Incidental Mutation 'R4803:Tdrd9'
ID |
370498 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Tdrd9
|
Ensembl Gene |
ENSMUSG00000054003 |
Gene Name |
tudor domain containing 9 |
Synonyms |
4930441E05Rik |
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.192)
|
Stock # |
R4803 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
12 |
Chromosomal Location |
111937993-112035288 bp(+) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
A to T
at 111963269 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Lysine to Stop codon
at position 115
(K115*)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000079009]
|
AlphaFold |
Q14BI7 |
Predicted Effect |
probably null
Transcript: ENSMUST00000079009
AA Change: K274*
|
SMART Domains |
Protein: ENSMUSP00000078022 Gene: ENSMUSG00000054003 AA Change: K274*
Domain | Start | End | E-Value | Type |
low complexity region
|
29 |
40 |
N/A |
INTRINSIC |
low complexity region
|
70 |
81 |
N/A |
INTRINSIC |
DEXDc
|
132 |
327 |
5.64e-21 |
SMART |
HELICc
|
404 |
502 |
3.22e-16 |
SMART |
low complexity region
|
547 |
561 |
N/A |
INTRINSIC |
HA2
|
565 |
666 |
1.9e-20 |
SMART |
TUDOR
|
944 |
1003 |
1.52e-7 |
SMART |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000191808
AA Change: K115*
|
Predicted Effect |
probably null
Transcript: ENSMUST00000192125
AA Change: K115*
|
Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.6%
- 20x: 93.4%
|
Validation Efficiency |
|
MGI Phenotype |
PHENOTYPE: Male homozygous mice are sterile, displaying small testis, arrest of male meiosis and abnormal spermatocyte morphology. Females are fertile. [provided by MGI curators]
|
Allele List at MGI |
|
Other mutations in this stock |
Total: 78 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Alkbh2 |
C |
T |
5: 114,262,287 (GRCm39) |
E148K |
probably damaging |
Het |
Anxa8 |
T |
A |
14: 33,814,579 (GRCm39) |
|
probably null |
Het |
Ap4e1 |
A |
G |
2: 126,891,479 (GRCm39) |
I83M |
probably benign |
Het |
Arhgap44 |
G |
C |
11: 64,943,921 (GRCm39) |
P197A |
probably benign |
Het |
Asb1 |
T |
A |
1: 91,480,051 (GRCm39) |
V157E |
probably damaging |
Het |
B3gat1 |
T |
A |
9: 26,666,986 (GRCm39) |
Y73N |
probably benign |
Het |
Bmp8a |
G |
A |
4: 123,218,362 (GRCm39) |
T219I |
possibly damaging |
Het |
Cacna1c |
G |
A |
6: 118,728,502 (GRCm39) |
S285F |
probably damaging |
Het |
Cd163 |
A |
G |
6: 124,289,389 (GRCm39) |
D369G |
probably damaging |
Het |
Ckap2l |
C |
T |
2: 129,111,176 (GRCm39) |
G674R |
probably damaging |
Het |
Cog2 |
A |
G |
8: 125,262,190 (GRCm39) |
Y276C |
probably damaging |
Het |
Col16a1 |
A |
T |
4: 129,948,901 (GRCm39) |
|
probably benign |
Het |
Col5a1 |
G |
A |
2: 27,901,353 (GRCm39) |
G1282R |
unknown |
Het |
Cyp2c29 |
A |
T |
19: 39,313,439 (GRCm39) |
M351L |
probably benign |
Het |
Cyp4f15 |
T |
A |
17: 32,911,554 (GRCm39) |
D145E |
probably benign |
Het |
Defb48 |
T |
C |
14: 63,221,906 (GRCm39) |
Y4C |
