Incidental Mutation 'R4797:Vmn2r90'
ID 369167
Institutional Source Beutler Lab
Gene Symbol Vmn2r90
Ensembl Gene ENSMUSG00000092120
Gene Name vomeronasal 2, receptor 90
Synonyms EG626942
MMRRC Submission 042421-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.139) question?
Stock # R4797 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 17924203-17954429 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 17932567 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Isoleucine at position 158 (T158I)
Ref Sequence ENSEMBL: ENSMUSP00000126650 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000169805] [ENSMUST00000231659] [ENSMUST00000232078] [ENSMUST00000232113]
AlphaFold E9PXJ8
Predicted Effect probably damaging
Transcript: ENSMUST00000169805
AA Change: T158I

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000126650
Gene: ENSMUSG00000092120
AA Change: T158I

DomainStartEndE-ValueType
signal peptide 1 18 N/A INTRINSIC
Pfam:ANF_receptor 77 471 1.8e-43 PFAM
Pfam:NCD3G 514 567 3e-22 PFAM
Pfam:7tm_3 600 835 9.8e-54 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000231659
Predicted Effect silent
Transcript: ENSMUST00000232078
Predicted Effect silent
Transcript: ENSMUST00000232113
Meta Mutation Damage Score 0.6467 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.8%
Validation Efficiency 96% (69/72)
Allele List at MGI
Other mutations in this stock
Total: 64 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca9 T C 11: 110,008,945 (GRCm39) T1195A probably benign Het
Apobr G A 7: 126,186,756 (GRCm39) E756K probably benign Het
Arpc3 A G 5: 122,542,215 (GRCm39) E77G possibly damaging Het
Atp2b2 A T 6: 113,766,847 (GRCm39) M464K possibly damaging Het
Atxn7l2 A G 3: 108,111,866 (GRCm39) S379P probably damaging Het
Ccdc91 A T 6: 147,493,641 (GRCm39) E344D unknown Het
Cdc42bpg G A 19: 6,370,477 (GRCm39) R1190Q probably damaging Het
Cdh17 C A 4: 11,810,390 (GRCm39) Q694K probably benign Het
Chordc1 G T 9: 18,203,672 (GRCm39) probably benign Het
Copg1 A G 6: 87,880,450 (GRCm39) probably benign Het
Dcbld1 T C 10: 52,160,223 (GRCm39) V37A probably damaging Het
Ddb2 A G 2: 91,067,163 (GRCm39) probably benign Het
Dok5 A T 2: 170,672,042 (GRCm39) R115* probably null Het
Drc7 T C 8: 95,800,925 (GRCm39) I649T probably damaging Het
Efr3a A G 15: 65,729,437 (GRCm39) T713A probably damaging Het
Epg5 G A 18: 78,073,614 (GRCm39) D2494N probably benign Het
Eps15 G A 4: 109,223,727 (GRCm39) probably benign Het
Glb1l3 T C 9: 26,739,742 (GRCm39) D356G probably damaging Het
Gm1818 A T 12: 48,602,393 (GRCm39) noncoding transcript Het
Gsta5 A T 9: 78,211,679 (GRCm39) Y147F probably benign Het
Hcrtr2 C A 9: 76,161,816 (GRCm39) M191I probably damaging Het
Heatr1 G A 13: 12,426,929 (GRCm39) E685K probably benign Het
Hsd3b2 A T 3: 98,618,979 (GRCm39) L322Q probably damaging Het
Hsd3b9 T A 3: 98,363,747 (GRCm39) R62* probably null Het
Htra4 T C 8: 25,523,675 (GRCm39) T297A probably damaging Het
Il22 C A 10: 118,041,058 (GRCm39) R55S probably damaging Het
Ints1 G A 5: 139,757,631 (GRCm39) T324M possibly damaging Het
Ints15 A G 5: 143,297,504 (GRCm39) F181S probably benign Het
