Incidental Mutation 'R0413:Lrp6'
| ID |
36788 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Lrp6
|
| Ensembl Gene |
ENSMUSG00000030201 |
| Gene Name |
low density lipoprotein receptor-related protein 6 |
| Synonyms |
ska, Cd, skax26, ska26 |
| MMRRC Submission |
038615-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably essential
(E-score: 0.964)
|
| Stock # |
R0413 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
6 |
| Chromosomal Location |
134423439-134543876 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 134484587 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Aspartic acid to Glutamic Acid
at position 345
(D345E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000032322
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000032322]
[ENSMUST00000126836]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000032322
AA Change: D345E
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000032322
Gene: ENSMUSG00000030201
AA Change: D345E
| Domain | Start | End | E-Value | Type |
|---|
|
LY
|
43 |
85 |
1.55e-2 |
SMART |
|
LY
|
87 |
129 |
1.91e-11 |
SMART |
|
LY
|
130 |
173 |
5.19e-13 |
SMART |
|
LY
|
174 |
216 |
1.39e-13 |
SMART |
|
LY
|
217 |
258 |
2.87e-6 |
SMART |
|
EGF
|
285 |
324 |
2.16e-1 |
SMART |
|
low complexity region
|
330 |
341 |
N/A |
INTRINSIC |
|
LY
|
352 |
394 |
1.29e-8 |
SMART |
|
LY
|
395 |
437 |
5.73e-15 |
SMART |
|
LY
|
438 |
481 |
1.07e-14 |
SMART |
|
LY
|
482 |
524 |
3.07e-15 |
SMART |
|
LY
|
525 |
565 |
4.66e-6 |
SMART |
|
EGF
|
591 |
628 |
1.47e-3 |
SMART |
|
LY
|
654 |
696 |
2.06e-7 |
SMART |
|
LY
|
697 |
739 |
3.73e-14 |
SMART |
|
LY
|
740 |
783 |
3.37e-12 |
SMART |
|
LY
|
784 |
825 |
1.17e-6 |
SMART |
|
LY
|
827 |
865 |
1.91e-2 |
SMART |
|
EGF
|
892 |
930 |
7.35e-4 |
SMART |
|
LY
|
957 |
999 |
1.41e-5 |
SMART |
|
LY
|
1005 |
1048 |
5.32e-1 |
SMART |
|
LY
|
1049 |
1093 |
5e-6 |
SMART |
|
LY
|
1094 |
1136 |
4.25e-9 |
SMART |
|
LY
|
1137 |
1177 |
1.91e-2 |
SMART |
|
EGF
|
1206 |
1250 |
1.23e1 |
SMART |
|
LDLa
|
1248 |
1287 |
2.42e-12 |
SMART |
|
LDLa
|
1288 |
1324 |
4.37e-10 |
SMART |
|
LDLa
|
1325 |
1362 |
1.66e-10 |
SMART |
|
transmembrane domain
|
1371 |
1393 |
N/A |
INTRINSIC |
|
low complexity region
|
1429 |
1438 |
N/A |
INTRINSIC |
|
low complexity region
|
1444 |
1457 |
N/A |
INTRINSIC |
|
low complexity region
|
1508 |
1524 |
N/A |
INTRINSIC |
|
low complexity region
|
1566 |
1573 |
N/A |
INTRINSIC |
|
low complexity region
|
1596 |
1608 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000126836
|
| SMART Domains |
Protein: ENSMUSP00000144733
Gene: ENSMUSG00000030201
| Domain | Start | End | E-Value | Type |
|---|
|
LY
|
23 |
65 |
6.8e-16 |
SMART |
|
LY
|
66 |
107 |
1.4e-8 |
SMART |
|
| Meta Mutation Damage Score |
0.2468 |
| Coding Region Coverage |
- 1x: 99.3%
- 3x: 98.6%
- 10x: 97.0%
- 20x: 94.9%
|
| Validation Efficiency |
99% (99/100) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the low density lipoprotein (LDL) receptor gene family. LDL receptors are transmembrane cell surface proteins involved in receptor-mediated endocytosis of lipoprotein and protein ligands. The protein encoded by this gene functions as a receptor or, with Frizzled, a co-receptor for Wnt and thereby transmits the canonical Wnt/beta-catenin signaling cascade. Through its interaction with the Wnt/beta-catenin signaling cascade this gene plays a role in the regulation of cell differentiation, proliferation, and migration and the development of many cancer types. This protein undergoes gamma-secretase dependent RIP- (regulated intramembrane proteolysis) processing but the precise locations of the cleavage sites have not been determined.[provided by RefSeq, Dec 2009]
