Mutagenetix > Incidental Mutation

Incidental Mutation 'R4788:Zfhx3'

367258

Institutional Source

Beutler Lab

Gene Symbol

Zfhx3

Ensembl Gene

ENSMUSG00000038872

Gene Name

zinc finger homeobox 3

Synonyms

Sci, A230102L03Rik, WBP9, Atbf1

Accession Numbers

Essential gene?

Probably essential (E-score: 0.919) question?

Stock #

R4788 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

109005975-109688268 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 109520842 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Serine to Proline at position 655 (S655P)

Ref Sequence

ENSEMBL: ENSMUSP00000152353 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000043896] [ENSMUST00000188994] [ENSMUST00000220518]

AlphaFold

no structure available at present

Predicted Effect

probably damaging
Transcript: ENSMUST00000043896
AA Change: S655P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000044612
Gene: ENSMUSG00000038872
AA Change: S655P

Domain	Start	End	E-Value	Type
ZnF_C2H2	79	103	7.89e0	SMART
low complexity region	110	127	N/A	INTRINSIC
low complexity region	148	165	N/A	INTRINSIC
ZnF_C2H2	282	305	1.36e1	SMART
low complexity region	393	411	N/A	INTRINSIC
coiled coil region	453	496	N/A	INTRINSIC
low complexity region	500	523	N/A	INTRINSIC
ZnF_C2H2	641	664	3.47e0	SMART
ZnF_C2H2	672	695	6.78e-3	SMART
ZnF_U1	724	758	5.71e-1	SMART
ZnF_C2H2	727	751	4.87e-4	SMART
low complexity region	771	785	N/A	INTRINSIC
low complexity region	796	804	N/A	INTRINSIC
ZnF_C2H2	805	829	6.67e-2	SMART
ZnF_U1	982	1016	2.35e0	SMART
ZnF_C2H2	985	1009	4.57e0	SMART
ZnF_C2H2	1041	1065	3.99e0	SMART
ZnF_U1	1086	1120	1.36e0	SMART
ZnF_C2H2	1089	1113	1.33e-1	SMART
ZnF_C2H2	1233	1256	4.11e-2	SMART
ZnF_C2H2	1262	1285	4.34e-1	SMART
ZnF_C2H2	1370	1395	1.08e-1	SMART
ZnF_C2H2	1411	1433	3.34e-2	SMART
ZnF_C2H2	1439	1462	8.09e-1	SMART
low complexity region	1500	1512	N/A	INTRINSIC
ZnF_U1	1552	1586	1.05e0	SMART
ZnF_C2H2	1555	1579	8.22e-2	SMART
ZnF_U1	1603	1637	4.19e0	SMART
ZnF_C2H2	1606	1630	1.16e-1	SMART
low complexity region	1643	1669	N/A	INTRINSIC
low complexity region	1734	1776	N/A	INTRINSIC
low complexity region	1792	1802	N/A	INTRINSIC
low complexity region	1842	1878	N/A	INTRINSIC
low complexity region	1881	1894	N/A	INTRINSIC
low complexity region	1967	1985	N/A	INTRINSIC
ZnF_C2H2	1990	2013	1.62e0	SMART
low complexity region	2041	2088	N/A	INTRINSIC
low complexity region	2110	2125	N/A	INTRINSIC
HOX	2152	2214	1.13e-16	SMART
HOX	2249	2311	2.41e-20	SMART
ZnF_C2H2	2335	2355	1.72e1	SMART
low complexity region	2383	2414	N/A	INTRINSIC
low complexity region	2458	2473	N/A	INTRINSIC
low complexity region	2476	2521	N/A	INTRINSIC
ZnF_C2H2	2539	2561	1.79e-2	SMART
low complexity region	2606	2619	N/A	INTRINSIC
HOX	2650	2712	2.97e-20	SMART
ZnF_C2H2	2720	2743	7.67e-2	SMART
low complexity region	2929	2950	N/A	INTRINSIC
HOX	2954	3016	1.07e-17	SMART
ZnF_U1	3029	3063	1.8e-1	SMART
ZnF_C2H2	3032	3056	8.31e0	SMART
low complexity region	3130	3144	N/A	INTRINSIC
low complexity region	3181	3235	N/A	INTRINSIC
low complexity region	3237	3256	N/A	INTRINSIC
low complexity region	3268	3282	N/A	INTRINSIC
low complexity region	3290	3299	N/A	INTRINSIC
coiled coil region	3362	3417	N/A	INTRINSIC
low complexity region	3452	3476	N/A	INTRINSIC
ZnF_C2H2	3489	3509	1.45e2	SMART
ZnF_U1	3546	3580	1.36e0	SMART
ZnF_C2H2	3549	3573	1.77e1	SMART
low complexity region	3602	3633	N/A	INTRINSIC
low complexity region	3642	3674	N/A	INTRINSIC

