Incidental Mutation 'R4786:Or8g34'
ID 367103
Institutional Source Beutler Lab
Gene Symbol Or8g34
Ensembl Gene ENSMUSG00000094745
Gene Name olfactory receptor family 8 subfamily G member 34
Synonyms GA_x6K02T2PVTD-33158015-33158950, MOR171-42, Olfr954, MOR171-53
MMRRC Submission 041995-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.070) question?
Stock # R4786 (G1)
Quality Score 225
Status Not validated
Chromosome 9
Chromosomal Location 39372729-39373673 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 39373137 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Leucine at position 134 (I134L)
Ref Sequence ENSEMBL: ENSMUSP00000151116 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000080329] [ENSMUST00000214818]
AlphaFold Q9EQB6
Predicted Effect probably benign
Transcript: ENSMUST00000080329
AA Change: I137L

PolyPhen 2 Score 0.072 (Sensitivity: 0.94; Specificity: 0.84)
SMART Domains Protein: ENSMUSP00000079205
Gene: ENSMUSG00000094745
AA Change: I137L

DomainStartEndE-ValueType
Pfam:7tm_4 34 311 2.6e-52 PFAM
Pfam:7TM_GPCR_Srsx 38 264 3e-5 PFAM
Pfam:7tm_1 44 293 1e-21 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000214818
AA Change: I134L

PolyPhen 2 Score 0.157 (Sensitivity: 0.92; Specificity: 0.87)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000219910
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.7%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 86 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700097O09Rik A T 12: 55,106,321 (GRCm39) I134N possibly damaging Het
Acvr1c T C 2: 58,170,366 (GRCm39) Y414C probably damaging Het
Adam32 A C 8: 25,353,509 (GRCm39) S693R probably damaging Het
Aldh2 A T 5: 121,710,887 (GRCm39) F314Y probably benign Het
Anks1 A G 17: 28,271,704 (GRCm39) D874G possibly damaging Het
Ap4b1 T A 3: 103,726,120 (GRCm39) V372E probably benign Het
Aqp12 G A 1: 92,934,177 (GRCm39) C18Y probably damaging Het
Arap1 T A 7: 101,034,212 (GRCm39) I218N possibly damaging Het
Arhgap42 C A 9: 9,238,703 (GRCm39) E28* probably null Het
Asb5 G A 8: 55,038,874 (GRCm39) E247K probably benign Het
Atg9b T C 5: 24,591,087 (GRCm39) D781G possibly damaging Het
Atxn10 A G 15: 85,271,344 (GRCm39) H294R probably benign Het
Bod1l G T 5: 41,976,781 (GRCm39) T1511K probably benign Het
Btnl2 A T 17: 34,582,322 (GRCm39) N296I probably damaging Het
Camta1 A T 4: 151,374,496 (GRCm39) L168H probably damaging Het
Cant1 A T 11: 118,299,665 (GRCm39) V265E possibly damaging Het
Ccdc157 T C 11: 4,101,861 (GRCm39) D20G probably damaging Het
Cd209c T G 8: 3,995,698 (GRCm39) T35P possibly damaging Het
Cdc20b G A 13: 113,215,268 (GRCm39) V279M probably damaging Het
Cdh18 T A 15: 23,410,873 (GRCm39) W453R probably null Het
Cdh24 A G 14: 54,875,007 (GRCm39) S333P possibly damaging Het
Ceacam11 T C 7: 17,706,239 (GRCm39) probably null Het
Ciz1 C T 2: 32,267,539 (GRCm39) P150L probably damaging Het
Crip3 C A 17: 46,741,968 (GRCm39) Q152K possibly damaging Het
Dars2 G A 1: 160,888,330 (GRCm39) R197W probably damaging Het
