Incidental Mutation 'R0418:Suco'
ID 36848
Institutional Source Beutler Lab
Gene Symbol Suco
Ensembl Gene ENSMUSG00000040297
Gene Name SUN domain containing ossification factor
Synonyms AI848100, osteopotentia, Opt
MMRRC Submission 038620-MU
Accession Numbers
Essential gene? Possibly essential (E-score: 0.557) question?
Stock # R0418 (G1)
Quality Score 225
Status Validated
Chromosome 1
Chromosomal Location 161643683-161704251 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 161662419 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Isoleucine at position 671 (V671I)
Ref Sequence ENSEMBL: ENSMUSP00000044815 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000048377]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000048377
AA Change: V671I

PolyPhen 2 Score 0.106 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000044815
Gene: ENSMUSG00000040297
AA Change: V671I

DomainStartEndE-ValueType
signal peptide 1 29 N/A INTRINSIC
low complexity region 32 41 N/A INTRINSIC
low complexity region 117 145 N/A INTRINSIC
low complexity region 208 224 N/A INTRINSIC
low complexity region 272 284 N/A INTRINSIC
Pfam:Sad1_UNC 325 455 9e-43 PFAM
low complexity region 665 683 N/A INTRINSIC
low complexity region 745 758 N/A INTRINSIC
coiled coil region 933 1009 N/A INTRINSIC
low complexity region 1014 1030 N/A INTRINSIC
low complexity region 1105 1119 N/A INTRINSIC
low complexity region 1163 1176 N/A INTRINSIC
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194106
Predicted Effect noncoding transcript
Transcript: ENSMUST00000194388
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.6%
  • 10x: 97.1%
  • 20x: 95.2%
Validation Efficiency 98% (64/65)
MGI Phenotype PHENOTYPE: Mice homozygous for a mutation in this gene display background strain-dependent neonatal and postnatal lethality, and impaired osteoblast differentiation resulting in impaired bone formation, brittle bones, and impaired fracture repair. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
A930018P22Rik G T 2: 103,953,675 (GRCm39) probably null Het
Abca14 T C 7: 119,806,657 (GRCm39) L19P probably damaging Het
Abcb1a T A 5: 8,763,281 (GRCm39) V603E probably damaging Het
Acsl5 A G 19: 55,261,238 (GRCm39) D65G probably benign Het
Acss3 T C 10: 106,859,773 (GRCm39) Y311C probably damaging Het
Ak8 T G 2: 28,623,868 (GRCm39) I151S possibly damaging Het
Aldh1a1 T C 19: 20,606,413 (GRCm39) probably benign Het
Aldh1l1 A G 6: 90,546,875 (GRCm39) R393G possibly damaging Het
Ankhd1 T A 18: 36,767,353 (GRCm39) L1164Q probably damaging Het
Ascc3 G T 10: 50,625,022 (GRCm39) V1637L probably benign Het
Atf5 A G 7: 44,462,821 (GRCm39) M101T possibly damaging Het
Det1 T C 7: 78,493,765 (GRCm39) T80A probably benign Het
Dpp9 C T 17: 56,501,404 (GRCm39) probably benign Het
Fam13c A G 10: 70,370,591 (GRCm39) R244G probably damaging Het
Fat3 A T 9: 16,158,192 (GRCm39) N1139K probably damaging Het
Fbxo17 A G 7: 28,432,916 (GRCm39) T146A possibly damaging Het
Fli1 T C 9: 32,363,425 (GRCm39) probably benign Het
Glb1l2 T G 9: 26,705,397 (GRCm39) D151A probably damaging Het
Gli2 G A 1: 118,768,220 (GRCm39) T669I possibly damaging Het
Igsf3 C A 3: 101,342,751 (GRCm39) R463S probably damaging Het
Il1rl2 T C 1: 40,365,662 (GRCm39) V3A unknown Het
Irx3 G A 8: 92,526,708 (GRCm39) S332F probably benign Het
Katnb1 C T 8: 95,822,286 (GRCm39) T303M possibly damaging Het
Lrrc31 A T 3: 30,743,383 (GRCm39) L194Q probably damaging Het