unknown |
Het |
Dnaaf3 |
T |
C |
7: 4,529,903 (GRCm39) |
Q292R |
probably benign |
Het |
Dnah11 |
T |
C |
12: 118,091,343 (GRCm39) |
M930V |
possibly damaging |
Het |
Dnaja2 |
A |
T |
8: 86,280,029 (GRCm39) |
I50K |
probably damaging |
Het |
Dnm2 |
A |
G |
9: 21,385,925 (GRCm39) |
N316S |
probably damaging |
Het |
Dusp12 |
A |
G |
1: 170,708,175 (GRCm39) |
Y181H |
possibly damaging |
Het |
Efemp1 |
T |
G |
11: 28,871,795 (GRCm39) |
F437V |
possibly damaging |
Het |
Eps8l3 |
T |
A |
3: 107,798,325 (GRCm39) |
V464D |
probably damaging |
Het |
Fat2 |
A |
T |
11: 55,175,886 (GRCm39) |
L1609Q |
probably benign |
Het |
Fbxw24 |
C |
T |
9: 109,453,910 (GRCm39) |
V79I |
probably benign |
Het |
Fgl2 |
A |
T |
5: 21,580,918 (GRCm39) |
Q420L |
probably benign |
Het |
Filip1 |
T |
C |
9: 79,727,396 (GRCm39) |
K408E |
probably benign |
Het |
Fkbp9 |
A |
C |
6: 56,852,692 (GRCm39) |
I471L |
probably benign |
Het |
Fndc1 |
A |
T |
17: 7,972,538 (GRCm39) |
S1465T |
probably damaging |
Het |
Fry |
A |
T |
5: 150,322,998 (GRCm39) |
T1050S |
probably benign |
Het |
Gm12258 |
G |
A |
11: 58,749,856 (GRCm39) |
V344I |
probably benign |
Het |
Gtf3c1 |
A |
G |
7: 125,262,712 (GRCm39) |
V1049A |
probably damaging |
Het |
Ireb2 |
A |
G |
9: 54,814,098 (GRCm39) |
E829G |
probably benign |
Het |
Itih5 |
G |
A |
2: 10,245,392 (GRCm39) |
V494I |
probably benign |
Het |
Krt75 |
A |
T |
15: 101,476,507 (GRCm39) |
D419E |
probably benign |
Het |
Lama1 |
T |
C |
17: 68,116,266 (GRCm39) |
S2378P |
probably damaging |
Het |
Lcorl |
T |
A |
5: 45,904,623 (GRCm39) |
|
probably null |
Het |
Man2a1 |
A |
T |
17: 64,966,004 (GRCm39) |
H314L |
probably damaging |
Het |
Mthfd1l |
T |
A |
10: 3,957,840 (GRCm39) |
H292Q |
possibly damaging |
Het |
Ocm |
A |
T |
5: 143,960,686 (GRCm39) |
M87K |
possibly damaging |
Het |
Oplah |
A |
G |
15: 76,186,968 (GRCm39) |
Y616H |
probably damaging |
Het |
Or4s2b |
A |
T |
2: 88,508,366 (GRCm39) |
S56C |
probably benign |
Het |
Or52e4 |
A |
C |
7: 104,705,863 (GRCm39) |
I137L |
probably benign |
Het |
Or5b99 |
T |
C |
19: 12,976,533 (GRCm39) |
L61P |
probably damaging |
Het |
Or5p58 |
A |
C |
7: 107,694,666 (GRCm39) |
I37S |
probably damaging |
Het |
Or8c13 |
C |
A |
9: 38,091,546 (GRCm39) |
S191I |
probably damaging |
Het |
Or8g32 |
A |
G |
9: 39,305,932 (GRCm39) |
T282A |
probably benign |
Het |
Pde3a |
G |
A |
6: 141,404,812 (GRCm39) |
V346M |
probably damaging |
Het |
Pdlim1 |
T |
A |
19: 40,231,892 (GRCm39) |
E162V |
possibly damaging |
Het |
Pdzd2 |
C |
G |
15: 12,374,681 (GRCm39) |
S1818T |
probably benign |
Het |
Phf24 |
G |
A |
4: 42,933,731 (GRCm39) |
G38S |
probably damaging |
Het |
Plekhg1 |
T |
C |
10: 3,907,186 (GRCm39) |
V701A |
probably benign |
Het |
Ppard |
C |
G |
17: 28,505,348 (GRCm39) |
R12G |
unknown |
Het |
Ptprz1 |
A |
G |
6: 23,001,545 (GRCm39) |
S1212G |
probably benign |
Het |
Rab3il1 |
C |
A |
19: 10,004,808 (GRCm39) |
Q110K |
