Incidental Mutation 'R4795:Lrrk1'
ID |
368940 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Lrrk1
|
Ensembl Gene |
ENSMUSG00000015133 |
Gene Name |
leucine-rich repeat kinase 1 |
Synonyms |
D130026O16Rik, C230002E15Rik |
MMRRC Submission |
041996-MU
|
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R4795 (G1)
|
Quality Score |
225 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
65908493-66038089 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to A
at 65912413 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Phenylalanine
at position 1716
(I1716F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000015277
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000015277]
[ENSMUST00000145954]
|
AlphaFold |
Q3UHC2 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000015277
AA Change: I1716F
PolyPhen 2
Score 0.941 (Sensitivity: 0.80; Specificity: 0.94)
|
SMART Domains |
Protein: ENSMUSP00000015277 Gene: ENSMUSG00000015133 AA Change: I1716F
Domain | Start | End | E-Value | Type |
ANK
|
86 |
116 |
9.33e2 |
SMART |
ANK
|
119 |
148 |
1.14e2 |
SMART |
ANK
|
152 |
182 |
8.36e1 |
SMART |
ANK
|
193 |
223 |
2.6e1 |
SMART |
LRR
|
278 |
300 |
2.84e2 |
SMART |
LRR
|
301 |
325 |
7.79e0 |
SMART |
LRR
|
328 |
351 |
3.27e1 |
SMART |
LRR_TYP
|
379 |
401 |
2.53e-2 |
SMART |
LRR
|
403 |
427 |
5.89e1 |
SMART |
LRR
|
472 |
493 |
5.27e1 |
SMART |
LRR
|
548 |
569 |
2.92e2 |
SMART |
LRR
|
570 |
594 |
5.88e0 |
SMART |
Pfam:Arf
|
625 |
786 |
2e-8 |
PFAM |
Pfam:Roc
|
640 |
761 |
3.1e-24 |
PFAM |
Pfam:Ras
|
640 |
782 |
2.2e-7 |
PFAM |
Pfam:COR
|
844 |
1046 |
4.7e-26 |
PFAM |
low complexity region
|
1109 |
1119 |
N/A |
INTRINSIC |
low complexity region
|
1209 |
1222 |
N/A |
INTRINSIC |
Pfam:Pkinase
|
1243 |
1521 |
7.8e-40 |
PFAM |
Pfam:Pkinase_Tyr
|
1244 |
1520 |
9.4e-39 |
PFAM |
low complexity region
|
1642 |
1654 |
N/A |
INTRINSIC |
low complexity region
|
1839 |
1846 |
N/A |
INTRINSIC |
low complexity region
|
1852 |
1871 |
N/A |
INTRINSIC |
low complexity region
|
1957 |
1970 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000131239
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000137181
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000145954
|
SMART Domains |
Protein: ENSMUSP00000114938 Gene: ENSMUSG00000015133
Domain | Start | End | E-Value | Type |
low complexity region
|
24 |
34 |
N/A |
INTRINSIC |
low complexity region
|
124 |
137 |
N/A |
INTRINSIC |
Pfam:Pkinase
|
158 |
435 |
6.6e-46 |
PFAM |
Pfam:Pkinase_Tyr
|
159 |
435 |
5.8e-40 |
PFAM |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000167705
|
Meta Mutation Damage Score |
0.2289 |
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.7%
|
Validation Efficiency |
98% (123/125) |
