Incidental Mutation 'R4776:Cic'
ID |
367928 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Cic
|
Ensembl Gene |
ENSMUSG00000005442 |
Gene Name |
capicua transcriptional repressor |
Synonyms |
1200010B10Rik |
MMRRC Submission |
042413-MU
|
Accession Numbers |
|
Essential gene? |
Probably essential
(E-score: 0.943)
|
Stock # |
R4776 (G1)
|
Quality Score |
160 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
24967129-24993584 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to G
at 24982308 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Serine to Alanine
at position 12
(S12A)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000005578
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000005578]
[ENSMUST00000163320]
[ENSMUST00000165239]
[ENSMUST00000169266]
|
AlphaFold |
Q924A2 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000005578
AA Change: S12A
PolyPhen 2
Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
|
SMART Domains |
Protein: ENSMUSP00000005578 Gene: ENSMUSG00000005442 AA Change: S12A
Domain | Start | End | E-Value | Type |
PDB:4J2L|D
|
21 |
48 |
6e-12 |
PDB |
low complexity region
|
106 |
120 |
N/A |
INTRINSIC |
low complexity region
|
124 |
138 |
N/A |
INTRINSIC |
HMG
|
199 |
269 |
1.24e-17 |
SMART |
low complexity region
|
415 |
431 |
N/A |
INTRINSIC |
low complexity region
|
473 |
486 |
N/A |
INTRINSIC |
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
low complexity region
|
525 |
555 |
N/A |
INTRINSIC |
low complexity region
|
567 |
583 |
N/A |
INTRINSIC |
low complexity region
|
645 |
660 |
N/A |
INTRINSIC |
low complexity region
|
729 |
740 |
N/A |
INTRINSIC |
low complexity region
|
782 |
803 |
N/A |
INTRINSIC |
low complexity region
|
837 |
859 |
N/A |
INTRINSIC |
low complexity region
|
939 |
951 |
N/A |
INTRINSIC |
low complexity region
|
1065 |
1080 |
N/A |
INTRINSIC |
low complexity region
|
1118 |
1132 |
N/A |
INTRINSIC |
low complexity region
|
1135 |
1155 |
N/A |
INTRINSIC |
low complexity region
|
1223 |
1253 |
N/A |
INTRINSIC |
low complexity region
|
1280 |
1313 |
N/A |
INTRINSIC |
low complexity region
|
1405 |
1418 |
N/A |
INTRINSIC |
low complexity region
|
1483 |
1494 |
N/A |
INTRINSIC |
low complexity region
|
1524 |
1547 |
N/A |
INTRINSIC |
low complexity region
|
1568 |
1603 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000163320
AA Change: S12A
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
SMART Domains |
Protein: ENSMUSP00000126659 Gene: ENSMUSG00000005442 AA Change: S12A
Domain | Start | End | E-Value | Type |
PDB:4J2L|D
|
21 |
48 |
6e-12 |
PDB |
low complexity region
|
106 |
120 |
N/A |
INTRINSIC |
low complexity region
|
124 |
138 |
N/A |
INTRINSIC |
HMG
|
199 |
269 |
1.24e-17 |
SMART |
low complexity region
|
415 |
431 |
N/A |
INTRINSIC |
low complexity region
|
473 |
486 |
N/A |
INTRINSIC |
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
low complexity region
|
525 |
555 |
N/A |
INTRINSIC |
low complexity region
|
567 |
583 |
N/A |
INTRINSIC |
