Incidental Mutation 'R4790:Ttc28'
| ID |
368437 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Ttc28
|
| Ensembl Gene |
ENSMUSG00000033209 |
| Gene Name |
tetratricopeptide repeat domain 28 |
| Synonyms |
TPRBK, 2310015L07Rik |
| MMRRC Submission |
042418-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4790 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
5 |
| Chromosomal Location |
111027669-111437646 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 111372083 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Methionine to Lysine
at position 844
(M844K)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000137609
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000040111]
[ENSMUST00000156290]
|
| AlphaFold |
Q80XJ3 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000040111
AA Change: M875K
PolyPhen 2
Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000136116
Gene: ENSMUSG00000033209
AA Change: M875K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
TPR
|
52 |
85 |
2.84e1 |
SMART |
|
TPR
|
86 |
119 |
5.03e-1 |
SMART |
|
TPR
|
120 |
153 |
2.11e-3 |
SMART |
|
TPR
|
268 |
301 |
8.51e0 |
SMART |
|
TPR
|
339 |
372 |
1.78e-1 |
SMART |
|
TPR
|
379 |
412 |
2.82e-4 |
SMART |
|
TPR
|
419 |
452 |
9.98e-5 |
SMART |
|
TPR
|
459 |
492 |
1.88e0 |
SMART |
|
TPR
|
499 |
532 |
1.11e1 |
SMART |
|
TPR
|
539 |
572 |
2.93e-2 |
SMART |
|
TPR
|
579 |
612 |
1.21e-3 |
SMART |
|
TPR
|
619 |
652 |
4.91e-4 |
SMART |
|
TPR
|
659 |
692 |
7.56e-5 |
SMART |
|
TPR
|
699 |
732 |
8.29e0 |
SMART |
|
TPR
|
739 |
772 |
1.63e0 |
SMART |
|
TPR
|
779 |
812 |
1.24e0 |
SMART |
|
TPR
|
819 |
852 |
7.98e-4 |
SMART |
|
TPR
|
859 |
892 |
8.74e0 |
SMART |
|
TPR
|
902 |
935 |
5.43e-6 |
SMART |
|
TPR
|
942 |
975 |
4.09e-1 |
SMART |
|
TPR
|
982 |
1015 |
9.98e-5 |
SMART |
|
TPR
|
1022 |
1055 |
7.12e-1 |
SMART |
|
TPR
|
1062 |
1095 |
5.69e0 |
SMART |
|
TPR
|
1102 |
1135 |
3.14e-2 |
SMART |
|
TPR
|
1142 |
1175 |
2.84e1 |
SMART |
|
low complexity region
|
1259 |
1277 |
N/A |
INTRINSIC |
|
Pfam:CHAT
|
1415 |
1738 |
7.3e-77 |
PFAM |
|
low complexity region
|
1972 |
1990 |
N/A |
INTRINSIC |
|
low complexity region
|
2014 |
2031 |
N/A |
INTRINSIC |
|
low complexity region
|
2033 |
2045 |
N/A |
INTRINSIC |
|
low complexity region
|
2155 |
2171 |
N/A |
INTRINSIC |
|
low complexity region
|
2283 |
2293 |
N/A |
INTRINSIC |
|
low complexity region
|
2327 |
2352 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000125470
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000156290
AA Change: M844K
PolyPhen 2
Score 0.942 (Sensitivity: 0.80; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000137609
Gene: ENSMUSG00000033209
AA Change: M844K
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
28 |
N/A |
INTRINSIC |
|
TPR
|
52 |
85 |
2.84e1 |
SMART |
|
TPR
|
86 |
119 |
5.03e-1 |
SMART |
|
TPR
|
120 |
153 |
2.11e-3 |
SMART |
|
TPR
|
268 |
301 |
8.51e0 |
SMART |
|
TPR
|
308 |
341 |
1.78e-1 |
SMART |
|
TPR
|
348 |
381 |
2.82e-4 |
SMART |
|
TPR
|
388 |
421 |
9.98e-5 |
SMART |
|
TPR
|
