Mutagenetix > Incidental Mutation

Incidental Mutation 'R4791:Mrc2'

368608

Institutional Source

Beutler Lab

Gene Symbol

Mrc2

Ensembl Gene

ENSMUSG00000020695

Gene Name

mannose receptor, C type 2

Synonyms

Endo180, uPARAP, novel lectin

MMRRC Submission

041976-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R4791 (G1)

Quality Score

225

Status

Not validated

Chromosome

Chromosomal Location

105183469-105241965 bp(+) (GRCm39)

Type of Mutation

splice site (5 bp from exon)

DNA Base Change (assembly)

G to A at 105239257 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000097909 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000021038] [ENSMUST00000100335]

AlphaFold

Q64449

Predicted Effect

probably benign
Transcript: ENSMUST00000021038

SMART Domains

Protein: ENSMUSP00000021038
Gene: ENSMUSG00000020695

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
RICIN	40	160	8.49e-12	SMART
FN2	179	227	4.83e-27	SMART
CLECT	234	359	1.15e-33	SMART
CLECT	381	504	1.47e-40	SMART
CLECT	520	644	6.82e-27	SMART
CLECT	668	808	2.71e-30	SMART
CLECT	824	950	6.77e-31	SMART

Predicted Effect

probably null
Transcript: ENSMUST00000100335

SMART Domains

Protein: ENSMUSP00000097909
Gene: ENSMUSG00000020695

Domain	Start	End	E-Value	Type
signal peptide	1	30	N/A	INTRINSIC
RICIN	40	160	8.49e-12	SMART
FN2	179	227	4.83e-27	SMART
CLECT	234	359	1.15e-33	SMART
CLECT	381	504	1.47e-40	SMART
CLECT	520	644	6.82e-27	SMART
CLECT	668	808	2.71e-30	SMART
CLECT	824	950	6.77e-31	SMART
CLECT	971	1107	3.91e-36	SMART
CLECT	1124	1243	1.04e-17	SMART
CLECT	1259	1392	9.08e-23	SMART
transmembrane domain	1412	1434	N/A	INTRINSIC

