Incidental Mutation 'R4791:Cr2'
| ID |
368533 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cr2
|
| Ensembl Gene |
ENSMUSG00000026616 |
| Gene Name |
complement receptor 2 |
| Synonyms |
C3DR, CD21, Cr-2, Cr1, Cr-1, CD35 |
| MMRRC Submission |
041976-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.112)
|
| Stock # |
R4791 (G1)
|
| Quality Score |
225 |
|
Status
|
Not validated
|
| Chromosome |
1 |
| Chromosomal Location |
194819119-194859024 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 194838243 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 698
(C698S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000080938
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000082321]
[ENSMUST00000193356]
[ENSMUST00000193801]
[ENSMUST00000195120]
[ENSMUST00000210219]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000082321
AA Change: C698S
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000080938
Gene: ENSMUSG00000026616
AA Change: C698S
| Domain | Start | End | E-Value | Type |
|---|
|
CCP
|
23 |
82 |
1.01e-11 |
SMART |
|
CCP
|
91 |
147 |
9.1e-14 |
SMART |
|
CCP
|
155 |
211 |
1.9e-16 |
SMART |
|
CCP
|
216 |
272 |
1.6e-9 |
SMART |
|
CCP
|
277 |
343 |
1.01e-11 |
SMART |
|
CCP
|
352 |
407 |
1.2e-13 |
SMART |
|
CCP
|
411 |
467 |
2.34e-16 |
SMART |
|
CCP
|
472 |
523 |
1.24e0 |
SMART |
|
CCP
|
528 |
594 |
4.48e-13 |
SMART |
|
CCP
|
603 |
658 |
1.95e-13 |
SMART |
|
CCP
|
718 |
778 |
1.75e-15 |
SMART |
|
CCP
|
787 |
842 |
2.06e-12 |
SMART |
|
CCP
|
850 |
906 |
7.92e-14 |
SMART |
|
CCP
|
911 |
967 |
1.29e-13 |
SMART |
|
transmembrane domain
|
975 |
997 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000192604
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000193356
AA Change: C401S
PolyPhen 2
Score 0.998 (Sensitivity: 0.27; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000141706
Gene: ENSMUSG00000026616
AA Change: C401S
| Domain | Start | End | E-Value | Type |
|---|
|
CCP
|
1 |
46 |
1.2e-1 |
SMART |
|
CCP
|
55 |
110 |
5.9e-16 |
SMART |
|
CCP
|
114 |
170 |
1.1e-18 |
SMART |
|
CCP
|
175 |
226 |
6.1e-3 |
SMART |
|
CCP
|
231 |
297 |
2.2e-15 |
SMART |
|
CCP
|
306 |
361 |
9.4e-16 |
SMART |
|
CCP
|
421 |
481 |
8.3e-18 |
SMART |
|
CCP
|
490 |
545 |
1e-14 |
SMART |
|
CCP
|
553 |
609 |
4e-16 |
SMART |
|
CCP
|
614 |
670 |
6.2e-16 |
SMART |
|
transmembrane domain
|
678 |
700 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193436
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000193801
|
| SMART Domains |
Protein: ENSMUSP00000141276
Gene: ENSMUSG00000026616
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
20 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000195120
AA Change: C698S
PolyPhen 2
Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)
|
| SMART Domains |
Protein: ENSMUSP00000141538
Gene: ENSMUSG00000026616
AA Change: C698S
| Domain | Start | End | E-Value | Type |
|---|
|
CCP
|
23 |
82 |
4.9e-14 |
SMART |
|
CCP
|
91 |
147 |
4.5e-16 |
SMART |
|
CCP
|
155 |
211 |
9.1e-19 |
SMART |
|
CCP
|
216 |
272 |
8e-12 |
SMART |
|
CCP
|
277 |
343 |
5e-14 |
SMART |
|
CCP
|
352 |
407 |
5.9e-16 |
SMART |
|
CCP
|
411 |
467 |
1.1e-18 |
SMART |
|
CCP
|
472 |
523 |
6.1e-3 |
SMART |
|
CCP
|
528 |
594 |
2.2e-15 |
SMART |
|
CCP
|
603 |
658 |
9.4e-16 |
SMART |
|
CCP
|
718 |
778 |
8.3e-18 |
SMART |
|
CCP
|
787 |
842 |
1e-14 |
SMART |
|
CCP
|
850 |
906 |
4e-16 |
SMART |
|
CCP
|
911 |
967 |
6.2e-16 |
