Incidental Mutation 'R4798:Pappa2'
| ID |
369177 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Pappa2
|
| Ensembl Gene |
ENSMUSG00000073530 |
| Gene Name |
pappalysin 2 |
| Synonyms |
PAPP-A2, placenta-specific 3, pregnancy-associated plasma preproprotein-A2, pregnancy-associated plasma protein-E, PLAC3, Pappe |
| MMRRC Submission |
042422-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4798 (G1)
|
| Quality Score |
205 |
|
Status
|
Validated
|
| Chromosome |
1 |
| Chromosomal Location |
158539297-158788019 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 158684949 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Serine
at position 730
(N730S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000124022
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000159861]
|
| AlphaFold |
E9PZ87 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000159861
AA Change: N730S
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000124022
Gene: ENSMUSG00000073530
AA Change: N730S
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
|
Pfam:Laminin_G_3
|
271 |
440 |
1.2e-25 |
PFAM |
|
NL
|
572 |
614 |
2.81e-5 |
SMART |
|
Pfam:Peptidase_M43
|
669 |
832 |
1.5e-12 |
PFAM |
|
Blast:FN3
|
844 |
1103 |
1e-169 |
BLAST |
|
low complexity region
|
1130 |
1139 |
N/A |
INTRINSIC |
|
low complexity region
|
1361 |
1370 |
N/A |
INTRINSIC |
|
CCP
|
1394 |
1457 |
4.97e0 |
SMART |
|
CCP
|
1462 |
1519 |
4.81e-1 |
SMART |
|
CCP
|
1523 |
1588 |
2.58e-4 |
SMART |
|
CCP
|
1593 |
1644 |
1.13e0 |
SMART |
|
NL
|
1720 |
1757 |
2.66e-6 |
SMART |
|
| Meta Mutation Damage Score |
0.6467 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.6%
|
| Validation Efficiency |
97% (111/114) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the pappalysin family of metzincin metalloproteinases. The encoded protein cleaves insulin-like growth factor-binding protein 5 and is thought to be a local regulator of insulin-like growth factor (IGF) bioavailability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
PHENOTYPE: Mice homozygous for a null mutation are viable and fertile but display postnatal growth retardation that is more pronounced in females compared to males. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
T |
C |
13: 77,471,843 (GRCm39) |
W1083R |
possibly damaging |
Het |
| Adamts10 |
T |
A |
17: 33,747,726 (GRCm39) |
L54Q |
probably damaging |
Het |
| Ankrd24 |
A |
C |
10: 81,479,149 (GRCm39) |
|
probably benign |
Het |
| Atg2b |
A |
G |
12: 105,618,888 (GRCm39) |
S813P |
probably benign |
Het |
| Atp13a3 |
T |
A |
16: 30,160,058 (GRCm39) |
I716F |
probably damaging |
Het |
| Atp6v1c1 |
T |
A |
15: 38,689,420 (GRCm39) |
W294R |
probably damaging |
Het |
| Atrnl1 |
G |
T |
19: 58,030,793 (GRCm39) |
A1312S |
probably benign |
Het |
| Bcl2 |
A |
T |
1: 106,640,338 (GRCm39) |
H91Q |
possibly damaging |
Het |
| Cacna1c |
G |
A |
6: 118,607,263 (GRCm39) |
Q1214* |
probably null |
Het |
| Cacna1g |
C |
A |
11: 94,324,673 (GRCm39) |
G1183W |
probably damaging |
Het |
| Capsl |
A |
T |
15: 9,461,828 (GRCm39) |
M75L |
probably benign |
Het |
| Ccdc122 |
T |
G |
14: 77,349,047 (GRCm39) |
|
probably benign |
Het |
| Ccdc57 |
T |
G |
11: 120,772,683 (GRCm39) |
R645S |
possibly damaging |
Het |
| Cdh8 |
T |
A |
8: 99,751,558 (GRCm39) |
R720* |
probably null |
Het |
| Cenpx |
T |
G |
11: 120,602,610 (GRCm39) |
|
probably benign |
Het |
| Clic3 |
T |
C |
2: 25,348,194 (GRCm39) |
S114P |
probably damaging |
Het |
| Cracdl |
A |
