Incidental Mutation 'IGL02956:Zfp276'
ID 365117
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Zfp276
Ensembl Gene ENSMUSG00000001065
Gene Name zinc finger protein (C2H2 type) 276
Synonyms D8Ertd377e, D8Ertd370e
Accession Numbers
Essential gene? Probably non essential (E-score: 0.163) question?
Stock # IGL02956
Quality Score
Status
Chromosome 8
Chromosomal Location 123980934-123996484 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 123981483 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Proline at position 10 (L10P)
Ref Sequence ENSEMBL: ENSMUSP00000001092 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000001092] [ENSMUST00000117643] [ENSMUST00000118279] [ENSMUST00000122363] [ENSMUST00000127664] [ENSMUST00000154450] [ENSMUST00000155869]
AlphaFold Q8CE64
Predicted Effect probably damaging
Transcript: ENSMUST00000001092
AA Change: L10P

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000001092
Gene: ENSMUSG00000001065
AA Change: L10P

DomainStartEndE-ValueType
low complexity region 18 41 N/A INTRINSIC
low complexity region 59 72 N/A INTRINSIC
Pfam:zf-AD 79 159 1.2e-13 PFAM
low complexity region 402 422 N/A INTRINSIC
ZnF_C2H2 434 458 2.24e-3 SMART
ZnF_C2H2 465 490 6.67e-2 SMART
ZnF_C2H2 496 518 1.38e-3 SMART
ZnF_C2H2 524 546 1.82e-3 SMART
ZnF_C2H2 554 577 4.79e-3 SMART
low complexity region 586 602 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000117643
SMART Domains Protein: ENSMUSP00000113748
Gene: ENSMUSG00000001062

DomainStartEndE-ValueType
low complexity region 96 108 N/A INTRINSIC
coiled coil region 187 220 N/A INTRINSIC
low complexity region 266 279 N/A INTRINSIC
low complexity region 442 453 N/A INTRINSIC
Pfam:VPS9 528 645 8.5e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000118279
SMART Domains Protein: ENSMUSP00000113634
Gene: ENSMUSG00000001062

DomainStartEndE-ValueType
low complexity region 96 108 N/A INTRINSIC
coiled coil region 187 220 N/A INTRINSIC
low complexity region 266 279 N/A INTRINSIC
low complexity region 442 453 N/A INTRINSIC
Pfam:VPS9 528 645 1.2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000122363
SMART Domains Protein: ENSMUSP00000113575
Gene: ENSMUSG00000001062

DomainStartEndE-ValueType
low complexity region 96 108 N/A INTRINSIC
coiled coil region 187 220 N/A INTRINSIC
low complexity region 266 279 N/A INTRINSIC
low complexity region 442 453 N/A INTRINSIC
Pfam:VPS9 528 644 5.6e-27 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000127664
SMART Domains Protein: ENSMUSP00000118564
Gene: ENSMUSG00000092329

DomainStartEndE-ValueType
Pfam:Glycos_transf_2 104 287 7.4e-31 PFAM
Pfam:Glyco_transf_7C 261 331 4.9e-8 PFAM
RICIN 406 531 9.28e-27 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000129591
Predicted Effect unknown
Transcript: ENSMUST00000154450
AA Change: L10P
SMART Domains Protein: ENSMUSP00000119771
Gene: ENSMUSG00000001065
AA Change: L10P

DomainStartEndE-ValueType
low complexity region 18 41 N/A INTRINSIC
low complexity region 59 72 N/A INTRINSIC
Pfam:zf-AD 79 159 1.9e-14 PFAM
low complexity region 183 203 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000137569
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146136
Predicted Effect noncoding transcript
Transcript: ENSMUST00000150356
Predicted Effect noncoding transcript
Transcript: ENSMUST00000146158
Predicted Effect noncoding transcript
Transcript: ENSMUST00000149490
Predicted Effect noncoding transcript
Transcript: ENSMUST00000147312
Predicted Effect noncoding transcript
Transcript: ENSMUST00000211828
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156896
Predicted Effect noncoding transcript
Transcript: ENSMUST00000130275
Predicted Effect probably benign
Transcript: ENSMUST00000155869
SMART Domains Protein: ENSMUSP00000122184
Gene: ENSMUSG00000001062

