Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02954:Fkbp15'

365059

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Fkbp15

Ensembl Gene

ENSMUSG00000066151

Gene Name

FK506 binding protein 15

Synonyms

C430014M02Rik, FKBP133

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

IGL02954

Quality Score

Status

Chromosome

Chromosomal Location

62218579-62278785 bp(-) (GRCm39)

Type of Mutation

splice site

DNA Base Change (assembly)

A to G at 62239302 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000103085 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000084527] [ENSMUST00000084528] [ENSMUST00000098033] [ENSMUST00000107461]

AlphaFold

Q6P9Q6

Predicted Effect

probably benign
Transcript: ENSMUST00000084527

SMART Domains

Protein: ENSMUSP00000081575
Gene: ENSMUSG00000066151

Domain	Start	End	E-Value	Type
low complexity region	59	68	N/A	INTRINSIC
Pfam:FKBP_C	190	286	4.8e-21	PFAM
low complexity region	302	322	N/A	INTRINSIC
low complexity region	326	338	N/A	INTRINSIC
internal_repeat_1	403	431	1.88e-10	PROSPERO
internal_repeat_1	472	500	1.88e-10	PROSPERO
coiled coil region	560	662	N/A	INTRINSIC
coiled coil region	684	790	N/A	INTRINSIC
coiled coil region	816	865	N/A	INTRINSIC
coiled coil region	916	943	N/A	INTRINSIC
low complexity region	952	964	N/A	INTRINSIC
low complexity region	983	994	N/A	INTRINSIC
low complexity region	1034	1045	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000084528

SMART Domains

Protein: ENSMUSP00000081576
Gene: ENSMUSG00000066151

Domain	Start	End	E-Value	Type
low complexity region	59	68	N/A	INTRINSIC
Pfam:FKBP_C	190	286	2.4e-21	PFAM
low complexity region	302	322	N/A	INTRINSIC
low complexity region	326	338	N/A	INTRINSIC
internal_repeat_1	403	431	2.74e-10	PROSPERO
internal_repeat_1	472	500	2.74e-10	PROSPERO
coiled coil region	560	662	N/A	INTRINSIC
coiled coil region	684	745	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000098033

SMART Domains

Protein: ENSMUSP00000095641
Gene: ENSMUSG00000066151

Domain	Start	End	E-Value	Type
low complexity region	59	68	N/A	INTRINSIC
Pfam:FKBP_C	190	286	1.9e-21	PFAM
low complexity region	302	322	N/A	INTRINSIC
low complexity region	326	338	N/A	INTRINSIC
internal_repeat_1	403	431	1.79e-8	PROSPERO
internal_repeat_1	472	500	1.79e-8	PROSPERO
coiled coil region	560	608	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000107461

SMART Domains

Protein: ENSMUSP00000103085
Gene: ENSMUSG00000066151

Domain	Start	End	E-Value	Type
low complexity region	59	68	N/A	INTRINSIC
Pfam:FKBP_C	190	286	2e-21	PFAM
low complexity region	302	322	N/A	INTRINSIC
low complexity region	326	338	N/A	INTRINSIC
internal_repeat_1	403	431	1.86e-8	PROSPERO
internal_repeat_1	472	500	1.86e-8	PROSPERO
coiled coil region	560	608	N/A	INTRINSIC