low complexity region
|
645 |
660 |
N/A |
INTRINSIC |
low complexity region
|
729 |
740 |
N/A |
INTRINSIC |
low complexity region
|
782 |
803 |
N/A |
INTRINSIC |
low complexity region
|
837 |
859 |
N/A |
INTRINSIC |
low complexity region
|
939 |
951 |
N/A |
INTRINSIC |
low complexity region
|
1064 |
1079 |
N/A |
INTRINSIC |
low complexity region
|
1117 |
1131 |
N/A |
INTRINSIC |
low complexity region
|
1134 |
1154 |
N/A |
INTRINSIC |
low complexity region
|
1222 |
1252 |
N/A |
INTRINSIC |
low complexity region
|
1279 |
1312 |
N/A |
INTRINSIC |
low complexity region
|
1405 |
1418 |
N/A |
INTRINSIC |
low complexity region
|
1483 |
1494 |
N/A |
INTRINSIC |
low complexity region
|
1524 |
1547 |
N/A |
INTRINSIC |
low complexity region
|
1568 |
1603 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000163819
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000164440
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000165239
AA Change: S12A
PolyPhen 2
Score 0.861 (Sensitivity: 0.83; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000128071 Gene: ENSMUSG00000005442 AA Change: S12A
Domain | Start | End | E-Value | Type |
PDB:4J2L|D
|
21 |
48 |
5e-12 |
PDB |
low complexity region
|
106 |
120 |
N/A |
INTRINSIC |
low complexity region
|
124 |
138 |
N/A |
INTRINSIC |
HMG
|
199 |
269 |
1.24e-17 |
SMART |
low complexity region
|
415 |
431 |
N/A |
INTRINSIC |
low complexity region
|
473 |
486 |
N/A |
INTRINSIC |
low complexity region
|
508 |
521 |
N/A |
INTRINSIC |
low complexity region
|
525 |
555 |
N/A |
INTRINSIC |
low complexity region
|
567 |
583 |
N/A |
INTRINSIC |
low complexity region
|
645 |
660 |
N/A |
INTRINSIC |
low complexity region
|
729 |
740 |
N/A |
INTRINSIC |
low complexity region
|
782 |
803 |
N/A |
INTRINSIC |
low complexity region
|
837 |
859 |
N/A |
INTRINSIC |
low complexity region
|
939 |
951 |
N/A |
INTRINSIC |
low complexity region
|
1065 |
1080 |
N/A |
INTRINSIC |
low complexity region
|
1118 |
1132 |
N/A |
INTRINSIC |
low complexity region
|
1135 |
1153 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167379
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000168956
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000169743
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000169266
|
SMART Domains |
Protein: ENSMUSP00000132351 Gene: ENSMUSG00000005442
Domain | Start | End | E-Value | Type |
low complexity region
|
9 |
23 |
N/A |
INTRINSIC |
low complexity region
|
33 |
73 |
N/A |
INTRINSIC |
low complexity region
|
151 |
165 |
N/A |
INTRINSIC |
Pfam:DUF4819
|
249 |
346 |
1.8e-23 |
PFAM |
low complexity region
|
351 |
367 |
N/A |
INTRINSIC |
low complexity region
|
403 |
427 |
N/A |
INTRINSIC |
low complexity region
|
445 |
457 |
N/A |
INTRINSIC |
low complexity region
|
462 |
475 |
N/A |
INTRINSIC |
low complexity region
|
618 |
633 |
N/A |
INTRINSIC |
low complexity region
|
673 |
685 |
N/A |
INTRINSIC |
low complexity region
|
724 |
734 |
N/A |
INTRINSIC |
low complexity region
|
740 |
751 |
N/A |
INTRINSIC |