Dctn4 A G 18: 60,688,267 (GRCm39) D394G probably damaging Het
Dido1 T C 2: 180,312,664 (GRCm39) Y1077C possibly damaging Het
Dnhd1 A G 7: 105,323,651 (GRCm39) T641A probably benign Het
Egln3 A T 12: 54,232,367 (GRCm39) I146N probably damaging Het
Eif2ak3 C T 6: 70,869,602 (GRCm39) T763M possibly damaging Het
Etfbkmt A T 6: 149,048,744 (GRCm39) M1L probably benign Het
Fam171a1 A T 2: 3,226,615 (GRCm39) I583F probably damaging Het
Fbxo38 A C 18: 62,662,745 (GRCm39) L249W probably damaging Het
Fxyd5 T C 7: 30,740,907 (GRCm39) probably benign Het
Gabrr3 C A 16: 59,250,463 (GRCm39) T154K probably benign Het
Gm7233 C A 14: 43,038,347 (GRCm39) D90E probably benign Het
Gm8186 A G 17: 26,318,014 (GRCm39) V61A probably benign Het
Gnao1 A G 8: 94,670,931 (GRCm39) I137V probably benign Het
Gnptab A G 10: 88,272,044 (GRCm39) M945V probably damaging Het
Gpsm1 G A 2: 26,212,493 (GRCm39) A78T probably benign Het
Gtf2b T C 3: 142,487,230 (GRCm39) L222P probably damaging Het
Hnrnpf A G 6: 117,900,857 (GRCm39) Y47C probably damaging Het
Itga6 A G 2: 71,669,034 (GRCm39) N608S possibly damaging Het
Kdm2b T C 5: 123,018,917 (GRCm39) probably null Het
Krit1 T A 5: 3,862,467 (GRCm39) H207Q possibly damaging Het
Ky A G 9: 102,419,186 (GRCm39) N398D probably benign Het
Lama1 T A 17: 68,080,854 (GRCm39) V1294E possibly damaging Het
Lef1 C T 3: 130,905,173 (GRCm39) T18I probably damaging Het
Lrp2 T C 2: 69,368,300 (GRCm39) N178S probably damaging Het
Lrrc36 A G 8: 106,181,910 (GRCm39) T525A probably benign Het
Map3k8 A T 18: 4,340,647 (GRCm39) C222* probably null Het
Mapre2 G C 18: 24,011,016 (GRCm39) S199T probably benign Het
Mcm3ap A G 10: 76,324,300 (GRCm39) N911S probably benign Het
Mroh4 G T 15: 74,482,083 (GRCm39) H722Q probably benign Het
Muc21 A T 17: 35,930,221 (GRCm39) probably benign Het
Myo5b A C 18: 74,828,451 (GRCm39) Y701S probably benign Het
Myt1l G T 12: 29,861,457 (GRCm39) V80L unknown Het
Ncoa7 C A 10: 30,531,638 (GRCm39) V24L probably benign Het
Nlrp10 A T 7: 108,524,445 (GRCm39) V345D probably damaging Het
Nmral1 C A 16: 4,534,288 (GRCm39) G51V probably damaging Het
Npc1 A G 18: 12,332,554 (GRCm39) I797T probably benign Het
Or4x6 A T 2: 89,949,351 (GRCm39) I197N possibly damaging Het
Or8g22 T A 9: 38,958,783 (GRCm39) R22* probably null Het
Pclo A T 5: 14,773,281 (GRCm39) I4419F unknown Het
Phf3 C A 1: 30,855,638 (GRCm39) E983* probably null Het
Pitpnm2 A T 5: 124,259,806 (GRCm39) Y1149* probably null Het
Sdc3 A T 4: 130,550,079 (GRCm39) T430S probably damaging Het
Sema3f A G 9: 107,559,881 (GRCm39) V671A probably benign Het
Sigirr T G 7: 140,671,346 (GRCm39) S379R probably benign Het
Slc25a23 T A 17: 57,354,326 (GRCm39) N360I possibly damaging Het
Slco6c1 A T 1: 97,015,720 (GRCm39) M357K probably benign Het
Sox14 C A 9: 99,757,018 (GRCm39) M240I probably benign Het
Stradb A T 1: 59,030,367 (GRCm39) probably benign Het
Szt2 A T 4: 118,256,259 (GRCm39) M200K probably benign Het
Tef T C 15: 81,699,453 (GRCm39) S85P probably benign Het
Thada T A 17: 84,766,283 (GRCm39) H41L possibly damaging Het
