Incidental Mutation 'IGL02969:Olfr805'
ID365717
Institutional Source Australian Phenomics Network (link to record)
Gene Symbol Olfr805
Ensembl Gene ENSMUSG00000096858
Gene Nameolfactory receptor 805
SynonymsGA_x6K02T2PULF-11402237-11401278, MOR110-4
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.093) question?
Stock #IGL02969
Quality Score
Status
Chromosome10
Chromosomal Location129721221-129729375 bp(-) (GRCm38)
Type of Mutationmissense
DNA Base Change (assembly) A to T at 129723196 bp
ZygosityHeterozygous
Amino Acid Change Methionine to Lysine at position 116 (M116K)
Ref Sequence ENSEMBL: ENSMUSP00000149493 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078876] [ENSMUST00000204717] [ENSMUST00000216794] [ENSMUST00000217219]
Predicted Effect probably damaging
Transcript: ENSMUST00000078876
AA Change: M116K

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000092874
Gene: ENSMUSG00000096858
AA Change: M116K

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 3.9e-52 PFAM
Pfam:7tm_1 39 288 5.1e-23 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000203573
AA Change: M116K
SMART Domains Protein: ENSMUSP00000144843
Gene: ENSMUSG00000096858
AA Change: M116K

DomainStartEndE-ValueType
Pfam:7tm_4 28 306 3.9e-52 PFAM
Pfam:7tm_1 39 288 5.1e-23 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000204717
Predicted Effect probably damaging
Transcript: ENSMUST00000216794
AA Change: M116K

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
Predicted Effect probably damaging
Transcript: ENSMUST00000217219
AA Change: M116K

PolyPhen 2 Score 0.992 (Sensitivity: 0.70; Specificity: 0.97)
Coding Region Coverage
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 37 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700011L22Rik A G 8: 79,220,237 probably benign Het
1700061G19Rik A T 17: 56,883,751 T440S probably damaging Het
Akap12 T A 10: 4,354,864 V558E probably damaging Het
Atg4c T C 4: 99,258,387 probably benign Het
Atg7 T A 6: 114,724,923 N673K possibly damaging Het
BC005561 C T 5: 104,519,343 T577I probably benign Het
Brpf3 A G 17: 28,821,305 D900G probably benign Het
C2cd5 T C 6: 143,079,943 Y176C probably damaging Het
Cep70 A T 9: 99,298,504 I571F possibly damaging Het
Cir1 C T 2: 73,303,776 G150R probably null Het
Cyp46a1 T C 12: 108,343,037 V68A probably damaging Het
Dlgap2 A G 8: 14,831,579 T883A possibly damaging Het
Dnah2 C A 11: 69,521,187 K249N possibly damaging Het
Dnajc11 A G 4: 151,978,046 K434R probably benign Het
Eri3 A G 4: 117,649,311 Y279C probably damaging Het
Gm3259 C T 5: 95,341,399 P234S probably benign Het
Hectd4 T A 5: 121,365,053 Y4362N possibly damaging Het
Ilk A G 7: 105,740,340 K85E possibly damaging Het
Insrr G T 3: 87,814,191 G1135* probably null Het
Itgax T A 7: 128,149,123 M1108K probably benign Het
Mpzl3 C T 9: 45,068,216 T155I probably benign Het
Olfr1308 A T 2: 111,960,567 C169S probably damaging Het
Pkd1l2 G A 8: 117,065,745 T436I probably benign Het
Polr2h A G 16: 20,719,057 Y68C probably damaging Het
Rhobtb3 A G 13: 75,943,431 S2P probably damaging Het
Slc24a5 T C 2: 125,083,227 S263P probably damaging Het
Spz1 T G 13: 92,575,343 K208N possibly damaging Het
Tbpl2 C A 2: 24,091,093 C231F probably damaging Het
Tdrd6 T C 17: 43,627,549 I869M probably damaging Het
Tesk1 G A 4: 43,447,027 E472K possibly damaging Het
Tesk1 C A 4: 43,447,026 C471* probably null Het
Tmem213 T A 6: 38,115,666 V111E probably damaging Het
Tmem232 A T 17: 65,256,563 Y612N possibly damaging Het
Ttn T C 2: 76,899,363 probably benign Het
Vmn2r113 G A 17: 22,958,617 V792I probably benign Het
Wdfy1 A G 1: 79,713,871 V273A probably benign Het
Wwp1 A G 4: 19,623,200 S762P probably damaging Het
Other mutations in Olfr805
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01141:Olfr805 APN 10 129722945 missense probably benign
IGL01341:Olfr805 APN 10 129722878 missense possibly damaging 0.87
IGL01960:Olfr805 APN 10 129722887 missense probably damaging 1.00
IGL02729:Olfr805 APN 10 129723521 missense probably benign 0.01
R0116:Olfr805 UTSW 10 129722977 missense probably damaging 1.00
R1236:Olfr805 UTSW 10 129722806 missense probably damaging 0.98
R1332:Olfr805 UTSW 10 129723247 missense probably damaging 1.00
R2428:Olfr805 UTSW 10 129722783 missense probably benign 0.05
R3725:Olfr805 UTSW 10 129723115 missense probably damaging 1.00
R3726:Olfr805 UTSW 10 129723115 missense probably damaging 1.00
R3804:Olfr805 UTSW 10 129723049 missense possibly damaging 0.93
R4365:Olfr805 UTSW 10 129723412 missense probably damaging 0.99
R4630:Olfr805 UTSW 10 129723481 missense probably damaging 1.00
R4735:Olfr805 UTSW 10 129722923 missense probably benign 0.06
R4923:Olfr805 UTSW 10 129722812 missense probably benign 0.03
R4962:Olfr805 UTSW 10 129722723 missense probably damaging 1.00
R5324:Olfr805 UTSW 10 129722945 missense probably benign
R5406:Olfr805 UTSW 10 129722930 missense probably damaging 1.00
Posted On2015-12-18