SMART |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000195737
|
| Predicted Effect |
unknown
Transcript: ENSMUST00000210219
AA Change: C1074S
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.9%
- 20x: 94.3%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a membrane protein, which functions as a receptor for Epstein-Barr virus (EBV) binding on B and T lymphocytes. Genetic variations in this gene are associated with susceptibility to systemic lupus erythematosus type 9 (SLEB9). Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
PHENOTYPE: Homozygotes for targeted null mutations exhibit impaired humoral immune responses to T cell-dependent antigens, with limited affinity maturation, and reduced memory B cell and germinal center formation. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 97 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc6 |
C |
T |
7: 45,631,584 (GRCm39) |
V1231M |
probably benign |
Het |
| Agl |
A |
G |
3: 116,580,177 (GRCm39) |
|
probably null |
Het |
| Ak7 |
T |
C |
12: 105,676,404 (GRCm39) |
F35L |
probably benign |
Het |
| Aldh1a1 |
A |
G |
19: 20,597,349 (GRCm39) |
N110S |
probably damaging |
Het |
| Arhgef5 |
C |
T |
6: 43,260,117 (GRCm39) |
L1368F |
probably damaging |
Het |
| Atp5mf |
T |
C |
5: 145,121,365 (GRCm39) |
Y72C |
possibly damaging |
Het |
| Atp6v0a2 |
T |
G |
5: 124,784,667 (GRCm39) |
F317V |
probably benign |
Het |
| Bank1 |
A |
T |
3: 135,960,690 (GRCm39) |
S56T |
probably benign |
Het |
| Cachd1 |
T |
A |
4: 100,775,282 (GRCm39) |
C166S |
probably damaging |
Het |
| Cand1 |
A |
G |
10: 119,046,607 (GRCm39) |
I961T |
probably benign |
Het |
| Ccdc73 |
G |
A |
2: 104,811,450 (GRCm39) |
|
probably null |
Het |
| Cct6b |
A |
T |
11: 82,632,830 (GRCm39) |
|
probably null |
Het |
| Chd2 |
A |
C |
7: 73,118,325 (GRCm39) |
S1098A |
probably benign |
Het |
| Col6a4 |
A |
T |
9: 105,957,401 (GRCm39) |
V141E |
possibly damaging |
Het |
| Col6a5 |
T |
C |
9: 105,807,983 (GRCm39) |
T1022A |
unknown |
Het |
| Dnaaf5 |
C |
A |
5: 139,170,405 (GRCm39) |
Q786K |
possibly damaging |
Het |
| Dnah6 |
T |
C |
6: 73,072,057 (GRCm39) |
D2423G |
probably benign |
Het |
| Dnhd1 |
T |
C |
7: 105,370,324 (GRCm39) |
F4583S |
probably damaging |
Het |
| Duoxa2 |
A |
T |
2: 122,131,679 (GRCm39) |
T123S |
probably damaging |
Het |
| Edem1 |
T |
G |
6: 108,818,595 (GRCm39) |
V201G |
probably damaging |
Het |
| Eef1d |
C |
T |
15: 75,775,531 (GRCm39) |
A43T |
possibly damaging |
Het |
| Elavl3 |
T |
C |
9: 21,935,974 (GRCm39) |
K249E |
probably damaging |
Het |
| Epg5 |
G |
T |
18: 77,992,211 (GRCm39) |
E303* |
probably null |
Het |
| Fam83h |
T |
C |
15: 75,874,217 (GRCm39) |
D1040G |
probably damaging |
Het |
| Fndc7 |
A |
T |
3: 108,783,975 (GRCm39) |
F211L |
probably benign |
Het |
| Fsip2 |
A |
G |
2: 82,812,452 (GRCm39) |
T2924A |
possibly damaging |
Het |
| Gm5616 |
T |
C |
9: 48,361,983 (GRCm39) |
|
noncoding transcript |
Het |
| Gpr135 |
T |
A |
12: 72,116,642 (GRCm39) |
D375V |
probably benign |
Het |
| Hgd |
A |
G |
16: 37,452,187 (GRCm39) |
*446W |
probably null |
Het |
| Hivep2 |
C |
A |
10: 14,004,713 (GRCm39) |
T437K |
probably benign |
Het |
| Htra2 |
A |
G |
6: 83,028,798 (GRCm39) |
L379P |
probably damaging |
Het |
| Hypk |
G |
T |
2: 121,288,136 (GRCm39) |
|
probably null |
Het |
| Ica1l |
A |
G |
1: 60,049,360 (GRCm39) |
F198L |
probably damaging |
Het |
| Igsf11 |
G |
A |
16: 38,845,226 (GRCm39) |
S319N |
probably damaging |
Het |