low complexity region
|
779 |
786 |
N/A |
INTRINSIC |
low complexity region
|
858 |
883 |
N/A |
INTRINSIC |
low complexity region
|
898 |
911 |
N/A |
INTRINSIC |
PDB:4J2L|D
|
930 |
955 |
5e-10 |
PDB |
low complexity region
|
1013 |
1027 |
N/A |
INTRINSIC |
low complexity region
|
1031 |
1045 |
N/A |
INTRINSIC |
HMG
|
1106 |
1176 |
1.24e-17 |
SMART |
low complexity region
|
1322 |
1338 |
N/A |
INTRINSIC |
low complexity region
|
1380 |
1393 |
N/A |
INTRINSIC |
low complexity region
|
1415 |
1428 |
N/A |
INTRINSIC |
low complexity region
|
1432 |
1462 |
N/A |
INTRINSIC |
low complexity region
|
1474 |
1490 |
N/A |
INTRINSIC |
low complexity region
|
1552 |
1567 |
N/A |
INTRINSIC |
low complexity region
|
1636 |
1647 |
N/A |
INTRINSIC |
low complexity region
|
1689 |
1710 |
N/A |
INTRINSIC |
low complexity region
|
1744 |
1766 |
N/A |
INTRINSIC |
low complexity region
|
1846 |
1858 |
N/A |
INTRINSIC |
low complexity region
|
1971 |
1986 |
N/A |
INTRINSIC |
low complexity region
|
2024 |
2038 |
N/A |
INTRINSIC |
low complexity region
|
2041 |
2061 |
N/A |
INTRINSIC |
low complexity region
|
2129 |
2159 |
N/A |
INTRINSIC |
low complexity region
|
2186 |
2219 |
N/A |
INTRINSIC |
low complexity region
|
2311 |
2324 |
N/A |
INTRINSIC |
low complexity region
|
2389 |
2400 |
N/A |
INTRINSIC |
low complexity region
|
2430 |
2453 |
N/A |
INTRINSIC |
low complexity region
|
2474 |
2509 |
N/A |
INTRINSIC |
|
Meta Mutation Damage Score |
0.0587 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.9%
|
Validation Efficiency |
98% (94/96) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is an ortholog of the Drosophila melanogaster capicua gene, and is a member of the high mobility group (HMG)-box superfamily of transcriptional repressors. This protein contains a conserved HMG domain that is involved in DNA binding and nuclear localization, and a conserved C-terminus. Studies suggest that the N-terminal region of this protein interacts with Atxn1 (GeneID:6310), to form a transcription repressor complex, and in vitro studies suggest that polyglutamine-expansion of ATXN1 may alter the repressor activity of this complex. Mutations in this gene have been associated with olidogdendrogliomas (PMID:21817013). In addition, translocation events resulting in gene fusions of this gene with both DUX4 (GeneID:100288687) and FOXO4 (GeneID:4303) have been associated with round cell sarcomas. There are multiple pseudogenes of this gene found on chromosomes 1, 4, 6, 7, 16, 20, and the Y chromosome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2015] PHENOTYPE: Mice homozygous for a gene trapped allele exhibit partial postnatal lethality, decreased body size, and severe lung alveolarization defects. [provided by MGI curators]
|
Allele List at MGI |
All alleles(61) : Targeted, other(4) Gene trapped(57)
|
Other mutations in this stock |
Total: 90 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
2610028H24Rik |
A |
T |
10: 76,293,346 (GRCm39) |
M156L |
probably benign |
Het |