possibly damaging |
Het |
Rin3 |
A |
T |
12: 102,327,642 (GRCm39) |
|
probably benign |
Het |
Rps6kb2 |
T |
A |
19: 4,208,677 (GRCm39) |
K280* |
probably null |
Het |
Slc27a6 |
G |
T |
18: 58,705,105 (GRCm39) |
L162F |
possibly damaging |
Het |
Slc6a19 |
T |
A |
13: 73,832,161 (GRCm39) |
I472F |
possibly damaging |
Het |
Spatc1l |
G |
A |
10: 76,405,206 (GRCm39) |
R196Q |
probably damaging |
Het |
Srp72 |
T |
C |
5: 77,132,231 (GRCm39) |
I273T |
probably damaging |
Het |
St8sia1 |
C |
A |
6: 142,813,649 (GRCm39) |
S171I |
probably benign |
Het |
Tas2r136 |
T |
C |
6: 132,754,455 (GRCm39) |
H224R |
probably damaging |
Het |
Tas2r140 |
A |
G |
6: 133,032,743 (GRCm39) |
V5A |
possibly damaging |
Het |
Tbce |
C |
T |
13: 14,194,446 (GRCm39) |
R71H |
probably damaging |
Het |
Thada |
T |
A |
17: 84,580,245 (GRCm39) |
H1403L |
probably damaging |
Het |
Thap1 |
AGCAGCATCTGCTCG |
AG |
8: 26,650,882 (GRCm39) |
|
probably null |
Het |
Timm44 |
A |
G |
8: 4,317,932 (GRCm39) |
S159P |
probably damaging |
Het |
Tlk2 |
T |
A |
11: 105,171,926 (GRCm39) |
C699S |
probably damaging |
Het |
Tmem178b |
A |
G |
6: 39,981,160 (GRCm39) |
K65R |
probably damaging |
Het |
Ttc28 |
T |
C |
5: 111,425,329 (GRCm39) |
V1718A |
possibly damaging |
Het |
Ttc6 |
T |
G |
12: 57,775,291 (GRCm39) |
C1662W |
probably damaging |
Het |
Ube2frt |
T |
A |
12: 36,140,729 (GRCm39) |
|
probably benign |
Het |
Unc13a |
C |
A |
8: 72,115,494 (GRCm39) |
|
probably null |
Het |
Vip |
A |
T |
10: 5,594,099 (GRCm39) |
I151F |
probably damaging |
Het |
Vps16 |
C |
T |
2: 130,280,030 (GRCm39) |
P85L |
probably benign |
Het |
Wdsub1 |
T |
C |
2: 59,700,743 (GRCm39) |
|
probably benign |
Het |
Zc3h12c |
T |
C |
9: 52,027,853 (GRCm39) |
D503G |
probably damaging |
Het |
|
Other mutations in Tdrd9 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01339:Tdrd9
|
APN |
12 |
112,006,868 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01373:Tdrd9
|
APN |
12 |
112,006,868 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01542:Tdrd9
|
APN |
12 |
112,013,423 (GRCm39) |
missense |
possibly damaging |
0.94 |
IGL02967:Tdrd9
|
APN |
12 |
111,958,922 (GRCm39) |
missense |
possibly damaging |
0.50 |
IGL03063:Tdrd9
|
APN |
12 |
112,010,733 (GRCm39) |
missense |
probably benign |
0.00 |
IGL03107:Tdrd9
|
APN |
12 |
112,009,274 (GRCm39) |
missense |
probably damaging |
0.98 |
R0433:Tdrd9
|
UTSW |
12 |
111,992,015 (GRCm39) |
nonsense |
probably null |
|
R0453:Tdrd9
|
UTSW |
12 |
112,034,673 (GRCm39) |
missense |
probably benign |
|
R0655:Tdrd9
|
UTSW |
12 |
112,006,899 (GRCm39) |
missense |
probably damaging |
1.00 |
R0666:Tdrd9
|
UTSW |
12 |
111,974,014 (GRCm39) |
intron |
probably benign |
|
R1073:Tdrd9
|
UTSW |
12 |
111,989,693 (GRCm39) |
missense |
probably damaging |
1.00 |
R1280:Tdrd9
|
UTSW |
12 |
112,005,842 (GRCm39) |
missense |
probably damaging |
1.00 |
R1386:Tdrd9
|
UTSW |
12 |
112,011,238 (GRCm39) |
missense |