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a multi-domain protein that is a leucine-rich repeat kinase and a GDP/GTP binding protein. The encoded protein is thought to play a role in the regulation of bone mass. Mice lacking a similar gene showed severe osteopetrosis, increased bone mineralization and decreased bone resorption. [provided by RefSeq, Jan 2017] PHENOTYPE: Mice homozygous for a knock-out allele exhibit preweaning lethality. Mice homozygous for another knock-out allele exhibit severe osteopetrosis. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 105 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Abca4 |
T |
G |
3: 121,969,772 (GRCm39) |
L2259R |
probably damaging |
Het |
Acd |
A |
G |
8: 106,427,647 (GRCm39) |
S2P |
possibly damaging |
Het |
Acsf3 |
A |
G |
8: 123,506,896 (GRCm39) |
Y63C |
possibly damaging |
Het |
Adam21 |
T |
C |
12: 81,607,748 (GRCm39) |
I5V |
probably benign |
Het |
Adamts6 |
C |
A |
13: 104,580,636 (GRCm39) |
S783* |
probably null |
Het |
Adamtsl1 |
T |
C |
4: 86,162,006 (GRCm39) |
|
probably null |
Het |
Adck2 |
T |
A |
6: 39,553,327 (GRCm39) |
S313T |
probably benign |
Het |
Adgb |
A |
G |
10: 10,233,616 (GRCm39) |
I1285T |
probably benign |
Het |
Angptl1 |
T |
A |
1: 156,688,153 (GRCm39) |
M485K |
possibly damaging |
Het |
Ank3 |
G |
A |
10: 69,694,095 (GRCm39) |
V289I |
probably benign |
Het |
Atp13a4 |
A |
G |
16: 29,308,826 (GRCm39) |
|
probably null |
Het |
Atp1a1 |
A |
G |
3: 101,491,091 (GRCm39) |
L648P |
probably benign |
Het |
Atp2a3 |
A |
G |
11: 72,863,855 (GRCm39) |
I194V |
probably benign |
Het |
Bglap |
A |
C |
3: 88,291,712 (GRCm39) |
I4S |
unknown |
Het |
Cacna1b |
T |
A |
2: 24,527,499 (GRCm39) |
T1621S |
possibly damaging |
Het |
Ccdc112 |
T |
A |
18: 46,420,739 (GRCm39) |
Q337L |
probably benign |
Het |
Ccdc121rt3 |
A |
G |
5: 112,503,165 (GRCm39) |
S180P |
possibly damaging |
Het |
Cd34 |
T |
G |
1: 194,633,319 (GRCm39) |
S194A |
probably damaging |
Het |
Cdh20 |
A |
G |
1: 104,868,989 (GRCm39) |
D160G |
probably damaging |
Het |
Clock |
T |
C |
5: 76,413,763 (GRCm39) |
K44R |
probably damaging |
Het |
Commd9 |
A |
G |
2: 101,729,241 (GRCm39) |
N116D |
probably benign |
Het |
Dab2 |
C |
A |
15: 6,459,092 (GRCm39) |
P335T |
probably benign |
Het |
Epb41l3 |
T |
A |
17: 69,555,714 (GRCm39) |
|
probably null |
Het |
Epha2 |
A |
G |
4: 141,049,727 (GRCm39) |
|
probably null |
Het |
Fam78b |
T |
C |
1: 166,906,216 (GRCm39) |
V125A |
probably benign |
Het |
Fars2 |
A |
T |
13: 36,721,400 (GRCm39) |
E448V |
probably damaging |
Het |
Fkbpl |
G |
A |
17: 34,864,303 (GRCm39) |
A24T |
probably benign |
Het |
Glyr1 |
A |
C |
16: 4,865,622 (GRCm39) |
V44G |
probably benign |
Het |
Gm1527 |
A |
G |
3: 28,974,812 (GRCm39) |