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000139308

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 39 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcb1a	G	T	5: 8,782,341 (GRCm39)	R908L	probably benign	Het
Abcc9	T	C	6: 142,592,007 (GRCm39)	N774S	probably damaging	Het
Alpk2	C	T	18: 65,439,207 (GRCm39)	V729I	probably benign	Het
Atf3	T	C	1: 190,903,852 (GRCm39)	N125D	probably damaging	Het
Bcat1	C	T	6: 144,964,945 (GRCm39)	G215D	probably damaging	Het
Bptf	G	T	11: 106,945,575 (GRCm39)	Q2555K	possibly damaging	Het
Cthrc1	A	G	15: 38,940,389 (GRCm39)		probably benign	Het
Cyp2c38	A	G	19: 39,379,520 (GRCm39)	M443T	probably damaging	Het
D6Wsu163e	C	T	6: 126,951,441 (GRCm39)		probably benign	Het
Dgkg	T	A	16: 22,441,003 (GRCm39)	E3D	probably benign	Het
Dnah8	G	T	17: 30,923,809 (GRCm39)	R1259L	probably benign	Het
Dnah9	A	G	11: 66,009,793 (GRCm39)	L698P	probably damaging	Het
Ebag9	A	C	15: 44,493,601 (GRCm39)	H141P	probably benign	Het
Emilin2	T	C	17: 71,563,526 (GRCm39)	R840G	probably benign	Het
Faap100	A	T	11: 120,262,957 (GRCm39)	H800Q	probably damaging	Het
Fh1	A	T	1: 175,437,301 (GRCm39)	I266N	probably damaging	Het
Gm17334	A	G	11: 53,663,654 (GRCm39)		probably benign	Het
Gm5773	G	T	3: 93,680,358 (GRCm39)	W10L	probably benign	Het
Gng13	T	C	17: 25,937,726 (GRCm39)	Y18H	probably damaging	Het
Hivep3	T	C	4: 119,990,838 (GRCm39)	S2113P	probably damaging	Het
Ift81	A	T	5: 122,748,248 (GRCm39)		probably benign	Het
Irak3	A	C	10: 120,012,147 (GRCm39)	L206V	probably damaging	Het
Kcng4	C	T	8: 120,359,792 (GRCm39)	A195T	probably benign	Het
Lrrc40	G	A	3: 157,747,302 (GRCm39)		probably benign	Het
Nars2	T	G	7: 96,689,100 (GRCm39)		probably null	Het
Nol8	T	C	13: 49,814,648 (GRCm39)	V234A	probably benign	Het
Or12j4	A	T	7: 140,046,353 (GRCm39)	K80*	probably null	Het
Or1o4	T	A	17: 37,591,195 (GRCm39)	N39Y	probably damaging	Het
Patz1	A	G	11: 3,241,761 (GRCm39)	Y383C	probably damaging	Het
Pdcd5	T	C	7: 35,343,089 (GRCm39)	Y152C	probably damaging	Het
Phkg1	A	G	5: 129,894,910 (GRCm39)	W214R	probably damaging	Het
Plxna1	A	G	6: 89,301,649 (GRCm39)	L1459P	probably damaging	Het
Pspc1	G	A	14: 57,009,217 (GRCm39)	P206S	probably benign	Het
St7	A	T	6: 17,848,030 (GRCm39)	N198I	probably damaging	Het
Supt3	A	G	17: 45,349,015 (GRCm39)	D249G	probably damaging	Het
Taf1c	T	C	8: 120,327,225 (GRCm39)	Y418C	probably damaging	Het
Tdrd6	A	G	17: 43,938,153 (GRCm39)	V965A	possibly damaging	Het
Ugt2b35	A	G	5: 87,159,180 (GRCm39)	N458S	probably benign	Het
Vmn1r8	A	G	6: 57,013,315 (GRCm39)	Y122C	probably benign	Het

