000220317]
AlphaFold Q8BJU0
Predicted Effect probably benign
Transcript: ENSMUST00000005067
SMART Domains Protein: ENSMUSP00000005067
Gene: ENSMUSG00000004937

DomainStartEndE-ValueType
Pfam:SGTA_dimer 3 64 2.5e-23 PFAM
TPR 92 125 1.49e-3 SMART
TPR 126 159 1.27e-6 SMART
TPR 160 193 1.06e-8 SMART
Blast:STI1 218 264 5e-16 BLAST
low complexity region 276 288 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000218208
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219126
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219297
Predicted Effect probably benign
Transcript: ENSMUST00000219401
Predicted Effect noncoding transcript
Transcript: ENSMUST00000220202
Predicted Effect probably benign
Transcript: ENSMUST00000220317
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein which is capable of interacting with the major nonstructural protein of parvovirus H-1 and 70-kDa heat shock cognate protein; however, its function is not known. Since this transcript is expressed ubiquitously in various tissues, this protein may serve a housekeeping function. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased neonatal death, subfertility, decreased body size, increased brain, intestine and heart weight, decreased serum insulin-like growth factor I level, large penis, and increased testis descent. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8a G A 11: 109,919,041 (GRCm39) probably benign Het
Actr3b T C 5: 26,053,481 (GRCm39) I270T possibly damaging Het
Adgrf2 T C 17: 43,021,384 (GRCm39) Y480C probably damaging Het
Arhgap27 T C 11: 103,229,174 (GRCm39) T514A probably damaging Het
BC031181 C T 18: 75,141,736 (GRCm39) probably benign Het
Cckbr C T 7: 105,083,238 (GRCm39) A147V probably damaging Het
Ccm2 G A 11: 6,546,195 (GRCm39) R335H probably damaging Het
Ces1d C A 8: 93,896,346 (GRCm39) probably null Het
Crabp1 T C 9: 54,672,232 (GRCm39) F16S possibly damaging Het
Crmp1 C T 5: 37,441,424 (GRCm39) A502V probably damaging Het
Ehhadh A T 16: 21,581,672 (GRCm39) V440D probably damaging Het
Galnt3 T A 2: 65,925,562 (GRCm39) I392L probably damaging Het
Gm12689 T A 4: 99,184,490 (GRCm39) N114K unknown Het
Hspa2 A G 12: 76,451,947 (GRCm39) T214A probably damaging Het
Itga7 T C 10: 128,769,952 (GRCm39) I32T probably benign Het
Itgal A G 7: 126,913,540 (GRCm39) S682G probably damaging Het
Kctd1 C T 18: 15,107,036 (GRCm39) probably null Het
Lrp1b T A 2: 41,202,571 (GRCm39) D439V probably damaging Het
Mdn1 A G 4: 32,734,366 (GRCm39) K3258E probably damaging Het
Mgat4c T C 10: 102,225,114 (GRCm39) S443P probably benign Het
Mylk G A 16: 34,742,158 (GRCm39) G890E probably benign Het
Mylk2 T A 2: 152,761,130 (GRCm39) L446* probably null Het
Niban1 A T 1: 151,525,176 (GRCm39) I194F probably damaging Het
Or2t26 T G 11: 49,039,719 (GRCm39) F212V probably damaging Het
Pi4k2b T C 5: 52,910,549 (GRCm39) F278L probably damaging Het
Pitpnm3 A G 11: 71,983,378 (GRCm39) S84P probably benign Het
Plxna2 T C 1: 194,431,617 (GRCm39) probably benign Het
Prr5l C A 2: 101,602,529 (GRCm39) probably null Het
Ptprs T C 17: 56,731,032 (GRCm39) T719A probably benign Het
Rasa3 T C 8: 13,648,280 (GRCm39) H128R probably benign Het
Rhox13 A G X: 37,218,652 (GRCm39) K205E probably damaging Het
Rif1 C A 2: 52,000,137 (GRCm39) S1197* probably null Het
Slc25a5 T A X: 36,061,506 (GRCm39) M239K probably damaging Het
Stil T A 4: 114,887,110 (GRCm39) H734Q probably benign Het
Stk32b T C 5: 37,688,883 (GRCm39) probably benign Het
Ubr4 T G 4: 139,152,606 (GRCm39) F1999C probably damaging Het
Wfdc2 A C 2: 164,406,009 (GRCm39) T86P probably benign Het
Zfp407 T C 18: 84,578,834 (GRCm39) S760G probably damaging Het
Zfp668 A T 7: 127,465,690 (GRCm39) L498Q possibly damaging Het
Other mutations in Sgta
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0194:Sgta UTSW 10 80,886,893 (GRCm39) missense probably benign 0.00
R0595:Sgta UTSW 10 80,884,742 (GRCm39) missense probably damaging 1.00
R1742:Sgta UTSW 10 80,882,111 (GRCm39) missense probably damaging 1.00
R1858:Sgta UTSW 10 80,884,695 (GRCm39) missense possibly damaging 0.50
R2015:Sgta UTSW 10 80,887,130 (GRCm39) missense probably damaging 1.00
R2406:Sgta UTSW 10 80,887,081 (GRCm39) missense possibly damaging 0.74
R5305:Sgta UTSW 10 80,882,081 (GRCm39) missense probably damaging 0.99
R5724:Sgta UTSW 10 80,883,522 (GRCm39) splice site probably null
R9746:Sgta UTSW 10 80,887,118 (GRCm39) missense possibly damaging 0.52
Z1176:Sgta UTSW 10 80,882,114 (GRCm39) missense possibly damaging 0.55
Z1177:Sgta UTSW 10 80,886,918 (GRCm39) missense possibly damaging 0.54
Posted On 2015-12-18