I542V |
possibly damaging |
Het |
Gm18856 |
C |
A |
13: 14,139,793 (GRCm39) |
|
probably benign |
Het |
Gm44501 |
A |
G |
17: 40,889,605 (GRCm39) |
K40E |
probably benign |
Het |
Hdhd5 |
T |
C |
6: 120,500,407 (GRCm39) |
H97R |
probably benign |
Het |
Hmcn1 |
A |
G |
1: 150,629,362 (GRCm39) |
V965A |
probably benign |
Het |
Hsf5 |
A |
G |
11: 87,526,446 (GRCm39) |
M373V |
probably benign |
Het |
Igbp1b |
C |
T |
6: 138,634,803 (GRCm39) |
E214K |
probably benign |
Het |
Iigp1 |
T |
A |
18: 60,522,964 (GRCm39) |
F27L |
probably benign |
Het |
Isl1 |
T |
C |
13: 116,441,966 (GRCm39) |
N89S |
probably benign |
Het |
Itga1 |
C |
A |
13: 115,171,921 (GRCm39) |
W61C |
probably damaging |
Het |
Itga5 |
T |
C |
15: 103,256,187 (GRCm39) |
R922G |
probably benign |
Het |
Kbtbd3 |
G |
A |
9: 4,331,073 (GRCm39) |
W482* |
probably null |
Het |
Kcnq1 |
A |
G |
7: 142,736,494 (GRCm39) |
T168A |
probably benign |
Het |
Lrch3 |
A |
G |
16: 32,826,074 (GRCm39) |
N631S |
probably damaging |
Het |
Ly75 |
T |
C |
2: 60,180,284 (GRCm39) |
E631G |
probably benign |
Het |
Map4 |
T |
C |
9: 109,864,331 (GRCm39) |
S519P |
probably benign |
Het |
Mroh2a |
A |
G |
1: 88,186,386 (GRCm39) |
S64G |
probably benign |
Het |
Mrtfa |
C |
T |
15: 80,901,234 (GRCm39) |
S419N |
probably damaging |
Het |
Muc5b |
A |
G |
7: 141,403,304 (GRCm39) |
E755G |
unknown |
Het |
Ncaph2 |
T |
G |
15: 89,255,010 (GRCm39) |
V478G |
probably damaging |
Het |
Ncbp1 |
A |
G |
4: 46,152,967 (GRCm39) |
R247G |
possibly damaging |
Het |
Necab1 |
G |
T |
4: 15,111,208 (GRCm39) |
D73E |
possibly damaging |
Het |
Nedd9 |
T |
C |
13: 41,471,376 (GRCm39) |
K208E |
probably benign |
Het |
Nfyb |
A |
T |
10: 82,588,202 (GRCm39) |
|
probably benign |
Het |
Nol4 |
T |
C |
18: 23,054,944 (GRCm39) |
Q162R |
probably damaging |
Het |
Nwd2 |
G |
A |
5: 63,962,776 (GRCm39) |
D787N |
probably benign |
Het |
Olfr908 |
T |
A |
9: 38,427,799 (GRCm39) |
M157K |
probably damaging |
Het |
Or10a5 |
A |
T |
7: 106,636,121 (GRCm39) |
Y253F |
probably benign |
Het |
Or11g7 |
A |
C |
14: 50,690,874 (GRCm39) |
M122L |
probably damaging |
Het |
Or13a22 |
A |
G |
7: 140,072,920 (GRCm39) |
D123G |
probably damaging |
Het |
Or5ac23 |
C |
T |
16: 59,149,213 (GRCm39) |
V220I |
probably benign |
Het |
Or6a2 |
C |
T |
7: 106,600,542 (GRCm39) |
G175D |
probably damaging |
Het |
Or6e1 |
A |
G |
14: 54,520,004 (GRCm39) |
M116T |
probably damaging |
Het |
Orai3 |
T |
C |
7: 127,373,060 (GRCm39) |
V187A |
probably benign |
Het |
Parn |
T |
C |
16: 13,424,066 (GRCm39) |
T444A |
probably benign |
Het |
Pcdh11x |
A |
C |
X: 119,309,937 (GRCm39) |
N460T |
probably damaging |
Het |
Pcnt |
C |
T |
10: 76,205,858 (GRCm39) |
R2516H |
probably benign |
Het |
Pde4d |
T |
A |
