Incidental Mutation 'R4798:Muc2'
| ID |
369217 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Muc2
|
| Ensembl Gene |
ENSMUSG00000025515 |
| Gene Name |
mucin 2 |
| Synonyms |
2010015E03Rik |
| MMRRC Submission |
042422-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.100)
|
| Stock # |
R4798 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
141276583-141308428 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
C to A
at 141307877 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Asparagine to Lysine
at position 834
(N834K)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000026590]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000026590
AA Change: N395K
PolyPhen 2
Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
|
| SMART Domains |
Protein: ENSMUSP00000026590
Gene: ENSMUSG00000025515
AA Change: N395K
| Domain | Start | End | E-Value | Type |
|---|
|
C8
|
1 |
63 |
1.65e-11 |
SMART |
|
VWC
|
120 |
188 |
5.48e-2 |
SMART |
|
VWC
|
229 |
293 |
2.38e-11 |
SMART |
|
Blast:VWD
|
299 |
363 |
4e-17 |
BLAST |
|
CT
|
380 |
463 |
3.6e-35 |
SMART |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000187945
AA Change: N834K
PolyPhen 2
Score 0.011 (Sensitivity: 0.96; Specificity: 0.78)
|
| Meta Mutation Damage Score |
0.0898 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.6%
|
| Validation Efficiency |
97% (111/114) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins produced by many epithelial tissues. The protein encoded by this gene is secreted and forms an insoluble mucous barrier that protects the gut lumen. The protein polymerizes into a gel of which 80% is composed of oligosaccharide side chains by weight. The protein features a central domain containing tandem repeats rich in threonine and proline that varies between 50 and 115 copies in different individuals. Downregulation of this gene has been observed in patients with Crohn disease and ulcerative colitis. [provided by RefSeq, Oct 2016]
PHENOTYPE: Homozygotes for a point mutation have soft feces at weaning and develop diarrhea associated with malapsorption syndrome. Homozygous null mutants pass blood in their feces at 6 months, and 65% of null mutants have intestinal tumors at 1 year. [provided by MGI curators]
|
| Allele List at MGI |
All alleles(7) : Targeted(3) Chemically induced(4)
|
| Other mutations in this stock |
Total: 105 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 2210408I21Rik |
T |
C |
13: 77,471,843 (GRCm39) |
W1083R |
possibly damaging |
Het |
| Adamts10 |
T |
A |
17: 33,747,726 (GRCm39) |
L54Q |
probably damaging |
Het |
| Ankrd24 |
A |
C |
10: 81,479,149 (GRCm39) |
|
probably benign |
Het |
| Atg2b |
A |
G |
12: 105,618,888 (GRCm39) |
S813P |
probably benign |
Het |
| Atp13a3 |
T |
A |
16: 30,160,058 (GRCm39) |
I716F |
probably damaging |
Het |
| Atp6v1c1 |
T |
A |
15: 38,689,420 (GRCm39) |
W294R |
probably damaging |
Het |
| Atrnl1 |
G |
T |
19: 58,030,793 (GRCm39) |
A1312S |
probably benign |
Het |
| Bcl2 |
A |
T |
1: 106,640,338 (GRCm39) |
H91Q |
possibly damaging |
Het |
| Cacna1c |
G |
A |
6: 118,607,263 (GRCm39) |
Q1214* |
probably null |
Het |
| Cacna1g |
C |
A |
11: 94,324,673 (GRCm39) |
G1183W |
probably damaging |
Het |
| Capsl |
A |
T |
15: 9,461,828 (GRCm39) |
M75L |
probably benign |
Het |
| Ccdc122 |
T |
G |
14: 77,349,047 (GRCm39) |
|
