Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL02939:Vmn2r108'

365942

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Vmn2r108

Ensembl Gene

ENSMUSG00000091805

Gene Name

vomeronasal 2, receptor 108

Synonyms

EG627805

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.073) question?

Stock #

IGL02939

Quality Score

Status

Chromosome

Chromosomal Location

20682635-20701498 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 20691545 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Histidine to Leucine at position 326 (H326L)

Ref Sequence

ENSEMBL: ENSMUSP00000130373 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000167314]

AlphaFold

E9PYS0

Predicted Effect

probably benign
Transcript: ENSMUST00000167314
AA Change: H326L

PolyPhen 2 Score 0.047 (Sensitivity: 0.94; Specificity: 0.83)

SMART Domains

Protein: ENSMUSP00000130373
Gene: ENSMUSG00000091805
AA Change: H326L

Domain	Start	End	E-Value	Type
signal peptide	1	19	N/A	INTRINSIC
Pfam:ANF_receptor	83	467	6e-33	PFAM
Pfam:NCD3G	510	563	9.2e-22	PFAM
Pfam:7tm_3	593	831	2.2e-51	PFAM

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 52 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Atp6ap1	A	G	X: 73,340,924 (GRCm39)	D47G	probably benign	Het
Atr	T	C	9: 95,747,314 (GRCm39)	F199L	probably benign	Het
Bivm	C	A	1: 44,182,120 (GRCm39)	H443N	probably benign	Het
Btnl2	A	T	17: 34,580,043 (GRCm39)	H192L	probably benign	Het
Ccdc178	A	T	18: 22,253,775 (GRCm39)	C155S	probably benign	Het
Celsr1	C	A	15: 85,785,673 (GRCm39)	V2934L	probably benign	Het
Celsr3	T	C	9: 108,726,652 (GRCm39)	S3294P	probably damaging	Het
Ddx10	T	A	9: 53,115,579 (GRCm39)	E585V	possibly damaging	Het
Elapor2	T	C	5: 9,511,478 (GRCm39)	Y947H	probably damaging	Het
Eps15l1	A	T	8: 73,138,606 (GRCm39)		probably benign	Het
Erlin1	G	T	19: 44,051,491 (GRCm39)	T70K	probably damaging	Het
Ext2	A	T	2: 93,534,964 (GRCm39)		probably null	Het
Fam124a	G	A	14: 62,793,368 (GRCm39)		probably null	Het
Fam53a	T	C	5: 33,765,103 (GRCm39)	D201G	probably damaging	Het
Fgf14	C	T	14: 124,369,891 (GRCm39)	G136D	possibly damaging	Het
Gdi2	A	T	13: 3,614,623 (GRCm39)	T323S	probably benign	Het
Gemin5	A	T	11: 58,047,556 (GRCm39)	N339K	probably damaging	Het
Golga4	A	G	9: 118,364,522 (GRCm39)	E286G	probably benign	Het
Golga4	A	C	9: 118,363,700 (GRCm39)	K233T	probably damaging	Het
Gosr1	A	G	11: 76,641,732 (GRCm39)		probably benign	Het
Haus8	A	G	8: 71,708,361 (GRCm39)		probably benign	Het
Itgb3bp	T	C	4: 99,690,373 (GRCm39)	T49A	probably null	Het
Ldlrad4	A	G	18: 68,387,585 (GRCm39)	D299G	probably damaging	Het
Lpo	A	G	11: 87,706,004 (GRCm39)	M273T	possibly damaging	Het
Map3k4	T	A	17: 12,491,036 (GRCm39)	S132C	probably damaging	Het
Mycbp2	T	G	14: 103,414,715 (GRCm39)	T2566P	probably benign	Het
Nalcn	T	C	14: 123,536,284 (GRCm39)	E1255G	probably null	Het
Nop56	A	T	2: 130,120,117 (GRCm39)	K157N	probably damaging	Het
Or10g9	C	T	9: 39,912,194 (GRCm39)	E110K	probably benign	Het
Or6c1	A	T	10: 129,517,857 (GRCm39)	Y250*	probably null	Het
Pcdh15	A	G	10: 74,340,648 (GRCm39)		probably benign	Het
Pi4ka	T	C	16: 17,172,074 (GRCm39)	H557R	probably damaging	Het
Plekha4	C	T	7: 45,181,787 (GRCm39)	Q64*	probably null	Het
Ppp2r3c	G	A	12: 55,345,192 (GRCm39)		probably benign	Het
Rgmb	C	T	17: 16,027,755 (GRCm39)	M321I	probably benign	Het
Rnf31	T	C	14: 55,833,131 (GRCm39)	S363P	probably benign	Het
Sap18b	T	A	8: 96,552,329 (GRCm39)	M113K	probably benign	Het
Scara3	T	A	14: 66,169,105 (GRCm39)	M171L	probably benign	Het
Slc9a2	T	G	1: 40,781,863 (GRCm39)	M364R	probably damaging	Het
Sorcs1	C	T	19: 50,666,368 (GRCm39)	W180*	probably null	Het
Stat6	T	A	10: 127,482,809 (GRCm39)	M10K	probably benign	Het
Sun1	T	C	5: 139,221,243 (GRCm39)		probably benign	Het
Tead2	T	C	7: 44,869,858 (GRCm39)		probably benign	Het
Tjp1	T	G	7: 64,964,638 (GRCm39)	E844D	probably damaging	Het
Tmtc2	A	G	10: 105,206,411 (GRCm39)	S295P	probably damaging	Het
Ttn	G	A	2: 76,612,756 (GRCm39)	R17108C	probably damaging	Het
Ubr1	T	C	2: 120,711,664 (GRCm39)		probably null	Het
Xdh	A	G	17: 74,250,840 (GRCm39)		probably null	Het
Zfp385b	A	G	2: 77,242,403 (GRCm39)	S439P	probably benign	Het
Zfp597	G	A	16: 3,683,805 (GRCm39)	S317L	probably benign	Het
Zfp638	A	G	6: 83,946,214 (GRCm39)	D1081G	probably damaging	Het
Zfp93	C	T	7: 23,974,509 (GRCm39)	H165Y	possibly damaging	Het