13: 110,074,705 (GRCm39) |
|
probably benign |
Het |
Pdgfra |
A |
G |
5: 75,349,972 (GRCm39) |
N952S |
probably benign |
Het |
Pgm2 |
A |
G |
5: 64,261,217 (GRCm39) |
Y237C |
probably damaging |
Het |
Plcb2 |
A |
G |
2: 118,541,605 (GRCm39) |
V975A |
probably benign |
Het |
Polk |
T |
C |
13: 96,625,764 (GRCm39) |
T347A |
probably benign |
Het |
Ppp6r1 |
C |
T |
7: 4,644,053 (GRCm39) |
V430M |
possibly damaging |
Het |
Ptges2 |
C |
A |
2: 32,286,334 (GRCm39) |
C16* |
probably null |
Het |
Relb |
A |
T |
7: 19,353,764 (GRCm39) |
I38N |
probably damaging |
Het |
Runx1t1 |
T |
A |
4: 13,837,767 (GRCm39) |
N51K |
probably damaging |
Het |
Samsn1 |
A |
G |
16: 75,680,733 (GRCm39) |
|
probably benign |
Het |
Scrn1 |
A |
G |
6: 54,497,754 (GRCm39) |
V279A |
possibly damaging |
Het |
Sec31b |
A |
G |
19: 44,520,185 (GRCm39) |
S200P |
probably benign |
Het |
Selp |
A |
G |
1: 163,972,475 (GRCm39) |
T705A |
probably benign |
Het |
Slc2a1 |
G |
A |
4: 118,989,642 (GRCm39) |
R61Q |
probably damaging |
Het |
Slit3 |
G |
A |
11: 35,542,647 (GRCm39) |
|
probably null |
Het |
Smo |
T |
A |
6: 29,755,573 (GRCm39) |
V415E |
probably damaging |
Het |
Spag8 |
C |
A |
4: 43,652,035 (GRCm39) |
V350L |
possibly damaging |
Het |
Tbck |
T |
G |
3: 132,413,559 (GRCm39) |
L132R |
possibly damaging |
Het |
Thnsl1 |
T |
A |
2: 21,216,856 (GRCm39) |
C203* |
probably null |
Het |
Tm9sf2 |
T |
A |
14: 122,387,252 (GRCm39) |
|
probably null |
Het |
Tmem131 |
A |
G |
1: 36,880,757 (GRCm39) |
V171A |
probably damaging |
Het |
Tmem209 |
T |
C |
6: 30,501,954 (GRCm39) |
T83A |
probably benign |
Het |
Tmem63a |
T |
C |
1: 180,782,416 (GRCm39) |
Y138H |
probably damaging |
Het |
Trim80 |
A |
G |
11: 115,338,769 (GRCm39) |
Y533C |
probably damaging |
Het |
Trpv2 |
A |
G |
11: 62,472,006 (GRCm39) |
D66G |
possibly damaging |
Het |
Trrap |
T |
A |
5: 144,769,298 (GRCm39) |
I2620N |
probably benign |
Het |
Ttyh3 |
A |
T |
5: 140,620,541 (GRCm39) |
I232N |
probably damaging |
Het |
Ube2dnl1 |
G |
A |
X: 113,815,482 (GRCm39) |
C119Y |
possibly damaging |
Het |
Unc13c |
T |
A |
9: 73,839,469 (GRCm39) |
S461C |
probably damaging |
Het |
Unc80 |
T |
G |
1: 66,567,100 (GRCm39) |
I902S |
probably damaging |
Het |
Usp42 |
C |
A |
5: 143,709,692 (GRCm39) |
G170W |
probably damaging |
Het |
Vldlr |
T |
C |
19: 27,216,252 (GRCm39) |
|
probably null |
Het |
Ywhab |
A |
G |
2: 163,857,265 (GRCm39) |
Y180C |
probably damaging |
Het |
Zan |
A |
T |
5: 137,379,112 (GRCm39) |
C5329* |
probably null |
Het |
Zbtb40 |
C |
T |
4: 136,725,953 (GRCm39) |
M535I |
probably benign |
Het |
Zdhhc1 |
CGGGGG |
CGGGGGG |
8: 106,210,376 (GRCm39) |
|
probably null |
Het |
Zfp318 |
A |
G |
17: 46,722,988 (GRCm39) |
T1664A |
probably benign |
Het |