probably benign |
Het |
| Ccdc57 |
T |
G |
11: 120,772,683 (GRCm39) |
R645S |
possibly damaging |
Het |
| Cdh8 |
T |
A |
8: 99,751,558 (GRCm39) |
R720* |
probably null |
Het |
| Cenpx |
T |
G |
11: 120,602,610 (GRCm39) |
|
probably benign |
Het |
| Clic3 |
T |
C |
2: 25,348,194 (GRCm39) |
S114P |
probably damaging |
Het |
| Cracdl |
A |
T |
1: 37,664,046 (GRCm39) |
D617E |
probably benign |
Het |
| Crtac1 |
A |
T |
19: 42,312,240 (GRCm39) |
W158R |
possibly damaging |
Het |
| Dennd2b |
C |
T |
7: 109,156,240 (GRCm39) |
G170D |
probably damaging |
Het |
| Dhrs11 |
T |
A |
11: 84,719,626 (GRCm39) |
Q33L |
probably benign |
Het |
| Dnah8 |
G |
A |
17: 30,967,542 (GRCm39) |
D2585N |
probably benign |
Het |
| Dpp9 |
G |
T |
17: 56,498,016 (GRCm39) |
Q647K |
probably damaging |
Het |
| Egf |
C |
T |
3: 129,510,327 (GRCm39) |
G64D |
probably damaging |
Het |
| Eif2b4 |
C |
T |
5: 31,346,864 (GRCm39) |
|
probably benign |
Het |
| Epas1 |
A |
G |
17: 87,113,267 (GRCm39) |
N151S |
probably benign |
Het |
| Fastkd1 |
A |
T |
2: 69,521,651 (GRCm39) |
I707K |
probably benign |
Het |
| Fbln2 |
A |
G |
6: 91,246,168 (GRCm39) |
T1005A |
probably benign |
Het |
| Fgfrl1 |
T |
A |
5: 108,851,363 (GRCm39) |
Y93* |
probably null |
Het |
| Fktn |
A |
G |
4: 53,744,637 (GRCm39) |
T306A |
probably benign |
Het |
| Gabbr2 |
T |
G |
4: 46,991,139 (GRCm39) |
Y96S |
possibly damaging |
Het |
| Gm16332 |
A |
T |
1: 139,819,396 (GRCm39) |
|
noncoding transcript |
Het |
| Gm5145 |
G |
T |
17: 20,790,810 (GRCm39) |
V63F |
probably damaging |
Het |
| Gm9970 |
G |
T |
5: 31,398,429 (GRCm39) |
|
probably benign |
Het |
| Gpr158 |
A |
G |
2: 21,787,993 (GRCm39) |
T545A |
probably damaging |
Het |
| Heatr1 |
G |
A |
13: 12,426,929 (GRCm39) |
E685K |
probably benign |
Het |
| Herc6 |
A |
T |
6: 57,581,151 (GRCm39) |
I284F |
probably damaging |
Het |
| Hook1 |
C |
G |
4: 95,890,794 (GRCm39) |
A301G |
possibly damaging |
Het |
| Hpcal4 |
T |
A |
4: 123,084,491 (GRCm39) |
M140K |
possibly damaging |
Het |
| Il11ra1 |
T |
C |
4: 41,766,096 (GRCm39) |
|
probably benign |
Het |
| Ildr1 |
A |
T |
16: 36,542,917 (GRCm39) |
H439L |
possibly damaging |
Het |
| Itga11 |
A |
G |
9: 62,684,009 (GRCm39) |
|
probably null |
Het |
| Jag2 |
A |
T |
12: 112,880,252 (GRCm39) |
D337E |
probably benign |
Het |
| Krt82 |
C |
T |
15: 101,458,923 (GRCm39) |
R39Q |
probably benign |
Het |
| L3mbtl4 |
T |
A |
17: 68,666,475 (GRCm39) |
M1K |
probably null |
Het |
| Lrrc32 |
T |
G |
7: 98,148,224 (GRCm39) |
F335V |
probably damaging |
Het |
| Lurap1l |
T |
A |
4: 80,829,650 (GRCm39) |
V20E |
probably damaging |
Het |
| Lyar |
T |
A |
5: 38,385,230 (GRCm39) |
V90D |
possibly damaging |
Het |
| Man2c1 |
C |
T |
9: 57,048,469 (GRCm39) |
R778* |
probably null |
Het |
| Mapk6 |
A |
G |
9: 75,295,714 (GRCm39) |
F595L |
probably benign |
Het |
| Mccc1 |
A |
G |
3: 36,039,150 (GRCm39) |
I281T |
probably damaging |
Het |
| Mep1b |
T |
C |
18: 21,226,311 (GRCm39) |
V391A |
probably damaging |
Het |
| Mier1 |
G |
A |
4: 102,988,195 (GRCm39) |
D40N |
probably damaging |
Het |
| Mkx |
T |
C |
18: 7,002,432 (GRCm39) |
H38R |
probably benign |
Het |
| Mroh4 |
A |
G |
15: 74,498,028 (GRCm39) |
L184P |
probably damaging |
Het |
| Mycl |
A |
G |
4: 122,894,049 (GRCm39) |
D283G |
probably damaging |
Het |
| Myh6 |
T |
C |
14: 55,190,750 (GRCm39) |
N975S |