| Il12rb1 |
T |
C |
8: 71,266,012 (GRCm39) |
S213P |
possibly damaging |
Het |
| Katnal1 |
C |
T |
5: 148,841,460 (GRCm39) |
V135M |
probably damaging |
Het |
| Kcnc4 |
G |
A |
3: 107,354,859 (GRCm39) |
P530S |
probably benign |
Het |
| Kcnu1 |
T |
C |
8: 26,403,780 (GRCm39) |
Y24H |
probably damaging |
Het |
| Kdm5b |
A |
G |
1: 134,558,538 (GRCm39) |
E1515G |
possibly damaging |
Het |
| Kif18a |
A |
T |
2: 109,118,220 (GRCm39) |
M12L |
probably benign |
Het |
| Klre1 |
T |
C |
6: 129,561,118 (GRCm39) |
S160P |
probably damaging |
Het |
| Lama2 |
A |
T |
10: 27,343,267 (GRCm39) |
H68Q |
probably damaging |
Het |
| Lgals8 |
T |
C |
13: 12,468,203 (GRCm39) |
K49R |
possibly damaging |
Het |
| Lmf1 |
G |
A |
17: 25,873,445 (GRCm39) |
V317M |
probably damaging |
Het |
| Lsr |
T |
C |
7: 30,657,977 (GRCm39) |
T328A |
probably damaging |
Het |
| Mark4 |
C |
T |
7: 19,185,582 (GRCm39) |
E51K |
probably benign |
Het |
| Mindy2 |
T |
C |
9: 70,541,283 (GRCm39) |
|
probably null |
Het |
| Mkks |
G |
A |
2: 136,718,082 (GRCm39) |
T400I |
probably benign |
Het |
| Mon2 |
T |
A |
10: 122,841,962 (GRCm39) |
M1544L |
probably benign |
Het |
| Mrc2 |
G |
A |
11: 105,239,257 (GRCm39) |
|
probably null |
Het |
| Myo5c |
T |
G |
9: 75,198,198 (GRCm39) |
L1341R |
probably damaging |
Het |
| Nin |
T |
C |
12: 70,090,581 (GRCm39) |
R945G |
possibly damaging |
Het |
| Nox4 |
T |
C |
7: 86,954,055 (GRCm39) |
V120A |
probably benign |
Het |
| Or1s2 |
T |
A |
19: 13,758,706 (GRCm39) |
C243* |
probably null |
Het |
| Or2aj4 |
G |
T |
16: 19,385,413 (GRCm39) |
H73Q |
possibly damaging |
Het |
| Or2z2 |
A |
T |
11: 58,346,370 (GRCm39) |
V135E |
possibly damaging |
Het |
| Or4a66 |
C |
T |
2: 88,531,242 (GRCm39) |
V144I |
probably benign |
Het |
| Or7g29 |
T |
C |
9: 19,287,105 (GRCm39) |
E24G |
probably benign |
Het |
| Plekha2 |
T |
A |
8: 25,532,778 (GRCm39) |
R398W |
probably damaging |
Het |
| Pradc1 |
A |
G |
6: 85,424,173 (GRCm39) |
W58R |
probably damaging |
Het |
| Pramel20 |
A |
G |
4: 143,297,559 (GRCm39) |
|
probably benign |
Het |
| Prrc2b |
A |
G |
2: 32,107,351 (GRCm39) |
|
probably null |
Het |
| Psg19 |
T |
A |
7: 18,528,071 (GRCm39) |
N224I |
probably damaging |
Het |
| Ranbp17 |
A |
C |
11: 33,437,746 (GRCm39) |
V164G |
probably benign |
Het |
| Rasgrp3 |
A |
G |
17: 75,807,168 (GRCm39) |
S211G |
probably benign |
Het |
| Rcc1l |
G |
A |
5: 134,192,615 (GRCm39) |
P270S |
possibly damaging |
Het |
| Rfx6 |
T |
A |
10: 51,596,040 (GRCm39) |
|
probably null |
Het |
| Rnf222 |
A |
T |
11: 68,783,845 (GRCm39) |
E137D |
probably damaging |
Het |
| Selenof |
T |
G |
3: 144,302,584 (GRCm39) |
Y120D |
probably damaging |
Het |
| Sema3b |
G |
T |
9: 107,481,012 (GRCm39) |
D108E |
probably damaging |
Het |
| Shank3 |
T |
A |
15: 89,384,557 (GRCm39) |
L143Q |
probably damaging |
Het |
| Shtn1 |
G |
C |
19: 59,039,305 (GRCm39) |
R45G |
probably damaging |
Het |
| Sirt4 |
T |
C |
5: 115,618,373 (GRCm39) |
T234A |
possibly damaging |
Het |
| Slc25a30 |
C |
A |
14: 76,000,806 (GRCm39) |
W266L |
probably benign |
Het |
| Spata20 |
A |
T |
11: 94,375,412 (GRCm39) |
N127K |
probably damaging |
Het |
| Spmip4 |
G |
T |
6: 50,572,817 (GRCm39) |
P32Q |
probably damaging |
Het |
| St14 |
C |
T |
9: 31,006,918 (GRCm39) |
G636D |
probably benign |
Het |
| Stat5a |
G |
A |
11: 100,756,289 (GRCm39) |
E170K |
probably damaging |
Het |
| Sugp2 |
C |
T |
8: 70,695,440 (GRCm39) |
R138C |
probably damaging |
