Incidental Mutation 'R4769:Micall2'
ID 366326
Institutional Source Beutler Lab
Gene Symbol Micall2
Ensembl Gene ENSMUSG00000036718
Gene Name MICAL-like 2
Synonyms MICAL-L2, Jrab, A930021H16Rik
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.352) question?
Stock # R4769 (G1)
Quality Score 222
Status Not validated
Chromosome 5
Chromosomal Location 139692451-139722091 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 139692641 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 911 (S911P)
Ref Sequence ENSEMBL: ENSMUSP00000127937 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044642] [ENSMUST00000170773]
AlphaFold Q3TN34
Predicted Effect unknown
Transcript: ENSMUST00000044642
AA Change: S994P
SMART Domains Protein: ENSMUSP00000039707
Gene: ENSMUSG00000036718
AA Change: S994P

DomainStartEndE-ValueType
CH 3 102 4.34e-20 SMART
LIM 187 241 1.62e-5 SMART
low complexity region 242 253 N/A INTRINSIC
low complexity region 326 344 N/A INTRINSIC
low complexity region 428 489 N/A INTRINSIC
low complexity region 502 518 N/A INTRINSIC
low complexity region 728 746 N/A INTRINSIC
low complexity region 755 770 N/A INTRINSIC
DUF3585 840 980 3.1e-63 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000164584
Predicted Effect probably benign
Transcript: ENSMUST00000165645
Predicted Effect probably damaging
Transcript: ENSMUST00000170773
AA Change: S911P

PolyPhen 2 Score 0.973 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000127937
Gene: ENSMUSG00000036718
AA Change: S911P

