Incidental Mutation 'R4792:Zfp607a'
ID 368670
Institutional Source Beutler Lab
Gene Symbol Zfp607a
Ensembl Gene ENSMUSG00000020420
Gene Name zinc finger protein 607A
Synonyms Zfp607, 4732475C15Rik
MMRRC Submission 042419-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.058) question?
Stock # R4792 (G1)
Quality Score 225
Status Validated
Chromosome 7
Chromosomal Location 27556952-27580250 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 27578078 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Histidine at position 383 (Y383H)
Ref Sequence ENSEMBL: ENSMUSP00000146006 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000053722] [ENSMUST00000205534] [ENSMUST00000205715]
AlphaFold Q3TQG9
Predicted Effect probably benign
Transcript: ENSMUST00000053722
AA Change: Y383H

PolyPhen 2 Score 0.231 (Sensitivity: 0.91; Specificity: 0.88)
SMART Domains Protein: ENSMUSP00000051496
Gene: ENSMUSG00000020420
AA Change: Y383H

DomainStartEndE-ValueType
KRAB 14 75 8.48e-36 SMART
ZnF_C2H2 173 195 2.91e-2 SMART
ZnF_C2H2 201 223 3.44e-4 SMART
ZnF_C2H2 229 251 3.83e-2 SMART
ZnF_C2H2 257 279 4.87e-4 SMART
ZnF_C2H2 285 307 1.38e-3 SMART
ZnF_C2H2 313 335 4.17e-3 SMART
ZnF_C2H2 341 363 2.86e-1 SMART
ZnF_C2H2 369 391 5.14e-3 SMART
ZnF_C2H2 397 419 1.2e-3 SMART
ZnF_C2H2 425 447 4.47e-3 SMART
ZnF_C2H2 453 475 1.1e-2 SMART
ZnF_C2H2 481 503 1.45e-2 SMART
ZnF_C2H2 509 531 1.12e-3 SMART
ZnF_C2H2 537 559 1.5e-4 SMART
ZnF_C2H2 565 587 8.34e-3 SMART
ZnF_C2H2 593 615 1.12e-3 SMART
ZnF_C2H2 621 643 6.42e-4 SMART
ZnF_C2H2 649 671 6.23e-2 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000205534
AA Change: Y383H

PolyPhen 2 Score 0.231 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect probably benign
Transcript: ENSMUST00000205715
AA Change: Y383H