Meta Mutation Damage Score

0.9755

Coding Region Coverage

1x: 99.2%
3x: 98.5%
10x: 96.9%
20x: 94.3%

Validation Efficiency

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]
PHENOTYPE: Homozygous mice are visibly normal, viable and have no reproductive defects. Mouse embryonic fibroblasts derived from null mice exhibit decreased migration while bone marrow-derived macrophages exhibit increased migration. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 97 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abcc6	C	T	7: 45,631,584 (GRCm39)	V1231M	probably benign	Het
Agl	A	G	3: 116,580,177 (GRCm39)		probably null	Het
Ak7	T	C	12: 105,676,404 (GRCm39)	F35L	probably benign	Het
Aldh1a1	A	G	19: 20,597,349 (GRCm39)	N110S	probably damaging	Het
Arhgef5	C	T	6: 43,260,117 (GRCm39)	L1368F	probably damaging	Het
Atp5mf	T	C	5: 145,121,365 (GRCm39)	Y72C	possibly damaging	Het
Atp6v0a2	T	G	5: 124,784,667 (GRCm39)	F317V	probably benign	Het
Bank1	A	T	3: 135,960,690 (GRCm39)	S56T	probably benign	Het
Cachd1	T	A	4: 100,775,282 (GRCm39)	C166S	probably damaging	Het
Cand1	A	G	10: 119,046,607 (GRCm39)	I961T	probably benign	Het
Ccdc73	G	A	2: 104,811,450 (GRCm39)		probably null	Het
Cct6b	A	T	11: 82,632,830 (GRCm39)		probably null	Het
Chd2	A	C	7: 73,118,325 (GRCm39)	S1098A	probably benign	Het
Col6a4	A	T	9: 105,957,401 (GRCm39)	V141E	possibly damaging	Het
Col6a5	T	C	9: 105,807,983 (GRCm39)	T1022A	unknown	Het
Cr2	A	T	1: 194,838,243 (GRCm39)	C698S	probably damaging	Het
Dnaaf5	C	A	5: 139,170,405 (GRCm39)	Q786K	possibly damaging	Het
Dnah6	T	C	6: 73,072,057 (GRCm39)	D2423G	probably benign	Het
Dnhd1	T	C	7: 105,370,324 (GRCm39)	F4583S	probably damaging	Het
Duoxa2	A	T	2: 122,131,679 (GRCm39)	T123S	probably damaging	Het
Edem1	T	G	6: 108,818,595 (GRCm39)	V201G	probably damaging	Het
Eef1d	C	T	15: 75,775,531 (GRCm39)	A43T	possibly damaging	Het
Elavl3	T	C	9: 21,935,974 (GRCm39)	K249E	probably damaging	Het
Epg5	G	T	18: 77,992,211 (GRCm39)	E303*	probably null	Het
Fam83h	T	C	15: 75,874,217 (GRCm39)	D1040G	probably damaging	Het
Fndc7	A	T	3: 108,783,975 (GRCm39)	F211L	probably benign	Het
Fsip2	A	G	2: 82,812,452 (GRCm39)	T2924A	possibly damaging	Het
Gm5616	T	C	9: 48,361,983 (GRCm39)		noncoding transcript	Het
Gpr135	T	A	12: 72,116,642 (GRCm39)	D375V	probably benign	Het
Hgd	A	G	16: 37,452,187 (GRCm39)	*446W	probably null	Het
Hivep2	C	A	10: 14,004,713 (GRCm39)	T437K	probably benign	Het
Htra2	A	G	6: 83,028,798 (GRCm39)	L379P	probably damaging	Het
Hypk	G	T	2: 121,288,136 (GRCm39)		probably null	Het
Ica1l	A	G	1: 60,049,360 (GRCm39)	F198L	probably damaging	Het
Igsf11	G	A	16: 38,845,226 (GRCm39)	S319N	probably damaging	Het
Il12rb1	T	C	8: 71,266,012 (GRCm39)	S213P	possibly damaging	Het
Katnal1	C	T	5: 148,841,460 (GRCm39)	V135M	probably damaging	Het
Kcnc4	G	A	3: 107,354,859 (GRCm39)	P530S	probably benign	Het
Kcnu1	T	C	8: 26,403,780 (GRCm39)	Y24H	probably damaging	Het
Kdm5b	A	G	1: 134,558,538 (GRCm39)	E1515G	possibly damaging	Het
Kif18a	A	T	2: 109,118,220 (GRCm39)	M12L	probably benign	Het
Klre1	T	C	6: 129,561,118 (GRCm39)	S160P	probably damaging	Het
Lama2	A	T	10: 27,343,267 (GRCm39)	H68Q	probably damaging	Het
Lgals8	T	C	13: 12,468,203 (GRCm39)	K49R	possibly damaging	Het
