Incidental Mutation 'R4769:Vmn1r78'
ID 366332
Institutional Source Beutler Lab
Gene Symbol Vmn1r78
Ensembl Gene ENSMUSG00000061602
Gene Name vomeronasal 1 receptor 78
Synonyms V1rg7
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R4769 (G1)
Quality Score 225
Status Not validated
Chromosome 7
Chromosomal Location 11886391-11887332 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 11886725 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Asparagine at position 112 (I112N)
Ref Sequence ENSEMBL: ENSMUSP00000154797 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000078039] [ENSMUST00000228244] [ENSMUST00000228664]
AlphaFold K7N608
Predicted Effect probably damaging
Transcript: ENSMUST00000078039
AA Change: I112N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
SMART Domains Protein: ENSMUSP00000077186
Gene: ENSMUSG00000061602
AA Change: I112N

DomainStartEndE-ValueType
Pfam:TAS2R 3 304 5.7e-8 PFAM
Pfam:V1R 12 301 1.5e-29 PFAM
Predicted Effect noncoding transcript
Transcript: ENSMUST00000209489
Predicted Effect probably damaging
Transcript: ENSMUST00000228244
AA Change: I112N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Predicted Effect probably damaging
Transcript: ENSMUST00000228664
AA Change: I112N

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.8%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 50 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
3425401B19Rik A C 14: 32,382,174 (GRCm39) S1264A probably benign Het
Adamts13 T G 2: 26,898,723 (GRCm39) Y1361* probably null Het
Ahrr A T 13: 74,362,331 (GRCm39) D389E probably damaging Het
Alx3 T C 3: 107,508,007 (GRCm39) F172S probably damaging Het
Antxrl A G 14: 33,795,027 (GRCm39) H485R possibly damaging Het
Aox4 A G 1: 58,298,307 (GRCm39) D1091G probably null Het
Btbd1 T A 7: 81,455,558 (GRCm39) Q271L probably benign Het
Cd209c A T 8: 3,994,953 (GRCm39) N70K probably benign Het
Cdc14a C T 3: 116,088,399 (GRCm39) probably null Het
Cenpe A G 3: 134,953,912 (GRCm39) M1641V probably benign Het
Clec2e G A 6: 129,077,790 (GRCm39) T16I probably benign Het
Clp1 T C 2: 84,556,219 (GRCm39) D87G possibly damaging Het
Dpy19l1 A T 9: 24,337,444 (GRCm39) F517I probably damaging Het
Dzip3 T C 16: 48,758,837 (GRCm39) N646S probably damaging Het
Ephx1 T A 1: 180,823,543 (GRCm39) Y188F possibly damaging Het
Etfa A T 9: 55,403,051 (GRCm39) H81Q possibly damaging Het
Gigyf2 T A 1: 87,368,571 (GRCm39) F1084I probably damaging Het
Heatr3 T C 8: 88,868,411 (GRCm39) probably null Het
Ift81 G T 5: 122,732,656 (GRCm39) H293N probably benign Het
Igkv9-120 G T 6: 68,027,351 (GRCm39) R88S possibly damaging Het
Il6 T G 5: 30,223,076 (GRCm39) L114* probably null Het
Ism2 A T 12: 87,346,355 (GRCm39) M42K probably benign Het
Lhx5 A G 5: 120,574,503 (GRCm39) E269G probably benign Het
Marveld1 T G 19: 42,136,434 (GRCm39) M116R possibly damaging Het
Micall2 A G 5: 139,692,641 (GRCm39) S911P probably damaging Het
Mier1 G A 4: 102,997,417 (GRCm39) R195H probably benign Het
Muc2 T A 7: 141,286,260 (GRCm39) probably null Het
Mybbp1a A G 11: 72,336,466 (GRCm39) K486R probably damaging Het
Ncapd2 A C 6: 125,162,708 (GRCm39) L179R probably damaging Het
Nos1 C T 5: 118,081,310 (GRCm39) Q1171* probably null Het
Nrg1 T A 8: 32,408,000 (GRCm39) I78F probably damaging Het
Or5d36 T G 2: 87,901,073 (GRCm39) T218P probably benign Het
Or6y1 T G 1: 174,276,524 (GRCm39) F112V possibly damaging Het
Plek2 C T 12: 78,953,664 (GRCm39) probably null Het
