Incidental Mutation 'R4786:Dido1'
| ID |
367061 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dido1
|
| Ensembl Gene |
ENSMUSG00000038914 |
| Gene Name |
death inducer-obliterator 1 |
| Synonyms |
D130048F08Rik, Datf1, 6720461J16Rik, dido, DIO-1, C130092D22Rik |
| MMRRC Submission |
041995-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.960)
|
| Stock # |
R4786 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
2 |
| Chromosomal Location |
180299757-180351792 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 180312664 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Tyrosine to Cysteine
at position 1077
(Y1077C)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000099346
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000037764]
[ENSMUST00000087517]
[ENSMUST00000103056]
[ENSMUST00000103057]
|
| AlphaFold |
Q8C9B9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000037764
AA Change: Y537C
PolyPhen 2
Score 0.176 (Sensitivity: 0.92; Specificity: 0.87)
|
| SMART Domains |
Protein: ENSMUSP00000048315
Gene: ENSMUSG00000038914
AA Change: Y537C
| Domain | Start | End | E-Value | Type |
|---|
|
TFS2M
|
129 |
230 |
1.16e-45 |
SMART |
|
low complexity region
|
397 |
422 |
N/A |
INTRINSIC |
|
low complexity region
|
483 |
497 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
512 |
618 |
4.9e-23 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000087517
AA Change: Y1077C
PolyPhen 2
Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000084794
Gene: ENSMUSG00000038914
AA Change: Y1077C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
1e-22 |
PFAM |
|
low complexity region
|
1253 |
1267 |
N/A |
INTRINSIC |
|
low complexity region
|
1279 |
1308 |
N/A |
INTRINSIC |
|
low complexity region
|
1372 |
1391 |
N/A |
INTRINSIC |
|
coiled coil region
|
1458 |
1502 |
N/A |
INTRINSIC |
|
low complexity region
|
1649 |
1680 |
N/A |
INTRINSIC |
|
low complexity region
|
1748 |
1766 |
N/A |
INTRINSIC |
|
low complexity region
|
1780 |
1792 |
N/A |
INTRINSIC |
|
low complexity region
|
1804 |
1815 |
N/A |
INTRINSIC |
|
internal_repeat_2
|
1816 |
1852 |
3.9e-5 |
PROSPERO |
|
internal_repeat_1
|
1819 |
1859 |
6.92e-7 |
PROSPERO |
|
internal_repeat_2
|
1926 |
1964 |
3.9e-5 |
PROSPERO |
|
internal_repeat_1
|
1940 |
1982 |
6.92e-7 |
PROSPERO |
|
low complexity region
|
2025 |
2045 |
N/A |
INTRINSIC |
|
low complexity region
|
2123 |
2160 |
N/A |
INTRINSIC |
|
low complexity region
|
2163 |
2177 |
N/A |
INTRINSIC |
|
low complexity region
|
2182 |
2239 |
N/A |
INTRINSIC |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000103056
AA Change: Y1077C
PolyPhen 2
Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000099345
Gene: ENSMUSG00000038914
AA Change: Y1077C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
4.7e-23 |
PFAM |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000103057
AA Change: Y1077C
PolyPhen 2
Score 0.845 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000099346
Gene: ENSMUSG00000038914
AA Change: Y1077C
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
134 |
155 |
N/A |
INTRINSIC |
|
PHD
|
267 |
317 |
1.19e-11 |
SMART |
|
low complexity region
|
430 |
446 |
N/A |
INTRINSIC |
|
TFS2M
|
669 |
770 |
1.16e-45 |
SMART |
|
low complexity region
|
937 |
962 |
N/A |
INTRINSIC |
|
low complexity region
|
1023 |
1037 |
N/A |
INTRINSIC |
|
Pfam:SPOC
|
1052 |
1158 |
4.7e-23 |
PFAM |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.0%