Other mutations in Vmn2r108

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00903:Vmn2r108	APN	17	20,682,774 (GRCm39)	missense	probably damaging	0.98
IGL01143:Vmn2r108	APN	17	20,682,727 (GRCm39)	missense	possibly damaging	0.82
IGL01311:Vmn2r108	APN	17	20,682,939 (GRCm39)	nonsense	probably null
IGL01411:Vmn2r108	APN	17	20,691,282 (GRCm39)	missense	probably benign	0.01
IGL01414:Vmn2r108	APN	17	20,691,942 (GRCm39)	missense	probably benign	0.00
IGL01536:Vmn2r108	APN	17	20,683,543 (GRCm39)	missense	probably damaging	1.00
IGL01748:Vmn2r108	APN	17	20,683,476 (GRCm39)	missense	probably benign	0.03
IGL01769:Vmn2r108	APN	17	20,691,280 (GRCm39)	missense	probably benign	0.02
IGL02022:Vmn2r108	APN	17	20,691,987 (GRCm39)	missense	possibly damaging	0.77
IGL02041:Vmn2r108	APN	17	20,683,398 (GRCm39)	missense	probably damaging	1.00
IGL02049:Vmn2r108	APN	17	20,691,608 (GRCm39)	missense	probably benign	0.00
IGL02344:Vmn2r108	APN	17	20,689,405 (GRCm39)	missense	probably damaging	1.00
IGL03202:Vmn2r108	APN	17	20,691,319 (GRCm39)	nonsense	probably null
PIT4498001:Vmn2r108	UTSW	17	20,683,279 (GRCm39)	missense	probably damaging	1.00
R0112:Vmn2r108	UTSW	17	20,691,897 (GRCm39)	missense	probably benign	0.07
R0505:Vmn2r108	UTSW	17	20,683,096 (GRCm39)	missense	possibly damaging	0.77
R0833:Vmn2r108	UTSW	17	20,691,721 (GRCm39)	missense	probably benign
R0836:Vmn2r108	UTSW	17	20,691,721 (GRCm39)	missense	probably benign
R0943:Vmn2r108	UTSW	17	20,691,397 (GRCm39)	nonsense	probably null
R1411:Vmn2r108	UTSW	17	20,683,107 (GRCm39)	missense	probably damaging	0.98
R1442:Vmn2r108	UTSW	17	20,692,623 (GRCm39)	nonsense	probably null
R1587:Vmn2r108	UTSW	17	20,692,383 (GRCm39)	missense	probably damaging	1.00
R1751:Vmn2r108	UTSW	17	20,682,786 (GRCm39)	missense	probably damaging	1.00
R1773:Vmn2r108	UTSW	17	20,689,335 (GRCm39)	missense	probably damaging	1.00
R2021:Vmn2r108	UTSW	17	20,691,252 (GRCm39)	missense	probably benign	0.00
R2159:Vmn2r108	UTSW	17	20,689,363 (GRCm39)	missense	probably benign	0.41
R2224:Vmn2r108	UTSW	17	20,701,295 (GRCm39)	nonsense	probably null
R2226:Vmn2r108	UTSW	17	20,701,295 (GRCm39)	nonsense	probably null
R2517:Vmn2r108	UTSW	17	20,692,577 (GRCm39)	missense	probably damaging	1.00
R3710:Vmn2r108	UTSW	17	20,682,932 (GRCm39)	missense	probably benign
R4470:Vmn2r108	UTSW	17	20,682,990 (GRCm39)	missense	probably damaging	1.00
R4686:Vmn2r108	UTSW	17	20,691,636 (GRCm39)	missense	probably damaging	0.99
R4729:Vmn2r108	UTSW	17	20,692,632 (GRCm39)	missense	probably damaging	0.99
R4799:Vmn2r108	UTSW	17	20,682,891 (GRCm39)	missense	probably damaging	1.00
R4993:Vmn2r108	UTSW	17	20,701,449 (GRCm39)	missense	probably benign	0.04
R5088:Vmn2r108	UTSW	17	20,690,454 (GRCm39)	missense	possibly damaging	0.46
R5213:Vmn2r108	UTSW	17	20,691,755 (GRCm39)	missense	probably benign	0.00
