Incidental Mutation 'IGL02963:Gm4788'
ID365416
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Gm4788
Ensembl Gene ENSMUSG00000070594
Gene Namepredicted gene 4788
Synonyms
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.074) question?
Stock #IGL02963
Quality Score
Status
Chromosome1
Chromosomal Location139697623-139781243 bp(-) (GRCm38)
Type of Mutationnonsense
DNA Base Change (assembly) G to A at 139731596 bp
ZygosityHeterozygous
Amino Acid Change Glutamine to Stop codon at position 732 (Q732*)
Ref Sequence ENSEMBL: ENSMUSP00000107620 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027612] [ENSMUST00000111986] [ENSMUST00000111989]
Predicted Effect probably null
Transcript: ENSMUST00000027612
AA Change: Q661*
SMART Domains Protein: ENSMUSP00000027612
Gene: ENSMUSG00000070594
AA Change: Q661*

DomainStartEndE-ValueType
CCP 28 88 1.65e-2 SMART
CCP 92 145 1.15e-10 SMART
CCP 151 208 5.65e-10 SMART
CCP 212 267 1.12e-4 SMART
CCP 272 325 4.52e-9 SMART
CCP 332 386 9.1e-14 SMART
CCP 393 446 1.58e-13 SMART
CCP 455 505 4.92e-1 SMART
CCP 511 564 8.9e-8 SMART
CCP 569 622 4.18e-13 SMART
CCP 627 681 3.5e-15 SMART
CCP 688 742 5.69e-15 SMART
CCP 746 807 2.77e0 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000111986
SMART Domains Protein: ENSMUSP00000107617
Gene: ENSMUSG00000070594

DomainStartEndE-ValueType
CCP 28 88 1.65e-2 SMART
CCP 92 145 1.15e-10 SMART
CCP 151 208 5.65e-10 SMART
CCP 212 267 1.12e-4 SMART
CCP 272 325 4.52e-9 SMART
CCP 333 387 9.1e-14 SMART
CCP 394 447 1.58e-13 SMART
CCP 456 506 4.92e-1 SMART
CCP 512 565 8.9e-8 SMART
CCP 571 635 2.66e-6 SMART
CCP 640 693 4.18e-13 SMART
CCP 700 754 5.69e-15 SMART
CCP 758 819 2.77e0 SMART
Predicted Effect probably null
Transcript: ENSMUST00000111989
AA Change: Q732*
SMART Domains Protein: ENSMUSP00000107620
Gene: ENSMUSG00000070594
AA Change: Q732*