- 20x: 94.7%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: This gene encodes a transcription factor involved in apoptosis. The encoded protein functions in cell cycle progression and plays a role in chromosomal stability. This protein regulates the self-renewal of embryonic stem cells. Disruption of this gene in mice causes symptoms similar to myelodysplastic/myeloproliferative diseases in humans. Mice lacking this gene show severely reduced fertility. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit severely reduced fertility; about one-half develop a transplantable disease characterized by anomalies in spleen, bone marrow, and peripheral blood and including anemia and various symptoms typical of myeloid dysplasia or myeloid proliferation. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(245) : Targeted, knock-out(1) Gene trapped(244) |
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2700097O09Rik |
A |
T |
12: 55,106,321 (GRCm39) |
I134N |
possibly damaging |
Het |
| Acvr1c |
T |
C |
2: 58,170,366 (GRCm39) |
Y414C |
probably damaging |
Het |
| Adam32 |
A |
C |
8: 25,353,509 (GRCm39) |
S693R |
probably damaging |
Het |
| Aldh2 |
A |
T |
5: 121,710,887 (GRCm39) |
F314Y |
probably benign |
Het |
| Anks1 |
A |
G |
17: 28,271,704 (GRCm39) |
D874G |
possibly damaging |
Het |
| Ap4b1 |
T |
A |
3: 103,726,120 (GRCm39) |
V372E |
probably benign |
Het |
| Aqp12 |
G |
A |
1: 92,934,177 (GRCm39) |
C18Y |
probably damaging |
Het |
| Arap1 |
T |
A |
7: 101,034,212 (GRCm39) |
I218N |
possibly damaging |
Het |
| Arhgap42 |
C |
A |
9: 9,238,703 (GRCm39) |
E28* |
probably null |
Het |
| Asb5 |
G |
A |
8: 55,038,874 (GRCm39) |
E247K |
probably benign |
Het |
| Atg9b |
T |
C |
5: 24,591,087 (GRCm39) |
D781G |
possibly damaging |
Het |
| Atxn10 |
A |
G |
15: 85,271,344 (GRCm39) |
H294R |
probably benign |
Het |
| Bod1l |
G |
T |
5: 41,976,781 (GRCm39) |
T1511K |
probably benign |
Het |
| Btnl2 |
A |
T |
17: 34,582,322 (GRCm39) |
N296I |
probably damaging |
Het |
| Camta1 |
A |
T |
4: 151,374,496 (GRCm39) |
L168H |
probably damaging |
Het |
| Cant1 |
A |
T |
11: 118,299,665 (GRCm39) |
V265E |
possibly damaging |
Het |
| Ccdc157 |
T |
C |
11: 4,101,861 (GRCm39) |
D20G |
probably damaging |
Het |
| Cd209c |
T |
G |
8: 3,995,698 (GRCm39) |
T35P |
possibly damaging |
Het |
| Cdc20b |
G |
A |
13: 113,215,268 (GRCm39) |
V279M |
probably damaging |
Het |
| Cdh18 |
T |
A |
15: 23,410,873 (GRCm39) |
W453R |
probably null |
Het |
| Cdh24 |
A |
G |
14: 54,875,007 (GRCm39) |
S333P |
possibly damaging |
Het |
| Ceacam11 |
T |
C |
7: 17,706,239 (GRCm39) |
|
probably null |
Het |
| Ciz1 |
C |
T |
2: 32,267,539 (GRCm39) |
P150L |
probably damaging |
Het |
| Crip3 |
C |
A |
17: 46,741,968 (GRCm39) |
Q152K |
possibly damaging |
Het |
| Dars2 |
G |
A |
1: 160,888,330 (GRCm39) |
R197W |
probably damaging |
Het |
| Dctn4 |
A |
G |
18: 60,688,267 (GRCm39) |
D394G |
probably damaging |
Het |
| Dnhd1 |
A |
G |
7: 105,323,651 (GRCm39) |
T641A |
probably benign |
Het |
| Egln3 |
A |
T |
12: 54,232,367 (GRCm39) |
I146N |
probably damaging |
Het |
| Eif2ak3 |
C |
T |
6: 70,869,602 (GRCm39) |
T763M |
possibly damaging |
Het |
| Etfbkmt |
A |
T |
6: 149,048,744 (GRCm39) |
M1L |
probably benign |
Het |
| Fam171a1 |
A |
T |
2: 3,226,615 (GRCm39) |
I583F |
probably damaging |
Het |
| Fbxo38 |
A |
C |
18: 62,662,745 (GRCm39) |
L249W |
probably damaging |
Het |
| Fxyd5 |
T |
C |
7: 30,740,907 (GRCm39) |
|
probably benign |
Het |
| Gabrr3 |
C |
A |
16: 59,250,463 (GRCm39) |
T154K |
probably benign |
Het |
| Gm7233 |
C |
A |
14: 43,038,347 (GRCm39) |
D90E |
probably benign |
Het |
| Gm8186 |
A |
G |
17: 26,318,014 (GRCm39) |
V61A |
probably benign |
Het |
| Gnao1 |
A |
G |
8: 94,670,931 (GRCm39) |
I137V |
probably benign |
Het |
| Gnptab |
A |
G |
10: 88,272,044 (GRCm39) |
M945V |
probably damaging |
Het |
| Gpsm1 |
G |
A |
2: 26,212,493 (GRCm39) |
A78T |