Het |
| Sult1e1 |
C |
A |
5: 87,734,589 (GRCm39) |
W119L |
possibly damaging |
Het |
| Sv2a |
T |
C |
3: 96,099,874 (GRCm39) |
V608A |
possibly damaging |
Het |
| Syne2 |
T |
C |
12: 75,956,018 (GRCm39) |
Y575H |
possibly damaging |
Het |
| Taok2 |
G |
A |
7: 126,467,304 (GRCm39) |
S167L |
possibly damaging |
Het |
| Thoc6 |
T |
C |
17: 23,889,041 (GRCm39) |
H151R |
possibly damaging |
Het |
| Tm9sf2 |
T |
C |
14: 122,377,062 (GRCm39) |
S197P |
probably benign |
Het |
| Tmem260 |
CAGGGACCGGCATAG |
CAG |
14: 48,749,451 (GRCm39) |
|
probably benign |
Het |
| Tmx2 |
G |
A |
2: 84,508,340 (GRCm39) |
P15L |
probably damaging |
Het |
| Top1mt |
C |
T |
15: 75,540,474 (GRCm39) |
|
probably null |
Het |
| Trpm6 |
T |
A |
19: 18,845,345 (GRCm39) |
S1682T |
probably benign |
Het |
| Trrap |
C |
T |
5: 144,740,087 (GRCm39) |
R1171W |
probably damaging |
Het |
| Ugt3a1 |
A |
G |
15: 9,361,665 (GRCm39) |
D147G |
probably damaging |
Het |
| Utp25 |
G |
A |
1: 192,810,575 (GRCm39) |
H143Y |
probably benign |
Het |
| Vnn3 |
A |
G |
10: 23,740,519 (GRCm39) |
H274R |
probably benign |
Het |
| Vwf |
C |
A |
6: 125,620,326 (GRCm39) |
T1668K |
|
Het |
| Zfp568 |
T |
C |
7: 29,714,608 (GRCm39) |
S162P |
probably damaging |
Het |
| Zfp658 |
T |
A |
7: 43,223,890 (GRCm39) |
C722S |
possibly damaging |
Het |
| Zfp808 |
T |
A |
13: 62,319,045 (GRCm39) |
H91Q |
probably damaging |
Het |
|
| Other mutations in Cr2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00587:Cr2
|
APN |
1 |
194,836,559 (GRCm39) |
missense |
possibly damaging |
0.76 |
|
IGL01326:Cr2
|
APN |
1 |
194,823,529 (GRCm39) |
missense |
probably null |
1.00 |
|
IGL01358:Cr2
|
APN |
1 |
194,842,128 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01410:Cr2
|
APN |
1 |
194,845,542 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01468:Cr2
|
APN |
1 |
194,850,843 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01608:Cr2
|
APN |
1 |
194,837,528 (GRCm39) |
missense |
possibly damaging |
0.50 |
|
IGL01810:Cr2
|
APN |
1 |
194,841,903 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
IGL01843:Cr2
|
APN |
1 |
194,833,222 (GRCm39) |
splice site |
probably benign |
|
|
IGL02332:Cr2
|
APN |
1 |
194,842,630 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02934:Cr2
|
APN |
1 |
194,836,633 (GRCm39) |
splice site |
probably benign |
|
|
IGL02938:Cr2
|
APN |
1 |
194,848,696 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03149:Cr2
|
APN |
1 |
194,848,674 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03327:Cr2
|
APN |
1 |
194,852,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03346:Cr2
|
APN |
1 |
194,852,067 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Pillar
|
UTSW |
1 |
194,838,196 (GRCm39) |
nonsense |
probably null |
|
|
PIT4354001:Cr2
|
UTSW |
1 |
194,848,617 (GRCm39) |
missense |
probably damaging |
1.00 |
|
PIT4418001:Cr2
|
UTSW |
1 |
194,839,760 (GRCm39) |
missense |
probably benign |
0.08 |
|
R0128:Cr2
|
UTSW |
1 |
194,848,539 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0130:Cr2
|
UTSW |
1 |
194,848,539 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0380:Cr2
|
UTSW |
1 |
194,839,715 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0538:Cr2
|
UTSW |
1 |
194,842,667 (GRCm39) |
splice site |
probably benign |
|
|
R0605:Cr2
|
UTSW |
1 |
194,845,904 (GRCm39) |
splice site |
probably benign |
|
|
R0626:Cr2
|
UTSW |
1 |
194,853,419 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R1135:Cr2
