Mutagenetix > Incidental Mutation

Incidental Mutation 'R0410:Or1m1'

36593

Institutional Source

Beutler Lab

Gene Symbol

Or1m1

Ensembl Gene

ENSMUSG00000054141

Gene Name

olfactory receptor family 1 subfamily M member 1

Synonyms

GA_x6K02T2PVTD-12498544-12497603, MTPCR51, Olfr24, MOR132-1

MMRRC Submission

038612-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.115) question?

Stock #

R0410 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

18665988-18666929 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to A at 18666137 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Phenylalanine at position 265 (V265F)

Ref Sequence

ENSEMBL: ENSMUSP00000149702 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000066997] [ENSMUST00000216754]

AlphaFold

Q8VFM9

Predicted Effect

probably damaging
Transcript: ENSMUST00000066997
AA Change: V265F

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)

SMART Domains

Protein: ENSMUSP00000064189
Gene: ENSMUSG00000054141
AA Change: V265F

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	5.6e-64	PFAM
Pfam:7TM_GPCR_Srsx	35	304	9.2e-9	PFAM
Pfam:7tm_1	41	290	3.2e-26	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000212239

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000214366

Predicted Effect

probably damaging
Transcript: ENSMUST00000216754
AA Change: V265F

PolyPhen 2 Score 0.965 (Sensitivity: 0.78; Specificity: 0.95)

Coding Region Coverage

1x: 99.3%
3x: 98.6%
10x: 97.1%
20x: 95.1%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 70 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4833420G17Rik	A	G	13: 119,606,268 (GRCm39)	D170G	probably benign	Het
Actrt3	C	T	3: 30,652,273 (GRCm39)	G274S	probably benign	Het
Adamts18	G	T	8: 114,440,990 (GRCm39)	C889*	probably null	Het
Alkbh6	C	T	7: 30,012,031 (GRCm39)	P104S	probably damaging	Het
Alms1	A	T	6: 85,564,785 (GRCm39)	E53V	unknown	Het
Ap3s1	T	C	18: 46,912,279 (GRCm39)	C100R	probably benign	Het
Apbb2	G	T	5: 66,609,149 (GRCm39)	A166E	possibly damaging	Het
Asph	A	G	4: 9,595,415 (GRCm39)	V174A	probably damaging	Het
Cacna2d2	T	C	9: 107,401,819 (GRCm39)	L758P	probably damaging	Het
Cacng5	A	G	11: 107,768,195 (GRCm39)	S271P	possibly damaging	Het
Camta1	C	A	4: 151,159,597 (GRCm39)	R1614L	probably damaging	Het
Chn1	A	T	2: 73,462,094 (GRCm39)	C236*	probably null	Het
Coro1b	T	C	19: 4,199,362 (GRCm39)	V7A	probably damaging	Het
Dhx16	A	G	17: 36,201,859 (GRCm39)	Y962C	probably damaging	Het
Dixdc1	T	C	9: 50,596,153 (GRCm39)	D152G	probably damaging	Het
Dmrt1	T	C	19: 25,483,467 (GRCm39)	S84P	probably damaging	Het
Dnah10	A	G	5: 124,832,799 (GRCm39)	D844G	probably benign	Het
Edn3	C	T	2: 174,603,482 (GRCm39)	P77S	possibly damaging	Het
Efcab7	T	C	4: 99,735,487 (GRCm39)		probably null	Het
Fam83g	A	G	11: 61,594,218 (GRCm39)	D584G	probably damaging	Het
Fbxo7	T	A	10: 85,865,102 (GRCm39)		probably null	Het
Ffar1	T	C	7: 30,560,055 (GRCm39)	T281A	probably benign	Het
Fntb	T	C	12: 76,934,826 (GRCm39)	V201A	probably benign	Het
Gart	C	A	16: 91,438,215 (GRCm39)	A101S	probably damaging	Het
Gbp9	T	C	5: 105,232,939 (GRCm39)	T238A	probably benign	Het
Hectd4	T	C	5: 121,424,329 (GRCm39)	L663S	possibly damaging	Het
Helz2	A	T	2: 180,872,386 (GRCm39)	V2512E	probably damaging	Het
Hip1	A	C	5: 135,487,009 (GRCm39)	L66R	probably damaging	Het
Iigp1	T	A	18: 60,523,375 (GRCm39)	D164E	probably benign	Het
Kcnip3	A	G	2: 127,301,986 (GRCm39)	S193P	probably damaging	Het
Klra9	T	A	6: 130,165,707 (GRCm39)	T103S	probably benign	Het
Meis2	T	C	2: 115,694,709 (GRCm39)	*471W	probably null	Het
Minar1	T	G	9: 89,484,256 (GRCm39)	E380D	probably damaging	Het
Mrpl21	T	C	19: 3,334,792 (GRCm39)	S45P	possibly damaging	Het
Mterf1b	A	G	5: 4,246,488 (GRCm39)	E43G	probably benign	Het
Mycbp2	G	T	14: 103,372,569 (GRCm39)	S4092R	probably damaging	Het
Nfatc3	A	T	8: 106,822,828 (GRCm39)	N538I	probably damaging	Het
Nphp4	T	C	4: 152,641,503 (GRCm39)	C1095R	probably benign	Het
Npm2	T	A	14: 70,889,993 (GRCm39)	T13S	probably benign	Het
Or7e176	T	A	9: 20,171,797 (GRCm39)	F220L	probably benign	Het
Plcg2	A	T	8: 118,342,112 (GRCm39)	I1158F	probably damaging	Het
Popdc3	T	C	10: 45,193,829 (GRCm39)	V210A	possibly damaging	Het
Postn	T	C	3: 54,292,698 (GRCm39)	L755S	possibly damaging	Het
Prdx6b	T	C	2: 80,123,373 (GRCm39)	F61L	probably damaging	Het
Rars1	C	T	11: 35,716,847 (GRCm39)	R223H	probably damaging	Het
Robo1	G	A	16: 72,768,872 (GRCm39)	G479D	possibly damaging	Het
Scaf4	A	G	16: 90,057,058 (GRCm39)	Y98H	unknown	Het
Scn4a	A	G	11: 106,214,775 (GRCm39)	I1274T	probably damaging	Het
Senp2	G	T	16: 21,828,444 (GRCm39)	R18L	probably damaging	Het
Six5	T	A	7: 18,830,381 (GRCm39)	V336D	probably damaging	Het
Slc31a2	G	A	4: 62,210,890 (GRCm39)	E8K	probably benign	Het
Slc4a7	A	T	14: 14,738,299 (GRCm38)	T184S	probably damaging	Het
Slco2a1	T	A	9: 102,950,513 (GRCm39)		probably null	Het
Smr3a	T	G	5: 88,156,070 (GRCm39)		probably benign	Het
Sqor	T	C	2: 122,629,442 (GRCm39)	V100A	probably benign	Het
Srarp	T	C	4: 141,160,459 (GRCm39)	N125D	possibly damaging	Het
Stam	T	C	2: 14,143,802 (GRCm39)	V364A	probably benign	Het
Tgm5	T	C	2: 120,908,039 (GRCm39)	I46V	possibly damaging	Het
Tie1	A	T	4: 118,337,766 (GRCm39)	V443E	probably damaging	Het
Tipin	T	C	9: 64,195,397 (GRCm39)	M1T	probably null	Het
Tnc	T	C	4: 63,925,931 (GRCm39)	T950A	probably benign	Het
Tns3	T	C	11: 8,385,852 (GRCm39)	D1382G	probably benign	Het
Tor1aip1	A	G	1: 155,911,686 (GRCm39)	V99A	possibly damaging	Het
Trim16	C	T	11: 62,711,297 (GRCm39)		probably benign	Het
Ttn	G	T	2: 76,618,701 (GRCm39)	N14448K	possibly damaging	Het
Ttn	C	T	2: 76,717,204 (GRCm39)		probably benign	Het
Tut4	A	G	4: 108,343,752 (GRCm39)	R255G	probably benign	Het
Vmn1r23	A	G	6: 57,903,175 (GRCm39)	I201T	probably benign	Het
Vmn2r13	T	A	5: 109,321,679 (GRCm39)	K339N	probably benign	Het
Yap1	A	G	9: 8,001,468 (GRCm39)	Y173H	probably damaging	Het