probably benign |
Het |
| Gtf2b |
T |
C |
3: 142,487,230 (GRCm39) |
L222P |
probably damaging |
Het |
| Hnrnpf |
A |
G |
6: 117,900,857 (GRCm39) |
Y47C |
probably damaging |
Het |
| Itga6 |
A |
G |
2: 71,669,034 (GRCm39) |
N608S |
possibly damaging |
Het |
| Kdm2b |
T |
C |
5: 123,018,917 (GRCm39) |
|
probably null |
Het |
| Krit1 |
T |
A |
5: 3,862,467 (GRCm39) |
H207Q |
possibly damaging |
Het |
| Ky |
A |
G |
9: 102,419,186 (GRCm39) |
N398D |
probably benign |
Het |
| Lama1 |
T |
A |
17: 68,080,854 (GRCm39) |
V1294E |
possibly damaging |
Het |
| Lef1 |
C |
T |
3: 130,905,173 (GRCm39) |
T18I |
probably damaging |
Het |
| Lrp2 |
T |
C |
2: 69,368,300 (GRCm39) |
N178S |
probably damaging |
Het |
| Lrrc36 |
A |
G |
8: 106,181,910 (GRCm39) |
T525A |
probably benign |
Het |
| Map3k8 |
A |
T |
18: 4,340,647 (GRCm39) |
C222* |
probably null |
Het |
| Mapre2 |
G |
C |
18: 24,011,016 (GRCm39) |
S199T |
probably benign |
Het |
| Mcm3ap |
A |
G |
10: 76,324,300 (GRCm39) |
N911S |
probably benign |
Het |
| Mroh4 |
G |
T |
15: 74,482,083 (GRCm39) |
H722Q |
probably benign |
Het |
| Muc21 |
A |
T |
17: 35,930,221 (GRCm39) |
|
probably benign |
Het |
| Myo5b |
A |
C |
18: 74,828,451 (GRCm39) |
Y701S |
probably benign |
Het |
| Myt1l |
G |
T |
12: 29,861,457 (GRCm39) |
V80L |
unknown |
Het |
| Ncoa7 |
C |
A |
10: 30,531,638 (GRCm39) |
V24L |
probably benign |
Het |
| Nlrp10 |
A |
T |
7: 108,524,445 (GRCm39) |
V345D |
probably damaging |
Het |
| Nmral1 |
C |
A |
16: 4,534,288 (GRCm39) |
G51V |
probably damaging |
Het |
| Npc1 |
A |
G |
18: 12,332,554 (GRCm39) |
I797T |
probably benign |
Het |
| Or4x6 |
A |
T |
2: 89,949,351 (GRCm39) |
I197N |
possibly damaging |
Het |
| Or8g22 |
T |
A |
9: 38,958,783 (GRCm39) |
R22* |
probably null |
Het |
| Or8g34 |
A |
T |
9: 39,373,137 (GRCm39) |
I134L |
probably benign |
Het |
| Pclo |
A |
T |
5: 14,773,281 (GRCm39) |
I4419F |
unknown |
Het |
| Phf3 |
C |
A |
1: 30,855,638 (GRCm39) |
E983* |
probably null |
Het |
| Pitpnm2 |
A |
T |
5: 124,259,806 (GRCm39) |
Y1149* |
probably null |
Het |
| Sdc3 |
A |
T |
4: 130,550,079 (GRCm39) |
T430S |
probably damaging |
Het |
| Sema3f |
A |
G |
9: 107,559,881 (GRCm39) |
V671A |
probably benign |
Het |
| Sigirr |
T |
G |
7: 140,671,346 (GRCm39) |
S379R |
probably benign |
Het |
| Slc25a23 |
T |
A |
17: 57,354,326 (GRCm39) |
N360I |
possibly damaging |
Het |
| Slco6c1 |
A |
T |
1: 97,015,720 (GRCm39) |
M357K |
probably benign |
Het |
| Sox14 |
C |
A |
9: 99,757,018 (GRCm39) |
M240I |
probably benign |
Het |
| Stradb |
A |
T |
1: 59,030,367 (GRCm39) |
|
probably benign |
Het |
| Szt2 |
A |
T |
4: 118,256,259 (GRCm39) |
M200K |
probably benign |
Het |
| Tef |
T |
C |
15: 81,699,453 (GRCm39) |
S85P |
probably benign |
Het |
| Thada |
T |
A |
17: 84,766,283 (GRCm39) |
H41L |
possibly damaging |
Het |
| Tinagl1 |
A |
G |
4: 130,067,724 (GRCm39) |
F90S |
probably benign |
Het |
| Tnfaip1 |
G |
A |
11: 78,421,045 (GRCm39) |
T5I |
possibly damaging |
Het |
| Tnfrsf23 |
A |
T |
7: 143,233,801 (GRCm39) |
V59D |
probably damaging |
Het |
| Tnpo3 |
A |
G |
6: 29,578,541 (GRCm39) |
V311A |
probably benign |
Het |
| Trak1 |
T |
A |
9: 121,301,560 (GRCm39) |
M772K |
probably benign |
Het |
| Ubash3a |
A |
G |
17: 31,436,938 (GRCm39) |
D185G |
probably benign |
Het |
| Vmn2r120 |
T |
C |
17: 57,829,048 (GRCm39) |
T516A |
probably benign |
Het |
| Wdr4 |
A |
C |
17: 31,728,785 (GRCm39) |
L130R |
probably damaging |
Het |
| Zfp12 |
T |
C |
5: 143,231,257 (GRCm39) |
I528T |
probably damaging |
Het |
| Zfp607a |
T |
C |
7: 27,578,838 (GRCm39) |
L636P |
probably damaging |
Het |
|
| Other mutations in Dido1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00425:Dido1