Lmf1	G	A	17: 25,873,445 (GRCm39)	V317M	probably damaging	Het
Lsr	T	C	7: 30,657,977 (GRCm39)	T328A	probably damaging	Het
Mark4	C	T	7: 19,185,582 (GRCm39)	E51K	probably benign	Het
Mindy2	T	C	9: 70,541,283 (GRCm39)		probably null	Het
Mkks	G	A	2: 136,718,082 (GRCm39)	T400I	probably benign	Het
Mon2	T	A	10: 122,841,962 (GRCm39)	M1544L	probably benign	Het
Myo5c	T	G	9: 75,198,198 (GRCm39)	L1341R	probably damaging	Het
Nin	T	C	12: 70,090,581 (GRCm39)	R945G	possibly damaging	Het
Nox4	T	C	7: 86,954,055 (GRCm39)	V120A	probably benign	Het
Or1s2	T	A	19: 13,758,706 (GRCm39)	C243*	probably null	Het
Or2aj4	G	T	16: 19,385,413 (GRCm39)	H73Q	possibly damaging	Het
Or2z2	A	T	11: 58,346,370 (GRCm39)	V135E	possibly damaging	Het
Or4a66	C	T	2: 88,531,242 (GRCm39)	V144I	probably benign	Het
Or7g29	T	C	9: 19,287,105 (GRCm39)	E24G	probably benign	Het
Plekha2	T	A	8: 25,532,778 (GRCm39)	R398W	probably damaging	Het
Pradc1	A	G	6: 85,424,173 (GRCm39)	W58R	probably damaging	Het
Pramel20	A	G	4: 143,297,559 (GRCm39)		probably benign	Het
Prrc2b	A	G	2: 32,107,351 (GRCm39)		probably null	Het
Psg19	T	A	7: 18,528,071 (GRCm39)	N224I	probably damaging	Het
Ranbp17	A	C	11: 33,437,746 (GRCm39)	V164G	probably benign	Het
Rasgrp3	A	G	17: 75,807,168 (GRCm39)	S211G	probably benign	Het
Rcc1l	G	A	5: 134,192,615 (GRCm39)	P270S	possibly damaging	Het
Rfx6	T	A	10: 51,596,040 (GRCm39)		probably null	Het
Rnf222	A	T	11: 68,783,845 (GRCm39)	E137D	probably damaging	Het
Selenof	T	G	3: 144,302,584 (GRCm39)	Y120D	probably damaging	Het
Sema3b	G	T	9: 107,481,012 (GRCm39)	D108E	probably damaging	Het
Shank3	T	A	15: 89,384,557 (GRCm39)	L143Q	probably damaging	Het
Shtn1	G	C	19: 59,039,305 (GRCm39)	R45G	probably damaging	Het
Sirt4	T	C	5: 115,618,373 (GRCm39)	T234A	possibly damaging	Het
Slc25a30	C	A	14: 76,000,806 (GRCm39)	W266L	probably benign	Het
Spata20	A	T	11: 94,375,412 (GRCm39)	N127K	probably damaging	Het
Spmip4	G	T	6: 50,572,817 (GRCm39)	P32Q	probably damaging	Het
St14	C	T	9: 31,006,918 (GRCm39)	G636D	probably benign	Het
Stat5a	G	A	11: 100,756,289 (GRCm39)	E170K	probably damaging	Het
Sugp2	C	T	8: 70,695,440 (GRCm39)	R138C	probably damaging	Het
Sult1e1	C	A	5: 87,734,589 (GRCm39)	W119L	possibly damaging	Het
Sv2a	T	C	3: 96,099,874 (GRCm39)	V608A	possibly damaging	Het
Syne2	T	C	12: 75,956,018 (GRCm39)	Y575H	possibly damaging	Het
Taok2	G	A	7: 126,467,304 (GRCm39)	S167L	possibly damaging	Het
Thoc6	T	C	17: 23,889,041 (GRCm39)	H151R	possibly damaging	Het
Tm9sf2	T	C	14: 122,377,062 (GRCm39)	S197P	probably benign	Het
Tmem260	CAGGGACCGGCATAG	CAG	14: 48,749,451 (GRCm39)		probably benign	Het
Tmx2	G	A	2: 84,508,340 (GRCm39)	P15L	probably damaging	Het
Top1mt	C	T	15: 75,540,474 (GRCm39)		probably null	Het
Trpm6	T	A	19: 18,845,345 (GRCm39)	S1682T	probably benign	Het
Trrap	C	T	5: 144,740,087 (GRCm39)	R1171W	probably damaging	Het
Ugt3a1	A	G	15: 9,361,665 (GRCm39)	D147G	probably damaging	Het
Utp25	G	A	1: 192,810,575 (GRCm39)	H143Y	probably benign	Het
Vnn3	A	G	10: 23,740,519 (GRCm39)	H274R	probably benign	Het
Vwf	C	A	6: 125,620,326 (GRCm39)	T1668K		Het
Zfp568	T	C	7: 29,714,608 (GRCm39)	S162P	probably damaging	Het
Zfp658	T	A	7: 43,223,890 (GRCm39)	C722S	possibly damaging	Het
Zfp808	T	A	13: 62,319,045 (GRCm39)	H91Q	probably damaging	Het

