Incidental Mutation 'R4789:Wnk3'
ID 367370
Institutional Source Beutler Lab
Gene Symbol Wnk3
Ensembl Gene ENSMUSG00000041245
Gene Name WNK lysine deficient protein kinase 3
Synonyms Wnk3-ps, Prkwnk3, Wnk3
Accession Numbers
Essential gene? Probably non essential (E-score: 0.189) question?
Stock # R4789 (G1)
Quality Score 225
Status Not validated
Chromosome X
Chromosomal Location 149981074-150103148 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 149993933 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Stop codon at position 331 (Y331*)
Ref Sequence ENSEMBL: ENSMUSP00000138822 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000096285] [ENSMUST00000149140] [ENSMUST00000184392] [ENSMUST00000184730]
AlphaFold Q80XP9
Predicted Effect probably null
Transcript: ENSMUST00000096285
AA Change: Y331*
SMART Domains Protein: ENSMUSP00000138839
Gene: ENSMUSG00000041245
AA Change: Y331*

DomainStartEndE-ValueType
low complexity region 121 136 N/A INTRINSIC
S_TKc 146 404 4.88e-68 SMART
Pfam:OSR1_C 425 462 7.9e-23 PFAM
low complexity region 518 531 N/A INTRINSIC
internal_repeat_1 765 806 2.88e-5 PROSPERO
low complexity region 1511 1532 N/A INTRINSIC
coiled coil region 1535 1579 N/A INTRINSIC
low complexity region 1580 1600 N/A INTRINSIC
low complexity region 1656 1670 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000121545
Predicted Effect noncoding transcript
Transcript: ENSMUST00000131844
Predicted Effect probably null
Transcript: ENSMUST00000149140
AA Change: Y331*
SMART Domains Protein: ENSMUSP00000139255
Gene: ENSMUSG00000041245
AA Change: Y331*

DomainStartEndE-ValueType
low complexity region 121 136 N/A INTRINSIC
S_TKc 146 404 4.88e-68 SMART
Pfam:OSR1_C 425 462 2.3e-23 PFAM
low complexity region 518 531 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000184392
AA Change: Y331*
SMART Domains Protein: ENSMUSP00000139037
Gene: ENSMUSG00000041245
AA Change: Y331*

DomainStartEndE-ValueType
low complexity region 121 136 N/A INTRINSIC
S_TKc 146 404 4.88e-68 SMART
Pfam:OSR1_C 425 462 7.8e-23 PFAM
low complexity region 518 531 N/A INTRINSIC
internal_repeat_1 733 774 2.87e-5 PROSPERO
low complexity region 1479 1500 N/A INTRINSIC
coiled coil region 1503 1547 N/A INTRINSIC
low complexity region 1548 1568 N/A INTRINSIC
low complexity region 1624 1638 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000184730
AA Change: Y331*
SMART Domains Protein: ENSMUSP00000138822
Gene: ENSMUSG00000041245
AA Change: Y331*