DomainStartEndE-ValueType
SCOP:d1bkra_ 1 25 9e-5 SMART
Blast:DUF3585 1 45 2e-7 BLAST
LIM 104 158 1.62e-5 SMART
low complexity region 159 170 N/A INTRINSIC
low complexity region 243 261 N/A INTRINSIC
low complexity region 345 406 N/A INTRINSIC
low complexity region 419 435 N/A INTRINSIC
low complexity region 645 663 N/A INTRINSIC
low complexity region 672 687 N/A INTRINSIC
DUF3585 757 897 3.1e-63 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000198319
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A C 14: 32,382,174 (GRCm39) S1264A probably benign Het
Adamts13 T G 2: 26,898,723 (GRCm39) Y1361* probably null Het
Ahrr A T 13: 74,362,331 (GRCm39) D389E probably damaging Het
Alx3 T C 3: 107,508,007 (GRCm39) F172S probably damaging Het
Antxrl A G 14: 33,795,027 (GRCm39) H485R possibly damaging Het
Aox4 A G 1: 58,298,307 (GRCm39) D1091G probably null Het
Btbd1 T A 7: 81,455,558 (GRCm39) Q271L probably benign Het
Cd209c A T 8: 3,994,953 (GRCm39) N70K probably benign Het
Cdc14a C T 3: 116,088,399 (GRCm39) probably null Het
Cenpe A G 3: 134,953,912 (GRCm39) M1641V probably benign Het
Clec2e G A 6: 129,077,790 (GRCm39) T16I probably benign Het
Clp1 T C 2: 84,556,219 (GRCm39) D87G possibly damaging Het
Dpy19l1 A T 9: 24,337,444 (GRCm39) F517I probably damaging Het
Dzip3 T C 16: 48,758,837 (GRCm39) N646S probably damaging Het
Ephx1 T A 1: 180,823,543 (GRCm39) Y188F possibly damaging Het
Etfa A T 9: 55,403,051 (GRCm39) H81Q possibly damaging Het
Gigyf2 T A 1: 87,368,571 (GRCm39) F1084I probably damaging Het
Heatr3 T C 8: 88,868,411 (GRCm39) probably null Het
Ift81 G T 5: 122,732,656 (GRCm39) H293N probably benign Het
Igkv9-120 G T 6: 68,027,351 (GRCm39) R88S possibly damaging Het
Il6 T G 5: 30,223,076 (GRCm39) L114* probably null Het
Ism2 A T 12: 87,346,355 (GRCm39) M42K probably benign Het
Lhx5 A G 5: 120,574,503 (GRCm39) E269G probably benign Het
Marveld1 T G 19: 42,136,434 (GRCm39) M116R possibly damaging Het
Mier1 G A 4: 102,997,417 (GRCm39) R195H probably benign Het
Muc2 T A 7: 141,286,260 (GRCm39) probably null Het
Mybbp1a A G 11: 72,336,466 (GRCm39) K486R probably damaging Het
Ncapd2 A C 6: 125,162,708 (GRCm39) L179R probably damaging Het
Nos1 C T 5: 118,081,310 (GRCm39) Q1171* probably null Het
Nrg1 T A 8: 32,408,000 (GRCm39) I78F probably damaging Het
Or5d36 T G 2: 87,901,073 (GRCm39) T218P probably benign Het
Or6y1 T G 1: 174,276,524 (GRCm39) F112V possibly damaging Het
Plek2 C T 12: 78,953,664 (GRCm39) probably null Het
Plod2 A G 9: 92,477,325 (GRCm39) H339R probably damaging Het
Pold1 C T 7: 44,184,495 (GRCm39) C835Y probably damaging Het
Polr1a A G 6: 71,927,852 (GRCm39) I868V probably benign Het
Prss54 C A 8: 96,286,003 (GRCm39) V357L probably benign Het
Rbbp8 T A 18: 11,855,727 (GRCm39) S625T probably damaging Het
Rgs1 A T 1: 144,123,667 (GRCm39) L86Q probably damaging Het
Ripk4 T A 16: 97,545,262 (GRCm39) N462Y probably damaging Het
Rsf1 C T 7: 97,325,429 (GRCm39) L1011F probably damaging Het
Slc19a3 G A 1: 82,997,062 (GRCm39) T382I probably damaging Het
Slc9a2 G A 1: 40,765,534 (GRCm39) R308Q probably damaging Het
Top2b T A 14: 16,398,991 (GRCm38) L537Q probably damaging Het
Trim45 C A 3: 100,839,050 (GRCm39) probably benign Het
Umodl1 G T 17: 31,202,976 (GRCm39) R443M possibly damaging Het
Vmn1r11 G A 6: 57,114,597 (GRCm39) R87K probably damaging Het
Vmn1r78 T A 7: 11,886,725 (GRCm39) I112N probably damaging Het
Zeb2 T G 2: 44,886,447 (GRCm39) E825A probably damaging Het
Zfp930 A T 8: 69,679,344 (GRCm39) I50F probably benign Het
Other mutations in Micall2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00231:Micall2 APN 5 139,703,311 (GRCm39) critical splice acceptor site probably null
IGL00496:Micall2 APN 5 139,702,083 (GRCm39) missense probably benign 0.01
IGL02641:Micall2 APN 5 139,705,094 (GRCm39) missense probably damaging 1.00
IGL03245:Micall2 APN 5 139,705,014 (GRCm39) missense probably damaging 1.00
IGL03252:Micall2 APN 5 139,702,481 (GRCm39) missense probably benign 0.01
R1214:Micall2 UTSW 5 139,697,396 (GRCm39) missense probably damaging 0.97
R1468:Micall2 UTSW 5 139,705,097 (GRCm39) missense probably damaging 1.00
R1468:Micall2 UTSW 5 139,705,097 (GRCm39) missense probably damaging 1.00
R1831:Micall2 UTSW 5 139,702,508 (GRCm39) missense probably benign 0.09
R1833:Micall2 UTSW 5 139,702,508 (GRCm39) missense probably benign 0.09
R1969:Micall2 UTSW 5 139,721,885 (GRCm39) missense probably damaging 1.00
R2023:Micall2 UTSW 5 139,703,266 (GRCm39) missense possibly damaging 0.51
R2060:Micall2 UTSW 5 139,697,317 (GRCm39) missense probably damaging 0.98
R2330:Micall2 UTSW 5 139,703,270 (GRCm39) missense probably damaging 1.00
R3820:Micall2 UTSW 5 139,701,611 (GRCm39) missense possibly damaging 0.92
R4299:Micall2 UTSW 5 139,695,226 (GRCm39) intron probably benign
R4334:Micall2 UTSW 5 139,699,105 (GRCm39) missense probably damaging 1.00
R4451:Micall2 UTSW 5 139,692,852 (GRCm39) missense probably damaging 1.00
R4911:Micall2 UTSW 5 139,702,580 (GRCm39) missense probably damaging 1.00
R4996:Micall2 UTSW 5 139,696,344 (GRCm39) missense probably benign 0.31
R5118:Micall2 UTSW 5 139,702,202 (GRCm39) missense probably damaging 1.00
R5155:Micall2 UTSW 5 139,695,986 (GRCm39) missense probably damaging 1.00
R5475:Micall2 UTSW 5 139,702,224 (GRCm39) missense probably damaging 1.00
R5750:Micall2 UTSW 5 139,701,456 (GRCm39) splice site probably null
R5998:Micall2 UTSW 5 139,692,666 (GRCm39) critical splice acceptor site probably null
R6181:Micall2 UTSW 5 139,702,506 (GRCm39) missense probably benign 0.41
R6852:Micall2 UTSW 5 139,701,548 (GRCm39) missense possibly damaging 0.90
R7046:Micall2 UTSW 5 139,694,699 (GRCm39) unclassified probably benign
R7395:Micall2 UTSW 5 139,702,124 (GRCm39) missense possibly damaging 0.78
R8514:Micall2 UTSW 5 139,701,977 (GRCm39) missense probably damaging 1.00
R8889:Micall2 UTSW 5 139,703,254 (GRCm39) missense probably damaging 0.98
R8892:Micall2 UTSW 5 139,703,254 (GRCm39) missense probably damaging 0.98
R8960:Micall2 UTSW 5 139,702,025 (GRCm39) missense probably benign 0.23
R9060:Micall2 UTSW 5 139,705,035 (GRCm39) missense probably damaging 1.00
R9209:Micall2 UTSW 5 139,696,170 (GRCm39) missense unknown
R9227:Micall2 UTSW 5 139,701,827 (GRCm39) missense unknown
R9230:Micall2 UTSW 5 139,701,827 (GRCm39) missense unknown
R9260:Micall2 UTSW 5 139,695,453 (GRCm39) missense unknown
R9452:Micall2 UTSW 5 139,703,311 (GRCm39) critical splice acceptor site probably null
Z1088:Micall2 UTSW 5 139,702,050 (GRCm39) missense probably benign 0.12
Z1088:Micall2 UTSW 5 139,692,649 (GRCm39) missense probably damaging 1.00
Z1177:Micall2 UTSW 5 139,696,057 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- TATTGAGGTGACGAGGACCCAG -3'
(R):5'- TGATCCCTGTAGCTCTCCAG -3'

Sequencing Primer
(F):5'- TGACGAGGACCCAGAGTGG -3'
(R):5'- ACCTGGGTAATTATGGGGCACAATC -3'
Posted On 2015-12-21