Incidental Mutation 'R0413:Vmn2r94'
ID 36838
Institutional Source Beutler Lab
Gene Symbol Vmn2r94
Ensembl Gene ENSMUSG00000090417
Gene Name vomeronasal 2, receptor 94
Synonyms EG665227
MMRRC Submission 038615-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.092) question?
Stock # R0413 (G1)
Quality Score 155
Status Validated
Chromosome 17
Chromosomal Location 18461384-18498018 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 18464080 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Isoleucine at position 737 (F737I)
Ref Sequence ENSEMBL: ENSMUSP00000126386 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000172190] [ENSMUST00000231457] [ENSMUST00000231815]
AlphaFold E9PZK8
Predicted Effect probably damaging
Transcript: ENSMUST00000172190
AA Change: F737I

PolyPhen 2 Score 0.976 (Sensitivity: 0.76; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000126386
Gene: ENSMUSG00000090417
AA Change: F737I

DomainStartEndE-ValueType
Pfam:ANF_receptor 42 425 1.7e-35 PFAM
Pfam:NCD3G 469 522 3.5e-21 PFAM
Pfam:7tm_3 553 790 1.7e-51 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231457
Predicted Effect probably benign
Transcript: ENSMUST00000231815
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.0%
  • 20x: 94.9%
Validation Efficiency 99% (99/100)
Allele List at MGI
Other mutations in this stock
Total: 97 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcb11 A G 2: 69,158,355 (GRCm39) probably benign Het
Adh1 C T 3: 137,986,193 (GRCm39) T60I probably benign Het
Agtpbp1 T A 13: 59,661,966 (GRCm39) I282F probably damaging Het
Arih2 G T 9: 108,493,916 (GRCm39) Q166K probably damaging Het
Cacna1s A G 1: 136,025,947 (GRCm39) T1031A probably benign Het
Ccdc102a C A 8: 95,629,914 (GRCm39) E542D probably benign Het
Cdk1 T C 10: 69,180,929 (GRCm39) I94V probably benign Het
Cep290 C T 10: 100,359,176 (GRCm39) Q969* probably null Het
Cilp2 A G 8: 70,335,643 (GRCm39) S452P probably benign Het
Col12a1 T C 9: 79,606,642 (GRCm39) T594A probably damaging Het
Cpox A G 16: 58,491,232 (GRCm39) T148A possibly damaging Het
Csf3r A G 4: 125,933,460 (GRCm39) probably benign Het
Csmd1 A T 8: 16,760,530 (GRCm39) C202S probably damaging Het
Dlgap4 T C 2: 156,604,746 (GRCm39) S261P probably damaging Het
Dnah9 T A 11: 65,998,961 (GRCm39) Y1029F probably damaging Het
Dok5 T C 2: 170,671,880 (GRCm39) probably benign Het
Dusp11 A T 6: 85,929,352 (GRCm39) probably benign Het
Edar T C 10: 58,465,262 (GRCm39) N34D probably benign Het
Efcab7 C T 4: 99,766,943 (GRCm39) T56I probably damaging Het
Entpd1 G A 19: 40,699,729 (GRCm39) V47I probably benign Het
Ephx4 A G 5: 107,551,601 (GRCm39) N62S probably benign Het
Etaa1 A T 11: 17,896,350 (GRCm39) L589* probably null Het
Fam135b T A 15: 71,335,670 (GRCm39) N508I probably benign Het
Fam193a T C 5: 34,623,552 (GRCm39) V27A possibly damaging Het
Fmnl1 A G 11: 103,084,889 (GRCm39) probably benign Het
Fstl1 A C 16: 37,641,516 (GRCm39) probably null Het
Gbp4 G A 5: 105,268,972 (GRCm39) R394C possibly damaging Het
Gemin4 T C 11: 76,102,148 (GRCm39) Y871C probably benign Het
