Incidental Mutation 'R4790:Dapk1'
| ID |
368498 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Dapk1
|
| Ensembl Gene |
ENSMUSG00000021559 |
| Gene Name |
death associated protein kinase 1 |
| Synonyms |
DAP-Kinase, D13Ucla1, 2810425C21Rik, 2310039H24Rik |
| MMRRC Submission |
042418-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4790 (G1)
|
| Quality Score |
217 |
|
Status
|
Not validated
|
| Chromosome |
13 |
| Chromosomal Location |
60749761-60911005 bp(+) (GRCm39) |
| Type of Mutation |
frame shift |
| DNA Base Change (assembly) |
AT to A
at 60870919 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000153607
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000044083]
[ENSMUST00000077453]
[ENSMUST00000226059]
|
| AlphaFold |
Q80YE7 |
| Predicted Effect |
probably null
Transcript: ENSMUST00000044083
|
| SMART Domains |
Protein: ENSMUSP00000040825
Gene: ENSMUSG00000021559
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000077453
|
| SMART Domains |
Protein: ENSMUSP00000076666
Gene: ENSMUSG00000021559
| Domain | Start | End | E-Value | Type |
|---|
|
S_TKc
|
13 |
275 |
6.35e-99 |
SMART |
|
low complexity region
|
295 |
306 |
N/A |
INTRINSIC |
|
ANK
|
378 |
407 |
5.09e-2 |
SMART |
|
ANK
|
411 |
440 |
6.61e-1 |
SMART |
|
ANK
|
444 |
473 |
7.64e-6 |
SMART |
|
ANK
|
477 |
506 |
2.13e-4 |
SMART |
|
ANK
|
510 |
539 |
1.31e-4 |
SMART |
|
ANK
|
543 |
572 |
7.83e-3 |
SMART |
|
ANK
|
576 |
605 |
8.52e-4 |
SMART |
|
ANK
|
609 |
638 |
1.85e-4 |
SMART |
|
ANK
|
642 |
671 |
7.29e2 |
SMART |
|
low complexity region
|
711 |
725 |
N/A |
INTRINSIC |
|
Pfam:COR
|
984 |
1176 |
4.2e-10 |
PFAM |
|
DEATH
|
1299 |
1396 |
2.65e-18 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000224340
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000224789
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000226059
|
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.5%
- 20x: 93.2%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
PHENOTYPE: Mice homozygous for a knock-out allele show decreased sensitivity to ER stress-induced cell death and reduced tunicamycin-induced kidney damage. Mice homozygous for a gene trapped allele show decreased infarct size and neuronal death with improved neurological scores after ischemic brain injury. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 118 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abca5 |
T |
G |
11: 110,202,236 (GRCm39) |
T390P |
possibly damaging |
Het |
| Acss3 |
A |
T |
10: 106,859,563 (GRCm39) |
Y345* |
probably null |
Het |
| Adam26b |
A |
T |
8: 43,973,764 (GRCm39) |
S413T |
probably benign |
Het |
| Angpt2 |
T |
A |
8: 18,764,098 (GRCm39) |
Q148L |
probably damaging |
Het |
| Ank3 |
T |
A |
10: 69,823,981 (GRCm39) |
Y883* |
probably null |
Het |
| Ankrd52 |
A |
G |
10: 128,216,814 (GRCm39) |
K190E |
possibly damaging |
Het |
| Anks1b |
A |
G |
10: 89,999,137 (GRCm39) |
R415G |
probably damaging |
Het |
| Ano3 |
T |
A |
2: 110,715,264 (GRCm39) |
Q58L |
probably benign |
Het |
| Aoc1l2 |
T |
A |
6: 48,907,486 (GRCm39) |
I162N |