DomainStartEndE-ValueType
CCP 28 88 1.65e-2 SMART
CCP 92 145 1.15e-10 SMART
CCP 151 208 5.65e-10 SMART
CCP 212 267 1.12e-4 SMART
CCP 272 325 4.52e-9 SMART
CCP 333 387 9.1e-14 SMART
CCP 394 447 1.58e-13 SMART
CCP 456 506 4.92e-1 SMART
CCP 512 565 8.9e-8 SMART
CCP 571 635 2.66e-6 SMART
CCP 640 693 4.18e-13 SMART
CCP 698 752 3.5e-15 SMART
CCP 759 813 5.69e-15 SMART
CCP 817 878 2.77e0 SMART
Coding Region Coverage
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 47 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca3 T A 17: 24,384,529 L565Q probably damaging Het
Ap1b1 G T 11: 5,033,738 A664S possibly damaging Het
Arhgap44 A T 11: 65,031,663 I348N probably damaging Het
Bahcc1 T C 11: 120,274,932 S1005P possibly damaging Het
Cdh20 T A 1: 104,934,098 M1K probably null Het
Cpsf3 T C 12: 21,302,422 S387P probably damaging Het
Cyp2j6 T C 4: 96,518,184 E450G probably damaging Het
Cyr61 A G 3: 145,647,875 Y311H probably damaging Het
Dusp13 T C 14: 21,733,807 T147A possibly damaging Het
Eif3c T C 7: 126,556,820 T493A probably benign Het
Ell2 T C 13: 75,769,643 V564A possibly damaging Het
Gtf2ird1 T G 5: 134,389,687 E478D probably benign Het
Gys2 A T 6: 142,449,428 probably null Het
H2-T3 T C 17: 36,189,634 T104A probably damaging Het
Herc1 T C 9: 66,388,823 S567P probably damaging Het
Kcnq3 A T 15: 66,285,826 probably benign Het
Kdm7a T C 6: 39,143,230 H935R probably damaging Het
Lcat A T 8: 105,939,956 F311L probably damaging Het
Manf A G 9: 106,891,139 S49P possibly damaging Het
Med25 T C 7: 44,892,256 K37E probably damaging Het
Ms4a4b T A 19: 11,454,698 I61K probably damaging Het
Muc5b T C 7: 141,864,264 I3649T probably damaging Het
Myo18a T G 11: 77,842,018 probably benign Het
Ncoa4 T C 14: 32,176,509 C429R probably damaging Het
Olfr113 A G 17: 37,574,854 S190P probably benign Het
Pigk G T 3: 152,766,461 E337* probably null Het
Pigz A T 16: 31,944,535 Y137F probably damaging Het
Ppp1r12b A G 1: 134,886,548 L339P probably damaging Het
Rasa2 C A 9: 96,570,785 L349F probably damaging Het
Reep4 A G 14: 70,547,970 S186G possibly damaging Het
Rfx7 A G 9: 72,617,616 K696R probably benign Het
Rnf220 A G 4: 117,490,192 F8L probably damaging Het
Rprm T C 2: 54,085,214 T31A probably benign Het
Sez6 T A 11: 77,962,949 L148Q possibly damaging Het
Sh2d6 C T 6: 72,517,601 V96I probably benign Het
Slc16a9 G T 10: 70,267,136 V81F probably damaging Het
Slc9a9 T A 9: 95,020,714 probably null Het
Sppl3 T A 5: 115,061,603 L22Q probably damaging Het
Ssc5d T C 7: 4,944,327 S1227P probably benign Het
Tbc1d1 T A 5: 64,264,366 V238E probably damaging Het
Tmco6 G A 18: 36,738,745 probably null Het
Tyr A G 7: 87,483,997 V287A probably benign Het
Uvrag A T 7: 98,906,490 probably null Het
Vmn1r167 A G 7: 23,505,550 S14P possibly damaging Het
Vmn1r171 A G 7: 23,632,688 T113A possibly damaging Het
Wnk4 A G 11: 101,276,213 probably benign Het
Zan T C 5: 137,456,250 T1431A unknown Het
Other mutations in Gm4788
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00906:Gm4788 APN 1 139731574 missense probably damaging 0.99
IGL01088:Gm4788 APN 1 139698085 utr 3 prime probably benign
IGL01419:Gm4788 APN 1 139739644 critical splice acceptor site probably null
IGL01552:Gm4788 APN 1 139739302 missense probably damaging 1.00
IGL01924:Gm4788 APN 1 139739206 missense probably damaging 0.99
IGL02032:Gm4788 APN 1 139774546 missense probably damaging 1.00
IGL02254:Gm4788 APN 1 139733405 splice site probably benign
IGL02318:Gm4788 APN 1 139781097 missense probably benign 0.20
IGL02527:Gm4788 APN 1 139753045 missense probably damaging 1.00
IGL02531:Gm4788 APN 1 139774569 missense probably benign 0.10
IGL02587:Gm4788 APN 1 139701930 missense probably damaging 1.00
IGL02644:Gm4788 APN 1 139781167 start codon destroyed probably null 0.63
IGL02852:Gm4788 APN 1 139774016 missense probably damaging 1.00
IGL03084:Gm4788 APN 1 139781142 missense possibly damaging 0.94
R0131:Gm4788 UTSW 1 139754271 missense probably damaging 0.98
R0131:Gm4788 UTSW 1 139754271 missense probably damaging 0.98
R0132:Gm4788 UTSW 1 139754271 missense probably damaging 0.98
R0549:Gm4788 UTSW 1 139739488 missense probably damaging 1.00
R0558:Gm4788 UTSW 1 139739492 missense probably damaging 0.99
R0610:Gm4788 UTSW 1 139701846 missense probably benign 0.20
R1341:Gm4788 UTSW 1 139732393 missense probably damaging 0.98
R1460:Gm4788 UTSW 1 139698196 missense probably damaging 0.99
R1544:Gm4788 UTSW 1 139736870 missense probably damaging 1.00
R1873:Gm4788 UTSW 1 139774660 missense probably damaging 0.97
R2032:Gm4788 UTSW 1 139733255 splice site probably benign
R2111:Gm4788 UTSW 1 139774679 splice site probably benign
R2179:Gm4788 UTSW 1 139731541 missense probably damaging 1.00
R3806:Gm4788 UTSW 1 139753035 missense probably damaging 1.00
R4356:Gm4788 UTSW 1 139732310 missense probably damaging 1.00
R4747:Gm4788 UTSW 1 139698184 missense probably damaging 1.00
R4838:Gm4788 UTSW 1 139733443 missense probably damaging 1.00
R4867:Gm4788 UTSW 1 139774475 critical splice donor site probably null
R4910:Gm4788 UTSW 1 139774563 missense probably damaging 1.00
R4911:Gm4788 UTSW 1 139774563 missense probably damaging 1.00
R5050:Gm4788 UTSW 1 139736840 missense probably damaging 0.99
R5120:Gm4788 UTSW 1 139753103 missense probably benign 0.39
R5259:Gm4788 UTSW 1 139740495 missense probably damaging 1.00
R5504:Gm4788 UTSW 1 139701820 missense probably benign 0.18
R5825:Gm4788 UTSW 1 139774598 synonymous probably null
R5949:Gm4788 UTSW 1 139733149 missense probably damaging 0.98
R6140:Gm4788 UTSW 1 139732395 missense probably damaging 1.00
R6200:Gm4788 UTSW 1 139754335 missense probably damaging 0.97
R6254:Gm4788 UTSW 1 139754390 missense probably damaging 0.98
R6255:Gm4788 UTSW 1 139753011 nonsense probably null
R6334:Gm4788 UTSW 1 139773924 unclassified probably null
R6611:Gm4788 UTSW 1 139732390 missense probably damaging 1.00
R6798:Gm4788 UTSW 1 139698121 missense probably benign 0.20
R6800:Gm4788 UTSW 1 139701981 missense possibly damaging 0.85
R6895:Gm4788 UTSW 1 139740472 missense possibly damaging 0.84
R6904:Gm4788 UTSW 1 139731653 missense possibly damaging 0.79
R6994:Gm4788 UTSW 1 139736930 missense possibly damaging 0.67
R7173:Gm4788 UTSW 1 139731677 nonsense probably null
R7184:Gm4788 UTSW 1 139733084 missense possibly damaging 0.65
R7192:Gm4788 UTSW 1 139739295 missense probably damaging 0.96
R7205:Gm4788 UTSW 1 139753050 nonsense probably null
R7308:Gm4788 UTSW 1 139754303 missense possibly damaging 0.71
X0009:Gm4788 UTSW 1 139733549 missense probably benign 0.08
X0024:Gm4788 UTSW 1 139733509 missense probably damaging 1.00
Z1088:Gm4788 UTSW 1 139754261 missense probably damaging 0.99
Posted On2015-12-18