|
UTSW |
1 |
194,839,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1396:Cr2
|
UTSW |
1 |
194,851,561 (GRCm39) |
splice site |
probably null |
|
|
R1422:Cr2
|
UTSW |
1 |
194,853,433 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1467:Cr2
|
UTSW |
1 |
194,839,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1467:Cr2
|
UTSW |
1 |
194,839,817 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1511:Cr2
|
UTSW |
1 |
194,837,580 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1572:Cr2
|
UTSW |
1 |
194,845,622 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1714:Cr2
|
UTSW |
1 |
194,833,994 (GRCm39) |
missense |
possibly damaging |
0.46 |
|
R1748:Cr2
|
UTSW |
1 |
194,838,213 (GRCm39) |
nonsense |
probably null |
|
|
R1761:Cr2
|
UTSW |
1 |
194,837,431 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1824:Cr2
|
UTSW |
1 |
194,839,624 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1893:Cr2
|
UTSW |
1 |
194,837,495 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1990:Cr2
|
UTSW |
1 |
194,836,458 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1991:Cr2
|
UTSW |
1 |
194,836,458 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R1992:Cr2
|
UTSW |
1 |
194,836,458 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R2191:Cr2
|
UTSW |
1 |
194,845,689 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2276:Cr2
|
UTSW |
1 |
194,839,676 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2277:Cr2
|
UTSW |
1 |
194,839,676 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R3548:Cr2
|
UTSW |
1 |
194,838,196 (GRCm39) |
nonsense |
probably null |
|
|
R3743:Cr2
|
UTSW |
1 |
194,832,274 (GRCm39) |
splice site |
probably benign |
|
|
R3941:Cr2
|
UTSW |
1 |
194,848,122 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3963:Cr2
|
UTSW |
1 |
194,842,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4211:Cr2
|
UTSW |
1 |
194,838,636 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4484:Cr2
|
UTSW |
1 |
194,836,482 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4546:Cr2
|
UTSW |
1 |
194,853,349 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R4801:Cr2
|
UTSW |
1 |
194,845,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4802:Cr2
|
UTSW |
1 |
194,845,619 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4874:Cr2
|
UTSW |
1 |
194,858,878 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R4885:Cr2
|
UTSW |
1 |
194,841,039 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R4889:Cr2
|
UTSW |
1 |
194,858,893 (GRCm39) |
missense |
possibly damaging |
0.70 |
|
R5154:Cr2
|
UTSW |
1 |
194,841,754 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5574:Cr2
|
UTSW |
1 |
194,823,544 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5594:Cr2
|
UTSW |
1 |
194,839,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5645:Cr2
|
UTSW |
1 |
194,836,581 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5700:Cr2
|
UTSW |
1 |
194,842,065 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5929:Cr2
|
UTSW |
1 |
194,853,419 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R6237:Cr2
|
UTSW |
1 |
194,839,810 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6299:Cr2
|
UTSW |
1 |
194,850,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6368:Cr2
|
UTSW |
1 |
194,850,780 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6406:Cr2
|
UTSW |
1 |
194,852,079 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6618:Cr2