Get1 T G 16: 95,954,217 (GRCm39) S105R probably benign Het
Gm7247 T C 14: 51,760,929 (GRCm39) V166A probably benign Het
Gpcpd1 A T 2: 132,406,543 (GRCm39) probably benign Het
Gpnmb A G 6: 49,019,737 (GRCm39) D36G probably benign Het
Ido2 C T 8: 25,048,159 (GRCm39) probably null Het
Igfn1 G A 1: 135,895,334 (GRCm39) T1744I probably benign Het
Inf2 T G 12: 112,568,110 (GRCm39) F221V probably damaging Het
Itga10 T A 3: 96,556,375 (GRCm39) I170N probably damaging Het
Lrp6 A T 6: 134,484,587 (GRCm39) D345E probably damaging Het
Macf1 A T 4: 123,366,062 (GRCm39) S2900T probably benign Het
Med13 C A 11: 86,190,033 (GRCm39) probably benign Het
Morc3 T C 16: 93,667,362 (GRCm39) V507A probably damaging Het
Myadm AC ACC 7: 3,345,276 (GRCm39) probably null Het
Myl6 C T 10: 128,328,091 (GRCm39) probably benign Het
Mylk T C 16: 34,742,314 (GRCm39) V942A probably benign Het
Myorg G T 4: 41,498,585 (GRCm39) H348Q probably benign Het
Ncdn G T 4: 126,644,327 (GRCm39) T165K possibly damaging Het
Ncf1 T C 5: 134,251,656 (GRCm39) probably benign Het
Neb T C 2: 52,180,751 (GRCm39) probably benign Het
Nid1 T A 13: 13,656,681 (GRCm39) I604N probably benign Het
Nsrp1 T C 11: 76,936,997 (GRCm39) R400G probably benign Het
Nup43 T G 10: 7,546,791 (GRCm39) I137S probably benign Het
Nynrin A G 14: 56,109,648 (GRCm39) N1585S possibly damaging Het
Obscn T A 11: 58,893,823 (GRCm39) Y6748F probably benign Het
Omg A G 11: 79,393,661 (GRCm39) S66P possibly damaging Het
Or13a27 A T 7: 139,925,108 (GRCm39) S265T possibly damaging Het
Or2y1d T C 11: 49,322,212 (GRCm39) V303A possibly damaging Het
Or4c15 A G 2: 88,759,906 (GRCm39) V251A probably benign Het
Or51b6b A T 7: 103,309,957 (GRCm39) F167I possibly damaging Het
Or52z1 A G 7: 103,437,362 (GRCm39) Y41H probably damaging Het
Or5ak22 T C 2: 85,230,019 (GRCm39) N286S probably damaging Het
Or8g27 A G 9: 39,129,566 (GRCm39) I304M probably benign Het
Or8k24 G A 2: 86,216,058 (GRCm39) R235C probably benign Het
Ormdl1 C T 1: 53,347,978 (GRCm39) probably benign Het
Ovch2 T A 7: 107,381,243 (GRCm39) I552L probably benign Het
Pcare T G 17: 72,059,212 (GRCm39) D155A probably benign Het
Pcsk9 G T 4: 106,311,538 (GRCm39) T231N probably damaging Het
Pgpep1 T C 8: 71,110,100 (GRCm39) N22S probably damaging Het
Plb1 T C 5: 32,512,706 (GRCm39) F1355L probably damaging Het
Plcg1 G T 2: 160,603,349 (GRCm39) L1173F probably damaging Het
Plch2 A T 4: 155,091,373 (GRCm39) probably null Het
Ppp1r3g T A 13: 36,153,331 (GRCm39) F250L probably damaging Het
Prkcg A G 7: 3,368,095 (GRCm39) I381V probably benign Het
Pum2 C T 12: 8,763,464 (GRCm39) A207V probably benign Het
Rabac1 T C 7: 24,669,607 (GRCm39) E166G probably damaging Het
Rad21l G A 2: 151,493,851 (GRCm39) S450L probably benign Het
Rangap1 ACACTCA ACA 15: 81,600,876 (GRCm39) probably null Het
Reg3b G T 6: 78,348,824 (GRCm39) C40F probably damaging Het
Rfx2 A G 17: 57,091,418 (GRCm39) probably benign Het
Rrp15 G A 1: 186,481,346 (GRCm39) probably benign Het
Schip1 G T 3: 68,401,946 (GRCm39) G36C probably damaging Het
Sec61a2 A T 2: 5,881,165 (GRCm39) probably benign Het