PHENOTYPE: Animals homozygous for this mutation exhibit partial embryonic lethality, growth retardation, crooked tail, abnormal vertebrae, small skull with occasional bent nose, absence of the third molars and small and/or unerupted lower incisors. Heterozygotes exhibit a crooked tail and abnormal vertebrae. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcb11 |
A |
G |
2: 69,158,355 (GRCm39) |
|
probably benign |
Het |
| Adh1 |
C |
T |
3: 137,986,193 (GRCm39) |
T60I |
probably benign |
Het |
| Agtpbp1 |
T |
A |
13: 59,661,966 (GRCm39) |
I282F |
probably damaging |
Het |
| Arih2 |
G |
T |
9: 108,493,916 (GRCm39) |
Q166K |
probably damaging |
Het |
| Cacna1s |
A |
G |
1: 136,025,947 (GRCm39) |
T1031A |
probably benign |
Het |
| Ccdc102a |
C |
A |
8: 95,629,914 (GRCm39) |
E542D |
probably benign |
Het |
| Cdk1 |
T |
C |
10: 69,180,929 (GRCm39) |
I94V |
probably benign |
Het |
| Cep290 |
C |
T |
10: 100,359,176 (GRCm39) |
Q969* |
probably null |
Het |
| Cilp2 |
A |
G |
8: 70,335,643 (GRCm39) |
S452P |
probably benign |
Het |
| Col12a1 |
T |
C |
9: 79,606,642 (GRCm39) |
T594A |
probably damaging |
Het |
| Cpox |
A |
G |
16: 58,491,232 (GRCm39) |
T148A |
possibly damaging |
Het |
| Csf3r |
A |
G |
4: 125,933,460 (GRCm39) |
|
probably benign |
Het |
| Csmd1 |
A |
T |
8: 16,760,530 (GRCm39) |
C202S |
probably damaging |
Het |
| Dlgap4 |
T |
C |
2: 156,604,746 (GRCm39) |
S261P |
probably damaging |
Het |
| Dnah9 |
T |
A |
11: 65,998,961 (GRCm39) |
Y1029F |
probably damaging |
Het |
| Dok5 |
T |
C |
2: 170,671,880 (GRCm39) |
|
probably benign |
Het |
| Dusp11 |
A |
T |
6: 85,929,352 (GRCm39) |
|
probably benign |
Het |
| Edar |
T |
C |
10: 58,465,262 (GRCm39) |
N34D |
probably benign |
Het |
| Efcab7 |
C |
T |
4: 99,766,943 (GRCm39) |
T56I |
probably damaging |
Het |
| Entpd1 |
G |
A |
19: 40,699,729 (GRCm39) |
V47I |
probably benign |
Het |
| Ephx4 |
A |
G |
5: 107,551,601 (GRCm39) |
N62S |
probably benign |
Het |
| Etaa1 |
A |
T |
11: 17,896,350 (GRCm39) |
L589* |
probably null |
Het |
| Fam135b |
T |
A |
15: 71,335,670 (GRCm39) |
N508I |
probably benign |
Het |
| Fam193a |
T |
C |
5: 34,623,552 (GRCm39) |
V27A |
possibly damaging |
Het |
| Fmnl1 |
A |
G |
11: 103,084,889 (GRCm39) |
|
probably benign |
Het |
| Fstl1 |
A |
C |
16: 37,641,516 (GRCm39) |
|
probably null |
Het |
| Gbp4 |
G |
A |
5: 105,268,972 (GRCm39) |
R394C |
possibly damaging |
Het |
| Gemin4 |
T |
C |
11: 76,102,148 (GRCm39) |
Y871C |
probably benign |
Het |
| Get1 |
T |
G |
16: 95,954,217 (GRCm39) |
S105R |
probably benign |
Het |
| Gm7247 |
T |
C |
14: 51,760,929 (GRCm39) |
V166A |
probably benign |
Het |
| Gpcpd1 |
A |
T |
2: 132,406,543 (GRCm39) |
|
probably benign |
Het |
| Gpnmb |
A |
G |
6: 49,019,737 (GRCm39) |
D36G |
probably benign |
Het |
| Ido2 |
C |
T |
8: 25,048,159 (GRCm39) |
|
probably null |
Het |
| Igfn1 |
G |
A |
1: 135,895,334 (GRCm39) |
T1744I |
probably benign |
Het |
| Inf2 |
T |
G |
12: 112,568,110 (GRCm39) |
F221V |
probably damaging |
Het |
| Itga10 |
T |
A |
3: 96,556,375 (GRCm39) |
I170N |
probably damaging |
Het |
| Macf1 |
A |
T |