probably damaging |
Het |
| Arhgap39 |
A |
T |
15: 76,610,931 (GRCm39) |
M924K |
possibly damaging |
Het |
| AU040320 |
A |
G |
4: 126,741,008 (GRCm39) |
M910V |
possibly damaging |
Het |
| BC051019 |
T |
A |
7: 109,315,553 (GRCm39) |
H86L |
probably benign |
Het |
| C1qbp |
G |
A |
11: 70,870,856 (GRCm39) |
Q151* |
probably null |
Het |
| C4b |
G |
T |
17: 34,953,117 (GRCm39) |
D1069E |
probably benign |
Het |
| Casp1 |
C |
T |
9: 5,303,020 (GRCm39) |
T158I |
probably benign |
Het |
| Casq1 |
T |
C |
1: 172,044,404 (GRCm39) |
D141G |
probably damaging |
Het |
| Ccdc33 |
T |
A |
9: 57,937,240 (GRCm39) |
E653V |
probably damaging |
Het |
| Cd180 |
C |
T |
13: 102,839,330 (GRCm39) |
T71M |
probably damaging |
Het |
| Cdk4 |
T |
C |
10: 126,900,570 (GRCm39) |
L112P |
probably damaging |
Het |
| Celf2 |
A |
G |
2: 6,554,714 (GRCm39) |
F425S |
probably damaging |
Het |
| Chrm3 |
A |
T |
13: 9,927,698 (GRCm39) |
V446E |
probably benign |
Het |
| Chst9 |
A |
T |
18: 15,586,107 (GRCm39) |
L152H |
probably damaging |
Het |
| Cib2 |
A |
G |
9: 54,457,087 (GRCm39) |
|
probably null |
Het |
| Clec18a |
T |
C |
8: 111,798,717 (GRCm39) |
S366G |
probably damaging |
Het |
| Crebbp |
A |
G |
16: 3,997,983 (GRCm39) |
F34L |
probably damaging |
Het |
| Ddi1 |
T |
A |
9: 6,265,761 (GRCm39) |
M203L |
probably benign |
Het |
| Ddx20 |
G |
T |
3: 105,590,485 (GRCm39) |
S270R |
probably benign |
Het |
| Eddm13 |
A |
T |
7: 6,269,317 (GRCm39) |
K31* |
probably null |
Het |
| Espnl |
A |
T |
1: 91,272,146 (GRCm39) |
E458V |
probably damaging |
Het |
| Fat3 |
T |
C |
9: 15,909,780 (GRCm39) |
D2074G |
probably damaging |
Het |
| Fcf1 |
A |
G |
12: 85,020,902 (GRCm39) |
T61A |
probably benign |
Het |
| Fkbp15 |
T |
C |
4: 62,226,234 (GRCm39) |
R772G |
probably benign |
Het |
| Flnb |
T |
C |
14: 7,905,661 (GRCm38) |
V1137A |
probably benign |
Het |
| Fosb |
C |
A |
7: 19,043,313 (GRCm39) |
C15F |
probably damaging |
Het |
| Frem2 |
A |
T |
3: 53,424,162 (GRCm39) |
W3092R |
probably benign |
Het |
| Gm3248 |
T |
C |
14: 5,945,831 (GRCm38) |
I28V |
probably damaging |
Het |
| Gm4922 |
G |
T |
10: 18,659,916 (GRCm39) |
L269I |
possibly damaging |
Het |
| Gucy2e |
G |
A |
11: 69,119,274 (GRCm39) |
R627W |
probably damaging |
Het |
| Hephl1 |
T |
A |
9: 14,970,467 (GRCm39) |
E1009V |
probably damaging |
Het |
| Hsf4 |
A |
T |
8: 105,997,237 (GRCm39) |
Q61L |
probably damaging |
Het |
| Itgam |
T |
A |
7: 127,715,445 (GRCm39) |
N1046K |
probably benign |
Het |
| Itgav |
G |
A |
2: 83,586,154 (GRCm39) |
C138Y |
probably damaging |
Het |
| Itih4 |
A |
T |
14: 30,611,867 (GRCm39) |
Y157F |
probably damaging |
Het |
| Kcnt2 |
C |
T |
1: 140,282,254 (GRCm39) |
R80C |
probably damaging |
Het |
| Kdm4b |
G |
A |
17: 56,708,618 (GRCm39) |
V986M |
probably damaging |
Het |
| Lamb3 |
T |
A |
1: 193,022,194 (GRCm39) |
V1014D |
probably damaging |
Het |
| Lrrc74b |
G |
T |
16: 17,367,717 (GRCm39) |
N282K |
probably damaging |
Het |
| Map3k20 |
T |
A |
2: 72,272,048 (GRCm39) |
H725Q |
probably benign |
Het |
| Mink1 |
A |
G |
11: 70,489,867 (GRCm39) |
N81S |
