Incidental Mutation 'IGL02955:Or10am5'
ID 365089
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10am5
Ensembl Gene ENSMUSG00000048067
Gene Name olfactory receptor family 10 subfamily AM member 5
Synonyms Olfr1349, MOR232-8, GA_x6K02T2QGBW-3245761-3244808
Accession Numbers
Essential gene? Probably non essential (E-score: 0.062) question?
Stock # IGL02955
Quality Score
Status
Chromosome 7
Chromosomal Location 6517198-6523354 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 6517682 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 249 (T249A)
Ref Sequence ENSEMBL: ENSMUSP00000149880 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000051982] [ENSMUST00000207043] [ENSMUST00000207075] [ENSMUST00000207820] [ENSMUST00000213504] [ENSMUST00000213656] [ENSMUST00000216447]
AlphaFold Q7TQV1
Predicted Effect probably damaging
Transcript: ENSMUST00000051982
AA Change: T249A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000056639
Gene: ENSMUSG00000048067
AA Change: T249A

DomainStartEndE-ValueType
Pfam:7tm_4 40 317 1.9e-47 PFAM
Pfam:7tm_1 50 299 3.3e-18 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000122705
Predicted Effect probably benign
Transcript: ENSMUST00000207043
Predicted Effect probably benign
Transcript: ENSMUST00000207075
Predicted Effect probably damaging
Transcript: ENSMUST00000207820
AA Change: T249A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000213504
AA Change: T249A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000213656
AA Change: T249A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Predicted Effect probably damaging
Transcript: ENSMUST00000216447
AA Change: T249A

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 39 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abr T A 11: 76,309,991 (GRCm39) H840L probably damaging Het
Anks1 A G 17: 28,273,291 (GRCm39) D970G probably damaging Het
B4galnt4 A G 7: 140,644,591 (GRCm39) K162R probably null Het
Bicd2 T C 13: 49,531,691 (GRCm39) V311A probably benign Het
Cblif T C 19: 11,725,027 (GRCm39) L6P possibly damaging Het
Ccdc162 A G 10: 41,437,123 (GRCm39) L489P probably damaging Het
Cd55 G T 1: 130,377,219 (GRCm39) T38K probably damaging Het
Cep250 C A 2: 155,817,676 (GRCm39) A749E probably benign Het
Cntn3 G T 6: 102,255,262 (GRCm39) T212N probably damaging Het
Cntnap5c T A 17: 58,199,097 (GRCm39) probably benign Het
Dclre1c A G 2: 3,439,089 (GRCm39) E83G probably damaging Het
Dok4 T C 8: 95,592,256 (GRCm39) N244S probably damaging Het
Dync2h1 T C 9: 7,142,864 (GRCm39) T1151A probably benign Het
Fer G A 17: 64,298,712 (GRCm39) probably null Het
Hexb A G 13: 97,317,584 (GRCm39) probably benign Het
Ints5 T C 19: 8,875,014 (GRCm39) L991P probably damaging Het
Itga5 T C 15: 103,259,261 (GRCm39) D722G possibly damaging Het
Jup A G 11: 100,267,565 (GRCm39) I586T probably benign Het
Lig1 G A 7: 13,030,273 (GRCm39) G417R probably damaging Het
Lig4 A G 8: 10,022,103 (GRCm39) I559T possibly damaging Het
Mcm3ap A G 10: 76,343,300 (GRCm39) I1731V probably benign Het
Mfsd13a T G 19: 46,356,192 (GRCm39) V99G possibly damaging Het
Nelfcd A G 2: 174,264,391 (GRCm39) H153R probably damaging Het
Nlrp1b A G 11: 71,060,637 (GRCm39) Y724H possibly damaging Het
Npas3 C A 12: 53,548,048 (GRCm39) N101K probably damaging Het
Nuf2 A G 1: 169,334,807 (GRCm39) probably benign Het
Or11g7 C T 14: 50,691,442 (GRCm39) T311I probably damaging Het
Or5c1 A T 2: 37,222,013 (GRCm39) M85L probably benign Het
Polr3c A G 3: 96,621,628 (GRCm39) Y423H probably damaging Het
Pomgnt2 A G 9: 121,811,956 (GRCm39) L275P probably damaging Het
Ptprj T G 2: 90,298,808 (GRCm39) probably null Het
Pxdn T C 12: 30,053,156 (GRCm39) I931T probably damaging Het
Rad51b C T 12: 79,371,856 (GRCm39) Q190* probably null Het
Rpl10a T C 17: 28,547,967 (GRCm39) I36T probably damaging Het
Tagap1 T C 17: 7,223,781 (GRCm39) H305R probably damaging Het
Tmem154 A G 3: 84,591,508 (GRCm39) probably benign Het
Vil1 A G 1: 74,457,682 (GRCm39) E105G probably benign Het
Wdfy4 C A 14: 32,798,241 (GRCm39) C2055F probably damaging Het
Zfat T C 15: 68,052,963 (GRCm39) N277S probably damaging Het
Other mutations in Or10am5
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00917:Or10am5 APN 7 6,517,577 (GRCm39) missense probably damaging 1.00
IGL02350:Or10am5 APN 7 6,518,225 (GRCm39) missense probably damaging 1.00
IGL02357:Or10am5 APN 7 6,518,225 (GRCm39) missense probably damaging 1.00
R0593:Or10am5 UTSW 7 6,517,808 (GRCm39) missense probably benign 0.00
R2311:Or10am5 UTSW 7 6,517,741 (GRCm39) missense probably benign
R2396:Or10am5 UTSW 7 6,517,784 (GRCm39) missense probably damaging 0.98
R3699:Or10am5 UTSW 7 6,517,993 (GRCm39) missense probably damaging 0.99
R4095:Or10am5 UTSW 7 6,518,252 (GRCm39) missense possibly damaging 0.94
R5009:Or10am5 UTSW 7 6,517,546 (GRCm39) missense probably damaging 0.99
R6818:Or10am5 UTSW 7 6,517,550 (GRCm39) missense probably damaging 0.99
R7248:Or10am5 UTSW 7 6,517,520 (GRCm39) missense probably damaging 1.00
R7697:Or10am5 UTSW 7 6,517,645 (GRCm39) missense probably damaging 1.00
R7848:Or10am5 UTSW 7 6,517,861 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18