4930470P17Rik |
C |
T |
2: 170,421,644 (GRCm39) |
A79T |
unknown |
Het |
4930522L14Rik |
A |
G |
5: 109,884,739 (GRCm39) |
I373T |
probably benign |
Het |
Amotl1 |
G |
A |
9: 14,504,669 (GRCm39) |
Q217* |
probably null |
Het |
Ankrd28 |
A |
T |
14: 31,454,011 (GRCm39) |
C254S |
probably damaging |
Het |
Ap2a1 |
A |
G |
7: 44,550,970 (GRCm39) |
|
probably benign |
Het |
Arfgef3 |
A |
T |
10: 18,529,995 (GRCm39) |
S245T |
probably benign |
Het |
Atp1b2 |
A |
T |
11: 69,492,387 (GRCm39) |
D224E |
probably damaging |
Het |
Bmal1 |
A |
T |
7: 112,884,244 (GRCm39) |
K94I |
probably damaging |
Het |
Boc |
G |
A |
16: 44,308,084 (GRCm39) |
R924W |
probably damaging |
Het |
Btbd8 |
C |
A |
5: 107,658,317 (GRCm39) |
A1117E |
probably damaging |
Het |
Car14 |
C |
T |
3: 95,806,185 (GRCm39) |
G292D |
probably benign |
Het |
Cenpb |
T |
C |
2: 131,020,103 (GRCm39) |
|
probably benign |
Het |
Ces1b |
A |
T |
8: 93,789,658 (GRCm39) |
D423E |
possibly damaging |
Het |
Cfap54 |
T |
A |
10: 92,808,556 (GRCm39) |
N1373I |
possibly damaging |
Het |
Chrdl2 |
T |
C |
7: 99,655,748 (GRCm39) |
|
probably benign |
Het |
Csmd2 |
A |
T |
4: 128,336,685 (GRCm39) |
Q1421L |
probably benign |
Het |
D630039A03Rik |
T |
C |
4: 57,910,452 (GRCm39) |
H120R |
possibly damaging |
Het |
Dicer1 |
T |
A |
12: 104,658,705 (GRCm39) |
D1779V |
probably damaging |
Het |
Dock9 |
G |
T |
14: 121,847,509 (GRCm39) |
H1016N |
possibly damaging |
Het |
Dxo |
T |
C |
17: 35,057,974 (GRCm39) |
L352P |
probably damaging |
Het |
Eif2b5 |
T |
A |
16: 20,318,983 (GRCm39) |
F78I |
probably damaging |
Het |
Eri2 |
A |
G |
7: 119,384,169 (GRCm39) |
|
probably benign |
Het |
Fbxw7 |
T |
G |
3: 84,832,996 (GRCm39) |
L13V |
possibly damaging |
Het |
Fgf7 |
T |
A |
2: 125,877,703 (GRCm39) |
C23* |
probably null |
Het |
Fubp1 |
T |
A |
3: 151,927,705 (GRCm39) |
|
probably null |
Het |
Gm2663 |
A |
T |
6: 40,972,887 (GRCm39) |
I240N |
probably damaging |
Het |
Gnb1l |
C |
T |
16: 18,366,846 (GRCm39) |
Q140* |
probably null |
Het |
Gnptab |
G |
A |
10: 88,272,390 (GRCm39) |
R1010Q |
probably damaging |
Het |
Gtf2h1 |
G |
A |
7: 46,472,302 (GRCm39) |
W544* |
probably null |
Het |
Gucy2c |
C |
T |
6: 136,699,512 (GRCm39) |
E586K |
probably damaging |
Het |
Hc |
T |
A |
2: 34,929,746 (GRCm39) |
E232V |
probably benign |
Het |
Ifi207 |
T |
A |
1: 173,557,622 (GRCm39) |
D372V |
unknown |
Het |
Igkv8-28 |
A |
T |
6: 70,121,102 (GRCm39) |
V15E |
probably benign |
Het |
Il1rap |
A |
G |
16: 26,511,549 (GRCm39) |
S198G |
possibly damaging |
Het |
Lct |
A |
G |
1: 128,228,124 (GRCm39) |
I1123T |
probably damaging |
Het |
Lhcgr |
T |
C |
17: 89,050,125 (GRCm39) |
E467G |
probably damaging |
Het |
Macf1 |
C |
T |
4: 123,369,808 (GRCm39) |
R86K |
probably benign |
Het |
Maml3 |
T |
A |
3: 51,763,953 (GRCm39) |
Q337L |
probably benign |
Het |
Marchf10 |
T |
A |
11: 105,280,863 (GRCm39) |
D474V |
probably benign |
Het |
Marchf2 |
G |
T |
17: 33,928,890 (GRCm39) |
T2K |
probably damaging |
Het |
Mast1 |
A |
G |
8: 85,663,822 (GRCm39) |