Zfp7 |
T |
A |
15: 76,775,546 (GRCm39) |
C529* |
probably null |
Het |
Zfp768 |
T |
C |
7: 126,942,547 (GRCm39) |
Q527R |
possibly damaging |
Het |
Zfp975 |
T |
A |
7: 42,314,570 (GRCm39) |
|
probably null |
Het |
|
Other mutations in Lrrk1 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01365:Lrrk1
|
APN |
7 |
65,937,449 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01511:Lrrk1
|
APN |
7 |
65,915,198 (GRCm39) |
missense |
possibly damaging |
0.48 |
IGL02337:Lrrk1
|
APN |
7 |
65,929,164 (GRCm39) |
missense |
possibly damaging |
0.92 |
IGL02636:Lrrk1
|
APN |
7 |
65,958,407 (GRCm39) |
critical splice donor site |
probably null |
|
IGL02679:Lrrk1
|
APN |
7 |
65,924,620 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02711:Lrrk1
|
APN |
7 |
65,980,515 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02742:Lrrk1
|
APN |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
IGL02878:Lrrk1
|
APN |
7 |
65,912,311 (GRCm39) |
missense |
probably benign |
|
IGL03135:Lrrk1
|
APN |
7 |
65,912,638 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03191:Lrrk1
|
APN |
7 |
65,909,707 (GRCm39) |
missense |
probably damaging |
0.99 |
IGL03198:Lrrk1
|
APN |
7 |
65,956,642 (GRCm39) |
missense |
probably damaging |
1.00 |
combustion
|
UTSW |
7 |
65,912,413 (GRCm39) |
missense |
possibly damaging |
0.94 |
fluorine
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
halide
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
Heiland
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
liebster
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
magi
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
oxidation
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
phlogiston
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
Savior
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
wenig
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
R0105:Lrrk1
|
UTSW |
7 |
65,942,089 (GRCm39) |
missense |
probably damaging |
1.00 |
R0276:Lrrk1
|
UTSW |
7 |
65,946,011 (GRCm39) |
splice site |
probably benign |
|
R0505:Lrrk1
|
UTSW |
7 |
65,940,656 (GRCm39) |
splice site |
probably null |
|
R0609:Lrrk1
|
UTSW |
7 |
65,916,363 (GRCm39) |
splice site |
probably null |
|
R0650:Lrrk1
|
UTSW |
7 |
65,942,084 (GRCm39) |
missense |
probably damaging |
1.00 |
R0676:Lrrk1
|
UTSW |
7 |
65,944,729 (GRCm39) |
missense |
probably damaging |
1.00 |
R1157:Lrrk1
|
UTSW |
7 |
65,912,031 (GRCm39) |
missense |
probably benign |
0.00 |
R1435:Lrrk1
|
UTSW |
7 |
65,922,776 (GRCm39) |
missense |
probably damaging |
1.00 |
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
R1468:Lrrk1
|
UTSW |
7 |
65,909,722 (GRCm39) |
missense |
probably damaging |
1.00 |
R1498:Lrrk1
|
UTSW |
7 |
65,952,419 (GRCm39) |