Tinagl1 A G 4: 130,067,724 (GRCm39) F90S probably benign Het
Tnfaip1 G A 11: 78,421,045 (GRCm39) T5I possibly damaging Het
Tnfrsf23 A T 7: 143,233,801 (GRCm39) V59D probably damaging Het
Tnpo3 A G 6: 29,578,541 (GRCm39) V311A probably benign Het
Trak1 T A 9: 121,301,560 (GRCm39) M772K probably benign Het
Ubash3a A G 17: 31,436,938 (GRCm39) D185G probably benign Het
Vmn2r120 T C 17: 57,829,048 (GRCm39) T516A probably benign Het
Wdr4 A C 17: 31,728,785 (GRCm39) L130R probably damaging Het
Zfp12 T C 5: 143,231,257 (GRCm39) I528T probably damaging Het
Zfp607a T C 7: 27,578,838 (GRCm39) L636P probably damaging Het
Other mutations in Or8g34
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02704:Or8g34 APN 9 39,373,579 (GRCm39) missense probably damaging 0.98
IGL02793:Or8g34 APN 9 39,372,802 (GRCm39) missense probably benign 0.09
IGL02964:Or8g34 APN 9 39,373,077 (GRCm39) missense possibly damaging 0.88
IGL02979:Or8g34 APN 9 39,372,819 (GRCm39) missense probably benign 0.02
R0041:Or8g34 UTSW 9 39,372,772 (GRCm39) missense probably benign 0.34
R0153:Or8g34 UTSW 9 39,372,967 (GRCm39) missense probably damaging 0.99
R0269:Or8g34 UTSW 9 39,373,090 (GRCm39) missense probably damaging 1.00
R0426:Or8g34 UTSW 9 39,372,889 (GRCm39) missense probably damaging 1.00
R0731:Or8g34 UTSW 9 39,372,828 (GRCm39) missense probably damaging 1.00
R1800:Or8g34 UTSW 9 39,373,410 (GRCm39) missense probably damaging 1.00
R2340:Or8g34 UTSW 9 39,373,105 (GRCm39) missense probably damaging 1.00
R2901:Or8g34 UTSW 9 39,373,234 (GRCm39) missense probably damaging 0.97
R2912:Or8g34 UTSW 9 39,373,512 (GRCm39) missense probably damaging 1.00
R2939:Or8g34 UTSW 9 39,373,226 (GRCm39) missense probably benign 0.02
R2940:Or8g34 UTSW 9 39,373,226 (GRCm39) missense probably benign 0.02
R3081:Or8g34 UTSW 9 39,373,226 (GRCm39) missense probably benign 0.02
R3765:Or8g34 UTSW 9 39,372,920 (GRCm39) nonsense probably null
R4450:Or8g34 UTSW 9 39,373,328 (GRCm39) missense probably benign 0.00
R4515:Or8g34 UTSW 9 39,373,527 (GRCm39) nonsense probably null
R4961:Or8g34 UTSW 9 39,373,183 (GRCm39) missense probably damaging 1.00
R5219:Or8g34 UTSW 9 39,373,563 (GRCm39) missense probably benign 0.09
R5602:Or8g34 UTSW 9 39,373,326 (GRCm39) missense probably benign 0.00
R5887:Or8g34 UTSW 9 39,372,787 (GRCm39) missense probably damaging 1.00
R5950:Or8g34 UTSW 9 39,373,633 (GRCm39) missense probably benign 0.01
R6943:Or8g34 UTSW 9 39,373,159 (GRCm39) missense probably benign 0.05
R7567:Or8g34 UTSW 9 39,373,173 (GRCm39) missense possibly damaging 0.92
R8817:Or8g34 UTSW 9 39,373,387 (GRCm39) missense probably damaging 1.00
R9251:Or8g34 UTSW 9 39,373,668 (GRCm39) missense probably benign
X0060:Or8g34 UTSW 9 39,373,570 (GRCm39) missense probably damaging 1.00
Z1177:Or8g34 UTSW 9 39,372,997 (GRCm39) frame shift probably null
Predicted Primers PCR Primer
(F):5'- ACACACCCATGTACTATTTCCTCAG -3'
(R):5'- GCATGCAAGTTTCAAGAGGG -3'

Sequencing Primer
(F):5'- GTCCACAGTTGTTACCCCTAAAATG -3'
(R):5'- TTTCAAGAGGGGAAGGAAATCAC -3'
Posted On 2015-12-29