probably damaging |
Het |
| Mmp21 |
A |
G |
7: 133,276,759 (GRCm39) |
Y415H |
probably damaging |
Het |
| Mycbp2 |
A |
T |
14: 103,466,873 (GRCm39) |
W1297R |
probably damaging |
Het |
| Myh8 |
T |
C |
11: 67,170,789 (GRCm39) |
M95T |
probably damaging |
Het |
| Myo7b |
A |
T |
18: 32,133,158 (GRCm39) |
|
probably null |
Het |
| Nanog |
A |
G |
6: 122,684,874 (GRCm39) |
M20V |
probably benign |
Het |
| Ncapd3 |
A |
G |
9: 26,963,146 (GRCm39) |
I484V |
probably benign |
Het |
| Ndufa12 |
A |
T |
10: 94,056,620 (GRCm39) |
N116I |
probably benign |
Het |
| Nedd4l |
A |
G |
18: 65,337,016 (GRCm39) |
I668V |
possibly damaging |
Het |
| Nhsl3 |
C |
A |
4: 129,117,095 (GRCm39) |
R523L |
probably damaging |
Het |
| Nobox |
T |
C |
6: 43,282,480 (GRCm39) |
D309G |
probably benign |
Het |
| Npnt |
A |
G |
3: 132,596,523 (GRCm39) |
|
probably benign |
Het |
| Nrxn1 |
A |
C |
17: 90,762,477 (GRCm39) |
Y2D |
possibly damaging |
Het |
| Obox6 |
G |
T |
7: 15,568,502 (GRCm39) |
P125T |
possibly damaging |
Het |
| Ofcc1 |
G |
A |
13: 40,168,864 (GRCm39) |
T841I |
probably damaging |
Het |
| Or14j8 |
T |
C |
17: 38,263,633 (GRCm39) |
Y94C |
probably damaging |
Het |
| Or2ag15 |
C |
G |
7: 106,340,998 (GRCm39) |
V48L |
probably benign |
Het |
| Or4s2b |
T |
A |
2: 88,508,731 (GRCm39) |
N177K |
possibly damaging |
Het |
| Or56a3 |
T |
C |
7: 104,735,844 (GRCm39) |
|
probably benign |
Het |
| Or5ac20 |
A |
T |
16: 59,104,821 (GRCm39) |
V13D |
probably damaging |
Het |
| Or5an10 |
A |
G |
19: 12,276,305 (GRCm39) |
Y64H |
possibly damaging |
Het |
| Or8k32 |
T |
C |
2: 86,369,224 (GRCm39) |
T10A |
possibly damaging |
Het |
| Osm |
A |
T |
11: 4,188,435 (GRCm39) |
M21L |
probably benign |
Het |
| Otogl |
T |
A |
10: 107,657,894 (GRCm39) |
|
probably null |
Het |
| Otud4 |
T |
G |
8: 80,393,402 (GRCm39) |
S493A |
possibly damaging |
Het |
| Pars2 |
A |
G |
4: 106,508,308 (GRCm39) |
|
probably benign |
Het |
| Phlda3 |
T |
A |
1: 135,694,557 (GRCm39) |
V124E |
possibly damaging |
Het |
| Pias4 |
T |
C |
10: 80,993,326 (GRCm39) |
D199G |
probably damaging |
Het |
| Pm20d1 |
T |
C |
1: 131,739,777 (GRCm39) |
L375P |
probably benign |
Het |
| Pole2 |
T |
C |
12: 69,273,139 (GRCm39) |
I48V |
probably benign |
Het |
| Prrc2c |
T |
C |
1: 162,538,050 (GRCm39) |
R527G |
unknown |
Het |
| Rasgrf2 |
G |
T |
13: 92,136,135 (GRCm39) |
N592K |
probably damaging |
Het |
| Rbm7 |
A |
G |
9: 48,406,474 (GRCm39) |
L26P |
probably damaging |
Het |
| Rhag |
A |
G |
17: 41,142,181 (GRCm39) |
H208R |
probably benign |
Het |
| Rnf17 |
A |
G |
14: 56,671,812 (GRCm39) |
E268G |
probably damaging |
Het |
| Rnf220 |
A |
G |
4: 117,146,252 (GRCm39) |
V23A |
probably benign |
Het |
| Rnf7 |
A |
T |
9: 96,360,472 (GRCm39) |
V55D |
probably damaging |
Het |
| Sdr9c7 |
C |
A |
10: 127,739,448 (GRCm39) |
R188S |
possibly damaging |
Het |
| Senp6 |
T |
A |
9: 79,997,140 (GRCm39) |
N51K |
probably benign |
Het |
| Skint3 |
C |
A |
4: 112,113,095 (GRCm39) |
T235K |
possibly damaging |
Het |
| Slc10a5 |
A |
G |
3: 10,400,096 (GRCm39) |
F188S |
probably damaging |
Het |