|
APN |
2 |
180,325,782 (GRCm39) |
missense |
probably benign |
|
|
IGL00834:Dido1
|
APN |
2 |
180,331,319 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL01317:Dido1
|
APN |
2 |
180,313,550 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL01588:Dido1
|
APN |
2 |
180,330,668 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01834:Dido1
|
APN |
2 |
180,325,824 (GRCm39) |
splice site |
probably benign |
|
|
IGL02102:Dido1
|
APN |
2 |
180,304,040 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
IGL02556:Dido1
|
APN |
2 |
180,331,128 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL02756:Dido1
|
APN |
2 |
180,303,716 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02826:Dido1
|
APN |
2 |
180,325,751 (GRCm39) |
missense |
probably benign |
|
|
IGL02970:Dido1
|
APN |
2 |
180,331,208 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03110:Dido1
|
APN |
2 |
180,331,135 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03116:Dido1
|
APN |
2 |
180,312,772 (GRCm39) |
missense |
probably damaging |
1.00 |
|
3370:Dido1
|
UTSW |
2 |
180,313,335 (GRCm39) |
missense |
probably benign |
|
|
A4554:Dido1
|
UTSW |
2 |
180,317,164 (GRCm39) |
missense |
probably damaging |
1.00 |
|
H8441:Dido1
|
UTSW |
2 |
180,330,807 (GRCm39) |
missense |
probably benign |
0.12 |
|
R0044:Dido1
|
UTSW |
2 |
180,303,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0044:Dido1
|
UTSW |
2 |
180,303,612 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0054:Dido1
|
UTSW |
2 |
180,303,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0054:Dido1
|
UTSW |
2 |
180,303,267 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0127:Dido1
|
UTSW |
2 |
180,313,617 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0620:Dido1
|
UTSW |
2 |
180,301,644 (GRCm39) |
missense |
probably benign |
0.26 |
|
R0734:Dido1
|
UTSW |
2 |
180,301,835 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1390:Dido1
|
UTSW |
2 |
180,326,917 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R1445:Dido1
|
UTSW |
2 |
180,313,263 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
R1466:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1472:Dido1
|
UTSW |
2 |
180,302,513 (GRCm39) |
missense |
probably benign |
0.02 |
|
R1538:Dido1
|
UTSW |
2 |
180,326,763 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R1584:Dido1
|
UTSW |
2 |
180,304,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2020:Dido1
|
UTSW |
2 |
180,301,378 (GRCm39) |
missense |
unknown |
|
|
R2025:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2026:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2027:Dido1
|
UTSW |
2 |
180,330,974 (GRCm39) |
nonsense |
probably null |
|
|
R2089:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2091:Dido1
|
UTSW |
2 |
180,303,677 (GRCm39) |
missense |
probably benign |
0.29 |
|
R2495:Dido1
|
UTSW |
2 |
180,331,181 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2931:Dido1
|
UTSW |
2 |
180,303,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3418:Dido1
|
UTSW |
2 |
180,302,728 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R3735:Dido1
|
UTSW |
2 |
180,325,829 (GRCm39) |
splice site |
probably benign |
|
|
R4523:Dido1
|
UTSW |
2 |
180,314,085 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4674:Dido1
|
UTSW |
2 |
180,329,352 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4729:Dido1
|
UTSW |
2 |
180,329,443 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4762:Dido1
|
UTSW |
2 |
180,331,368 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4817:Dido1
|
UTSW |
2 |
180,303,209 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4892:Dido1
|
UTSW |
2 |