T |
1: 37,664,046 (GRCm39) |
D617E |
probably benign |
Het |
| Crtac1 |
A |
T |
19: 42,312,240 (GRCm39) |
W158R |
possibly damaging |
Het |
| Dennd2b |
C |
T |
7: 109,156,240 (GRCm39) |
G170D |
probably damaging |
Het |
| Dhrs11 |
T |
A |
11: 84,719,626 (GRCm39) |
Q33L |
probably benign |
Het |
| Dnah8 |
G |
A |
17: 30,967,542 (GRCm39) |
D2585N |
probably benign |
Het |
| Dpp9 |
G |
T |
17: 56,498,016 (GRCm39) |
Q647K |
probably damaging |
Het |
| Egf |
C |
T |
3: 129,510,327 (GRCm39) |
G64D |
probably damaging |
Het |
| Eif2b4 |
C |
T |
5: 31,346,864 (GRCm39) |
|
probably benign |
Het |
| Epas1 |
A |
G |
17: 87,113,267 (GRCm39) |
N151S |
probably benign |
Het |
| Fastkd1 |
A |
T |
2: 69,521,651 (GRCm39) |
I707K |
probably benign |
Het |
| Fbln2 |
A |
G |
6: 91,246,168 (GRCm39) |
T1005A |
probably benign |
Het |
| Fgfrl1 |
T |
A |
5: 108,851,363 (GRCm39) |
Y93* |
probably null |
Het |
| Fktn |
A |
G |
4: 53,744,637 (GRCm39) |
T306A |
probably benign |
Het |
| Gabbr2 |
T |
G |
4: 46,991,139 (GRCm39) |
Y96S |
possibly damaging |
Het |
| Gm16332 |
A |
T |
1: 139,819,396 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5145 |
G |
T |
17: 20,790,810 (GRCm39) |
V63F |
probably damaging |
Het |
| Gm9970 |
G |
T |
5: 31,398,429 (GRCm39) |
|
probably benign |
Het |
| Gpr158 |
A |
G |
2: 21,787,993 (GRCm39) |
T545A |
probably damaging |
Het |
| Heatr1 |
G |
A |
13: 12,426,929 (GRCm39) |
E685K |
probably benign |
Het |
| Herc6 |
A |
T |
6: 57,581,151 (GRCm39) |
I284F |
probably damaging |
Het |
| Hook1 |
C |
G |
4: 95,890,794 (GRCm39) |
A301G |
possibly damaging |
Het |
| Hpcal4 |
T |
A |
4: 123,084,491 (GRCm39) |
M140K |
possibly damaging |
Het |
| Il11ra1 |
T |
C |
4: 41,766,096 (GRCm39) |
|
probably benign |
Het |
| Ildr1 |
A |
T |
16: 36,542,917 (GRCm39) |
H439L |
possibly damaging |
Het |
| Itga11 |
A |
G |
9: 62,684,009 (GRCm39) |
|
probably null |
Het |
| Jag2 |
A |
T |
12: 112,880,252 (GRCm39) |
D337E |
probably benign |
Het |
| Krt82 |
C |
T |
15: 101,458,923 (GRCm39) |
R39Q |
probably benign |
Het |
| L3mbtl4 |
T |
A |
17: 68,666,475 (GRCm39) |
M1K |
probably null |
Het |
| Lrrc32 |
T |
G |
7: 98,148,224 (GRCm39) |
F335V |
probably damaging |
Het |
| Lurap1l |
T |
A |
4: 80,829,650 (GRCm39) |
V20E |
probably damaging |
Het |
| Lyar |
T |
A |
5: 38,385,230 (GRCm39) |
V90D |
possibly damaging |
Het |
| Man2c1 |
C |
T |
9: 57,048,469 (GRCm39) |
R778* |
probably null |
Het |
| Mapk6 |
A |
G |
9: 75,295,714 (GRCm39) |
F595L |
probably benign |
Het |
| Mccc1 |
A |
G |
3: 36,039,150 (GRCm39) |
I281T |
probably damaging |
Het |
| Mep1b |
T |
C |
18: 21,226,311 (GRCm39) |
V391A |
probably damaging |
Het |
| Mier1 |
G |
A |
4: 102,988,195 (GRCm39) |
D40N |
probably damaging |
Het |
| Mkx |
T |
C |
18: 7,002,432 (GRCm39) |
H38R |
probably benign |
Het |
| Mroh4 |
A |
G |
15: 74,498,028 (GRCm39) |
L184P |
probably damaging |
Het |
| Muc2 |
C |
A |
7: 141,307,877 (GRCm39) |
N834K |
probably benign |
Het |
| Mycl |
A |
G |
4: 122,894,049 (GRCm39) |
D283G |
probably damaging |
Het |
| Myh6 |
T |
C |
14: 55,190,750 (GRCm39) |
N975S |
probably damaging |
Het |
| Myl12a |
A |
G |
17: 71,303,297 (GRCm39) |
|
probably benign |
Het |
| Mysm1 |
T |
C |
4: 94,853,910 (GRCm39) |
T230A |
probably benign |
Het |
| Naca |
A |
G |
10: 127,883,672 (GRCm39) |
K2099R |
probably null |
Het |
| Nbeal1 |
T |
G |
1: 60,261,352 (GRCm39) |
|
probably null |
Het |
| Nedd1 |
A |
G |
10: 92,534,772 (GRCm39) |
V246A |
probably benign |
Het |