| Slc41a1 |
G |
A |
1: 131,758,690 (GRCm39) |
G111R |
probably damaging |
Het |
| Smarca1 |
T |
C |
X: 46,972,944 (GRCm39) |
D132G |
probably null |
Het |
| Snrnp48 |
C |
T |
13: 38,405,299 (GRCm39) |
R299W |
probably damaging |
Het |
| Sspo |
G |
A |
6: 48,437,705 (GRCm39) |
G1413D |
probably benign |
Het |
| Star |
T |
A |
8: 26,298,644 (GRCm39) |
H16Q |
probably damaging |
Het |
| Strc |
T |
C |
2: 121,206,075 (GRCm39) |
D779G |
probably benign |
Het |
| Sulf2 |
T |
C |
2: 165,931,215 (GRCm39) |
Y264C |
probably damaging |
Het |
| Supt7l |
A |
G |
5: 31,680,248 (GRCm39) |
S6P |
possibly damaging |
Het |
| Syne2 |
A |
G |
12: 76,067,165 (GRCm39) |
D4289G |
probably benign |
Het |
| Szrd1 |
A |
T |
4: 140,867,001 (GRCm39) |
|
probably null |
Het |
| Tada1 |
T |
C |
1: 166,219,523 (GRCm39) |
V275A |
possibly damaging |
Het |
| Tbr1 |
A |
T |
2: 61,641,932 (GRCm39) |
Y136F |
probably benign |
Het |
| Tbx20 |
T |
A |
9: 24,637,010 (GRCm39) |
H359L |
probably benign |
Het |
| Thbs4 |
G |
T |
13: 92,899,314 (GRCm39) |
D560E |
probably damaging |
Het |
| Tnfsf14 |
T |
C |
17: 57,497,740 (GRCm39) |
H164R |
probably damaging |
Het |
| Trmu |
T |
C |
15: 85,767,006 (GRCm39) |
S72P |
probably damaging |
Het |
| Tsnaxip1 |
C |
A |
8: 106,560,155 (GRCm39) |
Q36K |
probably benign |
Het |
| Ttc28 |
T |
A |
5: 111,372,083 (GRCm39) |
M844K |
possibly damaging |
Het |
| Tubgcp2 |
T |
C |
7: 139,579,201 (GRCm39) |
Y695C |
probably damaging |
Het |
| Ugt1a10 |
T |
A |
1: 87,984,009 (GRCm39) |
M269K |
probably damaging |
Het |
| Urb1 |
A |
T |
16: 90,566,443 (GRCm39) |
L1448* |
probably null |
Het |
| Vmn2r124 |
A |
T |
17: 18,269,855 (GRCm39) |
H37L |
probably damaging |
Het |
| Vmn2r44 |
T |
C |
7: 8,370,949 (GRCm39) |
N699S |
probably damaging |
Het |
| Vps35 |
A |
T |
8: 86,005,486 (GRCm39) |
|
probably null |
Het |
| Yipf1 |
G |
T |
4: 107,193,396 (GRCm39) |
|
probably null |
Het |
| Zfp395 |
A |
G |
14: 65,623,990 (GRCm39) |
N153S |
possibly damaging |
Het |
| Zfp395 |
A |
G |
14: 65,630,656 (GRCm39) |
D402G |
probably damaging |
Het |
| Zfp652 |
T |
C |
11: 95,640,435 (GRCm39) |
V120A |
probably damaging |
Het |
| Zp3r |
T |
C |
1: 130,510,629 (GRCm39) |
I364M |
probably damaging |
Het |
|
| Other mutations in Dapk1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00089:Dapk1
|
APN |
13 |
60,908,854 (GRCm39) |
missense |
probably benign |
0.23 |
|
IGL00500:Dapk1
|
APN |
13 |
60,908,618 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL00801:Dapk1
|
APN |
13 |
60,909,062 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL00903:Dapk1
|
APN |
13 |
60,909,211 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01468:Dapk1
|
APN |
13 |
60,908,612 (GRCm39) |
missense |
probably benign |
|
|
IGL01535:Dapk1
|
APN |
13 |
60,878,845 (GRCm39) |
splice site |
probably benign |
|
|
IGL01755:Dapk1
|
APN |
13 |
60,908,990 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
IGL01755:Dapk1
|
APN |
13 |
60,908,989 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01862:Dapk1
|
APN |
13 |
60,874,424 (GRCm39) |
missense |