probably benign |
0.21 |
R1521:Tdrd9
|
UTSW |
12 |
112,002,844 (GRCm39) |
missense |
probably damaging |
1.00 |
R1601:Tdrd9
|
UTSW |
12 |
111,989,687 (GRCm39) |
nonsense |
probably null |
|
R1651:Tdrd9
|
UTSW |
12 |
111,991,140 (GRCm39) |
missense |
probably damaging |
0.97 |
R1715:Tdrd9
|
UTSW |
12 |
112,002,873 (GRCm39) |
missense |
possibly damaging |
0.62 |
R1854:Tdrd9
|
UTSW |
12 |
112,011,246 (GRCm39) |
missense |
probably damaging |
1.00 |
R1905:Tdrd9
|
UTSW |
12 |
112,030,061 (GRCm39) |
splice site |
probably benign |
|
R2386:Tdrd9
|
UTSW |
12 |
111,982,334 (GRCm39) |
missense |
probably damaging |
1.00 |
R2863:Tdrd9
|
UTSW |
12 |
111,997,695 (GRCm39) |
missense |
probably benign |
|
R2915:Tdrd9
|
UTSW |
12 |
112,006,895 (GRCm39) |
missense |
probably damaging |
1.00 |
R2958:Tdrd9
|
UTSW |
12 |
112,008,106 (GRCm39) |
missense |
probably damaging |
0.97 |
R4033:Tdrd9
|
UTSW |
12 |
111,958,973 (GRCm39) |
missense |
possibly damaging |
0.58 |
R4087:Tdrd9
|
UTSW |
12 |
111,979,920 (GRCm39) |
nonsense |
probably null |
|
R4237:Tdrd9
|
UTSW |
12 |
112,034,059 (GRCm39) |
nonsense |
probably null |
|
R4482:Tdrd9
|
UTSW |
12 |
111,980,935 (GRCm39) |
critical splice donor site |
probably null |
|
R4501:Tdrd9
|
UTSW |
12 |
112,009,243 (GRCm39) |
missense |
probably benign |
0.00 |
R4502:Tdrd9
|
UTSW |
12 |
111,960,259 (GRCm39) |
missense |
probably damaging |
1.00 |
R4715:Tdrd9
|
UTSW |
12 |
112,008,123 (GRCm39) |
missense |
probably benign |
0.00 |
R5218:Tdrd9
|
UTSW |
12 |
112,029,909 (GRCm39) |
intron |
probably benign |
|
R5275:Tdrd9
|
UTSW |
12 |
112,018,346 (GRCm39) |
nonsense |
probably null |
|
R5295:Tdrd9
|
UTSW |
12 |
112,018,346 (GRCm39) |
nonsense |
probably null |
|
R5301:Tdrd9
|
UTSW |
12 |
112,002,963 (GRCm39) |
critical splice donor site |
probably null |
|
R5339:Tdrd9
|
UTSW |
12 |
111,993,556 (GRCm39) |
missense |
probably damaging |
1.00 |
R5500:Tdrd9
|
UTSW |
12 |
111,989,702 (GRCm39) |
missense |
probably benign |
0.02 |
R5573:Tdrd9
|
UTSW |
12 |
111,964,336 (GRCm39) |
splice site |
probably null |
|
R5590:Tdrd9
|
UTSW |
12 |
112,018,414 (GRCm39) |
missense |
probably benign |
0.01 |
R5891:Tdrd9
|
UTSW |
12 |
112,009,153 (GRCm39) |
missense |
probably damaging |
1.00 |
R6056:Tdrd9
|
UTSW |
12 |
111,951,475 (GRCm39) |
missense |
probably damaging |
1.00 |
R6057:Tdrd9
|
UTSW |
12 |
111,979,720 (GRCm39) |
missense |
possibly damaging |
0.85 |
R6125:Tdrd9
|
UTSW |
12 |
112,034,632 (GRCm39) |
missense |
possibly damaging |
0.89 |
R6254:Tdrd9
|
UTSW |
12 |
111,992,334 (GRCm39) |
splice site |
probably null |
|
R6335:Tdrd9
|
UTSW |
12 |
112,008,186 (GRCm39) |
critical splice donor site |
probably null |
|
R6345:Tdrd9
|
UTSW |
12 |
112,001,042 (GRCm39) |
missense |
probably damaging |
0.99 |
R6792:Tdrd9
|
UTSW |
12 |
111,993,547 (GRCm39) |
missense |
probably benign |
0.01 |
R6956:Tdrd9
|
UTSW |
12 |
112,002,788 (GRCm39) |
splice site |
