Incidental Mutation 'IGL02952:Or10ad1'
ID 364948
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10ad1
Ensembl Gene ENSMUSG00000090129
Gene Name olfactory receptor family 10 subfamily AD member 1
Synonyms MOR286-1, Olfr287, GA_x6K02T2NBG7-5548201-5549154
Accession Numbers
Essential gene? Probably non essential (E-score: 0.079) question?
Stock # IGL02952
Quality Score
Status
Chromosome 15
Chromosomal Location 98104852-98118937 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 98105470 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 265 (Y265C)
Ref Sequence ENSEMBL: ENSMUSP00000129271 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000142443] [ENSMUST00000170618]
AlphaFold E9PZS7
Predicted Effect noncoding transcript
Transcript: ENSMUST00000132068
Predicted Effect noncoding transcript
Transcript: ENSMUST00000141911
SMART Domains Protein: ENSMUSP00000121254
Gene: ENSMUSG00000090129

DomainStartEndE-ValueType
low complexity region 28 43 N/A INTRINSIC
Pfam:7tm_1 47 208 3.8e-26 PFAM
Pfam:7tm_4 145 212 6.3e-8 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142443
SMART Domains Protein: ENSMUSP00000119026
Gene: ENSMUSG00000075427

DomainStartEndE-ValueType
low complexity region 19 34 N/A INTRINSIC
Pfam:7tm_1 38 287 1.2e-32 PFAM
Pfam:7tm_4 136 280 3.9e-34 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000142443
Predicted Effect noncoding transcript
Transcript: ENSMUST00000145768
Predicted Effect noncoding transcript
Transcript: ENSMUST00000155603
SMART Domains Protein: ENSMUSP00000118682
Gene: ENSMUSG00000090129

DomainStartEndE-ValueType
Pfam:7tm_1 7 205 2.5e-30 PFAM
Pfam:7tm_4 105 209 4.5e-23 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000170618
AA Change: Y265C

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000129271
Gene: ENSMUSG00000090129
AA Change: Y265C

DomainStartEndE-ValueType
Pfam:7tm_4 37 313 1e-50 PFAM
Pfam:7tm_1 47 296 6e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206224
Predicted Effect noncoding transcript
Transcript: ENSMUST00000205339
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A T 6: 121,654,984 (GRCm39) D1436V probably damaging Het
Abca7 G T 10: 79,843,242 (GRCm39) R1239L probably damaging Het
Acp2 T C 2: 91,038,788 (GRCm39) probably benign Het
Adamts4 A G 1: 171,078,917 (GRCm39) N179S probably damaging Het
Adgrv1 T C 13: 81,581,755 (GRCm39) D4763G probably benign Het
Atp11b T C 3: 35,882,844 (GRCm39) V633A probably damaging Het
Cadm2 A T 16: 66,461,338 (GRCm39) I342K probably damaging Het
Capn10 T C 1: 92,872,896 (GRCm39) S541P probably damaging Het
Ccnf A G 17: 24,450,299 (GRCm39) L462P possibly damaging Het
Cdc27 T C 11: 104,408,290 (GRCm39) Y546C probably damaging Het
Cep120 G T 18: 53,816,300 (GRCm39) probably benign Het
Cetn2 T C X: 71,957,808 (GRCm39) probably null Het
Cyp1a1 C T 9: 57,609,993 (GRCm39) S469L probably benign Het
Dnah17 G A 11: 117,979,094 (GRCm39) T1766I probably benign Het
Doc2g G A 19: 4,056,719 (GRCm39) G345D possibly damaging Het
Dock4 T C 12: 40,760,902 (GRCm39) probably null Het
Dop1a T A 9: 86,414,975 (GRCm39) probably benign Het
Emilin2 C A 17: 71,587,816 (GRCm39) V99F probably damaging Het
Exoc8 A G 8: 125,624,275 (GRCm39) S31P probably benign Het
Gask1b T C 3: 79,793,646 (GRCm39) L38P probably damaging Het
Gm3115 T C 14: 4,084,302 (GRCm38) probably benign Het
Gm9742 T A 13: 8,079,930 (GRCm39) noncoding transcript Het
Gpr160 T C 3: 30,950,443 (GRCm39) Y172H probably benign Het
Ifnk T A 4: 35,152,495 (GRCm39) L141Q probably damaging Het
Klhl36 A G 8: 120,597,223 (GRCm39) E308G probably benign Het
Lrp1b T C 2: 41,396,715 (GRCm39) I450M probably benign Het
Noxa1 T C 2: 24,981,773 (GRCm39) Y110C probably damaging Het
Pkd2 A T 5: 104,628,026 (GRCm39) T367S possibly damaging Het
Polg2 T C 11: 106,663,539 (GRCm39) I385V possibly damaging Het
Ppp1r14bl A T 1: 23,141,071 (GRCm39) I81N probably damaging Het
Prr14l A G 5: 32,993,014 (GRCm39) S17P unknown Het
Prss22 C A 17: 24,215,697 (GRCm39) C75F probably damaging Het
Ptgs1 A G 2: 36,141,253 (GRCm39) K567E probably benign Het
Ptprz1 A G 6: 23,036,925 (GRCm39) I1141M probably damaging Het
R3hcc1l A G 19: 42,552,433 (GRCm39) K477E probably damaging Het
Riok1 A G 13: 38,232,866 (GRCm39) Y194C probably damaging Het
Smr2 T A 5: 88,236,095 (GRCm39) C16S possibly damaging Het
Stk25 A T 1: 93,553,798 (GRCm39) I187N probably damaging Het
Trhde T C 10: 114,636,478 (GRCm39) E243G probably damaging Het
Vmn2r3 T C 3: 64,186,256 (GRCm39) E143G probably damaging Het
Other mutations in Or10ad1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01368:Or10ad1 APN 15 98,105,381 (GRCm39) missense probably damaging 0.99
PIT4378001:Or10ad1 UTSW 15 98,105,452 (GRCm39) missense probably damaging 1.00
R1079:Or10ad1 UTSW 15 98,106,223 (GRCm39) missense probably damaging 0.98
R5932:Or10ad1 UTSW 15 98,105,296 (GRCm39) makesense probably null
R7839:Or10ad1 UTSW 15 98,106,026 (GRCm39) missense probably damaging 0.99
R8395:Or10ad1 UTSW 15 98,105,500 (GRCm39) missense probably benign 0.27
Posted On 2015-12-18