Incidental Mutation 'IGL02956:Mup4'
ID 365101
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Mup4
Ensembl Gene ENSMUSG00000041333
Gene Name major urinary protein 4
Synonyms Mup-4
Accession Numbers
Essential gene? Probably non essential (E-score: 0.055) question?
Stock # IGL02956
Quality Score
Status
Chromosome 4
Chromosomal Location 59956804-59960667 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 59959263 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glutamic Acid at position 77 (D77E)
Ref Sequence ENSEMBL: ENSMUSP00000075356 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000075973]
AlphaFold P11590
PDB Structure Major mouse urinary protein IV complexed with 2-sec-butyl-4,5-dihydrothiazole [X-RAY DIFFRACTION]
Major mouse urinary protein IV complexed with 2-heptanone [X-RAY DIFFRACTION]
Major mouse urinary protein IV complexed with 2-ethylhexanol [X-RAY DIFFRACTION]
Major mouse urinary protein IV complexed with 2,5-dimethylpyrazine [X-RAY DIFFRACTION]
Predicted Effect probably benign
Transcript: ENSMUST00000075973
AA Change: D77E

PolyPhen 2 Score 0.075 (Sensitivity: 0.93; Specificity: 0.85)
SMART Domains Protein: ENSMUSP00000075356
Gene: ENSMUSG00000041333
AA Change: D77E

DomainStartEndE-ValueType
signal peptide 1 16 N/A INTRINSIC
Pfam:Lipocalin 32 171 8.6e-38 PFAM
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts13 C T 2: 26,873,049 (GRCm39) A339V probably benign Het
Adck2 T C 6: 39,553,436 (GRCm39) V349A probably benign Het
Akna G T 4: 63,304,516 (GRCm39) T546K probably benign Het
Albfm1 A G 5: 90,727,497 (GRCm39) I372V possibly damaging Het
Ankrd29 T C 18: 12,393,993 (GRCm39) K274E probably damaging Het
Apc2 A T 10: 80,142,209 (GRCm39) N376I probably damaging Het
Cadps A G 14: 12,418,047 (GRCm38) probably benign Het
Cbl T C 9: 44,080,331 (GRCm39) T243A probably damaging Het
Cep15 A G 14: 12,287,326 (GRCm38) N29S probably benign Het
Cfap52 T C 11: 67,844,901 (GRCm39) E56G probably benign Het
Chd5 C A 4: 152,464,413 (GRCm39) P1561Q probably benign Het
Dscam A G 16: 96,602,472 (GRCm39) S657P probably damaging Het
Ece1 T C 4: 137,690,149 (GRCm39) F732L probably damaging Het
Eno2 T C 6: 124,740,082 (GRCm39) D199G probably damaging Het
Enpp3 A G 10: 24,650,841 (GRCm39) probably benign Het
Fbxl15 G T 19: 46,317,690 (GRCm39) C124F probably damaging Het
Fermt3 T C 19: 6,979,712 (GRCm39) S474G probably benign Het
Fkbp6 T C 5: 135,368,350 (GRCm39) E252G probably damaging Het
Gm6625 A T 8: 89,873,667 (GRCm39) noncoding transcript Het
Gnl1 T C 17: 36,298,504 (GRCm39) I416T probably benign Het
Gp1bb C A 16: 18,439,675 (GRCm39) A140S probably benign Het
Grin2c A G 11: 115,148,785 (GRCm39) V271A possibly damaging Het
Heatr1 T A 13: 12,430,940 (GRCm39) S1012T possibly damaging Het
Ighv5-6 T A 12: 113,589,523 (GRCm39) probably benign Het
Itga10 A G 3: 96,562,429 (GRCm39) E737G possibly damaging Het
Lmod2 A C 6: 24,603,631 (GRCm39) N202T probably damaging Het