4: 123,366,062 (GRCm39) |
S2900T |
probably benign |
Het |
| Med13 |
C |
A |
11: 86,190,033 (GRCm39) |
|
probably benign |
Het |
| Morc3 |
T |
C |
16: 93,667,362 (GRCm39) |
V507A |
probably damaging |
Het |
| Myadm |
AC |
ACC |
7: 3,345,276 (GRCm39) |
|
probably null |
Het |
| Myl6 |
C |
T |
10: 128,328,091 (GRCm39) |
|
probably benign |
Het |
| Mylk |
T |
C |
16: 34,742,314 (GRCm39) |
V942A |
probably benign |
Het |
| Myorg |
G |
T |
4: 41,498,585 (GRCm39) |
H348Q |
probably benign |
Het |
| Ncdn |
G |
T |
4: 126,644,327 (GRCm39) |
T165K |
possibly damaging |
Het |
| Ncf1 |
T |
C |
5: 134,251,656 (GRCm39) |
|
probably benign |
Het |
| Neb |
T |
C |
2: 52,180,751 (GRCm39) |
|
probably benign |
Het |
| Nid1 |
T |
A |
13: 13,656,681 (GRCm39) |
I604N |
probably benign |
Het |
| Nsrp1 |
T |
C |
11: 76,936,997 (GRCm39) |
R400G |
probably benign |
Het |
| Nup43 |
T |
G |
10: 7,546,791 (GRCm39) |
I137S |
probably benign |
Het |
| Nynrin |
A |
G |
14: 56,109,648 (GRCm39) |
N1585S |
possibly damaging |
Het |
| Obscn |
T |
A |
11: 58,893,823 (GRCm39) |
Y6748F |
probably benign |
Het |
| Omg |
A |
G |
11: 79,393,661 (GRCm39) |
S66P |
possibly damaging |
Het |
| Or13a27 |
A |
T |
7: 139,925,108 (GRCm39) |
S265T |
possibly damaging |
Het |
| Or2y1d |
T |
C |
11: 49,322,212 (GRCm39) |
V303A |
possibly damaging |
Het |
| Or4c15 |
A |
G |
2: 88,759,906 (GRCm39) |
V251A |
probably benign |
Het |
| Or51b6b |
A |
T |
7: 103,309,957 (GRCm39) |
F167I |
possibly damaging |
Het |
| Or52z1 |
A |
G |
7: 103,437,362 (GRCm39) |
Y41H |
probably damaging |
Het |
| Or5ak22 |
T |
C |
2: 85,230,019 (GRCm39) |
N286S |
probably damaging |
Het |
| Or8g27 |
A |
G |
9: 39,129,566 (GRCm39) |
I304M |
probably benign |
Het |
| Or8k24 |
G |
A |
2: 86,216,058 (GRCm39) |
R235C |
probably benign |
Het |
| Ormdl1 |
C |
T |
1: 53,347,978 (GRCm39) |
|
probably benign |
Het |
| Ovch2 |
T |
A |
7: 107,381,243 (GRCm39) |
I552L |
probably benign |
Het |
| Pcare |
T |
G |
17: 72,059,212 (GRCm39) |
D155A |
probably benign |
Het |
| Pcsk9 |
G |
T |
4: 106,311,538 (GRCm39) |
T231N |
probably damaging |
Het |
| Pgpep1 |
T |
C |
8: 71,110,100 (GRCm39) |
N22S |
probably damaging |
Het |
| Plb1 |
T |
C |
5: 32,512,706 (GRCm39) |
F1355L |
probably damaging |
Het |
| Plcg1 |
G |
T |
2: 160,603,349 (GRCm39) |
L1173F |
probably damaging |
Het |
| Plch2 |
A |
T |
4: 155,091,373 (GRCm39) |
|
probably null |
Het |
| Ppp1r3g |
T |
A |
13: 36,153,331 (GRCm39) |
F250L |
probably damaging |
Het |
| Prkcg |
A |
G |
7: 3,368,095 (GRCm39) |
I381V |
probably benign |
Het |
| Pum2 |
C |
T |
12: 8,763,464 (GRCm39) |
A207V |
probably benign |
Het |
| Rabac1 |
T |
C |
7: 24,669,607 (GRCm39) |
E166G |
probably damaging |
Het |
| Rad21l |
G |
A |
2: 151,493,851 (GRCm39) |
S450L |
probably benign |
Het |
| Rangap1 |
ACACTCA |
ACA |
15: 81,600,876 (GRCm39) |
|
probably null |
Het |
| Reg3b |
G |
T |
6: 78,348,824 (GRCm39) |
C40F |
probably damaging |
Het |
| Rfx2 |
A |
G |
17: 57,091,418 (GRCm39) |
|
probably benign |
Het |
| Rrp15 |
G |
A |
1: 186,481,346 (GRCm39) |
|
probably benign |
Het |
| Schip1 |
G |
T |
3: 68,401,946 (GRCm39) |
G36C |
probably damaging |
Het |
| Sec61a2 |
A |
T |
2: 5,881,165 (GRCm39) |
|
probably benign |
Het |
| Sema5a |
A |
G |
15: 32,669,590 (GRCm39) |
K705E |
probably damaging |
Het |
| Setx |
A |
G |
2: 29,029,290 (GRCm39) |
Y186C |
probably damaging |
Het |
| Slc22a23 |