Other mutations in Or1m1

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02346:Or1m1	APN	9	18,666,065 (GRCm39)	missense	probably damaging	0.97
IGL02371:Or1m1	APN	9	18,666,000 (GRCm39)	missense	probably benign	0.07
IGL02555:Or1m1	APN	9	18,666,769 (GRCm39)	missense	probably benign	0.40
IGL03025:Or1m1	APN	9	18,666,665 (GRCm39)	missense	probably benign	0.00
IGL03259:Or1m1	APN	9	18,666,811 (GRCm39)	missense	probably benign
IGL03050:Or1m1	UTSW	9	18,666,750 (GRCm39)	nonsense	probably null
R0310:Or1m1	UTSW	9	18,666,629 (GRCm39)	missense	possibly damaging	0.91
R2152:Or1m1	UTSW	9	18,666,391 (GRCm39)	missense	probably damaging	1.00
R2153:Or1m1	UTSW	9	18,666,391 (GRCm39)	missense	probably damaging	1.00
R2918:Or1m1	UTSW	9	18,666,775 (GRCm39)	missense	probably damaging	1.00
R4552:Or1m1	UTSW	9	18,666,430 (GRCm39)	missense	possibly damaging	0.60
R5073:Or1m1	UTSW	9	18,666,118 (GRCm39)	missense	possibly damaging	0.89
R5539:Or1m1	UTSW	9	18,666,134 (GRCm39)	missense	probably damaging	0.99
R5662:Or1m1	UTSW	9	18,666,896 (GRCm39)	missense	probably damaging	0.99
R6145:Or1m1	UTSW	9	18,666,865 (GRCm39)	missense	probably benign	0.06
R7125:Or1m1	UTSW	9	18,666,174 (GRCm39)	nonsense	probably null
R7196:Or1m1	UTSW	9	18,666,886 (GRCm39)	nonsense	probably null
R7607:Or1m1	UTSW	9	18,666,178 (GRCm39)	missense	possibly damaging	0.93
R9136:Or1m1	UTSW	9	18,666,175 (GRCm39)	missense	probably damaging	1.00
Z1177:Or1m1	UTSW	9	18,666,815 (GRCm39)	missense	possibly damaging	0.85

Predicted Primers

PCR Primer
(F):5'- GCTGCCTTGAAATTCCACAACATTCTG -3'
(R):5'- TGATTTCTGTCTGGCTACCAACACTG -3'

Sequencing Primer
(F):5'- GATTGATGATCAGGAGGATGTGC -3'
(R):5'- GAATGGTGATAGCCACACCTTTTG -3'

Posted On

2013-05-09