Lrp1 C T 10: 127,380,428 (GRCm39) V3908I probably benign Het
Lrrtm4 T C 6: 79,998,633 (GRCm39) V15A probably benign Het
Myh7b A T 2: 155,474,823 (GRCm39) E1787V probably damaging Het
Myh7b T A 2: 155,467,874 (GRCm39) M804K possibly damaging Het
Nup133 T C 8: 124,675,822 (GRCm39) S32G probably benign Het
Or13c7d T A 4: 43,770,399 (GRCm39) N204I probably benign Het
Or52h1 T C 7: 103,829,334 (GRCm39) I94V probably damaging Het
Or7d10 T C 9: 19,832,348 (GRCm39) V281A possibly damaging Het
Or8b8 A G 9: 37,809,404 (GRCm39) K235E probably damaging Het
Polr2m T C 9: 71,390,911 (GRCm39) D97G possibly damaging Het
Pou2f3 A G 9: 43,054,100 (GRCm39) probably benign Het
Rex1bd C A 8: 70,958,552 (GRCm39) V72F possibly damaging Het
Rgp1 A G 4: 43,581,505 (GRCm39) T261A possibly damaging Het
Satb2 A G 1: 56,987,334 (GRCm39) F84L probably damaging Het
Sec14l1 G A 11: 117,043,973 (GRCm39) D494N probably benign Het
Spn G A 7: 126,736,432 (GRCm39) T25M probably damaging Het
Trp73 G A 4: 154,148,920 (GRCm39) probably benign Het
Tsc22d2 A G 3: 58,324,967 (GRCm39) T620A unknown Het
Zfp276 T C 8: 123,981,483 (GRCm39) L10P probably damaging Het
Zfp93 T A 7: 23,974,400 (GRCm39) N128K probably benign Het
Other mutations in Mup4
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01550:Mup4 APN 4 59,960,120 (GRCm39) missense probably damaging 1.00
IGL03017:Mup4 APN 4 59,957,890 (GRCm39) missense probably damaging 0.99
IGL03139:Mup4 APN 4 59,958,482 (GRCm39) splice site probably benign
IGL03282:Mup4 APN 4 59,958,547 (GRCm39) missense possibly damaging 0.56
marine UTSW 4 59,960,622 (GRCm39) unclassified probably benign
R1440:Mup4 UTSW 4 59,958,076 (GRCm39) missense probably damaging 1.00
R1462:Mup4 UTSW 4 59,960,084 (GRCm39) missense possibly damaging 0.91
R1462:Mup4 UTSW 4 59,960,084 (GRCm39) missense possibly damaging 0.91
R1721:Mup4 UTSW 4 59,960,598 (GRCm39) start codon destroyed probably null
R2067:Mup4 UTSW 4 59,960,622 (GRCm39) unclassified probably benign
R2302:Mup4 UTSW 4 59,960,702 (GRCm39) splice site probably null
R2403:Mup4 UTSW 4 59,958,145 (GRCm39) missense probably damaging 0.98
R3431:Mup4 UTSW 4 59,959,192 (GRCm39) splice site probably null
R4487:Mup4 UTSW 4 59,960,547 (GRCm39) missense probably damaging 0.98
R5028:Mup4 UTSW 4 59,958,124 (GRCm39) missense possibly damaging 0.69
R5208:Mup4 UTSW 4 59,958,119 (GRCm39) missense probably damaging 1.00
R5430:Mup4 UTSW 4 59,960,044 (GRCm39) missense probably damaging 0.98
R6255:Mup4 UTSW 4 59,957,890 (GRCm39) missense probably damaging 0.99
R6304:Mup4 UTSW 4 59,960,084 (GRCm39) missense possibly damaging 0.91
R6745:Mup4 UTSW 4 59,960,091 (GRCm39) missense possibly damaging 0.50
R7326:Mup4 UTSW 4 59,960,046 (GRCm39) missense possibly damaging 0.95
R7606:Mup4 UTSW 4 59,958,568 (GRCm39) missense probably damaging 1.00
R8733:Mup4 UTSW 4 59,958,587 (GRCm39) missense probably damaging 0.99
X0026:Mup4 UTSW 4 59,960,559 (GRCm39) missense possibly damaging 0.46
Posted On 2015-12-18