PolyPhen 2 Score 0.231 (Sensitivity: 0.91; Specificity: 0.88)
Predicted Effect noncoding transcript
Transcript: ENSMUST00000206136
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.3%
Validation Efficiency 97% (89/92)
Allele List at MGI
Other mutations in this stock
Total: 82 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310061N02Rik A G 16: 88,504,651 (GRCm39) S49P possibly damaging Het
Abcb1a T C 5: 8,796,657 (GRCm39) probably null Het
Adgb G A 10: 10,274,647 (GRCm39) T770I probably damaging Het
Adgre4 A T 17: 56,098,491 (GRCm39) T134S probably benign Het
Aldh1a1 A G 19: 20,597,349 (GRCm39) N110S probably damaging Het
Alox5 C A 6: 116,437,964 (GRCm39) V8L possibly damaging Het
Ambra1 A G 2: 91,603,191 (GRCm39) T392A possibly damaging Het
Apob A G 12: 8,058,051 (GRCm39) I2145V probably benign Het
Arhgap39 A G 15: 76,625,717 (GRCm39) Y196H possibly damaging Het
Armh2 A G 13: 24,930,490 (GRCm39) probably benign Het
Carmil1 A G 13: 24,251,173 (GRCm39) L439S probably damaging Het
Carmil1 A T 13: 24,325,659 (GRCm39) S224T possibly damaging Het
Cfh G A 1: 140,028,561 (GRCm39) Q706* probably null Het
Chd2 A C 7: 73,118,325 (GRCm39) S1098A probably benign Het
Chrna5 A T 9: 54,911,985 (GRCm39) I158F probably damaging Het
Cilk1 A G 9: 78,060,975 (GRCm39) D207G probably damaging Het
Col6a5 T C 9: 105,807,983 (GRCm39) T1022A unknown Het
Cul7 T A 17: 46,967,976 (GRCm39) Y423* probably null Het
Cyp2e1 T C 7: 140,353,588 (GRCm39) Y342H probably benign Het
D630045J12Rik T C 6: 38,125,275 (GRCm39) K1580E probably damaging Het
Dnah6 A G 6: 73,066,651 (GRCm39) M2573T probably damaging Het
Dnai4 T C 4: 102,929,881 (GRCm39) K370R possibly damaging Het
Edem1 T A 6: 108,805,707 (GRCm39) probably benign Het
Erp29 C T 5: 121,585,237 (GRCm39) E86K probably benign Het
Esrp2 C A 8: 106,859,141 (GRCm39) R535L probably damaging Het
Gabrb2 C T 11: 42,420,330 (GRCm39) probably benign Het
Gpat3 C T 5: 101,005,039 (GRCm39) P58L probably benign Het
Herc1 T A 9: 66,403,266 (GRCm39) V4395E possibly damaging Het
Hivep2 C A 10: 14,004,713 (GRCm39) T437K probably benign Het
Hmgb2 G A 8: 57,966,344 (GRCm39) C106Y probably damaging Het
Hoxa10 T C 6: 52,209,481 (GRCm39) probably benign Het
Hsd3b1 T A 3: 98,760,226 (GRCm39) Y255F probably benign Het
Ighd T C 12: 113,379,819 (GRCm39) K42E probably benign Het
Ighv1-26 T C 12: 114,752,191 (GRCm39) Y51C possibly damaging Het
Ighv5-2 C T 12: 113,542,419 (GRCm39) E19K possibly damaging Het
Ipo11 T C 13: 106,970,668 (GRCm39) probably benign Het
Itk C T 11: 46,235,658 (GRCm39) probably benign Het
Kat6a T A 8: 23,430,592 (GRCm39) H1982Q unknown Het
Kdm4d C T 9: 14,374,686 (GRCm39) V391I probably benign Het
Klk14 G A 7: 43,341,501 (GRCm39) C51Y probably damaging Het
Lgr6 T A 1: 134,949,544 (GRCm39) S229C probably benign Het
Lhx9 T A 1: 138,766,089 (GRCm39) Y233F possibly damaging Het
Lmf1 G A 17: 25,873,445 (GRCm39) V317M probably damaging Het
Mapk4 T C 18: 74,070,321 (GRCm39) T191A probably damaging Het
Mrc2 G A 11: 105,239,257 (GRCm39) probably null Het
Naglu C T 11: 100,961,932 (GRCm39) T135M probably damaging Het
Nomo1 T A 7: 45,693,643 (GRCm39) probably null Het
Nop56 T A 2: 130,119,784 (GRCm39) V75E possibly damaging Het
Nr1i3 G A 1: 171,046,164 (GRCm39) C283Y probably damaging Het
Or4x6 T A 2: 89,949,174 (GRCm39) Y256F possibly damaging Het
Or51d1 G A 7: 102,347,933 (GRCm39) G163R probably damaging Het
Or6c38 T G 10: 128,929,489 (GRCm39) Y118S probably damaging Het
Pcdhga2 A G 18: 37,802,452 (GRCm39) S99G probably benign Het
Pcnx1 T A 12: 81,965,925 (GRCm39) D697E probably damaging Het
Plxnb1 G A 9: 108,939,716 (GRCm39) D1462N probably damaging Het
Pnn G T 12: 59,118,991 (GRCm39) V525F possibly damaging Het
Prrc2a A T 17: 35,375,463 (GRCm39) D1062E probably damaging Het
Prss35 T A 9: 86,637,722 (GRCm39) V164E probably damaging Het
Psapl1 T C 5: 36,362,547 (GRCm39) S380P probably benign Het
Rnf222 A T 11: 68,783,845 (GRCm39) E137D probably damaging Het
Rsph10b A G 5: 143,874,135 (GRCm39) T79A probably damaging Het
Sbf2 T C 7: 109,950,817 (GRCm39) Q1164R probably damaging Het