Sema5a A G 15: 32,669,590 (GRCm39) K705E probably damaging Het
Setx A G 2: 29,029,290 (GRCm39) Y186C probably damaging Het
Slc22a23 T C 13: 34,367,115 (GRCm39) E631G probably damaging Het
Slc5a5 T C 8: 71,344,319 (GRCm39) T134A possibly damaging Het
Stx7 T C 10: 24,057,492 (GRCm39) S173P probably damaging Het
Sybu T C 15: 44,536,668 (GRCm39) T353A probably damaging Het
Syde2 T A 3: 145,712,887 (GRCm39) N1008K probably damaging Het
Tiam1 T C 16: 89,606,253 (GRCm39) probably benign Het
Timm10b G A 7: 105,327,537 (GRCm39) E61K probably benign Het
Tm2d1 A G 4: 98,253,810 (GRCm39) I121T probably damaging Het
Trim75 T C 8: 65,435,892 (GRCm39) E186G probably benign Het
Tti1 T C 2: 157,837,396 (GRCm39) K895E probably benign Het
Vmn1r43 A G 6: 89,846,830 (GRCm39) S219P probably damaging Het
Vmn2r73 A T 7: 85,521,087 (GRCm39) S294T possibly damaging Het
Vsx2 A T 12: 84,616,777 (GRCm39) T21S probably benign Het
Zfp462 G T 4: 55,010,534 (GRCm39) R833S probably damaging Het
Zfpl1 G A 19: 6,132,482 (GRCm39) P143L probably damaging Het
Other mutations in Vmn2r94
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01396:Vmn2r94 APN 17 18,477,301 (GRCm39) missense probably damaging 1.00
IGL01676:Vmn2r94 APN 17 18,477,272 (GRCm39) missense probably benign
IGL01687:Vmn2r94 APN 17 18,473,574 (GRCm39) missense possibly damaging 0.64
IGL02113:Vmn2r94 APN 17 18,477,937 (GRCm39) missense probably damaging 0.99
IGL02408:Vmn2r94 APN 17 18,473,523 (GRCm39) missense probably benign 0.01
IGL02451:Vmn2r94 APN 17 18,478,453 (GRCm39) missense possibly damaging 0.95
IGL02755:Vmn2r94 APN 17 18,464,761 (GRCm39) missense probably benign 0.01
IGL02822:Vmn2r94 APN 17 18,463,882 (GRCm39) missense probably benign 0.00
IGL02868:Vmn2r94 APN 17 18,464,316 (GRCm39) missense possibly damaging 0.75
IGL03008:Vmn2r94 APN 17 18,477,908 (GRCm39) missense probably benign 0.05
R0112:Vmn2r94 UTSW 17 18,463,866 (GRCm39) missense probably benign
R0371:Vmn2r94 UTSW 17 18,477,556 (GRCm39) missense probably benign 0.11
R0627:Vmn2r94 UTSW 17 18,477,427 (GRCm39) missense probably damaging 1.00
R0737:Vmn2r94 UTSW 17 18,497,695 (GRCm39) nonsense probably null
R0815:Vmn2r94 UTSW 17 18,477,973 (GRCm39) missense probably damaging 1.00
R0863:Vmn2r94 UTSW 17 18,477,973 (GRCm39) missense probably damaging 1.00
R1125:Vmn2r94 UTSW 17 18,477,717 (GRCm39) missense probably damaging 1.00
R1276:Vmn2r94 UTSW 17 18,477,344 (GRCm39) missense possibly damaging 0.47
R1491:Vmn2r94 UTSW 17 18,477,965 (GRCm39) missense probably damaging 1.00
R1500:Vmn2r94 UTSW 17 18,477,242 (GRCm39) missense probably benign 0.07
R1610:Vmn2r94 UTSW 17 18,463,995 (GRCm39) missense probably damaging 1.00
R1664:Vmn2r94 UTSW 17 18,464,406 (GRCm39) missense probably damaging 0.99
R1716:Vmn2r94 UTSW 17 18,477,635 (GRCm39) missense probably benign 0.01
R1843:Vmn2r94 UTSW 17 18,464,732 (GRCm39) missense probably benign 0.01
R1882:Vmn2r94 UTSW 17 18,464,476 (GRCm39) missense probably benign 0.07
R1936:Vmn2r94 UTSW 17 18,464,554 (GRCm39) nonsense probably null
R2273:Vmn2r94 UTSW 17 18,477,593 (GRCm39) missense probably benign 0.00