R5289:Vmn2r108	UTSW	17	20,691,866 (GRCm39)	missense	probably damaging	1.00
R5290:Vmn2r108	UTSW	17	20,691,665 (GRCm39)	missense	probably benign	0.00
R5713:Vmn2r108	UTSW	17	20,691,290 (GRCm39)	missense	probably damaging	1.00
R5753:Vmn2r108	UTSW	17	20,683,179 (GRCm39)	missense	probably damaging	0.99
R5792:Vmn2r108	UTSW	17	20,683,398 (GRCm39)	missense	probably damaging	0.99
R5798:Vmn2r108	UTSW	17	20,692,545 (GRCm39)	missense	probably benign	0.39
R5897:Vmn2r108	UTSW	17	20,691,580 (GRCm39)	missense	probably benign	0.01
R6018:Vmn2r108	UTSW	17	20,683,268 (GRCm39)	missense	possibly damaging	0.83
R6093:Vmn2r108	UTSW	17	20,701,402 (GRCm39)	missense	probably benign	0.00
R6156:Vmn2r108	UTSW	17	20,692,447 (GRCm39)	missense	probably benign	0.03
R6199:Vmn2r108	UTSW	17	20,682,644 (GRCm39)	missense	probably benign	0.01
R6259:Vmn2r108	UTSW	17	20,683,371 (GRCm39)	missense	possibly damaging	0.95
R6309:Vmn2r108	UTSW	17	20,691,660 (GRCm39)	missense	probably damaging	0.98
R6324:Vmn2r108	UTSW	17	20,691,977 (GRCm39)	nonsense	probably null
R6364:Vmn2r108	UTSW	17	20,691,260 (GRCm39)	missense	probably benign	0.00
R6446:Vmn2r108	UTSW	17	20,692,609 (GRCm39)	nonsense	probably null
R6541:Vmn2r108	UTSW	17	20,701,480 (GRCm39)	missense	probably benign	0.02
R7025:Vmn2r108	UTSW	17	20,691,345 (GRCm39)	missense	possibly damaging	0.67
R7063:Vmn2r108	UTSW	17	20,701,410 (GRCm39)	missense	probably damaging	1.00
R7092:Vmn2r108	UTSW	17	20,701,338 (GRCm39)	missense	probably benign	0.10
R7096:Vmn2r108	UTSW	17	20,682,762 (GRCm39)	missense	probably damaging	1.00
R7203:Vmn2r108	UTSW	17	20,683,038 (GRCm39)	missense	probably benign	0.12
R7458:Vmn2r108	UTSW	17	20,692,532 (GRCm39)	missense	probably benign	0.17
R7619:Vmn2r108	UTSW	17	20,692,457 (GRCm39)	missense	probably benign	0.02
R7841:Vmn2r108	UTSW	17	20,690,305 (GRCm39)	critical splice donor site	probably null
R7944:Vmn2r108	UTSW	17	20,691,890 (GRCm39)	missense	probably damaging	0.99
R8048:Vmn2r108	UTSW	17	20,691,762 (GRCm39)	missense	probably benign	0.29
R8213:Vmn2r108	UTSW	17	20,690,350 (GRCm39)	missense	probably benign	0.03
R8218:Vmn2r108	UTSW	17	20,683,465 (GRCm39)	missense	probably damaging	1.00
R8507:Vmn2r108	UTSW	17	20,683,195 (GRCm39)	nonsense	probably null
R8708:Vmn2r108	UTSW	17	20,682,687 (GRCm39)	missense	probably damaging	0.98
R8845:Vmn2r108	UTSW	17	20,691,361 (GRCm39)	missense	probably benign	0.03
R9030:Vmn2r108	UTSW	17	20,690,312 (GRCm39)	missense	probably benign	0.01
R9226:Vmn2r108	UTSW	17	20,691,330 (GRCm39)	missense	probably benign
R9278:Vmn2r108	UTSW	17	20,692,561 (GRCm39)	missense	probably benign	0.11
X0022:Vmn2r108	UTSW	17	20,691,371 (GRCm39)	missense	probably damaging	1.00
Z1088:Vmn2r108	UTSW	17	20,691,375 (GRCm39)	missense	probably benign	0.01
Z1177:Vmn2r108	UTSW	17	20,691,219 (GRCm39)	missense	probably damaging	0.99

Posted On

2015-12-18