180,316,822 (GRCm39) |
nonsense |
probably null |
|
|
R4979:Dido1
|
UTSW |
2 |
180,302,606 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5510:Dido1
|
UTSW |
2 |
180,326,966 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5586:Dido1
|
UTSW |
2 |
180,301,445 (GRCm39) |
nonsense |
probably null |
|
|
R5672:Dido1
|
UTSW |
2 |
180,313,696 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5863:Dido1
|
UTSW |
2 |
180,303,566 (GRCm39) |
missense |
probably benign |
0.02 |
|
R5943:Dido1
|
UTSW |
2 |
180,303,675 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5974:Dido1
|
UTSW |
2 |
180,313,290 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6123:Dido1
|
UTSW |
2 |
180,325,760 (GRCm39) |
missense |
probably benign |
0.07 |
|
R6214:Dido1
|
UTSW |
2 |
180,303,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6215:Dido1
|
UTSW |
2 |
180,303,945 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6248:Dido1
|
UTSW |
2 |
180,302,048 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6285:Dido1
|
UTSW |
2 |
180,302,940 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6349:Dido1
|
UTSW |
2 |
180,302,494 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6437:Dido1
|
UTSW |
2 |
180,316,806 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6477:Dido1
|
UTSW |
2 |
180,302,274 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6836:Dido1
|
UTSW |
2 |
180,304,100 (GRCm39) |
missense |
probably benign |
0.16 |
|
R7055:Dido1
|
UTSW |
2 |
180,303,002 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7289:Dido1
|
UTSW |
2 |
180,301,424 (GRCm39) |
missense |
unknown |
|
|
R7304:Dido1
|
UTSW |
2 |
180,329,286 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7343:Dido1
|
UTSW |
2 |
180,316,914 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R7363:Dido1
|
UTSW |
2 |
180,304,310 (GRCm39) |
nonsense |
probably null |
|
|
R7429:Dido1
|
UTSW |
2 |
180,331,319 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7594:Dido1
|
UTSW |
2 |
180,316,905 (GRCm39) |
missense |
probably benign |
|
|
R7629:Dido1
|
UTSW |
2 |
180,303,266 (GRCm39) |
missense |
probably benign |
|
|
R7899:Dido1
|
UTSW |
2 |
180,313,390 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R7946:Dido1
|
UTSW |
2 |
180,303,501 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R7951:Dido1
|
UTSW |
2 |
180,312,674 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8033:Dido1
|
UTSW |
2 |
180,316,635 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8069:Dido1
|
UTSW |
2 |
180,302,705 (GRCm39) |
missense |
probably benign |
|
|
R8331:Dido1
|
UTSW |
2 |
180,302,242 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8479:Dido1
|
UTSW |
2 |
180,315,022 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8936:Dido1
|
UTSW |
2 |
180,303,195 (GRCm39) |
missense |
probably benign |
|
|
R9089:Dido1
|
UTSW |
2 |
180,303,293 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9647:Dido1
|
UTSW |
2 |
180,315,068 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9648:Dido1
|
UTSW |
2 |
180,302,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9784:Dido1
|
UTSW |
2 |
180,325,354 (GRCm39) |
missense |
probably benign |
0.27 |
|
V1024:Dido1
|
UTSW |
2 |
180,330,807 (GRCm39) |
missense |
probably benign |
0.12 |
|
X0011:Dido1
|
UTSW |
2 |
180,302,627 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0019:Dido1
|
UTSW |
2 |
180,313,365 (GRCm39) |
missense |
possibly damaging |
0.62 |
|
| Predicted Primers |
PCR Primer
(F):5'- CATACTGCATAACCTGTTGCCAC -3'
(R):5'- TTGCTCCCAAGTATGAAGTCATC -3'
Sequencing Primer
(F):5'- GGGCAGCATGAAAACACAC -3'
(R):5'- CCAGAAGGAGATACAACCCT -3'
|
| Posted On |
2015-12-29 |
Incidental Mutation