Predicted Effect

probably benign
Transcript: ENSMUST00000188994

Predicted Effect

probably damaging
Transcript: ENSMUST00000220518
AA Change: S655P

PolyPhen 2 Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)

Coding Region Coverage

1x: 98.8%
3x: 98.4%
10x: 96.9%
20x: 94.4%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). This gene is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
PHENOTYPE: Mice homozygous for a gene trapped allele exhibit normal initial pituitary development but reduced GH and TSH-beta staining within the pituitary by E17.5. Mice homozygous for a knock-out allele exhibit prenatal lethality. Mice heterozygous for the same allele exhibit partial postnatal lethality, decreased body size and prolonged conception time. [provided by MGI curators]

Allele List at MGI

All alleles(18) : Gene trapped(18)

Other mutations in this stock

Total: 68 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	G	A	3: 121,960,361 (GRCm39)	D815N	probably damaging	Het
Abcc9	A	T	6: 142,566,456 (GRCm39)	C1135*	probably null	Het
Ap3b1	G	A	13: 94,702,149 (GRCm39)	M1067I	unknown	Het
Arhgap15	T	C	2: 43,638,902 (GRCm39)	M1T	probably null	Het
Boc	T	C	16: 44,320,796 (GRCm39)	D288G	probably damaging	Het
Brsk1	G	T	7: 4,701,954 (GRCm39)		probably null	Het
Cabp1	T	C	5: 115,313,530 (GRCm39)	N226S	probably benign	Het
Capn13	A	T	17: 73,644,427 (GRCm39)	Y367*	probably null	Het
Ccdc191	A	G	16: 43,777,185 (GRCm39)	E632G	probably damaging	Het
Cit	T	C	5: 116,071,565 (GRCm39)	S591P	probably damaging	Het
Ckmt1	T	C	2: 121,190,427 (GRCm39)	V118A	possibly damaging	Het
Cndp2	T	C	18: 84,693,289 (GRCm39)	N157S	probably damaging	Het
Col6a3	A	G	1: 90,700,672 (GRCm39)		probably null	Het
Coq2	A	T	5: 100,805,775 (GRCm39)	V287E	probably damaging	Het
Cpa6	T	C	1: 10,478,502 (GRCm39)	K278R	possibly damaging	Het
Cracdl	A	T	1: 37,670,556 (GRCm39)	I128K	probably damaging	Het
Cybb	C	G	X: 9,316,989 (GRCm39)	D246H	probably benign	Het
Cyp3a25	A	T	5: 145,921,892 (GRCm39)	Y347*	probably null	Het
Dcun1d4	G	T	5: 73,691,971 (GRCm39)	W160L	probably damaging	Het
Dennd4c	A	G	4: 86,738,200 (GRCm39)	T994A	probably benign	Het
Dhx57	T	C	17: 80,582,760 (GRCm39)	T229A	probably benign	Het
Dnah6	T	A	6: 73,106,513 (GRCm39)	R1741S	probably damaging	Het
Dock1	T	A	7: 134,747,213 (GRCm39)	V1508D	probably damaging	Het
Donson	T	C	16: 91,484,721 (GRCm39)	T117A	possibly damaging	Het
Dtnb	A	G	12: 3,822,699 (GRCm39)	D533G	probably damaging	Het
Fcrl5	A	G	3: 87,364,495 (GRCm39)	N470S	probably damaging	Het
