Incidental Mutation 'R4811:Or2y1e'
ID 369447
Institutional Source Beutler Lab
Gene Symbol Or2y1e
Ensembl Gene ENSMUSG00000101874
Gene Name olfactory receptor family 2 subfamily Y member 1E
Synonyms Olfr1391, GA_x6K02T2QP88-6107233-6106298, MOR256-27
MMRRC Submission 042430-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.077) question?
Stock # R4811 (G1)
Quality Score 225
Status Not validated
Chromosome 11
Chromosomal Location 49218240-49219175 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to G at 49218575 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Arginine at position 112 (S112R)
Ref Sequence ENSEMBL: ENSMUSP00000150635 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000187509] [ENSMUST00000215671]
AlphaFold Q8VFA4
Predicted Effect possibly damaging
Transcript: ENSMUST00000187509
AA Change: S112R

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000140343
Gene: ENSMUSG00000101874
AA Change: S112R

DomainStartEndE-ValueType
Pfam:7tm_1 41 289 2.2e-29 PFAM
Pfam:7tm_4 139 282 6.1e-42 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000215671
AA Change: S112R

PolyPhen 2 Score 0.814 (Sensitivity: 0.84; Specificity: 0.93)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.5%
  • 20x: 93.0%
Validation Efficiency
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 79 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930447A16Rik G A 15: 37,425,952 (GRCm39) probably benign Het
Adam3 C T 8: 25,201,740 (GRCm39) G208R probably benign Het
Arsg G T 11: 109,424,898 (GRCm39) V290L probably benign Het
Cad A G 5: 31,232,034 (GRCm39) T104A probably benign Het
Ccdc180 A G 4: 45,928,020 (GRCm39) N1185S probably damaging Het
Cdh18 A G 15: 23,226,877 (GRCm39) T113A probably benign Het
Crocc2 G A 1: 93,133,618 (GRCm39) A967T probably damaging Het
Cyp4f16 A G 17: 32,764,080 (GRCm39) T291A probably benign Het
Dcc T A 18: 71,432,554 (GRCm39) H1300L probably benign Het
Ddx23 T A 15: 98,545,352 (GRCm39) probably null Het
Dnhd1 T G 7: 105,363,488 (GRCm39) S4017A probably damaging Het
Erbb4 A T 1: 68,293,703 (GRCm39) F729L probably damaging Het
Ercc6 G T 14: 32,296,886 (GRCm39) R1292L probably benign Het
Fam186b C T 15: 99,178,118 (GRCm39) V403M probably benign Het
Fam227a T C 15: 79,499,628 (GRCm39) N576D possibly damaging Het
Fbln1 A G 15: 85,111,167 (GRCm39) probably null Het
Fbxw17 T C 13: 50,579,669 (GRCm39) V162A probably benign Het
Gas2l1 A C 11: 5,014,436 (GRCm39) I8S probably damaging Het
Golgb1 T C 16: 36,711,781 (GRCm39) L195P probably damaging Het
Gps2 A T 11: 69,806,754 (GRCm39) H233L probably damaging Het
Guf1 T G 5: 69,721,852 (GRCm39) probably null Het
H2-T9 A G 17: 36,438,668 (GRCm39) L241S probably damaging Het
Il1rap T A 16: 26,519,988 (GRCm39) probably null Het
Ints14 A G 9: 64,871,800 (GRCm39) Y46C probably damaging Het
Kalrn T G 16: 34,177,339 (GRCm39) Q293H probably damaging Het
Kank2 A G 9: 21,687,043 (GRCm39) L593P probably damaging Het
Krt19 T C 11: 100,032,174 (GRCm39) T297A possibly damaging Het
Lcp1 T C 14: 75,437,848 (GRCm39) V86A probably damaging Het
Lins1 T A 7: 66,357,898 (GRCm39) I11K probably benign Het
Lrba T C 3: 86,683,448 (GRCm39) F2757L probably damaging Het
Lyst T C 13: 13,951,685 (GRCm39) I3762T probably benign Het
Lyzl6 A G 11: 103,525,851 (GRCm39) S90P possibly damaging Het
Mfsd2a T A 4: 122,853,175 (GRCm39) Q38L probably benign Het
Mtss1 A G 15: 58,815,922 (GRCm39) F546S probably damaging Het
Myo5a G A 9: 75,048,825 (GRCm39) probably null Het
Naip6 C A 13: 100,422,299 (GRCm39) G1245W probably damaging Het
Ndfip1 C T 18: 38,584,645 (GRCm39) T107I probably benign Het
Nek8 C T 11: 78,058,544 (GRCm39) probably null Het
Nphs1 T C 7: 30,159,854 (GRCm39) V55A probably damaging Het
Nrp2 C A 1: 62,758,240 (GRCm39) H75Q probably damaging Het
Oas1e C T 5: 120,933,448 (GRCm39) S39N probably damaging Het
Or13g1 T C 7: 85,956,166 (GRCm39) T52A probably benign Het
Or5d37 A G 2: 87,923,876 (GRCm39) F135L probably benign Het