428 |
461 |
1.88e0 |
SMART |
|
TPR
|
468 |
501 |
1.11e1 |
SMART |
|
TPR
|
508 |
541 |
2.93e-2 |
SMART |
|
TPR
|
548 |
581 |
1.21e-3 |
SMART |
|
TPR
|
588 |
621 |
4.91e-4 |
SMART |
|
TPR
|
628 |
661 |
7.56e-5 |
SMART |
|
TPR
|
668 |
701 |
8.29e0 |
SMART |
|
TPR
|
708 |
741 |
1.63e0 |
SMART |
|
TPR
|
748 |
781 |
1.24e0 |
SMART |
|
TPR
|
788 |
821 |
7.98e-4 |
SMART |
|
TPR
|
828 |
861 |
8.74e0 |
SMART |
|
TPR
|
871 |
904 |
5.43e-6 |
SMART |
|
TPR
|
911 |
944 |
4.09e-1 |
SMART |
|
TPR
|
951 |
984 |
9.98e-5 |
SMART |
|
TPR
|
991 |
1024 |
7.12e-1 |
SMART |
|
TPR
|
1031 |
1064 |
5.69e0 |
SMART |
|
TPR
|
1071 |
1104 |
3.14e-2 |
SMART |
|
TPR
|
1111 |
1144 |
2.84e1 |
SMART |
|
low complexity region
|
1228 |
1246 |
N/A |
INTRINSIC |
|
Pfam:CHAT
|
1384 |
1707 |
1.1e-76 |
PFAM |
|
low complexity region
|
1941 |
1959 |
N/A |
INTRINSIC |
|
low complexity region
|
1983 |
2000 |
N/A |
INTRINSIC |
|
low complexity region
|
2002 |
2014 |
N/A |
INTRINSIC |
|
low complexity region
|
2124 |
2140 |
N/A |
INTRINSIC |
|
low complexity region
|
2252 |
2262 |
N/A |
INTRINSIC |
|
low complexity region
|
2296 |
2321 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.2%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 118 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca5 |
T |
G |
11: 110,202,236 (GRCm39) |
T390P |
possibly damaging |
Het |
| Acss3 |
A |
T |
10: 106,859,563 (GRCm39) |
Y345* |
probably null |
Het |
| Adam26b |
A |
T |
8: 43,973,764 (GRCm39) |
S413T |
probably benign |
Het |
| Angpt2 |
T |
A |
8: 18,764,098 (GRCm39) |
Q148L |
probably damaging |
Het |
| Ank3 |
T |
A |
10: 69,823,981 (GRCm39) |
Y883* |
probably null |
Het |
| Ankrd52 |
A |
G |
10: 128,216,814 (GRCm39) |
K190E |
possibly damaging |
Het |
| Anks1b |
A |
G |
10: 89,999,137 (GRCm39) |
R415G |
probably damaging |
Het |
| Ano3 |
T |
A |
2: 110,715,264 (GRCm39) |
Q58L |
probably benign |
Het |
| Aoc1l2 |
T |
A |
6: 48,907,486 (GRCm39) |
I162N |
probably damaging |
Het |
| Arhgap39 |
A |
T |
15: 76,610,931 (GRCm39) |
M924K |
possibly damaging |
Het |
| AU040320 |
A |
G |
4: 126,741,008 (GRCm39) |
M910V |
possibly damaging |
Het |
| BC051019 |
T |
A |
7: 109,315,553 (GRCm39) |
H86L |
probably benign |
Het |
| C1qbp |
G |
A |
11: 70,870,856 (GRCm39) |
Q151* |
probably null |
Het |
| C4b |
G |
T |
17: 34,953,117 (GRCm39) |
D1069E |
probably benign |
Het |
| Casp1 |
C |
T |
9: 5,303,020 (GRCm39) |
T158I |
probably benign |
Het |
| Casq1 |
T |
C |
1: 172,044,404 (GRCm39) |
D141G |
probably damaging |
Het |
| Ccdc33 |
T |
A |
9: 57,937,240 (GRCm39) |
E653V |
probably damaging |
Het |
| Cd180 |
C |
T |
13: 102,839,330 (GRCm39) |
T71M |
probably damaging |
Het |
| Cdk4 |
T |
C |
10: 126,900,570 (GRCm39) |
L112P |
probably damaging |
Het |
| Celf2 |
A |
G |
2: 6,554,714 (GRCm39) |
F425S |
probably damaging |
Het |
| Chrm3 |
A |
T |
13: 9,927,698 (GRCm39) |
V446E |
probably benign |
Het |
| Chst9 |
A |
T |
18: 15,586,107 (GRCm39) |
L152H |
probably damaging |
Het |
| Cib2 |
A |
G |
9: 54,457,087 (GRCm39) |
|