probably benign |
0.39 |
|
IGL01985:Dapk1
|
APN |
13 |
60,884,074 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02124:Dapk1
|
APN |
13 |
60,878,696 (GRCm39) |
missense |
probably benign |
|
|
IGL02376:Dapk1
|
APN |
13 |
60,844,208 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02449:Dapk1
|
APN |
13 |
60,867,584 (GRCm39) |
splice site |
probably benign |
|
|
IGL02490:Dapk1
|
APN |
13 |
60,897,148 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02503:Dapk1
|
APN |
13 |
60,909,621 (GRCm39) |
nonsense |
probably null |
|
|
IGL02516:Dapk1
|
APN |
13 |
60,844,161 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02544:Dapk1
|
APN |
13 |
60,899,031 (GRCm39) |
missense |
probably benign |
|
|
IGL02604:Dapk1
|
APN |
13 |
60,896,134 (GRCm39) |
missense |
probably benign |
|
|
IGL03035:Dapk1
|
APN |
13 |
60,864,587 (GRCm39) |
missense |
probably damaging |
0.99 |
|
H8562:Dapk1
|
UTSW |
13 |
60,909,126 (GRCm39) |
missense |
probably damaging |
0.98 |
|
P0026:Dapk1
|
UTSW |
13 |
60,865,963 (GRCm39) |
splice site |
probably benign |
|
|
R0116:Dapk1
|
UTSW |
13 |
60,908,914 (GRCm39) |
missense |
probably benign |
|
|
R0165:Dapk1
|
UTSW |
13 |
60,909,407 (GRCm39) |
missense |
probably benign |
0.39 |
|
R0357:Dapk1
|
UTSW |
13 |
60,877,372 (GRCm39) |
nonsense |
probably null |
|
|
R0446:Dapk1
|
UTSW |
13 |
60,873,101 (GRCm39) |
splice site |
probably null |
|
|
R0502:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0503:Dapk1
|
UTSW |
13 |
60,878,662 (GRCm39) |
splice site |
probably null |
|
|
R0597:Dapk1
|
UTSW |
13 |
60,909,198 (GRCm39) |
missense |
probably benign |
0.40 |
|
R0614:Dapk1
|
UTSW |
13 |
60,865,946 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0751:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0930:Dapk1
|
UTSW |
13 |
60,905,262 (GRCm39) |
missense |
probably benign |
0.14 |
|
R1023:Dapk1
|
UTSW |
13 |
60,878,799 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1033:Dapk1
|
UTSW |
13 |
60,869,679 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1101:Dapk1
|
UTSW |
13 |
60,864,599 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1184:Dapk1
|
UTSW |
13 |
60,844,112 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1430:Dapk1
|
UTSW |
13 |
60,901,957 (GRCm39) |
missense |
probably benign |
0.28 |
|
R1630:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1681:Dapk1
|
UTSW |
13 |
60,866,278 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1799:Dapk1
|
UTSW |
13 |
60,867,468 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2012:Dapk1
|
UTSW |
13 |
60,869,671 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2068:Dapk1
|
UTSW |
13 |
60,899,022 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2131:Dapk1
|
UTSW |
13 |
60,909,481 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R2131:Dapk1
|
UTSW |
13 |
60,877,345 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R2154:Dapk1
|
UTSW |
13 |
60,877,317 (GRCm39) |
missense |
probably benign |
0.36 |
|
R2288:Dapk1
|
UTSW |
13 |
60,909,563 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2312:Dapk1