Focad	T	A	4: 88,275,706 (GRCm39)	V1105E	unknown	Het
Fry	T	C	5: 150,323,101 (GRCm39)	V1084A	probably benign	Het
Gabra1	G	T	11: 42,037,980 (GRCm39)	R213S	probably damaging	Het
Gbp2b	A	C	3: 142,317,171 (GRCm39)	K509T	probably benign	Het
Gprc6a	T	C	10: 51,491,104 (GRCm39)	T811A	probably benign	Het
Hmgcs2	A	G	3: 98,198,400 (GRCm39)	D101G	probably damaging	Het
Ifna11	G	A	4: 88,738,245 (GRCm39)	W17*	probably null	Het
Ighv1-62-3	T	A	12: 115,424,672 (GRCm39)	M100L	probably benign	Het
Lgmn	T	A	12: 102,368,936 (GRCm39)	Y181F	probably benign	Het
Map4k4	T	C	1: 40,043,076 (GRCm39)	S644P	probably benign	Het
Med9	T	A	11: 59,839,266 (GRCm39)	N58K	probably benign	Het
Nav1	C	T	1: 135,397,461 (GRCm39)	A903T	probably benign	Het
Nop53	T	C	7: 15,676,240 (GRCm39)	E153G	possibly damaging	Het
Nop56	G	T	2: 130,120,820 (GRCm39)	V190L	probably benign	Het
Nyap2	A	T	1: 81,247,112 (GRCm39)	M687L	probably benign	Het
Or4a81	G	A	2: 89,619,480 (GRCm39)	S72F	probably damaging	Het
Or8g17	T	C	9: 38,930,217 (GRCm39)	T207A	probably benign	Het
Or8g26	A	G	9: 39,095,908 (GRCm39)	T145A	probably benign	Het
Osbp2	T	C	11: 3,813,320 (GRCm39)	K183R	probably benign	Het
Pappa2	A	G	1: 158,611,487 (GRCm39)	V1492A	possibly damaging	Het
Pax1	A	G	2: 147,208,124 (GRCm39)	Q244R	possibly damaging	Het
Pcdh9	C	A	14: 94,124,851 (GRCm39)	V317F	probably damaging	Het
Pkhd1l1	A	T	15: 44,361,417 (GRCm39)	Q489L	probably damaging	Het
Poln	A	T	5: 34,286,675 (GRCm39)	S164R	probably benign	Het
Ptf1a	T	C	2: 19,450,762 (GRCm39)	S31P	probably benign	Het
Rasal3	A	T	17: 32,618,312 (GRCm39)	D164E	probably benign	Het
Rnf170	A	G	8: 26,630,891 (GRCm39)	E168G	probably damaging	Het
Rubcn	A	G	16: 32,656,778 (GRCm39)		probably null	Het
Sec16b	A	T	1: 157,389,094 (GRCm39)	T830S	possibly damaging	Het
Sel1l3	A	G	5: 53,289,175 (GRCm39)	V882A	probably benign	Het
Sfpq	A	G	4: 126,919,791 (GRCm39)	E512G	probably damaging	Het
Sh3pxd2a	A	G	19: 47,302,518 (GRCm39)	L187P	probably damaging	Het
Skint6	C	T	4: 113,095,533 (GRCm39)	G42D	possibly damaging	Het
Slc7a2	A	G	8: 41,367,023 (GRCm39)	I526V	probably benign	Het
Spmip7	T	C	11: 11,438,652 (GRCm39)		probably null	Het
Ssh2	A	T	11: 77,320,624 (GRCm39)	N328Y	probably damaging	Het
Taok2	G	A	7: 126,467,304 (GRCm39)	S167L	possibly damaging	Het
Tom1l2	A	G	11: 60,139,844 (GRCm39)	L275P	probably damaging	Het
Trgv5	A	G	13: 19,376,724 (GRCm39)	K57R	probably benign	Het
Tyrp1	C	T	4: 80,763,180 (GRCm39)	R356*	probably null	Het
Zan	A	G	5: 137,440,375 (GRCm39)	L1953P	unknown	Het
Zmym1	T	C	4: 126,948,090 (GRCm39)	T94A	probably benign	Het