Other mutations in Mrc2

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01105:Mrc2	APN	11	105,219,567 (GRCm39)	missense	probably damaging	0.96
IGL01374:Mrc2	APN	11	105,238,469 (GRCm39)	nonsense	probably null
IGL01751:Mrc2	APN	11	105,216,560 (GRCm39)	missense	probably benign	0.00
IGL01780:Mrc2	APN	11	105,216,547 (GRCm39)	missense	probably damaging	1.00
IGL01835:Mrc2	APN	11	105,227,503 (GRCm39)	missense	probably damaging	1.00
IGL02350:Mrc2	APN	11	105,216,547 (GRCm39)	missense	probably damaging	1.00
IGL02357:Mrc2	APN	11	105,216,547 (GRCm39)	missense	probably damaging	1.00
IGL02829:Mrc2	APN	11	105,227,533 (GRCm39)	missense	possibly damaging	0.85
IGL02863:Mrc2	APN	11	105,224,446 (GRCm39)	splice site	probably benign
IGL02940:Mrc2	APN	11	105,231,997 (GRCm39)	missense	probably damaging	1.00
IGL02988:Mrc2	UTSW	11	105,216,397 (GRCm39)	missense	probably benign	0.04
R0254:Mrc2	UTSW	11	105,238,692 (GRCm39)	missense	probably benign	0.00
R0634:Mrc2	UTSW	11	105,238,518 (GRCm39)	missense	probably benign	0.01
R1102:Mrc2	UTSW	11	105,231,647 (GRCm39)	missense	probably benign
R1233:Mrc2	UTSW	11	105,239,241 (GRCm39)	missense	probably damaging	1.00
R1244:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R1458:Mrc2	UTSW	11	105,228,598 (GRCm39)	missense	probably benign	0.01
R1500:Mrc2	UTSW	11	105,238,551 (GRCm39)	missense	probably damaging	1.00
R1573:Mrc2	UTSW	11	105,227,482 (GRCm39)	missense	probably damaging	1.00
R1770:Mrc2	UTSW	11	105,229,619 (GRCm39)	missense	probably damaging	0.99
R1842:Mrc2	UTSW	11	105,228,546 (GRCm39)	missense	probably damaging	0.98
R2156:Mrc2	UTSW	11	105,238,682 (GRCm39)	splice site	probably null
R2165:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2265:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2266:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2267:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2268:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2269:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2270:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2271:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2272:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2296:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2298:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2300:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2326:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2518:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2519:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2520:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R2895:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3029:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3030:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3079:Mrc2	UTSW	11	105,227,539 (GRCm39)	missense	probably damaging	0.97
R3122:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3149:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3150:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3420:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3422:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3441:Mrc2	UTSW	11	105,238,542 (GRCm39)	missense	possibly damaging	0.87
R3726:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3731:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3800:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3820:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3821:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3837:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3838:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3849:Mrc2	UTSW	11	105,183,729 (GRCm39)	critical splice donor site	probably null
R3850:Mrc2	UTSW	11	105,183,729 (GRCm39)	critical splice donor site	probably null
R3914:Mrc2	UTSW	11	105,238,058 (GRCm39)	splice site	probably benign
R3932:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3933:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R3971:Mrc2	UTSW	11	105,218,857 (GRCm39)	missense	possibly damaging	0.65
R4105:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4107:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4113:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4274:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4399:Mrc2	UTSW	11	105,227,484 (GRCm39)	nonsense	probably null
R4477:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4478:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4493:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4494:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4495:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4547:Mrc2	UTSW	11	105,227,467 (GRCm39)	missense	probably benign	0.04
