Incidental Mutation 'IGL02953:Fopnl'
ID365008
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Fopnl
Ensembl Gene ENSMUSG00000022677
Gene NameFgfr1op N-terminal like
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.101) question?
Stock #IGL02953
Quality Score
Status
Chromosome16
Chromosomal Location14299244-14317405 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) T to C at 14304475 bp
ZygosityHeterozygous
Amino Acid Change Lysine to Glutamic Acid at position 142 (K142E)
Ref Sequence ENSEMBL: ENSMUSP00000023357 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023357] [ENSMUST00000120707]
Predicted Effect probably benign
Transcript: ENSMUST00000023357
AA Change: K142E

PolyPhen 2 Score 0.090 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000023357
Gene: ENSMUSG00000022677
AA Change: K142E

DomainStartEndE-ValueType
LisH 49 81 3.13e-4 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000120707
AA Change: E134G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000113348
Gene: ENSMUSG00000022677
AA Change: E134G

DomainStartEndE-ValueType
LisH 49 81 3.13e-4 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000148278
Predicted Effect noncoding transcript
Transcript: ENSMUST00000230495
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057N15Rik A G 16: 88,773,646 S169P possibly damaging Het
Adap2 G A 11: 80,154,300 G29R probably damaging Het
Adcy2 A T 13: 68,729,328 I431N probably damaging Het
Amer3 T C 1: 34,587,796 V372A probably damaging Het
Aspm T A 1: 139,457,419 V267D probably benign Het
Atp6v0b A T 4: 117,885,222 V111E probably damaging Het
Clmp T A 9: 40,774,387 L193Q probably damaging Het
Dcaf7 T G 11: 106,051,876 Y216* probably null Het
Dcbld2 T A 16: 58,451,737 D385E probably benign Het
Des T A 1: 75,363,644 D398E possibly damaging Het
Fancm C T 12: 65,121,966 T1701I probably benign Het
Fat1 C A 8: 45,024,314 D2132E probably damaging Het
Fkbp14 T C 6: 54,579,682 K161R probably damaging Het
Fuca2 C T 10: 13,507,429 probably benign Het
Gm4763 C T 7: 24,723,566 C109Y probably damaging Het
Habp2 T A 19: 56,314,232 probably null Het
Hectd4 T A 5: 121,365,053 Y4362N possibly damaging Het
Herc3 C T 6: 58,857,733 Q242* probably null Het
Igkv4-81 T C 6: 68,990,997 K40R probably benign Het
Irf5 C A 6: 29,536,672 H461N possibly damaging Het
Nav2 G A 7: 49,548,423 V1267M probably damaging Het
Nlk A G 11: 78,626,701 V155A probably benign Het
Nup214 C T 2: 31,988,229 H303Y possibly damaging Het
Pld1 A C 3: 28,112,247 M812L probably benign Het
Rab11fip3 C A 17: 26,067,679 R500L possibly damaging Het
Secisbp2l C T 2: 125,760,274 E389K probably benign Het
Serpina3a C T 12: 104,116,489 R174C probably benign Het
Spef2 T C 15: 9,713,243 R405G possibly damaging Het
Srpx A T X: 10,117,467 probably benign Het
St18 T A 1: 6,844,113 probably benign Het
Tcerg1 C T 18: 42,548,470 P561S probably damaging Het
Topbp1 T A 9: 103,328,435 N757K probably benign Het
Trrap G T 5: 144,815,964 L1782F probably damaging Het
Tut1 G T 19: 8,962,692 V347L probably damaging Het
Txnip T A 3: 96,558,366 V44D probably damaging Het
Usp8 C T 2: 126,737,937 T369I probably benign Het
Zzef1 A G 11: 72,855,398 N842S probably benign Het
Other mutations in Fopnl
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01532:Fopnl APN 16 14304511 missense probably benign 0.00
IGL02422:Fopnl APN 16 14300206 missense probably benign 0.06
R1459:Fopnl UTSW 16 14304516 missense possibly damaging 0.74
R1486:Fopnl UTSW 16 14300140 missense probably benign 0.17
R6399:Fopnl UTSW 16 14300145 frame shift probably null
R6609:Fopnl UTSW 16 14300145 frame shift probably null
R6610:Fopnl UTSW 16 14300145 frame shift probably null
R6612:Fopnl UTSW 16 14300145 frame shift probably null
R7382:Fopnl UTSW 16 14300145 frame shift probably null
R7383:Fopnl UTSW 16 14300145 frame shift probably null
Posted On2015-12-18