Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02964:Zfp747'

365471

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Zfp747

Ensembl Gene

ENSMUSG00000054381

Gene Name

zinc finger protein 747

Synonyms

6430604K15Rik

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.132) question?

Stock #

IGL02964

Quality Score

Status

Chromosome

Chromosomal Location

126971709-126975222 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 126973666 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Glutamic Acid to Glycine at position 168 (E168G)

Ref Sequence

ENSEMBL: ENSMUSP00000070685 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000067425] [ENSMUST00000205832]

AlphaFold

Q8BHM7

Predicted Effect

probably benign
Transcript: ENSMUST00000067425
AA Change: E168G

PolyPhen 2 Score 0.208 (Sensitivity: 0.92; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000070685
Gene: ENSMUSG00000054381
AA Change: E168G

Domain	Start	End	E-Value	Type
KRAB	22	82	3.64e-26	SMART
low complexity region	102	115	N/A	INTRINSIC
ZnF_C2H2	152	174	3.63e-3	SMART
ZnF_C2H2	180	202	1.47e-3	SMART
ZnF_C2H2	208	230	6.42e-4	SMART
ZnF_C2H2	236	258	3.63e-3	SMART
ZnF_C2H2	264	286	1.13e-4	SMART
ZnF_C2H2	292	314	1.45e-2	SMART
ZnF_C2H2	320	342	1.5e-4	SMART
ZnF_C2H2	348	371	2.49e-1	SMART
ZnF_C2H2	377	399	3.69e-4	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000205832

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000206942

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 46 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc3	T	C	11: 94,242,636 (GRCm39)	I1364V	possibly damaging	Het
Adamts19	T	A	18: 59,122,037 (GRCm39)	I813K	probably damaging	Het
Adamtsl1	G	T	4: 86,342,594 (GRCm39)	C1703F	probably damaging	Het
Atp2b4	T	A	1: 133,658,303 (GRCm39)	T536S	probably damaging	Het
Capg	T	A	6: 72,539,827 (GRCm39)	I340N	probably damaging	Het
Casc3	T	A	11: 98,719,749 (GRCm39)	M567K	probably damaging	Het
Chmp1a	T	C	8: 123,934,806 (GRCm39)	E50G	probably damaging	Het
Cryba1	T	C	11: 77,610,207 (GRCm39)		probably benign	Het
Dnah8	T	A	17: 30,965,735 (GRCm39)	Y2356N	probably damaging	Het
Ercc6	T	G	14: 32,292,060 (GRCm39)	S1141R	probably benign	Het
Exd2	T	A	12: 80,527,302 (GRCm39)	V165D	probably damaging	Het
Fbln1	A	T	15: 85,115,663 (GRCm39)	E233V	probably damaging	Het
Ftsj3	T	C	11: 106,143,163 (GRCm39)	K384E	probably damaging	Het
Ggt5	A	G	10: 75,439,962 (GRCm39)	I188V	probably benign	Het
Gm42742	A	T	7: 126,616,018 (GRCm39)	S26T	probably damaging	Het
Gucy1a2	T	A	9: 3,759,542 (GRCm39)	D449E	probably damaging	Het
Igfbp7	C	T	5: 77,499,188 (GRCm39)	S239N	possibly damaging	Het
Klf11	C	T	12: 24,705,626 (GRCm39)	A360V	probably damaging	Het
Kmt2e	T	A	5: 23,672,098 (GRCm39)		probably benign	Het
Magea8	A	T	X: 153,769,678 (GRCm39)	C144S	probably damaging	Het
Med4	A	G	14: 73,755,361 (GRCm39)	Q223R	probably damaging	Het
Mmd2	G	T	5: 142,555,232 (GRCm39)	F153L	probably damaging	Het
Nav3	C	A	10: 109,572,814 (GRCm39)	R1615L	probably damaging	Het
Nisch	A	G	14: 30,902,769 (GRCm39)		probably benign	Het
Nr1i3	A	T	1: 171,041,964 (GRCm39)	Y16F	probably benign	Het
Or5w1	C	A	2: 87,487,058 (GRCm39)	C69F	probably damaging	Het
Or7e169	G	A	9: 19,757,550 (GRCm39)	R122*	probably null	Het
Or7g16	A	G	9: 18,727,024 (GRCm39)	C189R	probably damaging	Het
Or8g34	A	G	9: 39,373,077 (GRCm39)	T117A	possibly damaging	Het
Ppil6	C	A	10: 41,383,479 (GRCm39)	H252N	probably benign	Het
Ppp6r2	C	T	15: 89,143,378 (GRCm39)	P175L	probably damaging	Het
Psme4	T	A	11: 30,741,095 (GRCm39)	Y90*	probably null	Het
Rbm20	C	A	19: 53,802,133 (GRCm39)	L214I	probably benign	Het
Rhox2f	T	C	X: 36,753,334 (GRCm39)	V24A	probably benign	Het
Scnm1	T	C	3: 95,040,348 (GRCm39)	K96E	probably benign	Het
Sec16a	A	C	2: 26,309,735 (GRCm39)	D2090E	probably benign	Het
Smg6	T	C	11: 74,821,576 (GRCm39)		probably null	Het
Snx2	T	C	18: 53,327,630 (GRCm39)	S119P	probably benign	Het
Stam	A	G	2: 14,120,779 (GRCm39)		probably benign	Het
Sult2b1	T	A	7: 45,384,698 (GRCm39)	E126V	probably benign	Het
Tor1aip1	T	C	1: 155,911,590 (GRCm39)	E131G	probably damaging	Het
Ttn	C	T	2: 76,619,040 (GRCm39)	C14367Y	probably damaging	Het
Ubr4	T	C	4: 139,135,131 (GRCm39)	F821S	possibly damaging	Het
Vmn1r32	T	C	6: 66,529,922 (GRCm39)	N285D	probably benign	Het
Vmn2r23	T	C	6: 123,718,741 (GRCm39)	L698P	possibly damaging	Het
Wnt8a	T	A	18: 34,675,474 (GRCm39)	L18Q	possibly damaging	Het