T |
C |
13: 34,367,115 (GRCm39) |
E631G |
probably damaging |
Het |
| Slc5a5 |
T |
C |
8: 71,344,319 (GRCm39) |
T134A |
possibly damaging |
Het |
| Stx7 |
T |
C |
10: 24,057,492 (GRCm39) |
S173P |
probably damaging |
Het |
| Sybu |
T |
C |
15: 44,536,668 (GRCm39) |
T353A |
probably damaging |
Het |
| Syde2 |
T |
A |
3: 145,712,887 (GRCm39) |
N1008K |
probably damaging |
Het |
| Tiam1 |
T |
C |
16: 89,606,253 (GRCm39) |
|
probably benign |
Het |
| Timm10b |
G |
A |
7: 105,327,537 (GRCm39) |
E61K |
probably benign |
Het |
| Tm2d1 |
A |
G |
4: 98,253,810 (GRCm39) |
I121T |
probably damaging |
Het |
| Trim75 |
T |
C |
8: 65,435,892 (GRCm39) |
E186G |
probably benign |
Het |
| Tti1 |
T |
C |
2: 157,837,396 (GRCm39) |
K895E |
probably benign |
Het |
| Vmn1r43 |
A |
G |
6: 89,846,830 (GRCm39) |
S219P |
probably damaging |
Het |
| Vmn2r73 |
A |
T |
7: 85,521,087 (GRCm39) |
S294T |
possibly damaging |
Het |
| Vmn2r94 |
A |
T |
17: 18,464,080 (GRCm39) |
F737I |
probably damaging |
Het |
| Vsx2 |
A |
T |
12: 84,616,777 (GRCm39) |
T21S |
probably benign |
Het |
| Zfp462 |
G |
T |
4: 55,010,534 (GRCm39) |
R833S |
probably damaging |
Het |
| Zfpl1 |
G |
A |
19: 6,132,482 (GRCm39) |
P143L |
probably damaging |
Het |
|
| Other mutations in Lrp6 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00340:Lrp6
|
APN |
6 |
134,433,053 (GRCm39) |
missense |
probably benign |
0.17 |
|
IGL00765:Lrp6
|
APN |
6 |
134,518,817 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL00898:Lrp6
|
APN |
6 |
134,456,702 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL00916:Lrp6
|
APN |
6 |
134,461,252 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00961:Lrp6
|
APN |
6 |
134,484,609 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL01620:Lrp6
|
APN |
6 |
134,488,225 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01765:Lrp6
|
APN |
6 |
134,433,108 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02066:Lrp6
|
APN |
6 |
134,427,900 (GRCm39) |
nonsense |
probably null |
|
|
IGL02067:Lrp6
|
APN |
6 |
134,457,359 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02169:Lrp6
|
APN |
6 |
134,490,290 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL02281:Lrp6
|
APN |
6 |
134,434,697 (GRCm39) |
missense |
probably benign |
0.40 |
|
IGL02484:Lrp6
|
APN |
6 |
134,518,886 (GRCm39) |
missense |
probably benign |
0.15 |
|
IGL02724:Lrp6
|
APN |
6 |
134,461,228 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02876:Lrp6
|
APN |
6 |
134,433,077 (GRCm39) |
missense |
probably benign |
0.43 |
|
IGL03011:Lrp6
|
APN |
6 |
134,497,380 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL03352:Lrp6
|
APN |
6 |
134,456,726 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Aileron
|
UTSW |
6 |
134,439,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Cielo
|
UTSW |
6 |
134,484,624 (GRCm39) |
nonsense |
probably null |
|
|
Coiled
|
UTSW |
6 |
134,484,521 (GRCm39) |
nonsense |
probably null |
|
|
flap
|
UTSW |
6 |
134,463,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
soar
|
UTSW |
6 |
134,488,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Swoop
|
UTSW |
6 |
134,463,504 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Upswing
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Wingman
|
UTSW |
6 |
134,434,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB004:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB014:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4494001:Lrp6
