Incidental Mutation 'IGL02961:Or10q3'
ID 365346
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Or10q3
Ensembl Gene ENSMUSG00000067545
Gene Name olfactory receptor family 10 subfamily Q member 3
Synonyms GA_x6K02T2RE5P-2222521-2221490, Olfr1419, MOR266-10
Accession Numbers
Essential gene? Probably non essential (E-score: 0.056) question?
Stock # IGL02961
Quality Score
Status
Chromosome 19
Chromosomal Location 11847510-11848669 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 11847695 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Asparagine to Isoleucine at position 295 (N295I)
Ref Sequence ENSEMBL: ENSMUSP00000148848 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000087857] [ENSMUST00000213954] [ENSMUST00000217617]
AlphaFold Q7TQS2
Predicted Effect probably damaging
Transcript: ENSMUST00000087857
AA Change: N295I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000085163
Gene: ENSMUSG00000067545
AA Change: N295I

DomainStartEndE-ValueType
Pfam:7tm_4 31 309 3.8e-55 PFAM
Pfam:7tm_1 41 291 2.8e-22 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000213954
AA Change: N295I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Predicted Effect probably damaging
Transcript: ENSMUST00000217617
AA Change: N295I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adgrv1 A G 13: 81,671,731 (GRCm39) V2288A probably damaging Het
Agbl4 T A 4: 110,437,318 (GRCm39) N76K probably damaging Het
AI182371 A T 2: 34,976,124 (GRCm39) V258E possibly damaging Het
Alg1 T A 16: 5,052,861 (GRCm39) N80K probably benign Het
Ambra1 A G 2: 91,741,793 (GRCm39) M963V possibly damaging Het
Avil C A 10: 126,844,175 (GRCm39) Q245K probably benign Het
Caml A G 13: 55,779,695 (GRCm39) N256S probably benign Het
Ccdc102a A C 8: 95,629,978 (GRCm39) I521S possibly damaging Het
Ccm2l A G 2: 152,920,521 (GRCm39) T393A probably benign Het
Cdh16 A G 8: 105,341,837 (GRCm39) V91A probably damaging Het
Chd7 A G 4: 8,751,542 (GRCm39) D13G probably damaging Het
Chsy1 T A 7: 65,821,530 (GRCm39) D588E probably benign Het
Cilp T A 9: 65,185,891 (GRCm39) V662E possibly damaging Het
Cog8 A G 8: 107,782,885 (GRCm39) probably benign Het
Cpb2 T C 14: 75,502,823 (GRCm39) V134A probably benign Het
Ctcfl T A 2: 172,943,712 (GRCm39) H546L possibly damaging Het
Dclre1c A G 2: 3,438,070 (GRCm39) D136G probably damaging Het
Dnah2 T A 11: 69,409,240 (GRCm39) E379D probably damaging Het
Extl3 A G 14: 65,294,408 (GRCm39) Y808H possibly damaging Het
Gm7247 T A 14: 51,602,812 (GRCm39) N49K probably damaging Het
Insr T C 8: 3,308,785 (GRCm39) I84V probably benign Het
Ipo7 C T 7: 109,646,223 (GRCm39) P541S probably benign Het
Kcnc3 T C 7: 44,240,916 (GRCm39) S203P probably damaging Het
Myo5a A G 9: 75,122,402 (GRCm39) D1732G probably benign Het
Or52d1 C A 7: 103,756,357 (GRCm39) Y290* probably null Het
Or5p68 T C 7: 107,945,334 (GRCm39) I285V probably benign Het
Or5w22 A G 2: 87,363,028 (GRCm39) Y217C probably damaging Het
Or6x1 T C 9: 40,098,897 (GRCm39) V162A probably benign Het
Pde3a T A 6: 141,405,426 (GRCm39) L426* probably null Het
Pkd1 T A 17: 24,797,089 (GRCm39) D8E possibly damaging Het
Polr3a A T 14: 24,517,108 (GRCm39) Y714* probably null Het
Pramel16 T C 4: 143,675,717 (GRCm39) T370A probably damaging Het
Prb1c A T 6: 132,338,371 (GRCm39) F282L unknown Het
Rasgrf1 T C 9: 89,863,702 (GRCm39) V556A possibly damaging Het
Rev3l T C 10: 39,703,941 (GRCm39) Y1996H possibly damaging Het
Rttn T C 18: 89,071,697 (GRCm39) L1248P probably damaging Het
Slc11a1 T C 1: 74,416,332 (GRCm39) L53P probably damaging Het
Slc22a27 T C 19: 7,903,886 (GRCm39) R84G probably damaging Het
Sptbn4 A G 7: 27,097,392 (GRCm39) L1302P probably damaging Het
Srm T C 4: 148,678,586 (GRCm39) V271A possibly damaging Het
Sycp2 A G 2: 178,022,655 (GRCm39) I492T probably benign Het
Tmprss13 A G 9: 45,256,301 (GRCm39) T472A probably damaging Het
Togaram1 A G 12: 65,013,484 (GRCm39) D245G probably damaging Het
Vmn1r184 A T 7: 25,967,075 (GRCm39) I274L probably benign Het
Vmn1r21 T C 6: 57,820,974 (GRCm39) M157V probably benign Het
Wdr90 C A 17: 26,067,649 (GRCm39) E1420* probably null Het
Zfp518a A T 19: 40,903,462 (GRCm39) R1130S probably benign Het
Other mutations in Or10q3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01845:Or10q3 APN 19 11,847,888 (GRCm39) missense probably benign 0.05
IGL01979:Or10q3 APN 19 11,848,587 (GRCm39) splice site probably benign
R0285:Or10q3 UTSW 19 11,848,502 (GRCm39) missense probably damaging 0.97
R0347:Or10q3 UTSW 19 11,847,797 (GRCm39) missense probably damaging 1.00
R1577:Or10q3 UTSW 19 11,847,741 (GRCm39) missense probably damaging 1.00
R2391:Or10q3 UTSW 19 11,848,180 (GRCm39) nonsense probably null
R3977:Or10q3 UTSW 19 11,847,869 (GRCm39) missense possibly damaging 0.82
R4660:Or10q3 UTSW 19 11,848,412 (GRCm39) missense possibly damaging 0.64
R5201:Or10q3 UTSW 19 11,847,995 (GRCm39) missense probably benign 0.21
R5995:Or10q3 UTSW 19 11,848,226 (GRCm39) missense possibly damaging 0.89
R6393:Or10q3 UTSW 19 11,848,091 (GRCm39) missense probably damaging 1.00
R7466:Or10q3 UTSW 19 11,847,680 (GRCm39) missense possibly damaging 0.94
R7828:Or10q3 UTSW 19 11,848,169 (GRCm39) missense probably damaging 1.00
R8400:Or10q3 UTSW 19 11,848,578 (GRCm39) start codon destroyed probably damaging 0.96
R9644:Or10q3 UTSW 19 11,848,574 (GRCm39) missense probably benign 0.01
Posted On 2015-12-18