probably null |
Het |
| Clec18a |
T |
C |
8: 111,798,717 (GRCm39) |
S366G |
probably damaging |
Het |
| Crebbp |
A |
G |
16: 3,997,983 (GRCm39) |
F34L |
probably damaging |
Het |
| Dapk1 |
AT |
A |
13: 60,870,919 (GRCm39) |
|
probably null |
Het |
| Ddi1 |
T |
A |
9: 6,265,761 (GRCm39) |
M203L |
probably benign |
Het |
| Ddx20 |
G |
T |
3: 105,590,485 (GRCm39) |
S270R |
probably benign |
Het |
| Eddm13 |
A |
T |
7: 6,269,317 (GRCm39) |
K31* |
probably null |
Het |
| Espnl |
A |
T |
1: 91,272,146 (GRCm39) |
E458V |
probably damaging |
Het |
| Fat3 |
T |
C |
9: 15,909,780 (GRCm39) |
D2074G |
probably damaging |
Het |
| Fcf1 |
A |
G |
12: 85,020,902 (GRCm39) |
T61A |
probably benign |
Het |
| Fkbp15 |
T |
C |
4: 62,226,234 (GRCm39) |
R772G |
probably benign |
Het |
| Flnb |
T |
C |
14: 7,905,661 (GRCm38) |
V1137A |
probably benign |
Het |
| Fosb |
C |
A |
7: 19,043,313 (GRCm39) |
C15F |
probably damaging |
Het |
| Frem2 |
A |
T |
3: 53,424,162 (GRCm39) |
W3092R |
probably benign |
Het |
| Gm3248 |
T |
C |
14: 5,945,831 (GRCm38) |
I28V |
probably damaging |
Het |
| Gm4922 |
G |
T |
10: 18,659,916 (GRCm39) |
L269I |
possibly damaging |
Het |
| Gucy2e |
G |
A |
11: 69,119,274 (GRCm39) |
R627W |
probably damaging |
Het |
| Hephl1 |
T |
A |
9: 14,970,467 (GRCm39) |
E1009V |
probably damaging |
Het |
| Hsf4 |
A |
T |
8: 105,997,237 (GRCm39) |
Q61L |
probably damaging |
Het |
| Itgam |
T |
A |
7: 127,715,445 (GRCm39) |
N1046K |
probably benign |
Het |
| Itgav |
G |
A |
2: 83,586,154 (GRCm39) |
C138Y |
probably damaging |
Het |
| Itih4 |
A |
T |
14: 30,611,867 (GRCm39) |
Y157F |
probably damaging |
Het |
| Kcnt2 |
C |
T |
1: 140,282,254 (GRCm39) |
R80C |
probably damaging |
Het |
| Kdm4b |
G |
A |
17: 56,708,618 (GRCm39) |
V986M |
probably damaging |
Het |
| Lamb3 |
T |
A |
1: 193,022,194 (GRCm39) |
V1014D |
probably damaging |
Het |
| Lrrc74b |
G |
T |
16: 17,367,717 (GRCm39) |
N282K |
probably damaging |
Het |
| Map3k20 |
T |
A |
2: 72,272,048 (GRCm39) |
H725Q |
probably benign |
Het |
| Mink1 |
A |
G |
11: 70,489,867 (GRCm39) |
N81S |
probably damaging |
Het |
| Mmp21 |
A |
G |
7: 133,276,759 (GRCm39) |
Y415H |
probably damaging |
Het |
| Mycbp2 |
A |
T |
14: 103,466,873 (GRCm39) |
W1297R |
probably damaging |
Het |
| Myh8 |
T |
C |
11: 67,170,789 (GRCm39) |
M95T |
probably damaging |
Het |
| Myo7b |
A |
T |
18: 32,133,158 (GRCm39) |
|
probably null |
Het |
| Nanog |
A |
G |
6: 122,684,874 (GRCm39) |
M20V |
probably benign |
Het |
| Ncapd3 |
A |
G |
9: 26,963,146 (GRCm39) |
I484V |
probably benign |
Het |
| Ndufa12 |
A |
T |
10: 94,056,620 (GRCm39) |
N116I |
probably benign |
Het |
| Nedd4l |
A |
G |
18: 65,337,016 (GRCm39) |
I668V |
possibly damaging |
Het |
| Nhsl3 |
C |
A |
4: 129,117,095 (GRCm39) |
R523L |
probably damaging |
Het |
| Nobox |
T |
C |
6: 43,282,480 (GRCm39) |
D309G |
probably benign |
Het |
| Npnt |
A |
G |
3: 132,596,523 (GRCm39) |
|
probably benign |
Het |
| Nrxn1 |
A |
C |
17: 90,762,477 (GRCm39) |
Y2D |
possibly damaging |
Het |
| Obox6 |
G |
T |