probably damaging |
Het |
| Myl12a |
A |
G |
17: 71,303,297 (GRCm39) |
|
probably benign |
Het |
| Mysm1 |
T |
C |
4: 94,853,910 (GRCm39) |
T230A |
probably benign |
Het |
| Naca |
A |
G |
10: 127,883,672 (GRCm39) |
K2099R |
probably null |
Het |
| Nbeal1 |
T |
G |
1: 60,261,352 (GRCm39) |
|
probably null |
Het |
| Nedd1 |
A |
G |
10: 92,534,772 (GRCm39) |
V246A |
probably benign |
Het |
| Nid2 |
A |
G |
14: 19,839,829 (GRCm39) |
D806G |
probably benign |
Het |
| Ninl |
G |
A |
2: 150,801,801 (GRCm39) |
R156* |
probably null |
Het |
| Obscn |
T |
A |
11: 58,960,685 (GRCm39) |
I3418F |
probably damaging |
Het |
| Or8g37 |
T |
A |
9: 39,731,193 (GRCm39) |
V86E |
probably benign |
Het |
| Pappa2 |
T |
C |
1: 158,684,949 (GRCm39) |
N730S |
probably damaging |
Het |
| Pcm1 |
G |
A |
8: 41,746,715 (GRCm39) |
D1305N |
probably damaging |
Het |
| Pcsk4 |
A |
T |
10: 80,158,938 (GRCm39) |
I485N |
probably damaging |
Het |
| Phldb2 |
T |
C |
16: 45,646,237 (GRCm39) |
R111G |
probably damaging |
Het |
| Prdm10 |
T |
C |
9: 31,252,569 (GRCm39) |
F385S |
probably damaging |
Het |
| Prkcsh |
C |
T |
9: 21,923,034 (GRCm39) |
P351L |
probably damaging |
Het |
| Prrc2a |
G |
A |
17: 35,369,018 (GRCm39) |
P2006L |
probably damaging |
Het |
| Rad51c |
T |
C |
11: 87,286,204 (GRCm39) |
D251G |
probably damaging |
Het |
| Radil |
A |
G |
5: 142,470,918 (GRCm39) |
F1088L |
probably benign |
Het |
| Rere |
C |
A |
4: 150,699,624 (GRCm39) |
|
probably benign |
Het |
| Rnf167 |
T |
A |
11: 70,540,961 (GRCm39) |
C196S |
probably benign |
Het |
| Robo2 |
T |
A |
16: 74,149,633 (GRCm39) |
Y65F |
probably damaging |
Het |
| Scarf2 |
G |
A |
16: 17,621,371 (GRCm39) |
C319Y |
probably damaging |
Het |
| Sec24c |
A |
G |
14: 20,743,780 (GRCm39) |
D995G |
probably damaging |
Het |
| Selenbp1 |
T |
C |
3: 94,851,211 (GRCm39) |
L369S |
probably benign |
Het |
| Sgpl1 |
A |
T |
10: 60,959,123 (GRCm39) |
I53K |
possibly damaging |
Het |
| Sh3bp5 |
C |
A |
14: 31,099,452 (GRCm39) |
R265L |
probably benign |
Het |
| Slc1a6 |
A |
T |
10: 78,635,952 (GRCm39) |
Y339F |
probably damaging |
Het |
| Smchd1 |
G |
T |
17: 71,667,048 (GRCm39) |
Y1781* |
probably null |
Het |
| Smg1 |
T |
C |
7: 117,779,697 (GRCm39) |
S1233G |
probably benign |
Het |
| Snap91 |
A |
T |
9: 86,665,507 (GRCm39) |
|
probably benign |
Het |
| Snx29 |
T |
A |
16: 11,238,600 (GRCm39) |
L112Q |
probably damaging |
Het |
| Sptbn5 |
T |
C |
2: 119,889,622 (GRCm39) |
|
probably benign |
Het |
| Srl |
A |
T |
16: 4,310,222 (GRCm39) |
H502Q |
possibly damaging |
Het |
| St8sia3 |
A |
G |
18: 64,404,820 (GRCm39) |
M366V |
probably benign |
Het |
| Stk19 |
A |
T |
17: 35,041,485 (GRCm39) |
|
probably benign |
Het |
| Syngap1 |
G |
A |
17: 27,180,423 (GRCm39) |
A611T |
probably benign |
Het |
| Tas2r113 |
A |
G |
6: 132,870,670 (GRCm39) |
T233A |
possibly damaging |
Het |
| Tbcc |
G |
A |
17: 47,202,145 (GRCm39) |
W177* |
probably null |
Het |
| Tcstv3 |
T |
A |
13: 120,779,618 (GRCm39) |
|
probably null |
Het |
| Trav13-5 |
T |
A |
14: 54,033,408 (GRCm39) |
C106S |
probably damaging |
Het |
| Trmt61a |
G |
A |
12: 111,645,147 (GRCm39) |
V28M |
possibly damaging |
Het |
| Ubap2l |
G |
A |
3: 89,928,210 (GRCm39) |
T553M |
probably damaging |
Het |
| Urb1 |
T |
C |
16: 90,554,715 (GRCm39) |
N1839S |
probably benign |
Het |
| Ush2a |
T |
C |