Ints7 T C 1: 191,329,045 (GRCm39) V268A probably damaging Het
Kctd20 G A 17: 29,185,766 (GRCm39) V370I probably damaging Het
Lama1 T A 17: 68,023,770 (GRCm39) M55K probably benign Het
Larp1 C A 11: 57,938,806 (GRCm39) S494* probably null Het
Ldb3 A T 14: 34,277,470 (GRCm39) H262Q possibly damaging Het
Lepr C A 4: 101,637,244 (GRCm39) T711K possibly damaging Het
Mon2 T C 10: 122,852,422 (GRCm39) I984V probably benign Het
Naip2 T A 13: 100,298,243 (GRCm39) S598C probably damaging Het
Oasl1 A G 5: 115,066,217 (GRCm39) M112V probably benign Het
Or2d2b A T 7: 106,705,234 (GRCm39) M278K probably benign Het
Or6c214 A T 10: 129,590,390 (GRCm39) S310T probably benign Het
Or7c19 G T 8: 85,957,567 (GRCm39) A148S probably benign Het
P2ry1 T A 3: 60,910,881 (GRCm39) S7T probably benign Het
Pidd1 G T 7: 141,022,899 (GRCm39) R98S possibly damaging Het
Pkd1l1 A C 11: 8,911,340 (GRCm39) F312L unknown Het
Pla2r1 A T 2: 60,334,524 (GRCm39) M416K possibly damaging Het
Pold1 T C 7: 44,191,325 (GRCm39) E194G possibly damaging Het
Poldip2 T A 11: 78,404,813 (GRCm39) Y77N probably damaging Het
Ppp2r3d G T 9: 101,089,179 (GRCm39) N381K probably benign Het
Prrc2a G A 17: 35,369,018 (GRCm39) P2006L probably damaging Het
Rnd2 C T 11: 101,359,825 (GRCm39) L57F probably damaging Het
Rsu1 A G 2: 13,221,537 (GRCm39) probably benign Het
Selenoi T A 5: 30,457,740 (GRCm39) W90R probably damaging Het
Spag17 T A 3: 99,891,795 (GRCm39) D216E possibly damaging Het
Spata31 C A 13: 65,070,556 (GRCm39) Y901* probably null Het
Ssrp1 T A 2: 84,876,066 (GRCm39) Y607* probably null Het
Stk10 T A 11: 32,548,471 (GRCm39) N346K probably benign Het
Surf1 G T 2: 26,806,358 (GRCm39) probably benign Het
Synj2 A T 17: 6,084,163 (GRCm39) E283V probably damaging Het
Tg G A 15: 66,629,855 (GRCm39) probably null Het
Traf1 A T 2: 34,846,289 (GRCm39) D42E probably benign Het
Ttn T C 2: 76,571,209 (GRCm39) I26561M probably damaging Het
Ubp1 T C 9: 113,785,070 (GRCm39) Y128H probably damaging Het
Vmn1r216 T A 13: 23,283,506 (GRCm39) I63K probably benign Het
Vmn1r49 T A 6: 90,049,612 (GRCm39) H130L probably benign Het
Vps13d T C 4: 144,780,725 (GRCm39) S885G probably damaging Het
Other mutations in Vmn2r90
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00092:Vmn2r90 APN 17 17,953,758 (GRCm39) missense probably benign 0.00
IGL01330:Vmn2r90 APN 17 17,953,542 (GRCm39) missense probably benign 0.00
IGL01989:Vmn2r90 APN 17 17,933,494 (GRCm39) nonsense probably null
IGL02080:Vmn2r90 APN 17 17,933,120 (GRCm39) missense probably damaging 1.00
IGL02112:Vmn2r90 APN 17 17,932,465 (GRCm39) missense probably damaging 0.98
IGL02123:Vmn2r90 APN 17 17,953,744 (GRCm39) missense probably benign 0.01
IGL02749:Vmn2r90 APN 17 17,947,122 (GRCm39) makesense probably null
IGL03114:Vmn2r90 APN 17 17,953,771 (GRCm39) missense probably damaging 1.00
R0131:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0131:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0132:Vmn2r90 UTSW 17 17,932,511 (GRCm39) missense probably benign 0.00
R0184:Vmn2r90 UTSW 17 17,947,139 (GRCm39) nonsense probably null
R0379:Vmn2r90 UTSW 17 17,948,401 (GRCm39) missense probably damaging 1.00
