Incidental Mutation 'IGL02952:Gpr160'
ID 364949
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gpr160
Ensembl Gene ENSMUSG00000037661
Gene Name G protein-coupled receptor 160
Synonyms 1700025D19Rik
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # IGL02952
Quality Score
Status
Chromosome 3
Chromosomal Location 30910099-30951341 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 30950443 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 172 (Y172H)
Ref Sequence ENSEMBL: ENSMUSP00000128666 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000046624] [ENSMUST00000046748] [ENSMUST00000108258] [ENSMUST00000108259] [ENSMUST00000108261] [ENSMUST00000147697] [ENSMUST00000166278] [ENSMUST00000168645] [ENSMUST00000194979]
AlphaFold Q3U3F9
Predicted Effect probably benign
Transcript: ENSMUST00000046624
SMART Domains Protein: ENSMUSP00000037862
Gene: ENSMUSG00000037652

DomainStartEndE-ValueType
low complexity region 18 40 N/A INTRINSIC
low complexity region 72 89 N/A INTRINSIC
low complexity region 92 142 N/A INTRINSIC
low complexity region 152 166 N/A INTRINSIC
low complexity region 206 224 N/A INTRINSIC
low complexity region 333 359 N/A INTRINSIC
low complexity region 393 419 N/A INTRINSIC
low complexity region 512 538 N/A INTRINSIC
low complexity region 564 578 N/A INTRINSIC
low complexity region 583 594 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000046748
AA Change: Y172H

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000045165
Gene: ENSMUSG00000037661
AA Change: Y172H

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108258
AA Change: Y172H

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000103893
Gene: ENSMUSG00000037661
AA Change: Y172H

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108259
AA Change: Y172H

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000103894
Gene: ENSMUSG00000037661
AA Change: Y172H

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000108261
AA Change: Y172H

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000103896
Gene: ENSMUSG00000037661
AA Change: Y172H

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000147697
Predicted Effect probably benign
Transcript: ENSMUST00000166278
AA Change: Y172H

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000128666
Gene: ENSMUSG00000037661
AA Change: Y172H

DomainStartEndE-ValueType
transmembrane domain 20 42 N/A INTRINSIC
transmembrane domain 54 76 N/A INTRINSIC
transmembrane domain 96 118 N/A INTRINSIC
transmembrane domain 138 160 N/A INTRINSIC
transmembrane domain 185 207 N/A INTRINSIC
transmembrane domain 240 262 N/A INTRINSIC
transmembrane domain 277 294 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000168645
SMART Domains Protein: ENSMUSP00000130142
Gene: ENSMUSG00000037652