7: 15,568,502 (GRCm39) |
P125T |
possibly damaging |
Het |
| Ofcc1 |
G |
A |
13: 40,168,864 (GRCm39) |
T841I |
probably damaging |
Het |
| Or14j8 |
T |
C |
17: 38,263,633 (GRCm39) |
Y94C |
probably damaging |
Het |
| Or2ag15 |
C |
G |
7: 106,340,998 (GRCm39) |
V48L |
probably benign |
Het |
| Or4s2b |
T |
A |
2: 88,508,731 (GRCm39) |
N177K |
possibly damaging |
Het |
| Or56a3 |
T |
C |
7: 104,735,844 (GRCm39) |
|
probably benign |
Het |
| Or5ac20 |
A |
T |
16: 59,104,821 (GRCm39) |
V13D |
probably damaging |
Het |
| Or5an10 |
A |
G |
19: 12,276,305 (GRCm39) |
Y64H |
possibly damaging |
Het |
| Or8k32 |
T |
C |
2: 86,369,224 (GRCm39) |
T10A |
possibly damaging |
Het |
| Osm |
A |
T |
11: 4,188,435 (GRCm39) |
M21L |
probably benign |
Het |
| Otogl |
T |
A |
10: 107,657,894 (GRCm39) |
|
probably null |
Het |
| Otud4 |
T |
G |
8: 80,393,402 (GRCm39) |
S493A |
possibly damaging |
Het |
| Pars2 |
A |
G |
4: 106,508,308 (GRCm39) |
|
probably benign |
Het |
| Phlda3 |
T |
A |
1: 135,694,557 (GRCm39) |
V124E |
possibly damaging |
Het |
| Pias4 |
T |
C |
10: 80,993,326 (GRCm39) |
D199G |
probably damaging |
Het |
| Pm20d1 |
T |
C |
1: 131,739,777 (GRCm39) |
L375P |
probably benign |
Het |
| Pole2 |
T |
C |
12: 69,273,139 (GRCm39) |
I48V |
probably benign |
Het |
| Prrc2c |
T |
C |
1: 162,538,050 (GRCm39) |
R527G |
unknown |
Het |
| Rasgrf2 |
G |
T |
13: 92,136,135 (GRCm39) |
N592K |
probably damaging |
Het |
| Rbm7 |
A |
G |
9: 48,406,474 (GRCm39) |
L26P |
probably damaging |
Het |
| Rhag |
A |
G |
17: 41,142,181 (GRCm39) |
H208R |
probably benign |
Het |
| Rnf17 |
A |
G |
14: 56,671,812 (GRCm39) |
E268G |
probably damaging |
Het |
| Rnf220 |
A |
G |
4: 117,146,252 (GRCm39) |
V23A |
probably benign |
Het |
| Rnf7 |
A |
T |
9: 96,360,472 (GRCm39) |
V55D |
probably damaging |
Het |
| Sdr9c7 |
C |
A |
10: 127,739,448 (GRCm39) |
R188S |
possibly damaging |
Het |
| Senp6 |
T |
A |
9: 79,997,140 (GRCm39) |
N51K |
probably benign |
Het |
| Skint3 |
C |
A |
4: 112,113,095 (GRCm39) |
T235K |
possibly damaging |
Het |
| Slc10a5 |
A |
G |
3: 10,400,096 (GRCm39) |
F188S |
probably damaging |
Het |
| Slc41a1 |
G |
A |
1: 131,758,690 (GRCm39) |
G111R |
probably damaging |
Het |
| Smarca1 |
T |
C |
X: 46,972,944 (GRCm39) |
D132G |
probably null |
Het |
| Snrnp48 |
C |
T |
13: 38,405,299 (GRCm39) |
R299W |
probably damaging |
Het |
| Sspo |
G |
A |
6: 48,437,705 (GRCm39) |
G1413D |
probably benign |
Het |
| Star |
T |
A |
8: 26,298,644 (GRCm39) |
H16Q |
probably damaging |
Het |
| Strc |
T |
C |
2: 121,206,075 (GRCm39) |
D779G |
probably benign |
Het |
| Sulf2 |
T |
C |
2: 165,931,215 (GRCm39) |
Y264C |
probably damaging |
Het |
| Supt7l |
A |
G |
5: 31,680,248 (GRCm39) |
S6P |
possibly damaging |
Het |
| Syne2 |
A |
G |
12: 76,067,165 (GRCm39) |
D4289G |
probably benign |
Het |
| Szrd1 |
A |
T |
4: 140,867,001 (GRCm39) |
|
probably null |
Het |
| Tada1 |
T |
C |
1: 166,219,523 (GRCm39) |
V275A |
possibly damaging |
Het |
| Tbr1 |
A |
T |
2: 61,641,932 (GRCm39) |
Y136F |
probably benign |