R4600:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4601:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4602:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4603:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4610:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4611:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4637:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4672:Mrc2	UTSW	11	105,233,923 (GRCm39)	missense	probably benign	0.22
R4674:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4675:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4693:Mrc2	UTSW	11	105,234,528 (GRCm39)	missense	probably benign	0.00
R4706:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4707:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4792:Mrc2	UTSW	11	105,239,257 (GRCm39)	splice site	probably null
R4888:Mrc2	UTSW	11	105,232,034 (GRCm39)	missense	probably damaging	0.99
R5523:Mrc2	UTSW	11	105,234,408 (GRCm39)	missense	probably benign
R5600:Mrc2	UTSW	11	105,224,492 (GRCm39)	missense	probably damaging	1.00
R5634:Mrc2	UTSW	11	105,227,040 (GRCm39)	nonsense	probably null
R5692:Mrc2	UTSW	11	105,227,468 (GRCm39)	missense	probably damaging	0.99
R5706:Mrc2	UTSW	11	105,223,169 (GRCm39)	missense	probably damaging	1.00
R5775:Mrc2	UTSW	11	105,228,639 (GRCm39)	missense	probably benign	0.00
R6140:Mrc2	UTSW	11	105,237,615 (GRCm39)	missense	probably benign
R6146:Mrc2	UTSW	11	105,216,470 (GRCm39)	missense	probably damaging	0.98
R6225:Mrc2	UTSW	11	105,237,646 (GRCm39)	missense	probably benign	0.01
R6437:Mrc2	UTSW	11	105,240,669 (GRCm39)	missense	probably damaging	1.00
R6618:Mrc2	UTSW	11	105,240,708 (GRCm39)	missense	probably damaging	1.00
R6675:Mrc2	UTSW	11	105,233,906 (GRCm39)	splice site	probably null
R6680:Mrc2	UTSW	11	105,216,579 (GRCm39)	missense	probably damaging	0.98
R6868:Mrc2	UTSW	11	105,219,244 (GRCm39)	missense	probably damaging	1.00
R6979:Mrc2	UTSW	11	105,239,461 (GRCm39)	missense	probably damaging	0.96
R7038:Mrc2	UTSW	11	105,223,062 (GRCm39)	missense	possibly damaging	0.46
R7303:Mrc2	UTSW	11	105,216,629 (GRCm39)	missense	probably damaging	1.00
R7320:Mrc2	UTSW	11	105,220,061 (GRCm39)	missense	possibly damaging	0.92
R7422:Mrc2	UTSW	11	105,183,609 (GRCm39)	start gained	probably benign
R7537:Mrc2	UTSW	11	105,183,623 (GRCm39)	missense	probably benign
R7640:Mrc2	UTSW	11	105,223,121 (GRCm39)	missense	possibly damaging	0.48
R7709:Mrc2	UTSW	11	105,237,285 (GRCm39)	missense	probably benign	0.10
R7885:Mrc2	UTSW	11	105,223,092 (GRCm39)	missense	probably damaging	0.98
R7976:Mrc2	UTSW	11	105,238,829 (GRCm39)	missense	possibly damaging	0.74
R8042:Mrc2	UTSW	11	105,239,181 (GRCm39)	missense	probably damaging	0.98
R8096:Mrc2	UTSW	11	105,234,333 (GRCm39)	missense	probably damaging	1.00
R8353:Mrc2	UTSW	11	105,223,137 (GRCm39)	missense	probably damaging	0.98
R8453:Mrc2	UTSW	11	105,223,137 (GRCm39)	missense	probably damaging	0.98
R8519:Mrc2	UTSW	11	105,238,132 (GRCm39)	missense	possibly damaging	0.62
R8771:Mrc2	UTSW	11	105,240,596 (GRCm39)	missense	probably benign
R8787:Mrc2	UTSW	11	105,238,465 (GRCm39)	missense	probably benign
R8925:Mrc2	UTSW	11	105,216,334 (GRCm39)	missense	probably benign	0.00
R8927:Mrc2	UTSW	11	105,216,334 (GRCm39)	missense	probably benign	0.00
R8991:Mrc2	UTSW	11	105,229,740 (GRCm39)	missense	probably benign
R9017:Mrc2	UTSW	11	105,216,711 (GRCm39)	missense	probably damaging	1.00
R9096:Mrc2	UTSW	11	105,231,398 (GRCm39)	missense	probably damaging	1.00
R9097:Mrc2	UTSW	11	105,231,398 (GRCm39)	missense	probably damaging	1.00
R9223:Mrc2	UTSW	11	105,220,093 (GRCm39)	missense	probably damaging	1.00
R9471:Mrc2	UTSW	11	105,234,559 (GRCm39)	missense	probably benign	0.03
R9531:Mrc2	UTSW	11	105,240,731 (GRCm39)	missense	possibly damaging	0.82
T0970:Mrc2	UTSW	11	105,238,453 (GRCm39)	missense	probably benign	0.41
X0004:Mrc2	UTSW	11	105,238,453 (GRCm39)	missense	probably benign	0.41
X0062:Mrc2	UTSW	11	105,238,301 (GRCm39)	critical splice donor site	probably null
Z1176:Mrc2	UTSW	11	105,238,186 (GRCm39)	nonsense	probably null
Z1176:Mrc2	UTSW	11	105,232,202 (GRCm39)	missense	possibly damaging	0.94

Predicted Primers

PCR Primer
(F):5'- CACTTGAGCTGCCAGAGAAGAG -3'
(R):5'- TGTGGAAGGAACCCATTGG -3'

Sequencing Primer
(F):5'- GGTCTATCACCATAAGGAGAATCTGC -3'
(R):5'- CCATTGGGAAGGTGTGGGAATG -3'

Posted On

2016-02-04