R2508:Vmn2r94 UTSW 17 18,477,736 (GRCm39) missense probably benign 0.32
R3436:Vmn2r94 UTSW 17 18,478,650 (GRCm39) splice site probably benign
R3917:Vmn2r94 UTSW 17 18,464,620 (GRCm39) missense probably benign
R3968:Vmn2r94 UTSW 17 18,478,647 (GRCm39) missense possibly damaging 0.95
R3969:Vmn2r94 UTSW 17 18,478,647 (GRCm39) missense possibly damaging 0.95
R4257:Vmn2r94 UTSW 17 18,464,433 (GRCm39) missense probably damaging 1.00
R4271:Vmn2r94 UTSW 17 18,463,940 (GRCm39) missense probably damaging 1.00
R4349:Vmn2r94 UTSW 17 18,464,605 (GRCm39) missense probably benign 0.01
R4436:Vmn2r94 UTSW 17 18,478,645 (GRCm39) missense probably damaging 1.00
R4603:Vmn2r94 UTSW 17 18,477,647 (GRCm39) missense probably benign 0.33
R4821:Vmn2r94 UTSW 17 18,477,293 (GRCm39) missense probably benign 0.02
R5288:Vmn2r94 UTSW 17 18,464,728 (GRCm39) missense probably damaging 1.00
R5725:Vmn2r94 UTSW 17 18,476,489 (GRCm39) missense possibly damaging 0.88
R5735:Vmn2r94 UTSW 17 18,464,066 (GRCm39) missense probably damaging 1.00
R6066:Vmn2r94 UTSW 17 18,477,695 (GRCm39) missense probably damaging 0.99
R6124:Vmn2r94 UTSW 17 18,464,321 (GRCm39) missense probably benign 0.01
R6189:Vmn2r94 UTSW 17 18,477,996 (GRCm39) missense probably benign 0.25
R6245:Vmn2r94 UTSW 17 18,478,385 (GRCm39) missense probably damaging 1.00
R6574:Vmn2r94 UTSW 17 18,476,421 (GRCm39) missense probably damaging 1.00
R7236:Vmn2r94 UTSW 17 18,477,811 (GRCm39) missense possibly damaging 0.49
R7317:Vmn2r94 UTSW 17 18,463,882 (GRCm39) missense probably benign 0.00
R7398:Vmn2r94 UTSW 17 18,477,603 (GRCm39) missense probably benign 0.00
R7399:Vmn2r94 UTSW 17 18,464,765 (GRCm39) critical splice acceptor site probably null
R7478:Vmn2r94 UTSW 17 18,477,767 (GRCm39) missense probably benign
R8099:Vmn2r94 UTSW 17 18,477,659 (GRCm39) missense probably benign 0.00
R8189:Vmn2r94 UTSW 17 18,478,618 (GRCm39) missense probably damaging 1.00
R8217:Vmn2r94 UTSW 17 18,463,986 (GRCm39) missense probably damaging 1.00
R8303:Vmn2r94 UTSW 17 18,464,433 (GRCm39) missense probably damaging 1.00
R8543:Vmn2r94 UTSW 17 18,463,984 (GRCm39) missense possibly damaging 0.45
R8684:Vmn2r94 UTSW 17 18,497,912 (GRCm39) start gained probably benign
R8889:Vmn2r94 UTSW 17 18,464,335 (GRCm39) missense possibly damaging 0.83
R8892:Vmn2r94 UTSW 17 18,464,335 (GRCm39) missense possibly damaging 0.83
R9282:Vmn2r94 UTSW 17 18,497,751 (GRCm39) missense possibly damaging 0.89
R9526:Vmn2r94 UTSW 17 18,477,261 (GRCm39) missense probably benign
R9647:Vmn2r94 UTSW 17 18,463,884 (GRCm39) missense probably benign 0.00
R9748:Vmn2r94 UTSW 17 18,463,989 (GRCm39) missense probably benign 0.21
R9789:Vmn2r94 UTSW 17 18,464,038 (GRCm39) missense probably damaging 1.00
RF014:Vmn2r94 UTSW 17 18,473,549 (GRCm39) nonsense probably null
X0011:Vmn2r94 UTSW 17 18,464,710 (GRCm39) missense possibly damaging 0.76
X0028:Vmn2r94 UTSW 17 18,464,237 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGGCGTCAGGACTTAGACTCAGAG -3'
(R):5'- AGATGCTCACACTGAACATGGACAC -3'

Sequencing Primer
(F):5'- CTTAGACTCAGAGATGCTGAATCAC -3'
(R):5'- CTGAACATGGACACATCATCCTTTTG -3'
Posted On 2013-05-09