nonsense |
probably null |
|
R1620:Lrrk1
|
UTSW |
7 |
66,031,286 (GRCm39) |
missense |
probably benign |
0.00 |
R1884:Lrrk1
|
UTSW |
7 |
65,912,185 (GRCm39) |
missense |
probably benign |
|
R1891:Lrrk1
|
UTSW |
7 |
65,929,048 (GRCm39) |
missense |
probably damaging |
1.00 |
R1989:Lrrk1
|
UTSW |
7 |
65,931,432 (GRCm39) |
missense |
probably damaging |
1.00 |
R2107:Lrrk1
|
UTSW |
7 |
65,929,030 (GRCm39) |
missense |
probably damaging |
1.00 |
R2140:Lrrk1
|
UTSW |
7 |
65,980,498 (GRCm39) |
missense |
probably damaging |
1.00 |
R2144:Lrrk1
|
UTSW |
7 |
65,945,911 (GRCm39) |
missense |
probably damaging |
0.98 |
R2147:Lrrk1
|
UTSW |
7 |
65,935,159 (GRCm39) |
splice site |
probably null |
|
R3176:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
R3276:Lrrk1
|
UTSW |
7 |
65,955,269 (GRCm39) |
missense |
possibly damaging |
0.69 |
R3886:Lrrk1
|
UTSW |
7 |
65,942,112 (GRCm39) |
missense |
probably damaging |
1.00 |
R3893:Lrrk1
|
UTSW |
7 |
65,928,268 (GRCm39) |
splice site |
probably benign |
|
R3906:Lrrk1
|
UTSW |
7 |
65,944,651 (GRCm39) |
missense |
possibly damaging |
0.84 |
R4259:Lrrk1
|
UTSW |
7 |
65,980,512 (GRCm39) |
missense |
probably damaging |
1.00 |
R4649:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
R4653:Lrrk1
|
UTSW |
7 |
65,922,801 (GRCm39) |
missense |
probably benign |
0.12 |
R4672:Lrrk1
|
UTSW |
7 |
65,929,120 (GRCm39) |
missense |
probably benign |
0.00 |
R4693:Lrrk1
|
UTSW |
7 |
65,912,235 (GRCm39) |
missense |
probably damaging |
1.00 |
R4729:Lrrk1
|
UTSW |
7 |
65,912,041 (GRCm39) |
missense |
probably benign |
|
R4737:Lrrk1
|
UTSW |
7 |
65,956,621 (GRCm39) |
missense |
probably benign |
0.09 |
R4911:Lrrk1
|
UTSW |
7 |
65,945,202 (GRCm39) |
missense |
probably damaging |
0.97 |
R5002:Lrrk1
|
UTSW |
7 |
65,982,111 (GRCm39) |
missense |
probably damaging |
1.00 |
R5254:Lrrk1
|
UTSW |
7 |
65,956,855 (GRCm39) |
missense |
probably benign |
0.00 |
R5407:Lrrk1
|
UTSW |
7 |
65,920,545 (GRCm39) |
missense |
probably benign |
0.20 |
R5482:Lrrk1
|
UTSW |
7 |
65,980,418 (GRCm39) |
missense |
probably benign |
|
R5600:Lrrk1
|
UTSW |
7 |
65,956,963 (GRCm39) |
missense |
probably benign |
0.31 |
R5615:Lrrk1
|
UTSW |
7 |
65,937,363 (GRCm39) |
missense |
probably damaging |
1.00 |
R6041:Lrrk1
|
UTSW |
7 |
65,911,881 (GRCm39) |
missense |
probably benign |
|
R6211:Lrrk1
|
UTSW |
7 |
65,952,458 (GRCm39) |
missense |
possibly damaging |
0.89 |
R6271:Lrrk1
|
UTSW |
7 |
65,956,851 (GRCm39) |
critical splice donor site |
probably null |
|
R6276:Lrrk1
|
UTSW |
7 |
65,956,587 (GRCm39) |
splice site |
probably null |
|
R6447:Lrrk1
|
UTSW |
7 |
65,952,476 (GRCm39) |
missense |
probably benign |
0.19 |
R6478:Lrrk1
|
UTSW |
7 |
65,912,481 (GRCm39) |
missense |