Het |
| Tbx20 |
T |
A |
9: 24,637,010 (GRCm39) |
H359L |
probably benign |
Het |
| Thbs4 |
G |
T |
13: 92,899,314 (GRCm39) |
D560E |
probably damaging |
Het |
| Tnfsf14 |
T |
C |
17: 57,497,740 (GRCm39) |
H164R |
probably damaging |
Het |
| Trmu |
T |
C |
15: 85,767,006 (GRCm39) |
S72P |
probably damaging |
Het |
| Tsnaxip1 |
C |
A |
8: 106,560,155 (GRCm39) |
Q36K |
probably benign |
Het |
| Tubgcp2 |
T |
C |
7: 139,579,201 (GRCm39) |
Y695C |
probably damaging |
Het |
| Ugt1a10 |
T |
A |
1: 87,984,009 (GRCm39) |
M269K |
probably damaging |
Het |
| Urb1 |
A |
T |
16: 90,566,443 (GRCm39) |
L1448* |
probably null |
Het |
| Vmn2r124 |
A |
T |
17: 18,269,855 (GRCm39) |
H37L |
probably damaging |
Het |
| Vmn2r44 |
T |
C |
7: 8,370,949 (GRCm39) |
N699S |
probably damaging |
Het |
| Vps35 |
A |
T |
8: 86,005,486 (GRCm39) |
|
probably null |
Het |
| Yipf1 |
G |
T |
4: 107,193,396 (GRCm39) |
|
probably null |
Het |
| Zfp395 |
A |
G |
14: 65,623,990 (GRCm39) |
N153S |
possibly damaging |
Het |
| Zfp395 |
A |
G |
14: 65,630,656 (GRCm39) |
D402G |
probably damaging |
Het |
| Zfp652 |
T |
C |
11: 95,640,435 (GRCm39) |
V120A |
probably damaging |
Het |
| Zp3r |
T |
C |
1: 130,510,629 (GRCm39) |
I364M |
probably damaging |
Het |
|
| Other mutations in Ttc28 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00516:Ttc28
|
APN |
5 |
111,373,554 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00963:Ttc28
|
APN |
5 |
111,434,255 (GRCm39) |
nonsense |
probably null |
|
|
IGL00969:Ttc28
|
APN |
5 |
111,373,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01366:Ttc28
|
APN |
5 |
111,233,037 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01528:Ttc28
|
APN |
5 |
111,249,826 (GRCm39) |
splice site |
probably benign |
|
|
IGL01558:Ttc28
|
APN |
5 |
111,431,828 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01973:Ttc28
|
APN |
5 |
111,372,101 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
IGL02040:Ttc28
|
APN |
5 |
111,040,802 (GRCm39) |
nonsense |
probably null |
|
|
IGL02432:Ttc28
|
APN |
5 |
111,371,101 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02531:Ttc28
|
APN |
5 |
111,373,716 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02819:Ttc28
|
APN |
5 |
111,414,449 (GRCm39) |
missense |
probably benign |
|
|
IGL02830:Ttc28
|
APN |
5 |
111,434,105 (GRCm39) |
missense |
probably benign |
0.10 |
|
IGL02893:Ttc28
|
APN |
5 |
111,433,251 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL03387:Ttc28
|
APN |
5 |
111,381,208 (GRCm39) |
missense |
probably benign |
0.07 |
|
PIT4131001:Ttc28
|
UTSW |
5 |
111,040,719 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0142:Ttc28
|
UTSW |
5 |
111,425,323 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0166:Ttc28
|
UTSW |
5 |
111,373,500 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0328:Ttc28
|
UTSW |
5 |
111,431,933 (GRCm39) |
splice site |
probably benign |
|
|
R0582:Ttc28
|
UTSW |
5 |
111,331,162 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0744:Ttc28
|
UTSW |
5 |