probably benign |
|
R6987:Tdrd9
|
UTSW |
12 |
111,992,027 (GRCm39) |
missense |
possibly damaging |
0.82 |
R7090:Tdrd9
|
UTSW |
12 |
111,958,904 (GRCm39) |
missense |
probably benign |
|
R7158:Tdrd9
|
UTSW |
12 |
112,002,800 (GRCm39) |
missense |
probably benign |
0.08 |
R7220:Tdrd9
|
UTSW |
12 |
111,980,888 (GRCm39) |
missense |
probably damaging |
1.00 |
R7478:Tdrd9
|
UTSW |
12 |
111,951,476 (GRCm39) |
missense |
probably damaging |
1.00 |
R7489:Tdrd9
|
UTSW |
12 |
112,034,071 (GRCm39) |
missense |
probably benign |
0.00 |
R7751:Tdrd9
|
UTSW |
12 |
111,958,982 (GRCm39) |
missense |
probably benign |
0.09 |
R7809:Tdrd9
|
UTSW |
12 |
111,999,155 (GRCm39) |
missense |
probably damaging |
0.99 |
R7844:Tdrd9
|
UTSW |
12 |
111,964,386 (GRCm39) |
missense |
possibly damaging |
0.63 |
R7854:Tdrd9
|
UTSW |
12 |
112,013,395 (GRCm39) |
missense |
probably benign |
0.00 |
R7903:Tdrd9
|
UTSW |
12 |
112,018,410 (GRCm39) |
missense |
possibly damaging |
0.95 |
R7938:Tdrd9
|
UTSW |
12 |
111,997,649 (GRCm39) |
missense |
possibly damaging |
0.86 |
R8018:Tdrd9
|
UTSW |
12 |
112,010,822 (GRCm39) |
missense |
probably damaging |
0.99 |
R8018:Tdrd9
|
UTSW |
12 |
111,999,180 (GRCm39) |
missense |
probably benign |
0.12 |
R8090:Tdrd9
|
UTSW |
12 |
111,982,369 (GRCm39) |
missense |
probably damaging |
1.00 |
R8157:Tdrd9
|
UTSW |
12 |
111,951,500 (GRCm39) |
missense |
probably benign |
0.44 |
R8198:Tdrd9
|
UTSW |
12 |
112,006,863 (GRCm39) |
missense |
probably damaging |
1.00 |
R8203:Tdrd9
|
UTSW |
12 |
111,992,064 (GRCm39) |
missense |
probably damaging |
1.00 |
R8512:Tdrd9
|
UTSW |
12 |
112,012,627 (GRCm39) |
missense |
probably benign |
|
R8721:Tdrd9
|
UTSW |
12 |
112,002,889 (GRCm39) |
missense |
probably damaging |
1.00 |
R8889:Tdrd9
|
UTSW |
12 |
111,979,718 (GRCm39) |
missense |
probably benign |
0.07 |
R8892:Tdrd9
|
UTSW |
12 |
111,979,718 (GRCm39) |
missense |
probably benign |
0.07 |
R9276:Tdrd9
|
UTSW |
12 |
111,980,935 (GRCm39) |
critical splice donor site |
probably null |
|
R9459:Tdrd9
|
UTSW |
12 |
111,992,007 (GRCm39) |
missense |
probably damaging |
1.00 |
R9484:Tdrd9
|
UTSW |
12 |
112,012,684 (GRCm39) |
missense |
probably damaging |
0.97 |
R9657:Tdrd9
|
UTSW |
12 |
112,002,824 (GRCm39) |
missense |
possibly damaging |
0.50 |
R9745:Tdrd9
|
UTSW |
12 |
112,009,130 (GRCm39) |
missense |
probably damaging |
0.99 |
X0018:Tdrd9
|
UTSW |
12 |
112,005,763 (GRCm39) |
missense |
probably benign |
0.24 |
Z1177:Tdrd9
|
UTSW |
12 |
111,982,355 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1177:Tdrd9
|
UTSW |
12 |
111,960,325 (GRCm39) |
missense |
probably damaging |
0.96 |
Z1177:Tdrd9
|
UTSW |
12 |
111,938,088 (GRCm39) |
missense |
probably benign |
0.08 |
|
Predicted Primers |
PCR Primer
(F):5'- TCTGATGCTGCAGTTACAGAC -3'
(R):5'- TCTGACCATAGAGTCCAAGATACTG -3'
Sequencing Primer
(F):5'- AGACCCACTGTGCTTACCTGG -3'
(R):5'- ACTCTAGCTATAGATCAGGCTGGC -3'
|
Posted On |
2016-02-04 |