|
probably null |
Het |
Med12l |
T |
C |
3: 59,140,633 (GRCm39) |
I868T |
probably damaging |
Het |
Msrb1 |
T |
C |
17: 24,959,147 (GRCm39) |
S100P |
probably damaging |
Het |
Nlrp4c |
T |
C |
7: 6,069,125 (GRCm39) |
L342P |
probably benign |
Het |
Nrxn3 |
T |
A |
12: 90,298,730 (GRCm39) |
V417E |
possibly damaging |
Het |
Ntng1 |
T |
A |
3: 109,842,029 (GRCm39) |
D248V |
probably damaging |
Het |
Oaz3 |
T |
C |
3: 94,342,305 (GRCm39) |
Q117R |
probably benign |
Het |
Or2a56 |
A |
G |
6: 42,932,455 (GRCm39) |
I8V |
probably benign |
Het |
Or4f58 |
A |
G |
2: 111,851,276 (GRCm39) |
Y308H |
probably benign |
Het |
Or52e2 |
A |
G |
7: 102,804,621 (GRCm39) |
L111P |
probably benign |
Het |
Osbpl3 |
A |
C |
6: 50,277,953 (GRCm39) |
S767A |
probably benign |
Het |
Pafah1b1 |
A |
T |
11: 74,576,697 (GRCm39) |
|
probably benign |
Het |
Pard6b |
A |
G |
2: 167,940,708 (GRCm39) |
T232A |
probably damaging |
Het |
Paxip1 |
A |
T |
5: 27,970,204 (GRCm39) |
C596S |
probably damaging |
Het |
Pnpla6 |
T |
C |
8: 3,573,818 (GRCm39) |
V422A |
probably benign |
Het |
Psmd6 |
A |
T |
14: 14,120,932 (GRCm38) |
|
probably benign |
Het |
Relch |
T |
A |
1: 105,647,260 (GRCm39) |
Y683* |
probably null |
Het |
Rock2 |
T |
A |
12: 17,027,741 (GRCm39) |
C1353S |
probably damaging |
Het |
Rpl31-ps17 |
C |
T |
12: 54,748,397 (GRCm39) |
|
noncoding transcript |
Het |
Sel1l |
T |
A |
12: 91,780,667 (GRCm39) |
H658L |
probably damaging |
Het |
Sh3yl1 |
T |
A |
12: 30,990,313 (GRCm39) |
L105Q |
probably damaging |
Het |
Shroom3 |
G |
T |
5: 93,090,945 (GRCm39) |
V1151F |
probably damaging |
Het |
Sirt1 |
T |
C |
10: 63,171,501 (GRCm39) |
K227E |
probably benign |
Het |
Slc25a34 |
A |
T |
4: 141,350,899 (GRCm39) |
F37I |
possibly damaging |
Het |
Slc39a5 |
T |
A |
10: 128,232,918 (GRCm39) |
I378F |
probably damaging |
Het |
Smarcad1 |
A |
T |
6: 65,075,808 (GRCm39) |
D731V |
probably null |
Het |
Sox6 |
T |
G |
7: 115,140,905 (GRCm39) |
K483N |
probably damaging |
Het |
Sp140 |
T |
A |
1: 85,538,549 (GRCm39) |
D95E |
possibly damaging |
Het |
Srgap1 |
G |
T |
10: 121,628,256 (GRCm39) |
D882E |
probably benign |
Het |
Syne4 |
T |
C |
7: 30,016,258 (GRCm39) |
|
probably benign |
Het |
Tasor2 |
A |
G |
13: 3,620,391 (GRCm39) |
F2170S |
probably damaging |
Het |
Tec |
T |
C |
5: 72,926,119 (GRCm39) |
Y289C |
probably benign |
Het |
Tmem102 |
A |
T |
11: 69,695,628 (GRCm39) |
Y115N |
probably damaging |
Het |
Tns2 |
C |
T |
15: 102,017,369 (GRCm39) |
R281C |
probably damaging |
Het |
Trav17 |
T |
A |
14: 54,044,097 (GRCm39) |
M1K |
probably null |
Het |
Trdn |
T |
A |
10: 33,275,078 (GRCm39) |
|
probably null |
Het |
Trp53 |
A |
T |
11: 69,477,747 (GRCm39) |
I8F |
probably benign |
Het |
Ttn |
T |
A |
2: 76,585,006 (GRCm39) |
D22064V |
probably damaging |
Het |
Ube3c |
G |
A |
5: 29,837,836 (GRCm39) |
|
probably null |
Het |
Ulk1 |
C |
T |
5: 110,936,813 (GRCm39) |
|
probably null |
Het |
Upp1 |
T |
C |
11: 9,085,976 (GRCm39) |
V271A |
probably damaging |
Het |
Vmn2r4 |
T |
C |