111,378,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0811:Ttc28
|
UTSW |
5 |
111,383,366 (GRCm39) |
missense |
probably benign |
0.24 |
|
R0812:Ttc28
|
UTSW |
5 |
111,383,366 (GRCm39) |
missense |
probably benign |
0.24 |
|
R0828:Ttc28
|
UTSW |
5 |
111,371,312 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0833:Ttc28
|
UTSW |
5 |
111,378,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1013:Ttc28
|
UTSW |
5 |
111,424,831 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1168:Ttc28
|
UTSW |
5 |
111,378,977 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1194:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1195:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1196:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1205:Ttc28
|
UTSW |
5 |
111,433,635 (GRCm39) |
missense |
probably benign |
0.04 |
|
R1386:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Ttc28
|
UTSW |
5 |
111,433,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1467:Ttc28
|
UTSW |
5 |
111,433,254 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1537:Ttc28
|
UTSW |
5 |
111,433,184 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R1539:Ttc28
|
UTSW |
5 |
111,248,677 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1558:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1560:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1561:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1566:Ttc28
|
UTSW |
5 |
111,373,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1768:Ttc28
|
UTSW |
5 |
111,425,034 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1775:Ttc28
|
UTSW |
5 |
111,424,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1909:Ttc28
|
UTSW |
5 |
111,431,920 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1911:Ttc28
|
UTSW |
5 |
111,428,616 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1970:Ttc28
|
UTSW |
5 |
111,383,501 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1990:Ttc28
|
UTSW |
5 |
111,424,188 (GRCm39) |
missense |
probably benign |
0.37 |
|
R1992:Ttc28
|
UTSW |
5 |
111,424,188 (GRCm39) |
missense |
probably benign |
0.37 |
|
R2066:Ttc28
|
UTSW |
5 |
111,373,799 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2112:Ttc28
|
UTSW |
5 |
111,424,139 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2158:Ttc28
|
UTSW |
5 |
111,325,483 (GRCm39) |
intron |
probably benign |
|
|
R2192:Ttc28
|
UTSW |
5 |
111,371,362 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2267:Ttc28
|
UTSW |
5 |
111,373,869 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R2384:Ttc28
|
UTSW |
5 |
111,424,074 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2989:Ttc28
|
UTSW |
5 |
111,371,881 (GRCm39) |
missense |
probably benign |
0.29 |
|
R3881:Ttc28
|
UTSW |
5 |
111,331,106 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3919:Ttc28
|
UTSW |
5 |
111,433,245 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R4455:Ttc28
|
UTSW |
5 |
111,371,924 (GRCm39) |
frame shift |
probably null |
|
|
R4456:Ttc28
|
UTSW |
5 |