|
UTSW |
1 |
194,839,687 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R6684:Cr2
|
UTSW |
1 |
194,853,329 (GRCm39) |
nonsense |
probably null |
|
|
R6720:Cr2
|
UTSW |
1 |
194,837,508 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6866:Cr2
|
UTSW |
1 |
194,833,999 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6915:Cr2
|
UTSW |
1 |
194,853,454 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7057:Cr2
|
UTSW |
1 |
194,833,918 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R7117:Cr2
|
UTSW |
1 |
194,842,909 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R7200:Cr2
|
UTSW |
1 |
194,845,557 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7209:Cr2
|
UTSW |
1 |
194,851,032 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7350:Cr2
|
UTSW |
1 |
194,837,594 (GRCm39) |
missense |
probably benign |
0.21 |
|
R7414:Cr2
|
UTSW |
1 |
194,832,344 (GRCm39) |
missense |
probably benign |
|
|
R7453:Cr2
|
UTSW |
1 |
194,847,565 (GRCm39) |
splice site |
probably null |
|
|
R7479:Cr2
|
UTSW |
1 |
194,840,718 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7480:Cr2
|
UTSW |
1 |
194,836,484 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7570:Cr2
|
UTSW |
1 |
194,851,648 (GRCm39) |
nonsense |
probably null |
|
|
R7666:Cr2
|
UTSW |
1 |
194,836,533 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7921:Cr2
|
UTSW |
1 |
194,833,975 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R7923:Cr2
|
UTSW |
1 |
194,850,995 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8396:Cr2
|
UTSW |
1 |
194,840,376 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8503:Cr2
|
UTSW |
1 |
194,845,850 (GRCm39) |
missense |
probably benign |
|
|
R8517:Cr2
|
UTSW |
1 |
194,838,207 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8773:Cr2
|
UTSW |
1 |
194,840,913 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8849:Cr2
|
UTSW |
1 |
194,839,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8896:Cr2
|
UTSW |
1 |
194,851,581 (GRCm39) |
missense |
possibly damaging |
0.58 |
|
R8938:Cr2
|
UTSW |
1 |
194,853,424 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9027:Cr2
|
UTSW |
1 |
194,834,029 (GRCm39) |
missense |
probably benign |
0.08 |
|
R9045:Cr2
|
UTSW |
1 |
194,837,680 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9116:Cr2
|
UTSW |
1 |
194,840,977 (GRCm39) |
nonsense |
probably null |
|
|
R9137:Cr2
|
UTSW |
1 |
194,850,640 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9476:Cr2
|
UTSW |
1 |
194,840,416 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9497:Cr2
|
UTSW |
1 |
194,850,743 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9510:Cr2
|
UTSW |
1 |
194,840,416 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R9752:Cr2
|
UTSW |
1 |
194,823,575 (GRCm39) |
missense |
probably benign |
0.37 |
|
R9799:Cr2
|
UTSW |
1 |
194,842,988 (GRCm39) |
missense |
probably benign |
0.02 |
|
X0028:Cr2
|
UTSW |
1 |
194,832,290 (GRCm39) |
missense |
probably benign |
0.09 |
|
X0066:Cr2
|
UTSW |
1 |
194,848,629 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Z1176:Cr2
|
UTSW |
1 |
194,836,461 (GRCm39) |
missense |
probably benign |
0.23 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGGAAACTAGAGCATGCTTTCGG -3'
(R):5'- ACAGGGGAAGGGCTTTTATG -3'
Sequencing Primer
(F):5'- CTAGAGCATGCTTTCGGTTAAATAAC -3'
(R):5'- GAAGGGCTTTTATGAGTGCTTC -3'
|
| Posted On |
2016-02-04 |
Incidental Mutation