3: 64,296,082 (GRCm39) |
E901G |
probably damaging |
Het |
Vmn2r96 |
G |
A |
17: 18,817,770 (GRCm39) |
G449D |
probably damaging |
Het |
Vps37b |
T |
C |
5: 124,144,675 (GRCm39) |
K165E |
probably damaging |
Het |
Vwf |
A |
T |
6: 125,543,268 (GRCm39) |
I185F |
possibly damaging |
Het |
Wasf2 |
A |
G |
4: 132,912,315 (GRCm39) |
T56A |
probably benign |
Het |
Zdhhc23 |
C |
G |
16: 43,793,952 (GRCm39) |
D241H |
possibly damaging |
Het |
Zfp276 |
T |
C |
8: 123,981,623 (GRCm39) |
S57P |
probably benign |
Het |
Zxdc |
A |
G |
6: 90,347,500 (GRCm39) |
H287R |
probably damaging |
Het |
|
Other mutations in Cic |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00092:Cic
|
APN |
7 |
24,991,549 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01668:Cic
|
APN |
7 |
24,990,629 (GRCm39) |
missense |
possibly damaging |
0.47 |
IGL02229:Cic
|
APN |
7 |
24,990,375 (GRCm39) |
missense |
probably damaging |
0.96 |
IGL02506:Cic
|
APN |
7 |
24,990,282 (GRCm39) |
missense |
probably benign |
|
IGL02794:Cic
|
APN |
7 |
24,985,069 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03065:Cic
|
APN |
7 |
24,985,246 (GRCm39) |
splice site |
probably benign |
|
IGL03304:Cic
|
APN |
7 |
24,984,274 (GRCm39) |
missense |
probably damaging |
1.00 |
Capuccino
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
Cassock
|
UTSW |
7 |
24,988,338 (GRCm39) |
nonsense |
probably null |
|
Monkey
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R4850_Cic_466
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
1mM(1):Cic
|
UTSW |
7 |
24,990,214 (GRCm39) |
splice site |
probably benign |
|
IGL03046:Cic
|
UTSW |
7 |
24,990,500 (GRCm39) |
missense |
probably damaging |
1.00 |
R0012:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0012:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0027:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0027:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0038:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0038:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0063:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0063:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0064:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0064:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0118:Cic
|
UTSW |
7 |
24,985,459 (GRCm39) |
missense |
probably damaging |
1.00 |
R0193:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0193:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0241:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0241:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0377:Cic
|
UTSW |
7 |
24,985,224 (GRCm39) |
missense |
probably damaging |
0.98 |
R0462:Cic
|
UTSW |
7 |
24,986,565 (GRCm39) |
missense |
probably damaging |
0.98 |
R0462:Cic
|
UTSW |
7 |
24,986,566 (GRCm39) |
missense |
probably damaging |
1.00 |
R0800:Cic
|
UTSW |
7 |
24,984,662 (GRCm39) |
missense |
probably benign |
|
R1253:Cic
|
UTSW |
7 |
24,990,373 (GRCm39) |
missense |
probably damaging |
1.00 |
R1458:Cic
|
UTSW |
7 |