DomainStartEndE-ValueType
low complexity region 96 108 N/A INTRINSIC
coiled coil region 187 223 N/A INTRINSIC
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 46 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adamts13 C T 2: 26,873,049 (GRCm39) A339V probably benign Het
Adck2 T C 6: 39,553,436 (GRCm39) V349A probably benign Het
Akna G T 4: 63,304,516 (GRCm39) T546K probably benign Het
Albfm1 A G 5: 90,727,497 (GRCm39) I372V possibly damaging Het
Ankrd29 T C 18: 12,393,993 (GRCm39) K274E probably damaging Het
Apc2 A T 10: 80,142,209 (GRCm39) N376I probably damaging Het
Cadps A G 14: 12,418,047 (GRCm38) probably benign Het
Cbl T C 9: 44,080,331 (GRCm39) T243A probably damaging Het
Cep15 A G 14: 12,287,326 (GRCm38) N29S probably benign Het
Cfap52 T C 11: 67,844,901 (GRCm39) E56G probably benign Het
Chd5 C A 4: 152,464,413 (GRCm39) P1561Q probably benign Het
Dscam A G 16: 96,602,472 (GRCm39) S657P probably damaging Het
Ece1 T C 4: 137,690,149 (GRCm39) F732L probably damaging Het
Eno2 T C 6: 124,740,082 (GRCm39) D199G probably damaging Het
Enpp3 A G 10: 24,650,841 (GRCm39) probably benign Het
Fbxl15 G T 19: 46,317,690 (GRCm39) C124F probably damaging Het
Fermt3 T C 19: 6,979,712 (GRCm39) S474G probably benign Het
Fkbp6 T C 5: 135,368,350 (GRCm39) E252G probably damaging Het
Gm6625 A T 8: 89,873,667 (GRCm39) noncoding transcript Het
Gnl1 T C 17: 36,298,504 (GRCm39) I416T probably benign Het
Gp1bb C A 16: 18,439,675 (GRCm39) A140S probably benign Het
Grin2c A G 11: 115,148,785 (GRCm39) V271A possibly damaging Het
Heatr1 T A 13: 12,430,940 (GRCm39) S1012T possibly damaging Het
Ighv5-6 T A 12: 113,589,523 (GRCm39) probably benign Het
Itga10 A G 3: 96,562,429 (GRCm39) E737G possibly damaging Het
Lmod2 A C 6: 24,603,631 (GRCm39) N202T probably damaging Het
Lrp1 C T 10: 127,380,428 (GRCm39) V3908I probably benign Het
Lrrtm4 T C 6: 79,998,633 (GRCm39) V15A probably benign Het
Mup4 A T 4: 59,959,263 (GRCm39) D77E probably benign Het
Myh7b A T 2: 155,474,823 (GRCm39) E1787V probably damaging Het
Myh7b T A 2: 155,467,874 (GRCm39) M804K possibly damaging Het
Nup133 T C 8: 124,675,822 (GRCm39) S32G probably benign Het
Or13c7d T A 4: 43,770,399 (GRCm39) N204I probably benign Het
Or52h1 T C 7: 103,829,334 (GRCm39) I94V probably damaging Het
Or7d10 T C 9: 19,832,348 (GRCm39) V281A possibly damaging Het
Or8b8 A G 9: 37,809,404 (GRCm39) K235E probably damaging Het
Polr2m T C 9: 71,390,911 (GRCm39) D97G possibly damaging Het
Pou2f3 A G 9: 43,054,100 (GRCm39) probably benign Het
Rex1bd C A 8: 70,958,552 (GRCm39) V72F possibly damaging Het
Rgp1 A G 4: 43,581,505 (GRCm39) T261A possibly damaging Het
Satb2 A G 1: 56,987,334 (GRCm39) F84L probably damaging Het
Sec14l1 G A 11: 117,043,973 (GRCm39) D494N probably benign Het
Spn G A 7: 126,736,432 (GRCm39) T25M probably damaging Het
Trp73 G A 4: 154,148,920 (GRCm39) probably benign Het
Tsc22d2 A G 3: 58,324,967 (GRCm39) T620A unknown Het
Zfp93 T A 7: 23,974,400 (GRCm39) N128K probably benign Het
Other mutations in Zfp276
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00726:Zfp276 APN 8 123,985,076 (GRCm39) missense probably benign 0.01
IGL02573:Zfp276 APN 8 123,991,736 (GRCm39) missense probably damaging 1.00
IGL02729:Zfp276 APN 8 123,994,555 (GRCm39) missense probably damaging 1.00
IGL03019:Zfp276 APN 8 123,994,673 (GRCm39) missense probably damaging 1.00
R0087:Zfp276 UTSW 8 123,991,786 (GRCm39) missense probably damaging 1.00
R0386:Zfp276 UTSW 8 123,986,242 (GRCm39) nonsense probably null
R1084:Zfp276 UTSW 8 123,981,462 (GRCm39) missense probably damaging 0.99
R4199:Zfp276 UTSW 8 123,994,564 (GRCm39) missense probably damaging 1.00
R4506:Zfp276 UTSW 8 123,991,666 (GRCm39) critical splice donor site probably null
R4584:Zfp276 UTSW 8 123,995,145 (GRCm39) utr 3 prime probably benign
R4776:Zfp276 UTSW 8 123,981,623 (GRCm39) missense probably benign
R4985:Zfp276 UTSW 8 123,994,646 (GRCm39) missense probably damaging 1.00
R5017:Zfp276 UTSW 8 123,991,716 (GRCm39) unclassified probably benign
R5018:Zfp276 UTSW 8 123,991,716 (GRCm39) unclassified probably benign
R5115:Zfp276 UTSW 8 123,991,716 (GRCm39) unclassified probably benign
R5116:Zfp276 UTSW 8 123,991,716 (GRCm39) unclassified probably benign
R5412:Zfp276 UTSW 8 123,982,520 (GRCm39) missense probably damaging 1.00
R5436:Zfp276 UTSW 8 123,992,021 (GRCm39) unclassified probably benign
R5822:Zfp276 UTSW 8 123,982,457 (GRCm39) missense probably benign
R6059:Zfp276 UTSW 8 123,994,562 (GRCm39) missense probably damaging 1.00
R6186:Zfp276 UTSW 8 123,982,672 (GRCm39) nonsense probably null
R6947:Zfp276 UTSW 8 123,981,643 (GRCm39) missense probably benign
R6975:Zfp276 UTSW 8 123,983,570 (GRCm39) nonsense probably null
R7313:Zfp276 UTSW 8 123,994,562 (GRCm39) missense probably damaging 1.00
R9055:Zfp276 UTSW 8 123,985,109 (GRCm39) missense probably damaging 1.00
Posted On 2015-12-18