Mutagenetix > Incidental Mutation

Incidental Mutation 'R0378:Tcl1b5'

36485

Institutional Source

Beutler Lab

Gene Symbol

Tcl1b5

Ensembl Gene

ENSMUSG00000000701

Gene Name

T cell leukemia/lymphoma 1B, 5

Synonyms

D12Ertd644e

MMRRC Submission

038584-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.083) question?

Stock #

R0378 (G1)

Quality Score

225

Status

Validated

Chromosome

Chromosomal Location

105142603-105147404 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 105145326 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tryptophan to Arginine at position 97 (W97R)

Ref Sequence

ENSEMBL: ENSMUSP00000000717 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000000717]

AlphaFold

P56845

Predicted Effect

probably damaging
Transcript: ENSMUST00000000717
AA Change: W97R

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000000717
Gene: ENSMUSG00000000701
AA Change: W97R

Domain	Start	End	E-Value	Type
Pfam:TCL1_MTCP1	1	117	1e-41	PFAM

Meta Mutation Damage Score

0.6467

Coding Region Coverage

1x: 99.4%
3x: 98.7%
10x: 97.0%
20x: 94.8%

Validation Efficiency

95% (40/42)

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts18	C	A	8: 114,469,749 (GRCm39)	R651L	probably damaging	Het
Amd1	T	C	10: 40,165,380 (GRCm39)	D317G	possibly damaging	Het
Artn	A	G	4: 117,784,815 (GRCm39)		probably benign	Het
Bub1b	T	A	2: 118,471,604 (GRCm39)	V988E	probably benign	Het
Cyp2c65	G	T	19: 39,061,662 (GRCm39)	C216F	probably benign	Het
Cyp3a11	T	C	5: 145,805,417 (GRCm39)	E200G	probably benign	Het
Cyp3a25	T	A	5: 145,923,652 (GRCm39)	K330N	probably damaging	Het
Duox2	C	A	2: 122,115,064 (GRCm39)	V1138L	probably benign	Het
Erc2	A	G	14: 27,733,651 (GRCm39)	D567G	probably damaging	Het
Eri2	A	G	7: 119,393,139 (GRCm39)		probably null	Het
Foxa3	A	G	7: 18,757,294 (GRCm39)	Y17H	probably damaging	Het
Fto	T	C	8: 92,200,940 (GRCm39)	S324P	probably damaging	Het
Get3	A	T	8: 85,751,893 (GRCm39)	M1K	probably null	Het
Gls2	T	G	10: 128,043,180 (GRCm39)	L457R	probably benign	Het
Gstcd	A	T	3: 132,692,169 (GRCm39)	L582H	probably damaging	Het
Gtf3c1	G	A	7: 125,246,786 (GRCm39)	R1508*	probably null	Het
Kif21a	T	C	15: 90,853,977 (GRCm39)		probably null	Het
Klra5	A	T	6: 129,883,577 (GRCm39)	D93E	possibly damaging	Het
Lgr5	T	C	10: 115,290,404 (GRCm39)	D456G	probably damaging	Het
Mau2	A	G	8: 70,483,305 (GRCm39)	S186P	probably damaging	Het
Msr1	T	C	8: 40,042,423 (GRCm39)	D384G	possibly damaging	Het
Ncf4	T	C	15: 78,137,503 (GRCm39)	V93A	probably damaging	Het
Oas1f	T	G	5: 120,994,489 (GRCm39)	C337G	probably damaging	Het
Or10al3	A	G	17: 38,011,932 (GRCm39)	M124V	probably damaging	Het
Or5p58	A	T	7: 107,694,429 (GRCm39)	F116Y	probably benign	Het
Or6c33	T	A	10: 129,853,872 (GRCm39)	L214H	probably damaging	Het
Pwwp3a	C	A	10: 80,074,713 (GRCm39)		probably null	Het
Rasl10b	T	C	11: 83,309,519 (GRCm39)	S159P	probably damaging	Het
Sephs1	A	G	2: 4,904,371 (GRCm39)	T250A	probably benign	Het
Smg8	C	A	11: 86,971,249 (GRCm39)	D841Y	probably damaging	Het
Sox7	T	C	14: 64,181,398 (GRCm39)	V65A	probably damaging	Het
Sp140	C	T	1: 85,547,772 (GRCm39)		probably benign	Het
Srsf10	A	G	4: 135,590,501 (GRCm39)	Y142C	possibly damaging	Het
Tcam1	G	A	11: 106,174,904 (GRCm39)	E120K	probably benign	Het
Tcerg1l	A	G	7: 137,878,384 (GRCm39)	V326A	probably benign	Het
Tmem108	T	C	9: 103,376,856 (GRCm39)	R198G	possibly damaging	Het
Ube2ql1	T	A	13: 69,887,017 (GRCm39)	Q148L	possibly damaging	Het
Vmn1r5	A	T	6: 56,962,570 (GRCm39)	I82L	probably benign	Het
Wdr6	A	T	9: 108,453,063 (GRCm39)	S273R	probably damaging	Het
Ylpm1	C	T	12: 85,043,850 (GRCm39)		probably benign	Het
Zfp90	G	A	8: 107,152,138 (GRCm39)	R617Q	possibly damaging	Het

Other mutations in Tcl1b5

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00932:Tcl1b5	APN	12	105,142,759 (GRCm39)	missense	probably benign	0.39
IGL01734:Tcl1b5	APN	12	105,145,214 (GRCm39)	missense	probably benign	0.08
IGL02545:Tcl1b5	APN	12	105,146,296 (GRCm39)	utr 3 prime	probably benign
IGL02948:Tcl1b5	APN	12	105,145,273 (GRCm39)	missense	probably benign	0.15
IGL03037:Tcl1b5	APN	12	105,145,273 (GRCm39)	missense	probably benign	0.15
R5424:Tcl1b5	UTSW	12	105,146,275 (GRCm39)	missense	possibly damaging	0.45
R6528:Tcl1b5	UTSW	12	105,145,258 (GRCm39)	missense	probably benign	0.43
R7033:Tcl1b5	UTSW	12	105,142,750 (GRCm39)	missense	probably damaging	1.00
R7651:Tcl1b5	UTSW	12	105,142,694 (GRCm39)	missense	possibly damaging	0.84
R7844:Tcl1b5	UTSW	12	105,142,815 (GRCm39)	critical splice donor site	probably null
R8127:Tcl1b5	UTSW	12	105,146,262 (GRCm39)	missense	probably benign	0.43
R8200:Tcl1b5	UTSW	12	105,145,212 (GRCm39)	missense	probably benign

Predicted Primers

PCR Primer
(F):5'- ACCCTGCTCCTAATGTACCGCTC -3'
(R):5'- GGAAGCATTACTTTCACACCTACACCA -3'

Sequencing Primer
(F):5'- CTCTCTGTTCCCTTCAGATTGAAAC -3'
(R):5'- ttcagtttgtctcatctcccc -3'

Posted On

2013-05-09