24,979,162 (GRCm39) |
intron |
probably benign |
|
R1462:Cic
|
UTSW |
7 |
24,971,032 (GRCm39) |
missense |
probably damaging |
0.98 |
R1462:Cic
|
UTSW |
7 |
24,971,032 (GRCm39) |
missense |
probably damaging |
0.98 |
R1519:Cic
|
UTSW |
7 |
24,993,235 (GRCm39) |
critical splice acceptor site |
probably null |
|
R1586:Cic
|
UTSW |
7 |
24,985,386 (GRCm39) |
missense |
probably damaging |
1.00 |
R1824:Cic
|
UTSW |
7 |
24,987,691 (GRCm39) |
missense |
probably damaging |
1.00 |
R1908:Cic
|
UTSW |
7 |
24,986,265 (GRCm39) |
missense |
probably damaging |
1.00 |
R2045:Cic
|
UTSW |
7 |
24,970,961 (GRCm39) |
missense |
possibly damaging |
0.53 |
R2063:Cic
|
UTSW |
7 |
24,972,876 (GRCm39) |
missense |
probably damaging |
0.98 |
R2161:Cic
|
UTSW |
7 |
24,987,559 (GRCm39) |
splice site |
probably null |
|
R2495:Cic
|
UTSW |
7 |
24,991,201 (GRCm39) |
splice site |
probably benign |
|
R2865:Cic
|
UTSW |
7 |
24,972,646 (GRCm39) |
missense |
probably damaging |
0.96 |
R3692:Cic
|
UTSW |
7 |
24,988,338 (GRCm39) |
nonsense |
probably null |
|
R3709:Cic
|
UTSW |
7 |
24,986,406 (GRCm39) |
missense |
probably damaging |
0.99 |
R3710:Cic
|
UTSW |
7 |
24,986,406 (GRCm39) |
missense |
probably damaging |
0.99 |
R3872:Cic
|
UTSW |
7 |
24,971,124 (GRCm39) |
missense |
possibly damaging |
0.92 |
R3946:Cic
|
UTSW |
7 |
24,971,771 (GRCm39) |
missense |
possibly damaging |
0.93 |
R4199:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
R4426:Cic
|
UTSW |
7 |
24,993,433 (GRCm39) |
utr 3 prime |
probably benign |
|
R4502:Cic
|
UTSW |
7 |
24,987,892 (GRCm39) |
missense |
probably damaging |
1.00 |
R4585:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
R4586:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
R4614:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
R4664:Cic
|
UTSW |
7 |
24,990,099 (GRCm39) |
small deletion |
probably benign |
|
R4688:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
frame shift |
probably null |
|
R4695:Cic
|
UTSW |
7 |
24,973,013 (GRCm39) |
missense |
possibly damaging |
0.72 |
R4696:Cic
|
UTSW |
7 |
24,987,908 (GRCm39) |
missense |
probably benign |
|
R4746:Cic
|
UTSW |
7 |
24,987,905 (GRCm39) |
missense |
probably damaging |
1.00 |
R4758:Cic
|
UTSW |
7 |
24,991,636 (GRCm39) |
missense |
possibly damaging |
0.62 |
R4767:Cic
|
UTSW |
7 |
24,971,025 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4820:Cic
|
UTSW |
7 |
24,971,157 (GRCm39) |
missense |
possibly damaging |
0.92 |
R4850:Cic
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
R4851:Cic
|
UTSW |
7 |
24,972,327 (GRCm39) |
missense |
probably damaging |
0.98 |
R4922:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
small insertion |
probably benign |
|
R4989:Cic
|
UTSW |
7 |
24,986,535 (GRCm39) |
missense |
probably damaging |
1.00 |
R5131:Cic
|
UTSW |
7 |
24,991,095 (GRCm39) |
small insertion |
probably benign |
|
R5718:Cic
|
UTSW |
7 |
24,972,203 (GRCm39) |
missense |
probably benign |
0.33 |
R5801:Cic
|
UTSW |
7 |
24,970,863 (GRCm39) |
missense |
possibly damaging |
0.93 |