|
UTSW |
6 |
134,456,741 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0008:Lrp6
|
UTSW |
6 |
134,462,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0008:Lrp6
|
UTSW |
6 |
134,462,716 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0201:Lrp6
|
UTSW |
6 |
134,427,860 (GRCm39) |
nonsense |
probably null |
|
|
R0295:Lrp6
|
UTSW |
6 |
134,434,656 (GRCm39) |
missense |
probably benign |
0.02 |
|
R0370:Lrp6
|
UTSW |
6 |
134,456,729 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0382:Lrp6
|
UTSW |
6 |
134,444,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0468:Lrp6
|
UTSW |
6 |
134,462,624 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R0492:Lrp6
|
UTSW |
6 |
134,457,481 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R0584:Lrp6
|
UTSW |
6 |
134,433,039 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0631:Lrp6
|
UTSW |
6 |
134,456,738 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R0738:Lrp6
|
UTSW |
6 |
134,519,008 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0907:Lrp6
|
UTSW |
6 |
134,484,488 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1273:Lrp6
|
UTSW |
6 |
134,444,470 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1548:Lrp6
|
UTSW |
6 |
134,436,392 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R1639:Lrp6
|
UTSW |
6 |
134,430,529 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
R1650:Lrp6
|
UTSW |
6 |
134,445,732 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1696:Lrp6
|
UTSW |
6 |
134,445,686 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1751:Lrp6
|
UTSW |
6 |
134,441,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1780:Lrp6
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2013:Lrp6
|
UTSW |
6 |
134,457,337 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2015:Lrp6
|
UTSW |
6 |
134,457,337 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2165:Lrp6
|
UTSW |
6 |
134,436,246 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2294:Lrp6
|
UTSW |
6 |
134,434,705 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2336:Lrp6
|
UTSW |
6 |
134,484,546 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2964:Lrp6
|
UTSW |
6 |
134,444,489 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3716:Lrp6
|
UTSW |
6 |
134,484,410 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4017:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4370:Lrp6
|
UTSW |
6 |
134,483,321 (GRCm39) |
nonsense |
probably null |
|
|
R4521:Lrp6
|
UTSW |
6 |
134,462,825 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4573:Lrp6
|
UTSW |
6 |
134,447,693 (GRCm39) |
nonsense |
probably null |
|
|
R4645:Lrp6
|
UTSW |
6 |
134,461,213 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4661:Lrp6
|
UTSW |
6 |
134,488,230 (GRCm39) |
missense |
probably benign |
|
|
R4688:Lrp6
|
UTSW |
6 |
134,456,706 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4784:Lrp6
|
UTSW |
6 |
134,456,502 (GRCm39) |
missense |
probably benign |
0.06 |
|
R5236:Lrp6
|
UTSW |
6 |
134,488,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5506:Lrp6
|
UTSW |
6 |
134,436,259 (GRCm39) |
missense |
probably benign |
0.09 |
|
R5508:Lrp6
|
UTSW |
6 |
134,441,479 (GRCm39) |
missense |
probably benign |
0.31 |
|
R6001:Lrp6
|
UTSW |
6 |
134,441,481 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6319:Lrp6