| Nid2 |
A |
G |
14: 19,839,829 (GRCm39) |
D806G |
probably benign |
Het |
| Ninl |
G |
A |
2: 150,801,801 (GRCm39) |
R156* |
probably null |
Het |
| Obscn |
T |
A |
11: 58,960,685 (GRCm39) |
I3418F |
probably damaging |
Het |
| Or8g37 |
T |
A |
9: 39,731,193 (GRCm39) |
V86E |
probably benign |
Het |
| Pcm1 |
G |
A |
8: 41,746,715 (GRCm39) |
D1305N |
probably damaging |
Het |
| Pcsk4 |
A |
T |
10: 80,158,938 (GRCm39) |
I485N |
probably damaging |
Het |
| Phldb2 |
T |
C |
16: 45,646,237 (GRCm39) |
R111G |
probably damaging |
Het |
| Prdm10 |
T |
C |
9: 31,252,569 (GRCm39) |
F385S |
probably damaging |
Het |
| Prkcsh |
C |
T |
9: 21,923,034 (GRCm39) |
P351L |
probably damaging |
Het |
| Prrc2a |
G |
A |
17: 35,369,018 (GRCm39) |
P2006L |
probably damaging |
Het |
| Rad51c |
T |
C |
11: 87,286,204 (GRCm39) |
D251G |
probably damaging |
Het |
| Radil |
A |
G |
5: 142,470,918 (GRCm39) |
F1088L |
probably benign |
Het |
| Rere |
C |
A |
4: 150,699,624 (GRCm39) |
|
probably benign |
Het |
| Rnf167 |
T |
A |
11: 70,540,961 (GRCm39) |
C196S |
probably benign |
Het |
| Robo2 |
T |
A |
16: 74,149,633 (GRCm39) |
Y65F |
probably damaging |
Het |
| Scarf2 |
G |
A |
16: 17,621,371 (GRCm39) |
C319Y |
probably damaging |
Het |
| Sec24c |
A |
G |
14: 20,743,780 (GRCm39) |
D995G |
probably damaging |
Het |
| Selenbp1 |
T |
C |
3: 94,851,211 (GRCm39) |
L369S |
probably benign |
Het |
| Sgpl1 |
A |
T |
10: 60,959,123 (GRCm39) |
I53K |
possibly damaging |
Het |
| Sh3bp5 |
C |
A |
14: 31,099,452 (GRCm39) |
R265L |
probably benign |
Het |
| Slc1a6 |
A |
T |
10: 78,635,952 (GRCm39) |
Y339F |
probably damaging |
Het |
| Smchd1 |
G |
T |
17: 71,667,048 (GRCm39) |
Y1781* |
probably null |
Het |
| Smg1 |
T |
C |
7: 117,779,697 (GRCm39) |
S1233G |
probably benign |
Het |
| Snap91 |
A |
T |
9: 86,665,507 (GRCm39) |
|
probably benign |
Het |
| Snx29 |
T |
A |
16: 11,238,600 (GRCm39) |
L112Q |
probably damaging |
Het |
| Sptbn5 |
T |
C |
2: 119,889,622 (GRCm39) |
|
probably benign |
Het |
| Srl |
A |
T |
16: 4,310,222 (GRCm39) |
H502Q |
possibly damaging |
Het |
| St8sia3 |
A |
G |
18: 64,404,820 (GRCm39) |
M366V |
probably benign |
Het |
| Stk19 |
A |
T |
17: 35,041,485 (GRCm39) |
|
probably benign |
Het |
| Syngap1 |
G |
A |
17: 27,180,423 (GRCm39) |
A611T |
probably benign |
Het |
| Tas2r113 |
A |
G |
6: 132,870,670 (GRCm39) |
T233A |
possibly damaging |
Het |
| Tbcc |
G |
A |
17: 47,202,145 (GRCm39) |
W177* |
probably null |
Het |
| Tcstv3 |
T |
A |
13: 120,779,618 (GRCm39) |
|
probably null |
Het |
| Trav13-5 |
T |
A |
14: 54,033,408 (GRCm39) |
C106S |
probably damaging |
Het |
| Trmt61a |
G |
A |
12: 111,645,147 (GRCm39) |
V28M |
possibly damaging |
Het |
| Ubap2l |
G |
A |
3: 89,928,210 (GRCm39) |
T553M |
probably damaging |
Het |
| Urb1 |
T |
C |
16: 90,554,715 (GRCm39) |
N1839S |
probably benign |
Het |
| Ush2a |
T |
C |
1: 188,475,742 (GRCm39) |
L2893P |
probably damaging |
Het |
| Usp24 |
G |
A |
4: 106,217,359 (GRCm39) |
V421M |
possibly damaging |
Het |
| Vmn1r43 |
T |
C |
6: 89,846,892 (GRCm39) |
E198G |
probably benign |
Het |
| Vps13d |
A |
C |
4: 144,904,626 (GRCm39) |
S130A |
probably damaging |
Het |
| Zfp426 |
T |
A |
9: 20,382,310 (GRCm39) |
I211F |
probably benign |
Het |
| Znfx1 |
T |
C |
2: 166,880,489 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Pappa2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01097:Pappa2
|
APN |
1 |
158,684,718 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01394:Pappa2