Plod2 A G 9: 92,477,325 (GRCm39) H339R probably damaging Het
Pold1 C T 7: 44,184,495 (GRCm39) C835Y probably damaging Het
Polr1a A G 6: 71,927,852 (GRCm39) I868V probably benign Het
Prss54 C A 8: 96,286,003 (GRCm39) V357L probably benign Het
Rbbp8 T A 18: 11,855,727 (GRCm39) S625T probably damaging Het
Rgs1 A T 1: 144,123,667 (GRCm39) L86Q probably damaging Het
Ripk4 T A 16: 97,545,262 (GRCm39) N462Y probably damaging Het
Rsf1 C T 7: 97,325,429 (GRCm39) L1011F probably damaging Het
Slc19a3 G A 1: 82,997,062 (GRCm39) T382I probably damaging Het
Slc9a2 G A 1: 40,765,534 (GRCm39) R308Q probably damaging Het
Top2b T A 14: 16,398,991 (GRCm38) L537Q probably damaging Het
Trim45 C A 3: 100,839,050 (GRCm39) probably benign Het
Umodl1 G T 17: 31,202,976 (GRCm39) R443M possibly damaging Het
Vmn1r11 G A 6: 57,114,597 (GRCm39) R87K probably damaging Het
Zeb2 T G 2: 44,886,447 (GRCm39) E825A probably damaging Het
Zfp930 A T 8: 69,679,344 (GRCm39) I50F probably benign Het
Other mutations in Vmn1r78
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01129:Vmn1r78 APN 7 11,887,165 (GRCm39) missense probably benign 0.10
IGL02019:Vmn1r78 APN 7 11,886,634 (GRCm39) missense probably damaging 0.99
IGL02143:Vmn1r78 APN 7 11,886,407 (GRCm39) missense probably benign
IGL02154:Vmn1r78 APN 7 11,886,472 (GRCm39) missense probably benign 0.22
IGL02290:Vmn1r78 APN 7 11,887,082 (GRCm39) missense probably damaging 1.00
IGL03012:Vmn1r78 APN 7 11,887,291 (GRCm39) missense probably benign 0.32
IGL03256:Vmn1r78 APN 7 11,886,725 (GRCm39) missense probably damaging 1.00
IGL03373:Vmn1r78 APN 7 11,887,270 (GRCm39) missense possibly damaging 0.86
IGL03384:Vmn1r78 APN 7 11,887,136 (GRCm39) missense possibly damaging 0.94
R0016:Vmn1r78 UTSW 7 11,887,279 (GRCm39) missense probably benign 0.02
R1445:Vmn1r78 UTSW 7 11,886,508 (GRCm39) missense possibly damaging 0.64
R1748:Vmn1r78 UTSW 7 11,887,250 (GRCm39) missense probably damaging 1.00
R2017:Vmn1r78 UTSW 7 11,887,270 (GRCm39) missense possibly damaging 0.86
R2032:Vmn1r78 UTSW 7 11,887,210 (GRCm39) missense probably benign 0.00
R2198:Vmn1r78 UTSW 7 11,886,487 (GRCm39) missense probably benign 0.06
R4330:Vmn1r78 UTSW 7 11,886,386 (GRCm39) splice site probably null
R4564:Vmn1r78 UTSW 7 11,886,485 (GRCm39) missense probably damaging 1.00
R4801:Vmn1r78 UTSW 7 11,886,891 (GRCm39) nonsense probably null
R4802:Vmn1r78 UTSW 7 11,886,891 (GRCm39) nonsense probably null
R4860:Vmn1r78 UTSW 7 11,886,683 (GRCm39) missense probably damaging 1.00
R4860:Vmn1r78 UTSW 7 11,886,683 (GRCm39) missense probably damaging 1.00
R5648:Vmn1r78 UTSW 7 11,886,693 (GRCm39) missense possibly damaging 0.92
R6561:Vmn1r78 UTSW 7 11,886,826 (GRCm39) missense probably damaging 1.00
R6869:Vmn1r78 UTSW 7 11,886,676 (GRCm39) missense probably benign 0.01
R6945:Vmn1r78 UTSW 7 11,886,832 (GRCm39) missense probably benign 0.01
R7793:Vmn1r78 UTSW 7 11,887,241 (GRCm39) missense probably benign 0.01
R7954:Vmn1r78 UTSW 7 11,887,227 (GRCm39) nonsense probably null
R8698:Vmn1r78 UTSW 7 11,886,539 (GRCm39) missense probably benign 0.06
R8830:Vmn1r78 UTSW 7 11,887,118 (GRCm39) missense probably damaging 0.98
R9624:Vmn1r78 UTSW 7 11,886,410 (GRCm39) missense probably benign
Z1088:Vmn1r78 UTSW 7 11,886,641 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGCACTTGACTTTTGCTAACTGC -3'
(R):5'- TACAGAGCAGTTGCCACATTTC -3'

Sequencing Primer
(F):5'- ACTTGACTTTTGCTAACTGCTTAAC -3'
(R):5'- AGCAGTTGCCACATTTCTGGAAG -3'
Posted On 2015-12-21