Other mutations in Fkbp15

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00659:Fkbp15	APN	4	62,251,917 (GRCm39)	splice site	probably benign
IGL01326:Fkbp15	APN	4	62,241,487 (GRCm39)	missense	probably damaging	0.98
IGL01822:Fkbp15	APN	4	62,270,741 (GRCm39)	missense	probably benign
IGL01925:Fkbp15	APN	4	62,241,450 (GRCm39)	missense	probably damaging	1.00
IGL02190:Fkbp15	APN	4	62,223,059 (GRCm39)	missense	possibly damaging	0.69
IGL02276:Fkbp15	APN	4	62,254,703 (GRCm39)	nonsense	probably null
IGL02310:Fkbp15	APN	4	62,258,553 (GRCm39)	missense	probably damaging	1.00
IGL02967:Fkbp15	APN	4	62,222,627 (GRCm39)	missense	probably damaging	0.96
IGL03136:Fkbp15	APN	4	62,258,466 (GRCm39)	splice site	probably benign
IGL03185:Fkbp15	APN	4	62,250,423 (GRCm39)	splice site	probably null
IGL03280:Fkbp15	APN	4	62,221,504 (GRCm39)	unclassified	probably benign
dura	UTSW	4	62,242,363 (GRCm39)	missense	probably damaging	0.96
mater	UTSW	4	62,244,373 (GRCm39)	missense	probably benign	0.22
R0419:Fkbp15	UTSW	4	62,244,373 (GRCm39)	missense	probably benign	0.22
R0838:Fkbp15	UTSW	4	62,242,363 (GRCm39)	missense	probably damaging	0.96
R1241:Fkbp15	UTSW	4	62,222,846 (GRCm39)	missense	possibly damaging	0.87
R1394:Fkbp15	UTSW	4	62,246,109 (GRCm39)	missense	probably benign	0.00
R1622:Fkbp15	UTSW	4	62,241,439 (GRCm39)	missense	possibly damaging	0.94
R1682:Fkbp15	UTSW	4	62,242,431 (GRCm39)	missense	probably damaging	0.98
R1823:Fkbp15	UTSW	4	62,255,328 (GRCm39)	missense	probably damaging	1.00
R1994:Fkbp15	UTSW	4	62,222,618 (GRCm39)	missense	probably benign	0.00
R2132:Fkbp15	UTSW	4	62,246,136 (GRCm39)	missense	probably damaging	1.00
R2133:Fkbp15	UTSW	4	62,246,136 (GRCm39)	missense	probably damaging	1.00
R2425:Fkbp15	UTSW	4	62,230,602 (GRCm39)	missense	probably benign	0.00
R2938:Fkbp15	UTSW	4	62,222,900 (GRCm39)	missense	probably benign	0.23
R3034:Fkbp15	UTSW	4	62,225,129 (GRCm39)	splice site	probably null
R3957:Fkbp15	UTSW	4	62,252,489 (GRCm39)	missense	probably benign	0.01
R3963:Fkbp15	UTSW	4	62,258,914 (GRCm39)	missense	probably damaging	1.00
R4235:Fkbp15	UTSW	4	62,254,693 (GRCm39)	missense	probably benign	0.38
R4334:Fkbp15	UTSW	4	62,221,456 (GRCm39)	missense	possibly damaging	0.95
R4366:Fkbp15	UTSW	4	62,254,651 (GRCm39)	missense	probably benign	0.38
R4717:Fkbp15	UTSW	4	62,226,306 (GRCm39)	missense	probably damaging	1.00
R4790:Fkbp15	UTSW	4	62,226,234 (GRCm39)	missense	probably benign	0.05
R5075:Fkbp15	UTSW	4	62,239,266 (GRCm39)	missense	probably damaging	0.96
R5176:Fkbp15	UTSW	4	62,230,560 (GRCm39)	missense	possibly damaging	0.68
R5419:Fkbp15	UTSW	4	62,246,114 (GRCm39)	missense	probably damaging	0.98
R5503:Fkbp15	UTSW	4	62,246,124 (GRCm39)	missense	probably benign	0.05
R5731:Fkbp15	UTSW	4	62,225,166 (GRCm39)	missense	probably benign	0.01
R5733:Fkbp15	UTSW	4	62,225,166 (GRCm39)	missense	probably benign	0.01
R5820:Fkbp15	UTSW	4	62,263,783 (GRCm39)	missense	probably benign	0.00
R5878:Fkbp15	UTSW	4	62,225,145 (GRCm39)	missense	probably benign
R5898:Fkbp15	UTSW	4	62,244,294 (GRCm39)	critical splice donor site	probably null
R5914:Fkbp15	UTSW	4	62,246,047 (GRCm39)	splice site	probably null
R6113:Fkbp15	UTSW	4	62,258,884 (GRCm39)	missense	probably benign	0.38
R6377:Fkbp15	UTSW	4	62,242,429 (GRCm39)	missense	probably damaging	1.00
R6427:Fkbp15	UTSW	4	62,241,439 (GRCm39)	missense	probably benign	0.01
R6464:Fkbp15	UTSW	4	62,226,315 (GRCm39)	missense	possibly damaging	0.92
R6528:Fkbp15	UTSW	4	62,250,507 (GRCm39)	missense	probably damaging	1.00
R6790:Fkbp15	UTSW	4	62,222,996 (GRCm39)	missense	probably benign	0.01
R6880:Fkbp15	UTSW	4	62,254,732 (GRCm39)	missense	possibly damaging	0.71
R6911:Fkbp15	UTSW	4	62,258,527 (GRCm39)	missense	probably damaging	1.00
R7371:Fkbp15	UTSW	4	62,239,293 (GRCm39)	missense	possibly damaging	0.89
R7410:Fkbp15	UTSW	4	62,258,536 (GRCm39)	missense	probably damaging	1.00
R7660:Fkbp15	UTSW	4	62,232,578 (GRCm39)	missense	probably benign	0.08
R7992:Fkbp15	UTSW	4	62,230,538 (GRCm39)	missense	probably damaging	1.00
R8486:Fkbp15	UTSW	4	62,230,521 (GRCm39)	nonsense	probably null
R8697:Fkbp15	UTSW	4	62,239,295 (GRCm39)	nonsense	probably null
R8880:Fkbp15	UTSW	4	62,232,602 (GRCm39)	missense	probably benign
R8998:Fkbp15	UTSW	4	62,242,365 (GRCm39)	missense	probably damaging	1.00
R9236:Fkbp15	UTSW	4	62,254,664 (GRCm39)	missense	probably damaging	0.97
R9382:Fkbp15	UTSW	4	62,237,210 (GRCm39)	missense	probably damaging	0.99
R9654:Fkbp15	UTSW	4	62,230,553 (GRCm39)	missense	probably benign	0.01
X0013:Fkbp15	UTSW	4	62,230,607 (GRCm39)	missense	probably benign	0.36

Posted On

2015-12-18