Lrrc37a T G 11: 103,394,264 (GRCm39) E387A probably benign Het
Mapk14 T C 17: 28,910,763 (GRCm39) I17T probably benign Het
Mtif2 A G 11: 29,483,401 (GRCm39) probably benign Het
Myo16 A G 8: 10,619,918 (GRCm39) T1490A probably benign Het
Nfasc A G 1: 132,539,333 (GRCm39) V399A probably damaging Het
Nhsl3 A G 4: 129,117,477 (GRCm39) S396P probably damaging Het
Nobox T C 6: 43,284,169 (GRCm39) K1E probably null Het
Nr2c1 A T 10: 94,017,374 (GRCm39) M371L probably benign Het
Oplah C T 15: 76,182,687 (GRCm39) R924H probably benign Het
Or10ak16 C T 4: 118,750,448 (GRCm39) T56I possibly damaging Het
Or51a10 G A 7: 103,698,979 (GRCm39) T194I probably benign Het
Pappa2 C A 1: 158,544,560 (GRCm39) C1756F probably damaging Het
Pdzd8 G A 19: 59,289,361 (GRCm39) R680C probably damaging Het
Rassf3 G A 10: 121,253,075 (GRCm39) T44M probably benign Het
Rmnd1 T C 10: 4,377,693 (GRCm39) probably null Het
Rnf126 C T 10: 79,598,477 (GRCm39) probably benign Het
Rnf144b T C 13: 47,397,966 (GRCm39) S299P probably benign Het
Ryr2 A G 13: 11,848,981 (GRCm39) probably benign Het
Scel T A 14: 103,840,690 (GRCm39) S511T probably benign Het
Slc16a10 G T 10: 39,916,627 (GRCm39) S138* probably null Het
Slc36a4 A T 9: 15,645,562 (GRCm39) I330F probably damaging Het
Slc5a8 A G 10: 88,722,420 (GRCm39) I84M probably benign Het
Spag9 T C 11: 93,982,579 (GRCm39) probably benign Het
Suox G A 10: 128,506,754 (GRCm39) P425S probably damaging Het
Tmem266 T A 9: 55,344,697 (GRCm39) V443E probably benign Het
Tmprss11f A T 5: 86,704,870 (GRCm39) I16N probably benign Het
Tnik T A 3: 28,625,029 (GRCm39) Y321* probably null Het
Tnrc6b T C 15: 80,797,524 (GRCm39) M1357T probably benign Het
Tpbg C A 9: 85,726,803 (GRCm39) Y257* probably null Het
Usp37 A T 1: 74,529,266 (GRCm39) S138T probably benign Het
Veph1 T A 3: 66,162,449 (GRCm39) R70* probably null Het
Vmn2r17 C T 5: 109,600,747 (GRCm39) P682S probably damaging Het
Vmn2r79 A C 7: 86,651,611 (GRCm39) N337H probably benign Het
Vstm2b A G 7: 40,551,876 (GRCm39) D68G probably damaging Het
Vwa7 G T 17: 35,236,933 (GRCm39) A167S possibly damaging Het
Zfp647 A T 15: 76,795,586 (GRCm39) I358N probably damaging Het
Zic2 CCCACCACCACCATCACCACCACCACC CCCACCATCACCACCACCACC 14: 122,713,776 (GRCm39) probably benign Het
Other mutations in Suco
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01432:Suco APN 1 161,661,689 (GRCm39) missense probably damaging 1.00
IGL01688:Suco APN 1 161,691,480 (GRCm39) splice site probably null
IGL01794:Suco APN 1 161,655,294 (GRCm39) missense probably benign 0.01
IGL01891:Suco APN 1 161,666,371 (GRCm39) missense probably damaging 1.00
IGL02028:Suco APN 1 161,684,428 (GRCm39) missense possibly damaging 0.95
IGL02102:Suco APN 1 161,655,274 (GRCm39) missense probably damaging 1.00
IGL02351:Suco APN 1 161,646,195 (GRCm39) missense probably benign 0.35
IGL02358:Suco APN 1 161,646,195 (GRCm39) missense probably benign 0.35
IGL02392:Suco APN 1 161,662,136 (GRCm39) missense probably benign 0.11
IGL02638:Suco APN 1 161,655,256 (GRCm39) missense probably damaging 1.00
IGL02650:Suco APN 1 161,676,322 (GRCm39) splice site probably benign
IGL03106:Suco APN 1 161,662,049 (GRCm39) missense possibly damaging 0.91
IGL03189:Suco APN 1 161,684,906 (GRCm39) unclassified probably benign
IGL03328:Suco APN 1 161,647,990 (GRCm39) missense probably damaging 0.99
girth UTSW 1 161,655,809 (GRCm39) missense possibly damaging 0.86