Other mutations in Zfhx3

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01011:Zfhx3	APN	8	109,520,226 (GRCm39)	missense	probably benign	0.00
IGL01946:Zfhx3	APN	8	109,660,561 (GRCm39)	missense	probably damaging	0.98
IGL01973:Zfhx3	APN	8	109,673,825 (GRCm39)	missense	probably damaging	1.00
IGL01983:Zfhx3	APN	8	109,673,866 (GRCm39)	missense	probably damaging	1.00
IGL02151:Zfhx3	APN	8	109,520,515 (GRCm39)	missense	probably damaging	1.00
IGL02405:Zfhx3	APN	8	109,682,374 (GRCm39)	missense	unknown
IGL02406:Zfhx3	APN	8	109,682,374 (GRCm39)	missense	unknown
IGL02408:Zfhx3	APN	8	109,682,004 (GRCm39)	splice site	probably benign
IGL02549:Zfhx3	APN	8	109,527,141 (GRCm39)	missense	probably damaging	1.00
IGL02601:Zfhx3	APN	8	109,583,462 (GRCm39)	missense	probably damaging	1.00
IGL02649:Zfhx3	APN	8	109,520,167 (GRCm39)	missense	possibly damaging	0.94
IGL03027:Zfhx3	APN	8	109,519,820 (GRCm39)	missense	probably damaging	0.98
IGL03053:Zfhx3	APN	8	109,673,132 (GRCm39)	missense	probably damaging	0.99
IGL03168:Zfhx3	APN	8	109,673,132 (GRCm39)	missense	probably damaging	0.99
IGL03194:Zfhx3	APN	8	109,521,359 (GRCm39)	missense	probably damaging	0.97
IGL03248:Zfhx3	APN	8	109,673,182 (GRCm39)	missense	probably damaging	1.00
FR4449:Zfhx3	UTSW	8	109,682,726 (GRCm39)	small insertion	probably benign
FR4589:Zfhx3	UTSW	8	109,682,733 (GRCm39)	small insertion	probably benign
FR4737:Zfhx3	UTSW	8	109,682,735 (GRCm39)	small insertion	probably benign
FR4737:Zfhx3	UTSW	8	109,682,734 (GRCm39)	small insertion	probably benign
FR4737:Zfhx3	UTSW	8	109,682,720 (GRCm39)	small insertion	probably benign
G5030:Zfhx3	UTSW	8	109,678,091 (GRCm39)	missense	possibly damaging	0.86
R0016:Zfhx3	UTSW	8	109,676,810 (GRCm39)	missense	probably benign	0.02
R0090:Zfhx3	UTSW	8	109,676,689 (GRCm39)	missense	possibly damaging	0.85
R0330:Zfhx3	UTSW	8	109,675,589 (GRCm39)	missense	probably damaging	1.00
R0332:Zfhx3	UTSW	8	109,673,255 (GRCm39)	missense	probably damaging	1.00
R0398:Zfhx3	UTSW	8	109,677,878 (GRCm39)	missense	probably damaging	0.98
R0539:Zfhx3	UTSW	8	109,527,141 (GRCm39)	missense	probably damaging	1.00
R0546:Zfhx3	UTSW	8	109,520,819 (GRCm39)	missense	probably damaging	1.00
R0614:Zfhx3	UTSW	8	109,675,599 (GRCm39)	nonsense	probably null
R0614:Zfhx3	UTSW	8	109,675,171 (GRCm39)	missense	probably benign	0.03
R0653:Zfhx3	UTSW	8	109,673,440 (GRCm39)	missense	possibly damaging	0.95