probably damaging |
0.96 |
R6615:Lrrk1
|
UTSW |
7 |
65,931,396 (GRCm39) |
missense |
probably damaging |
1.00 |
R6745:Lrrk1
|
UTSW |
7 |
65,922,749 (GRCm39) |
missense |
probably damaging |
1.00 |
R6836:Lrrk1
|
UTSW |
7 |
65,992,527 (GRCm39) |
missense |
probably benign |
0.05 |
R6995:Lrrk1
|
UTSW |
7 |
65,942,090 (GRCm39) |
missense |
probably damaging |
1.00 |
R7107:Lrrk1
|
UTSW |
7 |
65,937,191 (GRCm39) |
missense |
possibly damaging |
0.94 |
R7137:Lrrk1
|
UTSW |
7 |
65,935,027 (GRCm39) |
missense |
probably benign |
0.06 |
R7203:Lrrk1
|
UTSW |
7 |
65,920,573 (GRCm39) |
missense |
probably damaging |
1.00 |
R7224:Lrrk1
|
UTSW |
7 |
65,982,134 (GRCm39) |
missense |
probably damaging |
0.99 |
R7239:Lrrk1
|
UTSW |
7 |
65,911,903 (GRCm39) |
missense |
probably benign |
|
R7440:Lrrk1
|
UTSW |
7 |
65,940,602 (GRCm39) |
missense |
probably damaging |
1.00 |
R7515:Lrrk1
|
UTSW |
7 |
65,912,310 (GRCm39) |
missense |
probably benign |
|
R7593:Lrrk1
|
UTSW |
7 |
65,958,439 (GRCm39) |
missense |
probably benign |
0.12 |
R7728:Lrrk1
|
UTSW |
7 |
65,912,463 (GRCm39) |
missense |
probably benign |
0.00 |
R7984:Lrrk1
|
UTSW |
7 |
65,950,477 (GRCm39) |
splice site |
probably null |
|
R7993:Lrrk1
|
UTSW |
7 |
65,912,202 (GRCm39) |
missense |
probably benign |
0.00 |
R8009:Lrrk1
|
UTSW |
7 |
65,915,222 (GRCm39) |
missense |
possibly damaging |
0.82 |
R8037:Lrrk1
|
UTSW |
7 |
65,935,089 (GRCm39) |
missense |
probably benign |
|
R8101:Lrrk1
|
UTSW |
7 |
65,992,530 (GRCm39) |
missense |
probably benign |
|
R8116:Lrrk1
|
UTSW |
7 |
65,912,371 (GRCm39) |
missense |
possibly damaging |
0.95 |
R8126:Lrrk1
|
UTSW |
7 |
65,942,063 (GRCm39) |
missense |
probably damaging |
1.00 |
R8278:Lrrk1
|
UTSW |
7 |
65,928,432 (GRCm39) |
missense |
probably benign |
0.37 |
R8559:Lrrk1
|
UTSW |
7 |
65,932,075 (GRCm39) |
missense |
possibly damaging |
0.48 |
R8669:Lrrk1
|
UTSW |
7 |
65,912,344 (GRCm39) |
missense |
probably benign |
0.20 |
R8690:Lrrk1
|
UTSW |
7 |
65,952,477 (GRCm39) |
missense |
probably benign |
0.02 |
R8955:Lrrk1
|
UTSW |
7 |
65,919,573 (GRCm39) |
missense |
probably benign |
0.09 |
R9135:Lrrk1
|
UTSW |
7 |
65,928,357 (GRCm39) |
missense |
probably damaging |
1.00 |
R9380:Lrrk1
|
UTSW |
7 |
65,928,331 (GRCm39) |
missense |
probably damaging |
1.00 |
R9625:Lrrk1
|
UTSW |
7 |
65,909,666 (GRCm39) |
makesense |
probably null |
|
R9721:Lrrk1
|
UTSW |
7 |
65,924,623 (GRCm39) |
missense |
probably damaging |
1.00 |
RF018:Lrrk1
|
UTSW |
7 |
66,031,250 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
Predicted Primers |
PCR Primer
(F):5'- ACGTGTCCCTGAGAGGATTG -3'
(R):5'- AGAACTCCTTCCTGGTGCTG -3'
Sequencing Primer
(F):5'- TCCCTGAGAGGATTGGGGTCC -3'
(R):5'- CTTCCTGGTGCTGGCAGG -3'
|
Posted On |
2016-02-04 |