Other mutations in Zfp747

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03201:Zfp747	APN	7	126,973,180 (GRCm39)	missense	probably damaging	0.99
R0066:Zfp747	UTSW	7	126,973,772 (GRCm39)	missense	probably benign	0.00
R1056:Zfp747	UTSW	7	126,973,760 (GRCm39)	missense	probably benign
R1190:Zfp747	UTSW	7	126,973,726 (GRCm39)	missense	probably damaging	0.99
R1457:Zfp747	UTSW	7	126,973,676 (GRCm39)	missense	probably benign	0.37
R1727:Zfp747	UTSW	7	126,973,249 (GRCm39)	missense	probably damaging	0.99
R2072:Zfp747	UTSW	7	126,973,142 (GRCm39)	missense	possibly damaging	0.48
R2157:Zfp747	UTSW	7	126,974,929 (GRCm39)	missense	possibly damaging	0.92
R3724:Zfp747	UTSW	7	126,973,762 (GRCm39)	missense	probably benign	0.06
R4762:Zfp747	UTSW	7	126,973,498 (GRCm39)	missense	possibly damaging	0.92
R4770:Zfp747	UTSW	7	126,974,971 (GRCm39)	missense	probably damaging	0.99
R5135:Zfp747	UTSW	7	126,973,566 (GRCm39)	missense	probably damaging	0.98
R5355:Zfp747	UTSW	7	126,973,769 (GRCm39)	missense	possibly damaging	0.85
R6232:Zfp747	UTSW	7	126,973,306 (GRCm39)	missense	probably damaging	1.00
R6263:Zfp747	UTSW	7	126,975,138 (GRCm39)	start gained	probably benign
R6835:Zfp747	UTSW	7	126,973,219 (GRCm39)	missense	possibly damaging	0.56
R7638:Zfp747	UTSW	7	126,973,819 (GRCm39)	missense	probably benign	0.09
R7735:Zfp747	UTSW	7	126,973,672 (GRCm39)	missense	probably damaging	0.99
R8043:Zfp747	UTSW	7	126,973,225 (GRCm39)	missense	probably benign	0.00
R8543:Zfp747	UTSW	7	126,973,655 (GRCm39)	missense	probably damaging	0.99
R9132:Zfp747	UTSW	7	126,974,922 (GRCm39)	missense	probably damaging	0.99
R9329:Zfp747	UTSW	7	126,973,655 (GRCm39)	missense	probably damaging	0.99
R9415:Zfp747	UTSW	7	126,973,198 (GRCm39)	missense	possibly damaging	0.71
Z1176:Zfp747	UTSW	7	126,974,631 (GRCm39)	nonsense	probably null

Posted On

2015-12-18