R0718:Zfhx3	UTSW	8	109,682,282 (GRCm39)	missense	unknown
R0825:Zfhx3	UTSW	8	109,675,840 (GRCm39)	missense	probably damaging	0.99
R1143:Zfhx3	UTSW	8	109,521,043 (GRCm39)	missense	probably damaging	1.00
R1319:Zfhx3	UTSW	8	109,660,465 (GRCm39)	missense	probably damaging	0.99
R1347:Zfhx3	UTSW	8	109,527,330 (GRCm39)	splice site	probably benign
R1412:Zfhx3	UTSW	8	109,641,199 (GRCm39)	missense	possibly damaging	0.88
R1447:Zfhx3	UTSW	8	109,675,076 (GRCm39)	missense	probably benign	0.03
R1530:Zfhx3	UTSW	8	109,675,121 (GRCm39)	missense	probably damaging	1.00
R1745:Zfhx3	UTSW	8	109,682,494 (GRCm39)	missense	unknown
R1764:Zfhx3	UTSW	8	109,678,276 (GRCm39)	missense	probably benign	0.18
R1781:Zfhx3	UTSW	8	109,520,167 (GRCm39)	missense	probably benign	0.01
R1917:Zfhx3	UTSW	8	109,682,880 (GRCm39)	missense	unknown
R1956:Zfhx3	UTSW	8	109,520,774 (GRCm39)	missense	probably benign	0.02
R2049:Zfhx3	UTSW	8	109,671,809 (GRCm39)	missense	probably benign	0.01
R2196:Zfhx3	UTSW	8	109,526,885 (GRCm39)	missense	probably damaging	1.00
R3085:Zfhx3	UTSW	8	109,682,664 (GRCm39)	missense	unknown
R3765:Zfhx3	UTSW	8	109,519,394 (GRCm39)	missense	probably damaging	0.97
R4162:Zfhx3	UTSW	8	109,683,619 (GRCm39)	missense	unknown
R4243:Zfhx3	UTSW	8	109,518,952 (GRCm39)	missense	probably damaging	0.97
R4380:Zfhx3	UTSW	8	109,683,022 (GRCm39)	missense	unknown
R4433:Zfhx3	UTSW	8	109,682,269 (GRCm39)	missense	unknown
R4509:Zfhx3	UTSW	8	109,520,411 (GRCm39)	missense	probably benign	0.01
R4731:Zfhx3	UTSW	8	109,682,716 (GRCm39)	missense	unknown
R4812:Zfhx3	UTSW	8	109,674,593 (GRCm39)	missense	possibly damaging	0.83
R4893:Zfhx3	UTSW	8	109,683,639 (GRCm39)	missense	unknown
R4907:Zfhx3	UTSW	8	109,519,986 (GRCm39)	missense	probably damaging	0.99
R4935:Zfhx3	UTSW	8	109,674,482 (GRCm39)	missense	possibly damaging	0.92
R4943:Zfhx3	UTSW	8	109,674,949 (GRCm39)	missense	probably damaging	0.98
R5154:Zfhx3	UTSW	8	109,527,207 (GRCm39)	missense	probably damaging	1.00
R5377:Zfhx3	UTSW	8	109,677,817 (GRCm39)	missense	possibly damaging	0.95
R5388:Zfhx3	UTSW	8	109,673,446 (GRCm39)	missense	possibly damaging	0.88
R5434:Zfhx3	UTSW	8	109,519,031 (GRCm39)	missense	probably damaging	0.99
R5445:Zfhx3	UTSW	8	109,682,842 (GRCm39)	missense	unknown
R5541:Zfhx3	UTSW	8	109,675,583 (GRCm39)	missense	probably damaging	0.99
R5571:Zfhx3	UTSW	8	109,682,623 (GRCm39)	missense	unknown
R5700:Zfhx3	UTSW	8	109,660,499 (GRCm39)	missense	probably damaging	1.00