1: 188,475,742 (GRCm39) |
L2893P |
probably damaging |
Het |
| Usp24 |
G |
A |
4: 106,217,359 (GRCm39) |
V421M |
possibly damaging |
Het |
| Vmn1r43 |
T |
C |
6: 89,846,892 (GRCm39) |
E198G |
probably benign |
Het |
| Vps13d |
A |
C |
4: 144,904,626 (GRCm39) |
S130A |
probably damaging |
Het |
| Zfp426 |
T |
A |
9: 20,382,310 (GRCm39) |
I211F |
probably benign |
Het |
| Znfx1 |
T |
C |
2: 166,880,489 (GRCm39) |
|
probably null |
Het |
|
| Other mutations in Muc2 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
Eeyore
|
APN |
7 |
141,693,356 (GRCm38) |
missense |
probably benign |
0.35 |
|
kenny
|
APN |
7 |
0 () |
nonsense |
|
|
|
Winnie
|
APN |
7 |
141,286,029 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01303:Muc2
|
APN |
7 |
141,306,132 (GRCm39) |
missense |
probably benign |
|
|
IGL01482:Muc2
|
APN |
7 |
141,307,797 (GRCm39) |
missense |
probably damaging |
0.96 |
|
IGL01875:Muc2
|
APN |
7 |
141,306,477 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02088:Muc2
|
APN |
7 |
141,305,241 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02415:Muc2
|
APN |
7 |
141,305,609 (GRCm39) |
nonsense |
probably null |
|
|
IGL02548:Muc2
|
APN |
7 |
141,305,594 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02836:Muc2
|
APN |
7 |
141,300,450 (GRCm39) |
unclassified |
probably benign |
|
|
IGL03196:Muc2
|
APN |
7 |
141,301,367 (GRCm39) |
missense |
probably damaging |
0.97 |
|
Muskatenwein
|
UTSW |
7 |
141,307,176 (GRCm39) |
missense |
unknown |
|
|
nomoco
|
UTSW |
7 |
141,307,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Schlendrian
|
UTSW |
7 |
141,281,925 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Seco
|
UTSW |
7 |
141,284,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB001:Muc2
|
UTSW |
7 |
141,281,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
BB011:Muc2
|
UTSW |
7 |
141,281,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
E0370:Muc2
|
UTSW |
7 |
141,282,598 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0127:Muc2
|
UTSW |
7 |
141,302,691 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0179:Muc2
|
UTSW |
7 |
141,302,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0201:Muc2
|
UTSW |
7 |
141,699,185 (GRCm38) |
frame shift |
probably null |
|
|
R0299:Muc2
|
UTSW |
7 |
141,306,466 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0547:Muc2
|
UTSW |
7 |
141,699,185 (GRCm38) |
frame shift |
probably null |
|
|
R0699:Muc2
|
UTSW |
7 |
141,306,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0900:Muc2
|
UTSW |
7 |
141,699,185 (GRCm38) |
frame shift |
probably null |
|
|
R1348:Muc2
|
UTSW |
7 |
141,699,185 (GRCm38) |
frame shift |
probably null |
|
|
R1466:Muc2
|
UTSW |
7 |
141,302,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1466:Muc2
|
UTSW |
7 |
141,302,711 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1625:Muc2
|
UTSW |
7 |
141,283,405 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2010:Muc2
|
UTSW |
7 |
141,287,444 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2149:Muc2
|
UTSW |
7 |
141,699,185 (GRCm38) |
frame shift |
probably null |
|
|
R2163:Muc2
|
UTSW |
7 |
141,699,185 (GRCm38) |
frame shift |
probably null |
|
|
R3008:Muc2
|
UTSW |
7 |
141,281,347 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R3110:Muc2
|
UTSW |
7 |
141,299,225 (GRCm39) |
unclassified |
probably benign |