|
UTSW |
13 |
60,905,167 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2362:Dapk1
|
UTSW |
13 |
60,878,745 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R2400:Dapk1
|
UTSW |
13 |
60,900,030 (GRCm39) |
missense |
probably benign |
0.34 |
|
R2909:Dapk1
|
UTSW |
13 |
60,864,631 (GRCm39) |
critical splice donor site |
probably null |
|
|
R2926:Dapk1
|
UTSW |
13 |
60,867,564 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R3741:Dapk1
|
UTSW |
13 |
60,896,014 (GRCm39) |
missense |
probably benign |
0.09 |
|
R3810:Dapk1
|
UTSW |
13 |
60,908,503 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4374:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4375:Dapk1
|
UTSW |
13 |
60,909,403 (GRCm39) |
missense |
probably benign |
|
|
R4377:Dapk1
|
UTSW |
13 |
60,867,498 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4490:Dapk1
|
UTSW |
13 |
60,865,942 (GRCm39) |
missense |
probably benign |
0.26 |
|
R4576:Dapk1
|
UTSW |
13 |
60,869,636 (GRCm39) |
missense |
probably benign |
0.13 |
|
R4599:Dapk1
|
UTSW |
13 |
60,865,861 (GRCm39) |
missense |
probably benign |
0.22 |
|
R4682:Dapk1
|
UTSW |
13 |
60,898,961 (GRCm39) |
missense |
probably benign |
0.41 |
|
R4717:Dapk1
|
UTSW |
13 |
60,874,476 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4775:Dapk1
|
UTSW |
13 |
60,897,156 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4897:Dapk1
|
UTSW |
13 |
60,909,600 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4931:Dapk1
|
UTSW |
13 |
60,908,774 (GRCm39) |
missense |
probably benign |
0.04 |
|
R5113:Dapk1
|
UTSW |
13 |
60,869,592 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5503:Dapk1
|
UTSW |
13 |
60,873,126 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5948:Dapk1
|
UTSW |
13 |
60,877,209 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6012:Dapk1
|
UTSW |
13 |
60,909,476 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6035:Dapk1
|
UTSW |
13 |
60,909,013 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R6268:Dapk1
|
UTSW |
13 |
60,909,580 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6330:Dapk1
|
UTSW |
13 |
60,909,140 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6331:Dapk1
|
UTSW |
13 |
60,877,256 (GRCm39) |
nonsense |
probably null |
|
|
R6553:Dapk1
|
UTSW |
13 |
60,908,975 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6598:Dapk1
|
UTSW |
13 |
60,909,161 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6602:Dapk1
|
UTSW |
13 |
60,897,018 (GRCm39) |
missense |
probably benign |
0.20 |
|
R6640:Dapk1
|
UTSW |
13 |
60,864,628 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6684:Dapk1
|
UTSW |
13 |
60,908,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6747:Dapk1
|
UTSW |
13 |
60,873,154 (GRCm39) |
missense |
probably benign |
0.22 |
|
R6799:Dapk1
|
UTSW |
13 |
60,900,049 (GRCm39) |
missense |
probably benign |
|
|
R6809:Dapk1
|
UTSW |
13 |
60,899,103 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6915:Dapk1
|
UTSW |
13 |
60,844,256 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6949:Dapk1
|
UTSW |
13 |