Scn7a T C 2: 66,556,592 (GRCm39) D331G probably damaging Het
Shtn1 G C 19: 59,039,305 (GRCm39) R45G probably damaging Het
Sspo G A 6: 48,438,519 (GRCm39) S1529N probably benign Het
St8sia3 T A 18: 64,398,634 (GRCm39) V31E probably benign Het
Sult1b1 A T 5: 87,662,906 (GRCm39) W265R probably damaging Het
Supt5 G T 7: 28,015,754 (GRCm39) Q863K probably benign Het
Tbc1d31 A G 15: 57,804,124 (GRCm39) R380G probably benign Het
Tdpoz1 T A 3: 93,577,845 (GRCm39) D313V possibly damaging Het
Tmem260 CAGGGACCGGCATAG CAG 14: 48,749,451 (GRCm39) probably benign Het
Tpx2 A T 2: 152,727,016 (GRCm39) T428S probably damaging Het
Trip11 A T 12: 101,851,705 (GRCm39) H786Q probably benign Het
Trpc6 A T 9: 8,626,615 (GRCm39) M322L probably benign Het
Try10 T C 6: 41,332,386 (GRCm39) V14A probably benign Het
Unc13d A T 11: 115,961,108 (GRCm39) F416L probably damaging Het
Vmn2r75 A T 7: 85,812,378 (GRCm39) M547K possibly damaging Het
Zbp1 A G 2: 173,051,006 (GRCm39) F288S probably damaging Het
Zc3h11a T A 1: 133,568,436 (GRCm39) Q71L probably damaging Het
Zfp40 G A 17: 23,396,008 (GRCm39) T193I possibly damaging Het
Zfp622 T A 15: 25,987,128 (GRCm39) Y82* probably null Het
Zfp964 T C 8: 70,116,665 (GRCm39) F422L probably benign Het
Other mutations in Zfp607a
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00164:Zfp607a APN 7 27,577,214 (GRCm39) missense possibly damaging 0.55
IGL01019:Zfp607a APN 7 27,578,042 (GRCm39) missense probably damaging 1.00
IGL01412:Zfp607a APN 7 27,578,109 (GRCm39) missense probably damaging 0.99
IGL03206:Zfp607a APN 7 27,577,248 (GRCm39) missense possibly damaging 0.52
R0071:Zfp607a UTSW 7 27,577,694 (GRCm39) missense probably damaging 0.96
R0304:Zfp607a UTSW 7 27,578,637 (GRCm39) missense possibly damaging 0.92
R0685:Zfp607a UTSW 7 27,577,901 (GRCm39) missense probably damaging 0.97
R0726:Zfp607a UTSW 7 27,578,574 (GRCm39) missense probably benign 0.00
R1201:Zfp607a UTSW 7 27,578,736 (GRCm39) missense probably damaging 1.00
R1304:Zfp607a UTSW 7 27,565,000 (GRCm39) missense probably benign 0.00
R1648:Zfp607a UTSW 7 27,578,493 (GRCm39) missense probably benign 0.02
R1732:Zfp607a UTSW 7 27,577,884 (GRCm39) missense probably damaging 1.00
R2194:Zfp607a UTSW 7 27,578,805 (GRCm39) missense possibly damaging 0.73
R3793:Zfp607a UTSW 7 27,578,331 (GRCm39) missense probably benign 0.01
R3808:Zfp607a UTSW 7 27,578,826 (GRCm39) missense probably benign 0.01
R4296:Zfp607a UTSW 7 27,565,073 (GRCm39) missense probably damaging 1.00
R4786:Zfp607a UTSW 7 27,578,838 (GRCm39) missense probably damaging 1.00
R4915:Zfp607a UTSW 7 27,577,985 (GRCm39) missense probably benign 0.00
R4950:Zfp607a UTSW 7 27,578,176 (GRCm39) missense probably damaging 1.00
R5123:Zfp607a UTSW 7 27,578,523 (GRCm39) missense probably damaging 1.00
R5217:Zfp607a UTSW 7 27,577,269 (GRCm39) missense probably damaging 0.97
R5270:Zfp607a UTSW 7 27,577,730 (GRCm39) nonsense probably null
R5403:Zfp607a UTSW 7 27,578,744 (GRCm39) missense possibly damaging 0.54
R6010:Zfp607a UTSW 7 27,577,254 (GRCm39) nonsense probably null
R6224:Zfp607a UTSW 7 27,578,007 (GRCm39) missense probably damaging 1.00
R6939:Zfp607a UTSW 7 27,578,473 (GRCm39) nonsense probably null
R6953:Zfp607a UTSW 7 27,577,790 (GRCm39) missense possibly damaging 0.59
R7082:Zfp607a UTSW 7 27,578,183 (GRCm39) missense probably damaging 1.00
R7781:Zfp607a UTSW 7 27,565,000 (GRCm39) missense possibly damaging 0.90
R7909:Zfp607a UTSW 7 27,578,519 (GRCm39) missense probably damaging 1.00
R8191:Zfp607a UTSW 7 27,578,868 (GRCm39) missense possibly damaging 0.93
R8224:Zfp607a UTSW 7 27,577,536 (GRCm39) missense probably damaging 1.00
R8949:Zfp607a UTSW 7 27,577,944 (GRCm39) missense possibly damaging 0.56
R8962:Zfp607a UTSW 7 27,578,786 (GRCm39) missense possibly damaging 0.79
R9178:Zfp607a UTSW 7 27,577,382 (GRCm39) missense probably benign 0.00
R9802:Zfp607a UTSW 7 27,578,704 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCTTCATCGTTCTGGCTCAG -3'
(R):5'- ACTGGGAAGATGAAAAGCCTTTC -3'

Sequencing Primer
(F):5'- GTTCTGGCTCAGCTCACACG -3'
(R):5'- ACAGTCCTTACAGTTGAAGGGCTTC -3'
Posted On 2016-02-04