pleasingly UTSW 1 161,661,977 (GRCm39) missense possibly damaging 0.65
3-1:Suco UTSW 1 161,649,600 (GRCm39) intron probably benign
H8562:Suco UTSW 1 161,680,420 (GRCm39) missense probably damaging 1.00
H8786:Suco UTSW 1 161,680,420 (GRCm39) missense probably damaging 1.00
R0023:Suco UTSW 1 161,673,154 (GRCm39) splice site probably null
R0023:Suco UTSW 1 161,673,154 (GRCm39) splice site probably null
R0179:Suco UTSW 1 161,703,874 (GRCm39) splice site probably benign
R0299:Suco UTSW 1 161,681,379 (GRCm39) missense probably benign
R0481:Suco UTSW 1 161,689,882 (GRCm39) unclassified probably benign
R0610:Suco UTSW 1 161,691,601 (GRCm39) splice site probably benign
R0610:Suco UTSW 1 161,687,072 (GRCm39) missense probably benign
R0634:Suco UTSW 1 161,666,373 (GRCm39) missense possibly damaging 0.77
R0645:Suco UTSW 1 161,661,683 (GRCm39) missense probably damaging 1.00
R1276:Suco UTSW 1 161,685,025 (GRCm39) missense probably benign 0.10
R1720:Suco UTSW 1 161,661,623 (GRCm39) missense probably damaging 1.00
R1739:Suco UTSW 1 161,655,224 (GRCm39) critical splice donor site probably null
R1763:Suco UTSW 1 161,662,518 (GRCm39) missense possibly damaging 0.80
R1835:Suco UTSW 1 161,687,069 (GRCm39) nonsense probably null
R1988:Suco UTSW 1 161,646,380 (GRCm39) critical splice acceptor site probably null
R2939:Suco UTSW 1 161,676,220 (GRCm39) missense probably damaging 1.00
R3773:Suco UTSW 1 161,671,565 (GRCm39) splice site probably null
R3882:Suco UTSW 1 161,662,313 (GRCm39) missense probably benign 0.33
R4193:Suco UTSW 1 161,691,528 (GRCm39) missense probably benign 0.32
R4367:Suco UTSW 1 161,674,799 (GRCm39) missense probably damaging 1.00
R4397:Suco UTSW 1 161,672,421 (GRCm39) missense probably damaging 1.00
R4846:Suco UTSW 1 161,661,977 (GRCm39) missense possibly damaging 0.65
R4851:Suco UTSW 1 161,661,761 (GRCm39) missense probably damaging 1.00
R5224:Suco UTSW 1 161,662,274 (GRCm39) missense probably benign 0.06
R5329:Suco UTSW 1 161,660,999 (GRCm39) missense probably damaging 0.99
R6133:Suco UTSW 1 161,662,752 (GRCm39) nonsense probably null
R6632:Suco UTSW 1 161,655,809 (GRCm39) missense possibly damaging 0.86
R6643:Suco UTSW 1 161,687,001 (GRCm39) missense possibly damaging 0.71
R7378:Suco UTSW 1 161,689,780 (GRCm39) missense possibly damaging 0.76
R7405:Suco UTSW 1 161,655,783 (GRCm39) missense possibly damaging 0.65
R7509:Suco UTSW 1 161,672,903 (GRCm39) missense probably damaging 1.00
R7838:Suco UTSW 1 161,656,890 (GRCm39) missense probably benign 0.07
R7867:Suco UTSW 1 161,665,365 (GRCm39) missense possibly damaging 0.77
R7895:Suco UTSW 1 161,672,937 (GRCm39) splice site probably null
R8440:Suco UTSW 1 161,679,907 (GRCm39) missense probably damaging 1.00
R8453:Suco UTSW 1 161,650,586 (GRCm39) intron probably benign
R8781:Suco UTSW 1 161,645,951 (GRCm39) missense probably damaging 1.00
R8798:Suco UTSW 1 161,648,004 (GRCm39) missense probably damaging 1.00
R9292:Suco UTSW 1 161,671,574 (GRCm39) missense probably damaging 1.00
R9310:Suco UTSW 1 161,684,427 (GRCm39) missense probably damaging 1.00
R9380:Suco UTSW 1 161,646,074 (GRCm39) missense possibly damaging 0.61
R9411:Suco UTSW 1 161,666,356 (GRCm39) missense probably damaging 0.99
R9542:Suco UTSW 1 161,661,668 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTCAGCAGAACTAAAGCTCTCGGTC -3'
(R):5'- CCCTTTTGGGCAGTGGTGAACAAG -3'

Sequencing Primer
(F):5'- AACAGAACTCTCTTGGGTCATC -3'
(R):5'- AGTCGTCATCCTGGTTTGAG -3'
Posted On 2013-05-09