Incidental Mutation 'IGL02953:Lypd11'
ID 364990
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Lypd11
Ensembl Gene ENSMUSG00000058717
Gene Name Ly6/PLAUR domain containing 11
Synonyms Gm4763
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # IGL02953
Quality Score
Status
Chromosome 7
Chromosomal Location 24414456-24426333 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 24422991 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 109 (C109Y)
Ref Sequence ENSEMBL: ENSMUSP00000145595 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000081657] [ENSMUST00000205376]
AlphaFold Q8CFJ5
Predicted Effect probably damaging
Transcript: ENSMUST00000081657
AA Change: C57Y

PolyPhen 2 Score 0.996 (Sensitivity: 0.55; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000080361
Gene: ENSMUSG00000058717
AA Change: C57Y

DomainStartEndE-ValueType
low complexity region 24 35 N/A INTRINSIC
Pfam:UPAR_LY6 88 165 1.2e-8 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000205376
AA Change: C109Y

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206243
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057N15Rik A G 16: 88,570,534 (GRCm39) S169P possibly damaging Het
Adap2 G A 11: 80,045,126 (GRCm39) G29R probably damaging Het
Adcy2 A T 13: 68,877,447 (GRCm39) I431N probably damaging Het
Amer3 T C 1: 34,626,877 (GRCm39) V372A probably damaging Het
Aspm T A 1: 139,385,157 (GRCm39) V267D probably benign Het
Atp6v0b A T 4: 117,742,419 (GRCm39) V111E probably damaging Het
Cep20 T C 16: 14,122,339 (GRCm39) K142E probably benign Het
Clmp T A 9: 40,685,683 (GRCm39) L193Q probably damaging Het
Dcaf7 T G 11: 105,942,702 (GRCm39) Y216* probably null Het
Dcbld2 T A 16: 58,272,100 (GRCm39) D385E probably benign Het
Des T A 1: 75,340,288 (GRCm39) D398E possibly damaging Het
Fancm C T 12: 65,168,740 (GRCm39) T1701I probably benign Het
Fat1 C A 8: 45,477,351 (GRCm39) D2132E probably damaging Het
Fkbp14 T C 6: 54,556,667 (GRCm39) K161R probably damaging Het
Fuca2 C T 10: 13,383,173 (GRCm39) probably benign Het
Habp2 T A 19: 56,302,664 (GRCm39) probably null Het
Hectd4 T A 5: 121,503,116 (GRCm39) Y4362N possibly damaging Het
Herc3 C T 6: 58,834,718 (GRCm39) Q242* probably null Het
Igkv4-81 T C 6: 68,967,981 (GRCm39) K40R probably benign Het
Irf5 C A 6: 29,536,671 (GRCm39) H461N possibly damaging Het
Nav2 G A 7: 49,198,171 (GRCm39) V1267M probably damaging Het
Nlk A G 11: 78,517,527 (GRCm39) V155A probably benign Het
Nup214 C T 2: 31,878,241 (GRCm39) H303Y possibly damaging Het
Pld1 A C 3: 28,166,396 (GRCm39) M812L probably benign Het
Rab11fip3 C A 17: 26,286,653 (GRCm39) R500L possibly damaging Het
Secisbp2l C T 2: 125,602,194 (GRCm39) E389K probably benign Het
Serpina3a C T 12: 104,082,748 (GRCm39) R174C probably benign Het
Spef2 T C 15: 9,713,329 (GRCm39) R405G possibly damaging Het
Srpx A T X: 9,983,706 (GRCm39) probably benign Het
St18 T A 1: 6,914,337 (GRCm39) probably benign Het
Tcerg1 C T 18: 42,681,535 (GRCm39) P561S probably damaging Het
Topbp1 T A 9: 103,205,634 (GRCm39) N757K probably benign Het
Trrap G T 5: 144,752,774 (GRCm39) L1782F probably damaging Het
Tut1 G T 19: 8,940,056 (GRCm39) V347L probably damaging Het
Txnip T A 3: 96,465,682 (GRCm39) V44D probably damaging Het
Usp8 C T 2: 126,579,857 (GRCm39) T369I probably benign Het
Zzef1 A G 11: 72,746,224 (GRCm39) N842S probably benign Het
Other mutations in Lypd11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00840:Lypd11 APN 7 24,422,931 (GRCm39) missense probably damaging 0.99
IGL03349:Lypd11 APN 7 24,422,261 (GRCm39) missense probably damaging 0.99
R0144:Lypd11 UTSW 7 24,423,015 (GRCm39) missense possibly damaging 0.85
R0485:Lypd11 UTSW 7 24,422,170 (GRCm39) missense possibly damaging 0.84
R0652:Lypd11 UTSW 7 24,423,622 (GRCm39) missense possibly damaging 0.96
R0899:Lypd11 UTSW 7 24,422,737 (GRCm39) missense probably benign 0.00
R0963:Lypd11 UTSW 7 24,423,047 (GRCm39) missense probably benign 0.00
R5290:Lypd11 UTSW 7 24,422,836 (GRCm39) missense probably benign 0.04
R6134:Lypd11 UTSW 7 24,425,481 (GRCm39) missense probably damaging 1.00
R7128:Lypd11 UTSW 7 24,425,424 (GRCm39) critical splice donor site probably null
R7191:Lypd11 UTSW 7 24,422,759 (GRCm39) missense possibly damaging 0.88
R9061:Lypd11 UTSW 7 24,422,173 (GRCm39) missense possibly damaging 0.96
X0062:Lypd11 UTSW 7 24,422,724 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18