R5754:Zfhx3	UTSW	8	109,526,964 (GRCm39)	missense	probably damaging	0.99
R5867:Zfhx3	UTSW	8	109,520,078 (GRCm39)	missense	probably damaging	1.00
R5905:Zfhx3	UTSW	8	109,520,135 (GRCm39)	missense	probably damaging	1.00
R5922:Zfhx3	UTSW	8	109,673,330 (GRCm39)	missense	probably damaging	1.00
R5972:Zfhx3	UTSW	8	109,677,483 (GRCm39)	missense	possibly damaging	0.91
R6020:Zfhx3	UTSW	8	109,519,159 (GRCm39)	missense	probably damaging	1.00
R6028:Zfhx3	UTSW	8	109,520,135 (GRCm39)	missense	probably damaging	1.00
R6113:Zfhx3	UTSW	8	109,674,053 (GRCm39)	missense	probably benign	0.04
R6253:Zfhx3	UTSW	8	109,682,020 (GRCm39)	missense	possibly damaging	0.96
R6356:Zfhx3	UTSW	8	109,673,251 (GRCm39)	missense	probably damaging	1.00
R6800:Zfhx3	UTSW	8	109,676,149 (GRCm39)	missense	probably benign	0.20
R6829:Zfhx3	UTSW	8	109,676,915 (GRCm39)	missense	probably damaging	0.98
R6872:Zfhx3	UTSW	8	109,527,273 (GRCm39)	missense	probably damaging	1.00
R6873:Zfhx3	UTSW	8	109,527,273 (GRCm39)	missense	probably damaging	1.00
R6919:Zfhx3	UTSW	8	109,527,160 (GRCm39)	missense	probably damaging	1.00
R6921:Zfhx3	UTSW	8	109,678,024 (GRCm39)	missense	possibly damaging	0.53
R6925:Zfhx3	UTSW	8	109,683,453 (GRCm39)	missense	unknown
R6927:Zfhx3	UTSW	8	109,683,453 (GRCm39)	missense	unknown
R7152:Zfhx3	UTSW	8	109,674,839 (GRCm39)	missense	possibly damaging	0.94
R7169:Zfhx3	UTSW	8	109,678,030 (GRCm39)	missense	possibly damaging	0.86
R7214:Zfhx3	UTSW	8	109,675,493 (GRCm39)	missense	probably damaging	0.98
R7378:Zfhx3	UTSW	8	109,519,880 (GRCm39)	missense	probably damaging	0.99
R7391:Zfhx3	UTSW	8	109,674,475 (GRCm39)	missense	probably damaging	0.96
R7442:Zfhx3	UTSW	8	109,519,468 (GRCm39)	missense	probably damaging	0.97
R7636:Zfhx3	UTSW	8	109,673,441 (GRCm39)	missense	probably benign	0.25
R7649:Zfhx3	UTSW	8	109,678,276 (GRCm39)	missense	probably benign	0.18
R7699:Zfhx3	UTSW	8	109,677,754 (GRCm39)	missense	probably benign	0.18
R7728:Zfhx3	UTSW	8	109,678,201 (GRCm39)	missense	probably benign	0.01
R7780:Zfhx3	UTSW	8	109,678,283 (GRCm39)	missense	possibly damaging	0.53
R7904:Zfhx3	UTSW	8	109,677,695 (GRCm39)	missense	probably damaging	0.98
R8032:Zfhx3	UTSW	8	109,677,854 (GRCm39)	missense	possibly damaging	0.51
R8158:Zfhx3	UTSW	8	109,675,353 (GRCm39)	missense	possibly damaging	0.82
R8163:Zfhx3	UTSW	8	109,675,925 (GRCm39)	missense	probably damaging	1.00
R8215:Zfhx3	UTSW	8	109,677,349 (GRCm39)	missense	probably benign