|
APN |
1 |
158,592,674 (GRCm39) |
splice site |
probably benign |
|
|
IGL01570:Pappa2
|
APN |
1 |
158,642,110 (GRCm39) |
nonsense |
probably null |
|
|
IGL01618:Pappa2
|
APN |
1 |
158,684,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01717:Pappa2
|
APN |
1 |
158,684,702 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01804:Pappa2
|
APN |
1 |
158,764,089 (GRCm39) |
missense |
probably benign |
|
|
IGL01904:Pappa2
|
APN |
1 |
158,611,511 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02116:Pappa2
|
APN |
1 |
158,672,695 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02174:Pappa2
|
APN |
1 |
158,589,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02302:Pappa2
|
APN |
1 |
158,542,571 (GRCm39) |
missense |
probably benign |
0.38 |
|
IGL02422:Pappa2
|
APN |
1 |
158,764,503 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02572:Pappa2
|
APN |
1 |
158,678,786 (GRCm39) |
missense |
probably benign |
|
|
IGL02659:Pappa2
|
APN |
1 |
158,764,364 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL02887:Pappa2
|
APN |
1 |
158,609,829 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02981:Pappa2
|
APN |
1 |
158,678,714 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03128:Pappa2
|
APN |
1 |
158,764,054 (GRCm39) |
missense |
probably benign |
0.16 |
|
IGL03142:Pappa2
|
APN |
1 |
158,682,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03270:Pappa2
|
APN |
1 |
158,592,637 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
Fritas
|
UTSW |
1 |
158,675,533 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
Gulliver
|
UTSW |
1 |
158,684,706 (GRCm39) |
missense |
probably null |
1.00 |
|
Lilliputian
|
UTSW |
1 |
158,544,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Lilliputian2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
lilliputian3
|
UTSW |
1 |
158,609,973 (GRCm39) |
splice site |
probably null |
|
|
Pitzel
|
UTSW |
1 |
158,784,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
shrink
|
UTSW |
1 |
158,590,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,542,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0106:Pappa2
|
UTSW |
1 |
158,542,547 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0172:Pappa2
|
UTSW |
1 |
158,682,419 (GRCm39) |
critical splice donor site |
probably null |
|
|
R0194:Pappa2
|
UTSW |
1 |
158,592,671 (GRCm39) |
splice site |
probably benign |
|
|
R0418:Pappa2
|
UTSW |
1 |
158,544,560 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0421:Pappa2
|
UTSW |
1 |
158,675,650 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0441:Pappa2
|
UTSW |
1 |
158,590,628 (GRCm39) |
unclassified |
probably benign |
|
|
R0602:Pappa2
|
UTSW |
1 |
158,590,625 (GRCm39) |
unclassified |
probably benign |
|
|
R0630:Pappa2
|
UTSW |
1 |
158,660,343 (GRCm39) |
missense |
probably benign |
|
|
R0760:Pappa2
|
UTSW |
1 |
158,544,531 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1146:Pappa2
|
UTSW |
1 |
158,682,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1146:Pappa2
|
UTSW |
1 |
158,682,552 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1243:Pappa2
|
UTSW |
1 |
158,672,670 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1413:Pappa2
|
UTSW |
1 |
158,764,124 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1502:Pappa2
|
UTSW |
1 |
158,784,858 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1599:Pappa2
|
UTSW |
1 |
158,684,742 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1689:Pappa2
|
UTSW |
1 |