DomainStartEndE-ValueType
low complexity region 121 136 N/A INTRINSIC
S_TKc 146 404 4.88e-68 SMART
Pfam:OSR1_C 425 462 7.5e-23 PFAM
low complexity region 518 531 N/A INTRINSIC
internal_repeat_1 733 774 2.72e-5 PROSPERO
low complexity region 1432 1453 N/A INTRINSIC
coiled coil region 1456 1500 N/A INTRINSIC
low complexity region 1501 1521 N/A INTRINSIC
low complexity region 1577 1591 N/A INTRINSIC
Coding Region Coverage
  • 1x: 98.8%
  • 3x: 98.4%
  • 10x: 96.9%
  • 20x: 94.4%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a protein belonging to the 'with no lysine' family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase-3-dependent pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit lower blood pressure when fed a low-salt diet. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110004F10Rik C A 7: 115,692,757 (GRCm39) D20E probably benign Het
Abcb9 T A 5: 124,216,853 (GRCm39) M455L probably benign Het
Add2 G A 6: 86,095,752 (GRCm39) V475M probably benign Het
Apoh T A 11: 108,300,064 (GRCm39) Y238N probably damaging Het
Arpp21 A G 9: 111,896,360 (GRCm39) S681P probably benign Het
Atp1a3 A C 7: 24,698,389 (GRCm39) F149C probably damaging Het
B9d1 A G 11: 61,397,186 (GRCm39) D27G probably benign Het
Bfar T A 16: 13,503,001 (GRCm39) M1K probably null Het
Bok T C 1: 93,616,963 (GRCm39) V103A probably damaging Het
Brca1 A C 11: 101,414,758 (GRCm39) H1125Q probably benign Het
Card9 T A 2: 26,247,632 (GRCm39) M218L probably damaging Het
Cers1 T C 8: 70,776,018 (GRCm39) V303A probably damaging Het
Col6a5 T C 9: 105,814,534 (GRCm39) I493V unknown Het
Coro7 T C 16: 4,446,085 (GRCm39) Y880C probably damaging Het
Cyp2b19 T C 7: 26,463,801 (GRCm39) Y318H probably benign Het
Dennd3 T A 15: 73,394,131 (GRCm39) L52Q probably damaging Het
Dlat A T 9: 50,570,670 (GRCm39) C33S probably benign Het
Dmxl2 T A 9: 54,287,099 (GRCm39) Q2646L probably benign Het
Dnah3 T C 7: 119,610,295 (GRCm39) N1703D probably damaging Het
Dock10 T A 1: 80,518,998 (GRCm39) H1241L probably damaging Het
Fbxl17 T G 17: 63,794,910 (GRCm39) I391L probably benign Het
Fdxacb1 A G 9: 50,681,418 (GRCm39) D113G possibly damaging Het
Flii A G 11: 60,605,919 (GRCm39) S1185P probably benign Het
Gm14496 A T 2: 181,637,577 (GRCm39) Q217L possibly damaging Het
Heatr9 A T 11: 83,410,018 (GRCm39) D74E probably benign Het
Heca C A 10: 17,783,895 (GRCm39) E91* probably null Het
Ikzf4 T G 10: 128,468,575 (GRCm39) T635P probably benign Het
Kif17 C T 4: 138,008,688 (GRCm39) P382S probably damaging Het
Kmt5b T C 19: 3,865,330 (GRCm39) V775A probably benign Het
Mapk8ip2 T A 15: 89,343,241 (GRCm39) F661Y probably damaging Het
Mapkap1 A G 2: 34,423,859 (GRCm39) E111G possibly damaging Het
Med9 T A 11: 59,839,266 (GRCm39) N58K probably benign Het
Mid2 T A X: 139,578,981 (GRCm39) Y61N probably damaging Het
Mief1 T A 15: 80,132,080 (GRCm39) Y50* probably null Het
Mios T C 6: 8,235,429 (GRCm39) M859T probably benign Het
Muc5ac G T 7: 141,352,619 (GRCm39) C702F possibly damaging Het
Nkiras1 T C 14: 18,276,935 (GRCm38) probably benign Het
Or11i1 A C 3: 106,729,608 (GRCm39) I89R possibly damaging Het
Or11i1 T A 3: 106,729,624 (GRCm39) M84L possibly damaging Het
Or56a3b T G 7: 104,771,520 (GRCm39) H285Q probably null Het
Or5ae2 T A 7: 84,506,509 (GRCm39) C311S probably benign Het
Pcsk5 C T 19: 17,410,963 (GRCm39) V1810M probably benign Het
Pex1 T C 5: 3,680,270 (GRCm39) V964A probably damaging Het
Pgm2l1 A T 7: 99,916,794 (GRCm39) M471L probably benign Het
Pkd1l2 T C 8: 117,738,314 (GRCm39) T2182A probably damaging Het
Plscr1l1 G A 9: 92,233,084 (GRCm39) C69Y probably damaging Het
Polr1b T A 2: 128,951,257 (GRCm39) I290K probably benign Het
Prkg1 T A 19: 31,563,045 (GRCm39) M119L probably damaging Het
Rbl1 A G 2: 157,019,275 (GRCm39) V490A probably benign Het
Shtn1 G C 19: 59,039,305 (GRCm39) R45G probably damaging Het
Slc10a6 T A 5: 103,776,848 (GRCm39) Y84F probably benign Het
Slc25a23 T C 17: 57,366,597 (GRCm39) D26G probably damaging Het
Slc41a2 T C 10: 83,152,320 (GRCm39) K52E probably damaging Het
Slc4a5 T C 6: 83,247,951 (GRCm39) F501L probably benign Het
Slfn5 T A 11: 82,847,226 (GRCm39) M37K probably benign Het
Sptbn1 A C 11: 30,067,759 (GRCm39) F1818L probably benign Het
Taf3 T C 2: 9,956,770 (GRCm39) T466A probably damaging Het
Thbs2 C T 17: 14,891,750 (GRCm39) G929D probably damaging Het
Tmc3 A T 7: 83,271,746 (GRCm39) D995V probably damaging Het
Tmem262 T C 19: 6,130,452 (GRCm39) F59L possibly damaging Het
Triobp A G 15: 78,875,228 (GRCm39) D137G probably damaging Het
Tspear T C 10: 77,702,199 (GRCm39) F211L possibly damaging Het
Ttn A T 2: 76,728,670 (GRCm39) probably benign Het
Ugt2b5 T A 5: 87,287,550 (GRCm39) M206L probably benign Het
Ush1g A T 11: 115,209,466 (GRCm39) S243T probably damaging Het
Usp19 A T 9: 108,370,433 (GRCm39) T86S possibly damaging Het
Wdhd1 A G 14: 47,506,149 (GRCm39) V255A probably benign Het
Wdr11 G A 7: 129,220,394 (GRCm39) W594* probably null Het
Zfp429 A T 13: 67,538,523 (GRCm39) I307K probably benign Het
Zkscan14 T A 5: 145,132,444 (GRCm39) K362N probably damaging Het
Other mutations in Wnk3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00486:Wnk3 APN X 150,016,025 (GRCm39) missense probably damaging 1.00
IGL03033:Wnk3 APN X 150,059,924 (GRCm39) missense probably damaging 1.00
R3436:Wnk3 UTSW X 150,069,300 (GRCm39) missense probably benign 0.16
R4407:Wnk3 UTSW X 150,016,209 (GRCm39) missense probably benign 0.04
U24488:Wnk3 UTSW X 149,992,456 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GATTTACAGATTTCCTTTGAGGGG -3'
(R):5'- GTCAAGCATTCTACCACTAAGCC -3'

Sequencing Primer
(F):5'- CCTTTGAGGGGGCAGAAATTGAC -3'
(R):5'- ACTAAGCCACACACTTTGTTCC -3'
Posted On 2015-12-29