|
UTSW |
6 |
134,518,798 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6537:Lrp6
|
UTSW |
6 |
134,457,458 (GRCm39) |
missense |
probably benign |
|
|
R6552:Lrp6
|
UTSW |
6 |
134,431,692 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6559:Lrp6
|
UTSW |
6 |
134,490,217 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6575:Lrp6
|
UTSW |
6 |
134,518,934 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R6585:Lrp6
|
UTSW |
6 |
134,484,521 (GRCm39) |
nonsense |
probably null |
|
|
R6700:Lrp6
|
UTSW |
6 |
134,456,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6724:Lrp6
|
UTSW |
6 |
134,463,504 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7159:Lrp6
|
UTSW |
6 |
134,484,514 (GRCm39) |
missense |
probably benign |
|
|
R7266:Lrp6
|
UTSW |
6 |
134,484,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7339:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7341:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7342:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7348:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7359:Lrp6
|
UTSW |
6 |
134,427,923 (GRCm39) |
nonsense |
probably null |
|
|
R7366:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7368:Lrp6
|
UTSW |
6 |
134,427,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7501:Lrp6
|
UTSW |
6 |
134,463,471 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7548:Lrp6
|
UTSW |
6 |
134,484,471 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7652:Lrp6
|
UTSW |
6 |
134,488,208 (GRCm39) |
nonsense |
probably null |
|
|
R7771:Lrp6
|
UTSW |
6 |
134,439,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7927:Lrp6
|
UTSW |
6 |
134,497,513 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8717:Lrp6
|
UTSW |
6 |
134,434,711 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8726:Lrp6
|
UTSW |
6 |
134,484,624 (GRCm39) |
nonsense |
probably null |
|
|
R8792:Lrp6
|
UTSW |
6 |
134,463,549 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8812:Lrp6
|
UTSW |
6 |
134,433,141 (GRCm39) |
missense |
probably benign |
|
|
R8855:Lrp6
|
UTSW |
6 |
134,445,785 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8866:Lrp6
|
UTSW |
6 |
134,445,785 (GRCm39) |
missense |
probably benign |
0.04 |
|
R8994:Lrp6
|
UTSW |
6 |
134,518,656 (GRCm39) |
missense |
probably benign |
|
|
R9021:Lrp6
|
UTSW |
6 |
134,518,930 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9089:Lrp6
|
UTSW |
6 |
134,488,169 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9154:Lrp6
|
UTSW |
6 |
134,518,855 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9263:Lrp6
|
UTSW |
6 |
134,457,467 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9287:Lrp6
|
UTSW |
6 |
134,483,259 (GRCm39) |
missense |
probably benign |
0.21 |
|
R9545:Lrp6
|
UTSW |
6 |
134,483,329 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9574:Lrp6
|
UTSW |
6 |
134,447,662 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R9640:Lrp6
|
UTSW |
6 |
134,441,414 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Lrp6
|
UTSW |
6 |
134,433,120 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
Z1177:Lrp6
|
UTSW |
6 |
134,439,504 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AATCTGGGCCGTGACCACAAACTG -3'
(R):5'- AGTAAATCACAAGTGTGGGCCAAGC -3'
Sequencing Primer
(F):5'- TGACTGCCAGATCCATCTATGAAG -3'
(R):5'- AACTACTATGGCACTTGACCTG -3'
|
| Posted On |
2013-05-09 |
Incidental Mutation