|
|
R3112:Muc2
|
UTSW |
7 |
141,299,225 (GRCm39) |
unclassified |
probably benign |
|
|
R3424:Muc2
|
UTSW |
7 |
141,279,595 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3786:Muc2
|
UTSW |
7 |
141,283,590 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3854:Muc2
|
UTSW |
7 |
141,308,081 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3964:Muc2
|
UTSW |
7 |
141,286,233 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3965:Muc2
|
UTSW |
7 |
141,286,233 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3966:Muc2
|
UTSW |
7 |
141,286,233 (GRCm39) |
missense |
probably benign |
0.17 |
|
R3973:Muc2
|
UTSW |
7 |
141,300,541 (GRCm39) |
unclassified |
probably benign |
|
|
R3974:Muc2
|
UTSW |
7 |
141,300,541 (GRCm39) |
unclassified |
probably benign |
|
|
R3976:Muc2
|
UTSW |
7 |
141,300,541 (GRCm39) |
unclassified |
probably benign |
|
|
R4327:Muc2
|
UTSW |
7 |
141,281,577 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R4694:Muc2
|
UTSW |
7 |
141,306,082 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4764:Muc2
|
UTSW |
7 |
141,299,345 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R4769:Muc2
|
UTSW |
7 |
141,286,260 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4900:Muc2
|
UTSW |
7 |
141,303,280 (GRCm39) |
missense |
probably benign |
0.32 |
|
R5383:Muc2
|
UTSW |
7 |
141,307,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5489:Muc2
|
UTSW |
7 |
141,305,169 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5615:Muc2
|
UTSW |
7 |
141,277,446 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5856:Muc2
|
UTSW |
7 |
141,299,381 (GRCm39) |
unclassified |
probably benign |
|
|
R5919:Muc2
|
UTSW |
7 |
141,281,171 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R5953:Muc2
|
UTSW |
7 |
141,287,951 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5979:Muc2
|
UTSW |
7 |
141,305,143 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5979:Muc2
|
UTSW |
7 |
141,283,493 (GRCm39) |
splice site |
probably null |
|
|
R6175:Muc2
|
UTSW |
7 |
141,282,875 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6213:Muc2
|
UTSW |
7 |
141,305,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6281:Muc2
|
UTSW |
7 |
141,306,140 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6321:Muc2
|
UTSW |
7 |
141,287,397 (GRCm39) |
missense |
probably benign |
0.28 |
|
R6390:Muc2
|
UTSW |
7 |
141,305,883 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6485:Muc2
|
UTSW |
7 |
141,300,473 (GRCm39) |
unclassified |
probably benign |
|
|
R6582:Muc2
|
UTSW |
7 |
141,282,941 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6683:Muc2
|
UTSW |
7 |
141,305,214 (GRCm39) |
missense |
probably benign |
0.38 |
|
R6896:Muc2
|
UTSW |
7 |
141,306,432 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R6906:Muc2
|
UTSW |
7 |
141,284,976 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6924:Muc2
|
UTSW |
7 |
141,284,077 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R7040:Muc2
|
UTSW |
7 |
141,305,194 (GRCm39) |
missense |
unknown |
|
|
R7222:Muc2
|
UTSW |
7 |
141,290,758 (GRCm39) |
missense |
|
|
|
R7251:Muc2
|
UTSW |
7 |
141,278,965 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R7282:Muc2
|
UTSW |
7 |
141,306,481 (GRCm39) |
missense |
|
|
|
R7315:Muc2
|
UTSW |
7 |
141,276,645 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7421:Muc2