R1022:Vmn2r90 UTSW 17 17,948,400 (GRCm39) missense probably damaging 1.00
R1024:Vmn2r90 UTSW 17 17,948,400 (GRCm39) missense probably damaging 1.00
R1897:Vmn2r90 UTSW 17 17,953,566 (GRCm39) missense probably damaging 1.00
R1993:Vmn2r90 UTSW 17 17,933,525 (GRCm39) missense probably damaging 1.00
R2472:Vmn2r90 UTSW 17 17,948,408 (GRCm39) missense probably damaging 1.00
R2508:Vmn2r90 UTSW 17 17,954,229 (GRCm39) missense probably damaging 1.00
R2679:Vmn2r90 UTSW 17 17,933,131 (GRCm39) missense possibly damaging 0.46
R3409:Vmn2r90 UTSW 17 17,953,638 (GRCm39) missense probably benign 0.00
R4693:Vmn2r90 UTSW 17 17,953,956 (GRCm39) missense possibly damaging 0.91
R5258:Vmn2r90 UTSW 17 17,933,114 (GRCm39) missense probably benign 0.12
R5358:Vmn2r90 UTSW 17 17,924,412 (GRCm39) critical splice donor site probably null
R5445:Vmn2r90 UTSW 17 17,954,386 (GRCm39) missense probably benign 0.04
R5446:Vmn2r90 UTSW 17 17,932,464 (GRCm39) missense probably damaging 0.99
R5567:Vmn2r90 UTSW 17 17,932,336 (GRCm39) missense probably damaging 1.00
R5680:Vmn2r90 UTSW 17 17,947,034 (GRCm39) missense possibly damaging 0.93
R5686:Vmn2r90 UTSW 17 17,933,712 (GRCm39) missense probably benign 0.02
R5751:Vmn2r90 UTSW 17 17,954,128 (GRCm39) missense probably damaging 0.96
R6156:Vmn2r90 UTSW 17 17,953,606 (GRCm39) missense probably benign 0.01
R6185:Vmn2r90 UTSW 17 17,953,644 (GRCm39) missense probably damaging 1.00
R6450:Vmn2r90 UTSW 17 17,953,498 (GRCm39) missense possibly damaging 0.47
R6707:Vmn2r90 UTSW 17 17,948,364 (GRCm39) missense probably damaging 1.00
R6802:Vmn2r90 UTSW 17 17,932,351 (GRCm39) missense probably damaging 1.00
R6913:Vmn2r90 UTSW 17 17,924,323 (GRCm39) missense probably damaging 1.00
R7070:Vmn2r90 UTSW 17 17,924,313 (GRCm39) missense probably damaging 0.98
R7237:Vmn2r90 UTSW 17 17,924,249 (GRCm39) missense possibly damaging 0.92
R7503:Vmn2r90 UTSW 17 17,933,510 (GRCm39) missense not run
R7698:Vmn2r90 UTSW 17 17,953,596 (GRCm39) missense probably benign
R7943:Vmn2r90 UTSW 17 17,932,566 (GRCm39) missense probably damaging 1.00
R8072:Vmn2r90 UTSW 17 17,947,142 (GRCm39) missense probably damaging 1.00
R8128:Vmn2r90 UTSW 17 17,954,155 (GRCm39) missense probably damaging 1.00
R8295:Vmn2r90 UTSW 17 17,948,358 (GRCm39) missense probably benign 0.03
R8345:Vmn2r90 UTSW 17 17,933,127 (GRCm39) nonsense probably null
R8682:Vmn2r90 UTSW 17 17,932,344 (GRCm39) missense possibly damaging 0.95
R8716:Vmn2r90 UTSW 17 17,924,343 (GRCm39) missense probably damaging 0.98
R9041:Vmn2r90 UTSW 17 17,954,286 (GRCm39) missense probably benign 0.00
R9412:Vmn2r90 UTSW 17 17,954,213 (GRCm39) missense probably damaging 1.00
R9607:Vmn2r90 UTSW 17 17,953,638 (GRCm39) missense possibly damaging 0.88
R9705:Vmn2r90 UTSW 17 17,933,039 (GRCm39) missense possibly damaging 0.91
Z1088:Vmn2r90 UTSW 17 17,953,879 (GRCm39) missense probably damaging 1.00
Z1176:Vmn2r90 UTSW 17 17,933,079 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- GCCCTGTTATTTGCCATTGAGG -3'
(R):5'- GACAGGTCTCCAGTTTAAATAACCTAG -3'

Sequencing Primer
(F):5'- CCCTGTTATTTGCCATTGAGGAGATC -3'
(R):5'- GATGGTCTCATCCTCCTATCTTTC -3'
Posted On 2016-02-04