Or7h8 A T 9: 20,124,049 (GRCm39) I135F probably damaging Het
Pan3 T A 5: 147,466,868 (GRCm39) H632Q probably damaging Het
Paqr3 A C 5: 97,243,842 (GRCm39) S291A probably benign Het
Pcdh17 A C 14: 84,685,375 (GRCm39) D614A probably damaging Het
Pcyox1l T C 18: 61,830,606 (GRCm39) E422G possibly damaging Het
Pgr G T 9: 8,900,844 (GRCm39) E126* probably null Het
Pik3ap1 A G 19: 41,290,936 (GRCm39) V532A possibly damaging Het
Pla2g4c T C 7: 13,071,738 (GRCm39) I186T probably damaging Het
Pnkd G A 1: 74,388,564 (GRCm39) probably null Het
Poc1a A G 9: 106,226,908 (GRCm39) T334A probably damaging Het
Pou2f2 T A 7: 24,797,111 (GRCm39) K211* probably null Het
Rdh13 T C 7: 4,445,652 (GRCm39) E94G probably benign Het
Rnf186 A G 4: 138,694,498 (GRCm39) S13G probably benign Het
Ryr2 T C 13: 11,670,584 (GRCm39) R3471G probably damaging Het
Sbf2 T C 7: 109,971,742 (GRCm39) T831A probably damaging Het
Sh3gl2 A G 4: 85,316,403 (GRCm39) probably benign Het
Shoc1 T C 4: 59,082,404 (GRCm39) N408S probably benign Het
Snn T C 16: 10,890,397 (GRCm39) V72A probably benign Het
Sys1 T A 2: 164,306,344 (GRCm39) H99Q possibly damaging Het
Syt7 A G 19: 10,412,931 (GRCm39) K122R probably damaging Het
Tas1r2 T A 4: 139,396,311 (GRCm39) L550Q probably damaging Het
Tent5b T C 4: 133,213,681 (GRCm39) L184P probably benign Het
Thoc1 T C 18: 9,993,438 (GRCm39) I599T probably damaging Het
Tle3 C T 9: 61,281,279 (GRCm39) probably benign Het
Tll1 A C 8: 64,538,507 (GRCm39) V379G possibly damaging Het
Tnfrsf21 G A 17: 43,348,621 (GRCm39) E78K probably benign Het
Tpgs2 A G 18: 25,262,897 (GRCm39) probably benign Het
Trpm1 T C 7: 63,858,054 (GRCm39) L165P probably damaging Het
Trpm5 T C 7: 142,633,956 (GRCm39) Y750C probably damaging Het
Ttbk2 A C 2: 120,570,551 (GRCm39) S1201A possibly damaging Het
Ust T A 10: 8,121,705 (GRCm39) H301L probably damaging Het
Vwa5a T C 9: 38,647,249 (GRCm39) F543L probably benign Het
Yeats2 T A 16: 19,971,645 (GRCm39) probably null Het
Zfp85 T C 13: 67,897,745 (GRCm39) Y109C probably damaging Het
Zfr2 T A 10: 81,079,547 (GRCm39) V362E probably benign Het
Znrf3 A T 11: 5,237,420 (GRCm39) C134S probably benign Het
Other mutations in Or2y1e
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01768:Or2y1e APN 11 49,218,958 (GRCm39) missense probably damaging 1.00
IGL02171:Or2y1e APN 11 49,218,862 (GRCm39) missense possibly damaging 0.69
IGL03184:Or2y1e APN 11 49,218,568 (GRCm39) missense probably damaging 0.97
R0471:Or2y1e UTSW 11 49,218,744 (GRCm39) missense probably damaging 1.00
R0613:Or2y1e UTSW 11 49,218,575 (GRCm39) missense possibly damaging 0.81
R0616:Or2y1e UTSW 11 49,218,583 (GRCm39) missense probably damaging 1.00
R0825:Or2y1e UTSW 11 49,218,509 (GRCm39) missense probably benign 0.00
R1613:Or2y1e UTSW 11 49,218,520 (GRCm39) missense probably damaging 1.00
R3429:Or2y1e UTSW 11 49,218,868 (GRCm39) missense probably benign 0.00
R3727:Or2y1e UTSW 11 49,218,622 (GRCm39) missense probably benign 0.01
R4256:Or2y1e UTSW 11 49,218,304 (GRCm39) missense probably benign 0.20
R4459:Or2y1e UTSW 11 49,218,703 (GRCm39) missense probably damaging 1.00
R4552:Or2y1e UTSW 11 49,218,777 (GRCm39) missense probably benign 0.00
R4881:Or2y1e UTSW 11 49,219,124 (GRCm39) missense probably benign 0.43
R5838:Or2y1e UTSW 11 49,218,760 (GRCm39) missense probably damaging 0.99
R6804:Or2y1e UTSW 11 49,218,808 (GRCm39) missense probably benign 0.16
R6809:Or2y1e UTSW 11 49,218,687 (GRCm39) missense probably benign 0.00
R7763:Or2y1e UTSW 11 49,218,498 (GRCm39) missense probably benign 0.00
R7765:Or2y1e UTSW 11 49,218,571 (GRCm39) missense probably damaging 1.00
R7783:Or2y1e UTSW 11 49,219,029 (GRCm39) missense probably benign 0.00
R9050:Or2y1e UTSW 11 49,218,930 (GRCm39) missense possibly damaging 0.55
Predicted Primers PCR Primer
(F):5'- GACATTCGATTGCACACCCC -3'
(R):5'- CTTGAGGAAGACAGGCATCTC -3'

Sequencing Primer
(F):5'- TCGATTGCACACCCCCATGTAC -3'
(R):5'- TGATTCAGTCGATACCTGCAGAG -3'
Posted On 2016-02-04