R5949:Cic
|
UTSW |
7 |
24,971,730 (GRCm39) |
missense |
probably damaging |
1.00 |
R6000:Cic
|
UTSW |
7 |
24,971,423 (GRCm39) |
missense |
probably benign |
0.33 |
R6246:Cic
|
UTSW |
7 |
24,971,067 (GRCm39) |
missense |
probably damaging |
1.00 |
R6283:Cic
|
UTSW |
7 |
24,985,459 (GRCm39) |
missense |
probably damaging |
1.00 |
R6364:Cic
|
UTSW |
7 |
24,972,248 (GRCm39) |
missense |
possibly damaging |
0.72 |
R6481:Cic
|
UTSW |
7 |
24,987,706 (GRCm39) |
missense |
possibly damaging |
0.56 |
R6919:Cic
|
UTSW |
7 |
24,971,202 (GRCm39) |
missense |
probably benign |
0.04 |
R6920:Cic
|
UTSW |
7 |
24,990,107 (GRCm39) |
missense |
probably damaging |
1.00 |
R6995:Cic
|
UTSW |
7 |
24,970,736 (GRCm39) |
missense |
possibly damaging |
0.53 |
R7002:Cic
|
UTSW |
7 |
24,971,621 (GRCm39) |
missense |
probably damaging |
0.99 |
R7113:Cic
|
UTSW |
7 |
24,972,869 (GRCm39) |
missense |
probably benign |
0.08 |
R7560:Cic
|
UTSW |
7 |
24,972,278 (GRCm39) |
missense |
probably damaging |
0.98 |
R7680:Cic
|
UTSW |
7 |
24,991,856 (GRCm39) |
missense |
probably damaging |
0.96 |
R7698:Cic
|
UTSW |
7 |
24,972,597 (GRCm39) |
missense |
possibly damaging |
0.72 |
R7746:Cic
|
UTSW |
7 |
24,988,207 (GRCm39) |
missense |
probably damaging |
1.00 |
R7841:Cic
|
UTSW |
7 |
24,985,192 (GRCm39) |
missense |
probably damaging |
1.00 |
R7879:Cic
|
UTSW |
7 |
24,984,551 (GRCm39) |
missense |
probably benign |
0.10 |
R7916:Cic
|
UTSW |
7 |
24,987,715 (GRCm39) |
missense |
probably damaging |
0.99 |
R7920:Cic
|
UTSW |
7 |
24,971,384 (GRCm39) |
missense |
probably benign |
|
R8056:Cic
|
UTSW |
7 |
24,990,366 (GRCm39) |
missense |
possibly damaging |
0.90 |
R8226:Cic
|
UTSW |
7 |
24,987,213 (GRCm39) |
missense |
probably damaging |
1.00 |
R8281:Cic
|
UTSW |
7 |
24,971,249 (GRCm39) |
missense |
probably benign |
|
R8847:Cic
|
UTSW |
7 |
24,970,631 (GRCm39) |
missense |
probably damaging |
0.98 |
R8991:Cic
|
UTSW |
7 |
24,988,885 (GRCm39) |
missense |
probably damaging |
1.00 |
R9083:Cic
|
UTSW |
7 |
24,985,470 (GRCm39) |
missense |
probably damaging |
0.99 |
R9140:Cic
|
UTSW |
7 |
24,985,165 (GRCm39) |
missense |
probably damaging |
0.99 |
R9200:Cic
|
UTSW |
7 |
24,971,940 (GRCm39) |
missense |
probably damaging |
0.99 |
R9208:Cic
|
UTSW |
7 |
24,987,502 (GRCm39) |
missense |
probably benign |
0.07 |
R9301:Cic
|
UTSW |
7 |
24,991,117 (GRCm39) |
missense |
probably damaging |
1.00 |
R9408:Cic
|
UTSW |
7 |
24,971,414 (GRCm39) |
missense |
possibly damaging |
0.70 |
R9569:Cic
|
UTSW |
7 |
24,972,120 (GRCm39) |
missense |
possibly damaging |
0.85 |
R9752:Cic
|
UTSW |
7 |
24,971,403 (GRCm39) |
missense |
probably damaging |
0.96 |
V7732:Cic
|
UTSW |
7 |
24,991,670 (GRCm39) |
missense |
probably benign |
|
Z1176:Cic
|
UTSW |
7 |
24,970,444 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
Predicted Primers |
PCR Primer
(F):5'- AGGTTGACCTGGTGTTCAGC -3'
(R):5'- TGCCATCGCTAACCACTTGG -3'
Sequencing Primer
(F):5'- TTACCCGCCGGAGCTTC -3'
(R):5'- TTGGCCCCGCTAGACTCTAAAC -3'
|
Posted On |
2015-12-29 |