158,784,968 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1750:Pappa2
|
UTSW |
1 |
158,590,720 (GRCm39) |
nonsense |
probably null |
|
|
R1772:Pappa2
|
UTSW |
1 |
158,641,938 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R1832:Pappa2
|
UTSW |
1 |
158,684,886 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1905:Pappa2
|
UTSW |
1 |
158,631,073 (GRCm39) |
splice site |
probably null |
|
|
R1914:Pappa2
|
UTSW |
1 |
158,578,133 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2013:Pappa2
|
UTSW |
1 |
158,662,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2037:Pappa2
|
UTSW |
1 |
158,784,214 (GRCm39) |
nonsense |
probably null |
|
|
R2118:Pappa2
|
UTSW |
1 |
158,684,836 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2268:Pappa2
|
UTSW |
1 |
158,684,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2269:Pappa2
|
UTSW |
1 |
158,684,841 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2347:Pappa2
|
UTSW |
1 |
158,592,613 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3024:Pappa2
|
UTSW |
1 |
158,763,795 (GRCm39) |
missense |
probably benign |
0.00 |
|
R3706:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R3707:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R3708:Pappa2
|
UTSW |
1 |
158,662,488 (GRCm39) |
nonsense |
probably null |
|
|
R4600:Pappa2
|
UTSW |
1 |
158,642,015 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4737:Pappa2
|
UTSW |
1 |
158,784,582 (GRCm39) |
missense |
probably benign |
|
|
R4738:Pappa2
|
UTSW |
1 |
158,784,582 (GRCm39) |
missense |
probably benign |
|
|
R4739:Pappa2
|
UTSW |
1 |
158,784,582 (GRCm39) |
missense |
probably benign |
|
|
R4739:Pappa2
|
UTSW |
1 |
158,784,572 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4788:Pappa2
|
UTSW |
1 |
158,611,487 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4952:Pappa2
|
UTSW |
1 |
158,684,706 (GRCm39) |
missense |
probably null |
1.00 |
|
R5121:Pappa2
|
UTSW |
1 |
158,666,197 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5144:Pappa2
|
UTSW |
1 |
158,784,703 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5159:Pappa2
|
UTSW |
1 |
158,589,189 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5278:Pappa2
|
UTSW |
1 |
158,609,973 (GRCm39) |
splice site |
probably null |
|
|
R5428:Pappa2
|
UTSW |
1 |
158,642,355 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5452:Pappa2
|
UTSW |
1 |
158,666,172 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5477:Pappa2
|
UTSW |
1 |
158,784,308 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5504:Pappa2
|
UTSW |
1 |
158,675,615 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5852:Pappa2
|
UTSW |
1 |
158,544,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6003:Pappa2
|
UTSW |
1 |
158,763,820 (GRCm39) |
missense |
probably benign |
0.23 |
|
R6129:Pappa2
|
UTSW |
1 |
158,542,567 (GRCm39) |
nonsense |
probably null |
|
|
R6137:Pappa2
|
UTSW |
1 |
158,699,113 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6374:Pappa2
|
UTSW |
1 |
158,784,215 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6472:Pappa2
|
UTSW |
1 |
158,662,369 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6804:Pappa2
|
UTSW |
1 |
158,764,438 (GRCm39) |
missense |
probably benign |
0.24 |
|
R7020:Pappa2
|
UTSW |
1 |
158,675,579 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7051:Pappa2
|
UTSW |
1 |
158,784,753 (GRCm39) |
missense |
unknown |
|
|
R7082:Pappa2
|
UTSW |
1 |
158,590,689 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