111,371,924 (GRCm39) |
frame shift |
probably null |
|
|
R4522:Ttc28
|
UTSW |
5 |
111,428,038 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4548:Ttc28
|
UTSW |
5 |
111,419,090 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4591:Ttc28
|
UTSW |
5 |
111,371,147 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4633:Ttc28
|
UTSW |
5 |
111,371,867 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4700:Ttc28
|
UTSW |
5 |
111,424,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4714:Ttc28
|
UTSW |
5 |
111,433,095 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R4803:Ttc28
|
UTSW |
5 |
111,425,329 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R4840:Ttc28
|
UTSW |
5 |
111,433,947 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4969:Ttc28
|
UTSW |
5 |
111,424,121 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5019:Ttc28
|
UTSW |
5 |
111,249,930 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R5130:Ttc28
|
UTSW |
5 |
111,040,722 (GRCm39) |
missense |
probably benign |
|
|
R5150:Ttc28
|
UTSW |
5 |
111,373,555 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5214:Ttc28
|
UTSW |
5 |
111,325,489 (GRCm39) |
intron |
probably benign |
|
|
R5254:Ttc28
|
UTSW |
5 |
111,419,104 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5518:Ttc28
|
UTSW |
5 |
111,373,794 (GRCm39) |
missense |
probably benign |
0.17 |
|
R5851:Ttc28
|
UTSW |
5 |
111,383,335 (GRCm39) |
splice site |
probably benign |
|
|
R5931:Ttc28
|
UTSW |
5 |
111,232,975 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R6011:Ttc28
|
UTSW |
5 |
111,434,309 (GRCm39) |
missense |
probably benign |
|
|
R6176:Ttc28
|
UTSW |
5 |
111,371,851 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6221:Ttc28
|
UTSW |
5 |
111,419,114 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6398:Ttc28
|
UTSW |
5 |
111,424,142 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6717:Ttc28
|
UTSW |
5 |
111,433,302 (GRCm39) |
missense |
probably benign |
|
|
R6770:Ttc28
|
UTSW |
5 |
111,434,006 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6901:Ttc28
|
UTSW |
5 |
111,424,891 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R7038:Ttc28
|
UTSW |
5 |
111,414,445 (GRCm39) |
missense |
probably benign |
0.09 |
|
R7073:Ttc28
|
UTSW |
5 |
111,371,282 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R7101:Ttc28
|
UTSW |
5 |
111,232,958 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7135:Ttc28
|
UTSW |
5 |
111,427,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Ttc28
|
UTSW |
5 |
111,373,903 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7454:Ttc28
|
UTSW |
5 |
111,433,350 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7461:Ttc28
|
UTSW |
5 |
111,371,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7596:Ttc28
|
UTSW |
5 |
111,427,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7613:Ttc28
|
UTSW |
5 |
111,371,995 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7625:Ttc28
|
UTSW |
5 |
111,433,085 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7648:Ttc28