R8217:Zfhx3	UTSW	8	109,677,349 (GRCm39)	missense	probably benign
R8218:Zfhx3	UTSW	8	109,677,349 (GRCm39)	missense	probably benign
R8369:Zfhx3	UTSW	8	109,583,448 (GRCm39)	missense	possibly damaging	0.82
R8424:Zfhx3	UTSW	8	109,583,385 (GRCm39)	missense	probably damaging	0.98
R8482:Zfhx3	UTSW	8	109,674,511 (GRCm39)	missense	probably benign	0.02
R8504:Zfhx3	UTSW	8	109,583,549 (GRCm39)	missense	possibly damaging	0.95
R8871:Zfhx3	UTSW	8	109,676,867 (GRCm39)	missense	possibly damaging	0.85
R9144:Zfhx3	UTSW	8	109,676,794 (GRCm39)	missense	possibly damaging	0.53
R9202:Zfhx3	UTSW	8	109,677,920 (GRCm39)	missense	possibly damaging	0.92
R9213:Zfhx3	UTSW	8	109,676,756 (GRCm39)	missense	probably benign	0.18
R9218:Zfhx3	UTSW	8	109,520,501 (GRCm39)	missense	probably benign	0.17
R9370:Zfhx3	UTSW	8	109,521,340 (GRCm39)	missense	probably damaging	1.00
R9422:Zfhx3	UTSW	8	109,430,850 (GRCm39)	start gained	probably benign
R9530:Zfhx3	UTSW	8	109,527,010 (GRCm39)	missense	probably damaging	1.00
RF027:Zfhx3	UTSW	8	109,682,730 (GRCm39)	small insertion	probably benign
RF028:Zfhx3	UTSW	8	109,682,728 (GRCm39)	small insertion	probably benign
RF029:Zfhx3	UTSW	8	109,682,724 (GRCm39)	small insertion	probably benign
RF031:Zfhx3	UTSW	8	109,682,730 (GRCm39)	small insertion	probably benign
RF032:Zfhx3	UTSW	8	109,682,724 (GRCm39)	small insertion	probably benign
RF037:Zfhx3	UTSW	8	109,682,730 (GRCm39)	nonsense	probably null
RF038:Zfhx3	UTSW	8	109,682,733 (GRCm39)	small insertion	probably benign
RF040:Zfhx3	UTSW	8	109,682,733 (GRCm39)	small insertion	probably benign
RF042:Zfhx3	UTSW	8	109,682,730 (GRCm39)	small insertion	probably benign
RF042:Zfhx3	UTSW	8	109,682,720 (GRCm39)	small insertion	probably benign
RF054:Zfhx3	UTSW	8	109,682,728 (GRCm39)	small insertion	probably benign
RF060:Zfhx3	UTSW	8	109,682,720 (GRCm39)	small insertion	probably benign
X0019:Zfhx3	UTSW	8	109,678,285 (GRCm39)	missense	probably benign	0.00
X0026:Zfhx3	UTSW	8	109,675,777 (GRCm39)	missense	probably damaging	1.00
Z1088:Zfhx3	UTSW	8	109,677,989 (GRCm39)	missense	possibly damaging	0.72
Z1176:Zfhx3	UTSW	8	109,527,081 (GRCm39)	missense	probably damaging	1.00
Z1176:Zfhx3	UTSW	8	109,520,555 (GRCm39)	missense	probably benign	0.09

Predicted Primers

PCR Primer
(F):5'- AAGTGCCAATAAAGACAGTGCC -3'
(R):5'- GGAAAGGCTTGTAACCACACG -3'

Sequencing Primer
(F):5'- GCCAATAAAGACAGTGCCACAGC -3'
(R):5'- GCTTGTAACCACACGTGTAGC -3'

Posted On

2015-12-29