R7111:Pappa2
|
UTSW |
1 |
158,784,096 (GRCm39) |
missense |
probably benign |
0.38 |
|
R7213:Pappa2
|
UTSW |
1 |
158,764,456 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7575:Pappa2
|
UTSW |
1 |
158,642,100 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7587:Pappa2
|
UTSW |
1 |
158,678,701 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7826:Pappa2
|
UTSW |
1 |
158,764,010 (GRCm39) |
nonsense |
probably null |
|
|
R7957:Pappa2
|
UTSW |
1 |
158,589,131 (GRCm39) |
nonsense |
probably null |
|
|
R8007:Pappa2
|
UTSW |
1 |
158,609,874 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8050:Pappa2
|
UTSW |
1 |
158,675,970 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8063:Pappa2
|
UTSW |
1 |
158,764,126 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R8068:Pappa2
|
UTSW |
1 |
158,763,555 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8128:Pappa2
|
UTSW |
1 |
158,764,234 (GRCm39) |
missense |
possibly damaging |
0.75 |
|
R8264:Pappa2
|
UTSW |
1 |
158,682,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8317:Pappa2
|
UTSW |
1 |
158,592,530 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8499:Pappa2
|
UTSW |
1 |
158,764,092 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8744:Pappa2
|
UTSW |
1 |
158,611,487 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R8793:Pappa2
|
UTSW |
1 |
158,678,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8932:Pappa2
|
UTSW |
1 |
158,590,762 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9004:Pappa2
|
UTSW |
1 |
158,764,518 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R9004:Pappa2
|
UTSW |
1 |
158,763,979 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9088:Pappa2
|
UTSW |
1 |
158,763,927 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9191:Pappa2
|
UTSW |
1 |
158,684,988 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9243:Pappa2
|
UTSW |
1 |
158,763,763 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9280:Pappa2
|
UTSW |
1 |
158,675,533 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R9301:Pappa2
|
UTSW |
1 |
158,672,614 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9306:Pappa2
|
UTSW |
1 |
158,764,492 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9367:Pappa2
|
UTSW |
1 |
158,784,542 (GRCm39) |
missense |
probably benign |
0.40 |
|
R9471:Pappa2
|
UTSW |
1 |
158,642,029 (GRCm39) |
missense |
probably benign |
0.04 |
|
R9544:Pappa2
|
UTSW |
1 |
158,784,817 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9680:Pappa2
|
UTSW |
1 |
158,609,818 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
R9762:Pappa2
|
UTSW |
1 |
158,684,948 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9774:Pappa2
|
UTSW |
1 |
158,675,920 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9776:Pappa2
|
UTSW |
1 |
158,611,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
X0058:Pappa2
|
UTSW |
1 |
158,641,967 (GRCm39) |
missense |
probably null |
|
|
X0061:Pappa2
|
UTSW |
1 |
158,764,188 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,784,503 (GRCm39) |
missense |
probably benign |
|
|
Z1176:Pappa2
|
UTSW |
1 |
158,642,386 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1176:Pappa2
|
UTSW |
1 |
158,642,384 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- AAGCCACAGGTGTCATTAGC -3'
(R):5'- GGTGTCCATAGAACATAATTAGATGCC -3'
Sequencing Primer
(F):5'- CATTAGCTGGCTCTGGGTCC -3'
(R):5'- AGATGCCACTACGTTAGTTATAAAC -3'
|
| Posted On |
2016-02-04 |
Incidental Mutation