|
UTSW |
7 |
141,301,863 (GRCm39) |
missense |
|
|
|
R7556:Muc2
|
UTSW |
7 |
141,307,439 (GRCm39) |
missense |
|
|
|
R7651:Muc2
|
UTSW |
7 |
141,290,750 (GRCm39) |
missense |
|
|
|
R7710:Muc2
|
UTSW |
7 |
141,287,452 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R7776:Muc2
|
UTSW |
7 |
141,290,942 (GRCm39) |
missense |
|
|
|
R7813:Muc2
|
UTSW |
7 |
141,282,543 (GRCm39) |
splice site |
probably null |
|
|
R7843:Muc2
|
UTSW |
7 |
141,281,662 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7869:Muc2
|
UTSW |
7 |
141,303,471 (GRCm39) |
missense |
|
|
|
R7924:Muc2
|
UTSW |
7 |
141,281,631 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7993:Muc2
|
UTSW |
7 |
141,308,173 (GRCm39) |
missense |
|
|
|
R8053:Muc2
|
UTSW |
7 |
141,284,575 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8068:Muc2
|
UTSW |
7 |
141,298,422 (GRCm39) |
missense |
|
|
|
R8099:Muc2
|
UTSW |
7 |
141,299,175 (GRCm39) |
splice site |
probably null |
|
|
R8192:Muc2
|
UTSW |
7 |
141,305,215 (GRCm39) |
missense |
|
|
|
R8194:Muc2
|
UTSW |
7 |
141,290,801 (GRCm39) |
missense |
|
|
|
R8545:Muc2
|
UTSW |
7 |
141,306,130 (GRCm39) |
missense |
unknown |
|
|
R8701:Muc2
|
UTSW |
7 |
141,281,850 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8883:Muc2
|
UTSW |
7 |
141,287,469 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8894:Muc2
|
UTSW |
7 |
141,280,758 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8905:Muc2
|
UTSW |
7 |
141,279,643 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9024:Muc2
|
UTSW |
7 |
141,287,936 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9032:Muc2
|
UTSW |
7 |
141,287,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9085:Muc2
|
UTSW |
7 |
141,287,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9091:Muc2
|
UTSW |
7 |
141,290,816 (GRCm39) |
missense |
|
|
|
R9104:Muc2
|
UTSW |
7 |
141,286,224 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9114:Muc2
|
UTSW |
7 |
141,287,983 (GRCm39) |
nonsense |
probably null |
|
|
R9270:Muc2
|
UTSW |
7 |
141,290,816 (GRCm39) |
missense |
|
|
|
R9297:Muc2
|
UTSW |
7 |
141,302,759 (GRCm39) |
missense |
|
|
|
R9325:Muc2
|
UTSW |
7 |
141,298,559 (GRCm39) |
missense |
|
|
|
R9354:Muc2
|
UTSW |
7 |
141,307,157 (GRCm39) |
missense |
|
|
|
R9386:Muc2
|
UTSW |
7 |
141,279,389 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9529:Muc2
|
UTSW |
7 |
141,287,453 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R9550:Muc2
|
UTSW |
7 |
141,308,242 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9583:Muc2
|
UTSW |
7 |
141,300,559 (GRCm39) |
missense |
|
|
|
R9607:Muc2
|
UTSW |
7 |
141,305,190 (GRCm39) |
missense |
|
|
|
R9646:Muc2
|
UTSW |
7 |
141,276,643 (GRCm39) |
missense |
probably benign |
|
|
R9651:Muc2
|
UTSW |
7 |
141,288,014 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9774:Muc2
|
UTSW |
7 |
141,285,811 (GRCm39) |
missense |
probably benign |
|
|
R9784:Muc2
|
UTSW |
7 |
141,280,785 (GRCm39) |
nonsense |
probably null |
|
|
Z1176:Muc2
|
UTSW |
7 |
141,300,451 (GRCm39) |
missense |
|
|
|
Z1177:Muc2
|
UTSW |
7 |
141,298,531 (GRCm39) |
missense |
|
|
|
| Predicted Primers |
PCR Primer
(F):5'- AGTTAAGGGCTAGAGACATGCTC -3'
(R):5'- AGAGCACCTGTGATCCAGAC -3'
Sequencing Primer
(F):5'- GAGACATGCTCGGAGAAGG -3'
(R):5'- TGGACCTGGGCAGAGTAC -3'
|
| Posted On |
2016-02-04 |
Incidental Mutation