DomainStartEndE-ValueType
low complexity region 6 28 N/A INTRINSIC
low complexity region 60 77 N/A INTRINSIC
low complexity region 80 130 N/A INTRINSIC
low complexity region 140 154 N/A INTRINSIC
low complexity region 194 212 N/A INTRINSIC
low complexity region 321 347 N/A INTRINSIC
low complexity region 381 407 N/A INTRINSIC
low complexity region 500 526 N/A INTRINSIC
low complexity region 552 566 N/A INTRINSIC
low complexity region 571 601 N/A INTRINSIC
low complexity region 640 648 N/A INTRINSIC
low complexity region 658 686 N/A INTRINSIC
PDB:2L8E|A 775 811 7e-9 PDB
low complexity region 879 898 N/A INTRINSIC
SAM 914 980 1.6e-11 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000194979
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A2m A T 6: 121,654,984 (GRCm39) D1436V probably damaging Het
Abca7 G T 10: 79,843,242 (GRCm39) R1239L probably damaging Het
Acp2 T C 2: 91,038,788 (GRCm39) probably benign Het
Adamts4 A G 1: 171,078,917 (GRCm39) N179S probably damaging Het
Adgrv1 T C 13: 81,581,755 (GRCm39) D4763G probably benign Het
Atp11b T C 3: 35,882,844 (GRCm39) V633A probably damaging Het
Cadm2 A T 16: 66,461,338 (GRCm39) I342K probably damaging Het
Capn10 T C 1: 92,872,896 (GRCm39) S541P probably damaging Het
Ccnf A G 17: 24,450,299 (GRCm39) L462P possibly damaging Het
Cdc27 T C 11: 104,408,290 (GRCm39) Y546C probably damaging Het
Cep120 G T 18: 53,816,300 (GRCm39) probably benign Het
Cetn2 T C X: 71,957,808 (GRCm39) probably null Het
Cyp1a1 C T 9: 57,609,993 (GRCm39) S469L probably benign Het
Dnah17 G A 11: 117,979,094 (GRCm39) T1766I probably benign Het
Doc2g G A 19: 4,056,719 (GRCm39) G345D possibly damaging Het
Dock4 T C 12: 40,760,902 (GRCm39) probably null Het
Dop1a T A 9: 86,414,975 (GRCm39) probably benign Het
Emilin2 C A 17: 71,587,816 (GRCm39) V99F probably damaging Het
Exoc8 A G 8: 125,624,275 (GRCm39) S31P probably benign Het
Gask1b T C 3: 79,793,646 (GRCm39) L38P probably damaging Het
Gm3115 T C 14: 4,084,302 (GRCm38) probably benign Het
Gm9742 T A 13: 8,079,930 (GRCm39) noncoding transcript Het
Ifnk T A 4: 35,152,495 (GRCm39) L141Q probably damaging Het
Klhl36 A G 8: 120,597,223 (GRCm39) E308G probably benign Het
Lrp1b T C 2: 41,396,715 (GRCm39) I450M probably benign Het
Noxa1 T C 2: 24,981,773 (GRCm39) Y110C probably damaging Het
Or10ad1 T C 15: 98,105,470 (GRCm39) Y265C probably damaging Het
Pkd2 A T 5: 104,628,026 (GRCm39) T367S possibly damaging Het
Polg2 T C 11: 106,663,539 (GRCm39) I385V possibly damaging Het
Ppp1r14bl A T 1: 23,141,071 (GRCm39) I81N probably damaging Het
Prr14l A G 5: 32,993,014 (GRCm39) S17P unknown Het
Prss22 C A 17: 24,215,697 (GRCm39) C75F probably damaging Het
Ptgs1 A G 2: 36,141,253 (GRCm39) K567E probably benign Het
Ptprz1 A G 6: 23,036,925 (GRCm39) I1141M probably damaging Het
R3hcc1l A G 19: 42,552,433 (GRCm39) K477E probably damaging Het
Riok1 A G 13: 38,232,866 (GRCm39) Y194C probably damaging Het
Smr2 T A 5: 88,236,095 (GRCm39) C16S possibly damaging Het
Stk25 A T 1: 93,553,798 (GRCm39) I187N probably damaging Het
Trhde T C 10: 114,636,478 (GRCm39) E243G probably damaging Het
Vmn2r3 T C 3: 64,186,256 (GRCm39) E143G probably damaging Het
Other mutations in Gpr160
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00768:Gpr160 APN 3 30,950,098 (GRCm39) missense probably damaging 1.00
IGL01505:Gpr160 APN 3 30,950,002 (GRCm39) missense possibly damaging 0.90
R2259:Gpr160 UTSW 3 30,950,444 (GRCm39) missense probably damaging 0.99
R2416:Gpr160 UTSW 3 30,950,158 (GRCm39) missense probably benign 0.00
R4191:Gpr160 UTSW 3 30,950,863 (GRCm39) missense possibly damaging 0.65
R4688:Gpr160 UTSW 3 30,950,835 (GRCm39) missense probably benign 0.28
R5987:Gpr160 UTSW 3 30,950,612 (GRCm39) missense probably benign
R6209:Gpr160 UTSW 3 30,950,141 (GRCm39) missense possibly damaging 0.56
R6353:Gpr160 UTSW 3 30,950,171 (GRCm39) missense probably damaging 1.00
R7075:Gpr160 UTSW 3 30,950,926 (GRCm39) missense possibly damaging 0.52
R8261:Gpr160 UTSW 3 30,950,096 (GRCm39) missense probably benign 0.08
R8381:Gpr160 UTSW 3 30,949,930 (GRCm39) start codon destroyed probably null 0.99
R8785:Gpr160 UTSW 3 30,950,923 (GRCm39) missense probably damaging 1.00
R9273:Gpr160 UTSW 3 30,950,038 (GRCm39) missense probably benign 0.45
R9487:Gpr160 UTSW 3 30,950,914 (GRCm39) missense probably benign 0.44
R9728:Gpr160 UTSW 3 30,950,144 (GRCm39) missense probably damaging 0.96
Posted On 2015-12-18