|
UTSW |
5 |
111,331,258 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R7735:Ttc28
|
UTSW |
5 |
111,414,544 (GRCm39) |
splice site |
probably null |
|
|
R8030:Ttc28
|
UTSW |
5 |
111,433,922 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R8205:Ttc28
|
UTSW |
5 |
111,373,596 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R8246:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8247:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8269:Ttc28
|
UTSW |
5 |
111,425,325 (GRCm39) |
missense |
probably benign |
0.09 |
|
R8292:Ttc28
|
UTSW |
5 |
111,371,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8346:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8356:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8423:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8424:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8426:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8441:Ttc28
|
UTSW |
5 |
111,325,507 (GRCm39) |
nonsense |
probably null |
|
|
R8494:Ttc28
|
UTSW |
5 |
111,383,506 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R8508:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8510:Ttc28
|
UTSW |
5 |
111,381,207 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8729:Ttc28
|
UTSW |
5 |
111,383,509 (GRCm39) |
critical splice donor site |
probably null |
|
|
R8845:Ttc28
|
UTSW |
5 |
111,372,041 (GRCm39) |
missense |
probably benign |
0.11 |
|
R9003:Ttc28
|
UTSW |
5 |
111,424,896 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9185:Ttc28
|
UTSW |
5 |
111,371,342 (GRCm39) |
missense |
probably benign |
0.03 |
|
R9187:Ttc28
|
UTSW |
5 |
111,249,902 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9245:Ttc28
|
UTSW |
5 |
111,325,525 (GRCm39) |
missense |
unknown |
|
|
R9251:Ttc28
|
UTSW |
5 |
111,040,698 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R9372:Ttc28
|
UTSW |
5 |
111,331,073 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9466:Ttc28
|
UTSW |
5 |
111,330,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9563:Ttc28
|
UTSW |
5 |
111,371,092 (GRCm39) |
missense |
probably benign |
0.22 |
|
R9606:Ttc28
|
UTSW |
5 |
111,433,140 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9691:Ttc28
|
UTSW |
5 |
111,431,879 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9709:Ttc28
|
UTSW |
5 |
111,433,637 (GRCm39) |
missense |
probably damaging |
0.97 |
|
V8831:Ttc28
|
UTSW |
5 |
111,248,578 (GRCm39) |
missense |
probably benign |
0.11 |
|
Z1088:Ttc28
|
UTSW |
5 |
111,434,181 (GRCm39) |
missense |
probably benign |
0.00 |
|
Z1176:Ttc28
|
UTSW |
5 |
111,414,432 (GRCm39) |
missense |
possibly damaging |
0.59 |
|
Z1177:Ttc28
|
UTSW |
5 |
111,433,605 (GRCm39) |
missense |
probably benign |
0.10 |
|
Z1177:Ttc28
|
UTSW |
5 |
111,426,452 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- TACGACAAGGCCTTGGGTTAC -3'
(R):5'- TTGCATGCGGTTCAGACTC -3'
Sequencing Primer
(F):5'- GTTACCACACACAGGAGCTGG -3'
(R):5'- ATGCGGTTCAGACTCTGGGC -3'
|
| Posted On |
2016-02-04 |
Incidental Mutation