60,884,138 (GRCm39) |
missense |
probably benign |
0.11 |
|
R6979:Dapk1
|
UTSW |
13 |
60,896,095 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7161:Dapk1
|
UTSW |
13 |
60,844,209 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R7171:Dapk1
|
UTSW |
13 |
60,909,599 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7199:Dapk1
|
UTSW |
13 |
60,902,024 (GRCm39) |
missense |
probably benign |
0.02 |
|
R7203:Dapk1
|
UTSW |
13 |
60,844,149 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7404:Dapk1
|
UTSW |
13 |
60,867,455 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7448:Dapk1
|
UTSW |
13 |
60,898,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7480:Dapk1
|
UTSW |
13 |
60,905,311 (GRCm39) |
missense |
probably benign |
0.18 |
|
R7532:Dapk1
|
UTSW |
13 |
60,878,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7574:Dapk1
|
UTSW |
13 |
60,908,987 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7711:Dapk1
|
UTSW |
13 |
60,909,365 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7753:Dapk1
|
UTSW |
13 |
60,899,007 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R7804:Dapk1
|
UTSW |
13 |
60,873,153 (GRCm39) |
missense |
probably benign |
0.41 |
|
R7822:Dapk1
|
UTSW |
13 |
60,873,715 (GRCm39) |
missense |
probably benign |
0.05 |
|
R7973:Dapk1
|
UTSW |
13 |
60,909,377 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8103:Dapk1
|
UTSW |
13 |
60,897,009 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8121:Dapk1
|
UTSW |
13 |
60,909,212 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8245:Dapk1
|
UTSW |
13 |
60,878,710 (GRCm39) |
missense |
probably benign |
|
|
R8401:Dapk1
|
UTSW |
13 |
60,870,904 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8419:Dapk1
|
UTSW |
13 |
60,887,911 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8926:Dapk1
|
UTSW |
13 |
60,908,734 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9063:Dapk1
|
UTSW |
13 |
60,866,264 (GRCm39) |
missense |
probably benign |
0.06 |
|
R9131:Dapk1
|
UTSW |
13 |
60,909,208 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9176:Dapk1
|
UTSW |
13 |
60,866,262 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9301:Dapk1
|
UTSW |
13 |
60,866,125 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R9407:Dapk1
|
UTSW |
13 |
60,898,991 (GRCm39) |
nonsense |
probably null |
|
|
R9491:Dapk1
|
UTSW |
13 |
60,877,369 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9510:Dapk1
|
UTSW |
13 |
60,910,203 (GRCm39) |
missense |
unknown |
|
|
R9624:Dapk1
|
UTSW |
13 |
60,895,937 (GRCm39) |
missense |
probably benign |
0.31 |
|
R9726:Dapk1
|
UTSW |
13 |
60,898,948 (GRCm39) |
missense |
probably benign |
0.25 |
|
R9794:Dapk1
|
UTSW |
13 |
60,909,082 (GRCm39) |
missense |
probably damaging |
0.98 |
|
Z1176:Dapk1
|
UTSW |
13 |
60,908,618 (GRCm39) |
frame shift |
probably null |
|
|
| Predicted Primers |
PCR Primer
(F):5'- ACAGTCTGAACTTCCGTGGAG -3'
(R):5'- ATGGTGGCTGAGAGAATGCC -3'
Sequencing Primer
(F):5'- CGCCCCAAGAGGAATGTTG -3'
(R):5'- CTGAGAGAATGCCAAGTAAAGC -3'
|
| Posted On |
2016-02-04 |
Incidental Mutation