Incidental Mutation 'R4810:Larp4b'
ID 371026
Institutional Source Beutler Lab
Gene Symbol Larp4b
Ensembl Gene ENSMUSG00000033499
Gene Name La ribonucleoprotein 4B
Synonyms Larp5, D13Wsu64e
MMRRC Submission 042429-MU
Accession Numbers
Essential gene? Probably essential (E-score: 0.762) question?
Stock # R4810 (G1)
Quality Score 225
Status Not validated
Chromosome 13
Chromosomal Location 9143917-9224487 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 9208627 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 427 (T427A)
Ref Sequence ENSEMBL: ENSMUSP00000139578 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000091829] [ENSMUST00000188211] [ENSMUST00000188939]
AlphaFold Q6A0A2
Predicted Effect probably benign
Transcript: ENSMUST00000091829
SMART Domains Protein: ENSMUSP00000089437
Gene: ENSMUSG00000033499

DomainStartEndE-ValueType
LA 156 234 3.25e-36 SMART
RRM 239 309 6.25e-2 SMART
low complexity region 510 529 N/A INTRINSIC
low complexity region 586 597 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000188211
AA Change: T427A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000140993
Gene: ENSMUSG00000033499
AA Change: T427A

DomainStartEndE-ValueType
LA 156 234 3.25e-36 SMART
RRM 239 309 6.25e-2 SMART
low complexity region 510 529 N/A INTRINSIC
low complexity region 586 597 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000188939
AA Change: T427A

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000139578
Gene: ENSMUSG00000033499
AA Change: T427A

DomainStartEndE-ValueType
LA 156 234 3.25e-36 SMART
RRM 239 309 6.25e-2 SMART
low complexity region 510 529 N/A INTRINSIC
Coding Region Coverage
  • 1x: 99.2%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.1%
Validation Efficiency 99% (93/94)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of an evolutionarily conserved protein family implicated in RNA metabolism and translation. Members of this family are characterized by the presence of an La motif, which is often located adjacent to one or more RNA recognition motifs (RRM). Together, the two motifs constitute the functional region of the protein and enable its interaction with the RNA substrate. This protein family is divided into five sub-families: the genuine La proteins and four La-related protein (LARP) sub-families. The protein encoded by this gene belongs to LARP sub-family 4. It is a cytoplasmic protein that may play a stimulatory role in translation. [provided by RefSeq, Oct 2012]
Allele List at MGI
Other mutations in this stock
Total: 89 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2700049A03Rik T C 12: 71,236,216 (GRCm39) V1189A possibly damaging Het
A3galt2 T C 4: 128,649,356 (GRCm39) probably null Het
Abca12 T C 1: 71,342,771 (GRCm39) D903G probably benign Het
Abcc12 T C 8: 87,287,471 (GRCm39) M125V probably damaging Het
Adad1 A G 3: 37,146,183 (GRCm39) N517S probably damaging Het
Ankrd44 A G 1: 54,774,302 (GRCm39) probably benign Het
Armc7 A G 11: 115,379,787 (GRCm39) I162V probably benign Het
Art3 T A 5: 92,562,108 (GRCm39) V343D possibly damaging Het
Bcl9l A G 9: 44,419,650 (GRCm39) T1106A probably damaging Het
Ccdc141 T C 2: 76,876,099 (GRCm39) N644D possibly damaging Het
Ccdc154 T C 17: 25,382,472 (GRCm39) L98S probably damaging Het
Ccne1 A G 7: 37,799,018 (GRCm39) W237R probably damaging Het
Cd33 T C 7: 43,182,134 (GRCm39) I104V probably damaging Het
Ceacam1 A T 7: 25,173,945 (GRCm39) *237K probably null Het
Ces1e T A 8: 93,935,259 (GRCm39) I398F probably benign Het
Cfap44 T C 16: 44,271,898 (GRCm39) I1217T probably damaging Het
Clns1a T C 7: 97,363,224 (GRCm39) S199P probably benign Het
Cntn4 C A 6: 106,632,572 (GRCm39) T532K probably benign Het
Col11a2 C T 17: 34,276,086 (GRCm39) S470L probably damaging Het
Cst5 A T 2: 149,247,463 (GRCm39) R60* probably null Het
Cxcr6 A T 9: 123,639,227 (GRCm39) D83V probably damaging Het
Dis3l2 T C 1: 86,975,296 (GRCm39) V774A probably damaging Het
Dusp15 A G 2: 152,787,374 (GRCm39) L79P probably damaging Het
Elapor1 T A 3: 108,377,327 (GRCm39) probably benign Het
Eml6 A T 11: 29,705,011 (GRCm39) V1511E possibly damaging Het
Epha5 C T 5: 84,253,750 (GRCm39) D548N possibly damaging Het
Fam227b A G 2: 125,829,859 (GRCm39) F450L probably benign Het
Fam91a1 T A 15: 58,306,589 (GRCm39) L452Q probably damaging Het
Fbxo44 T C 4: 148,240,903 (GRCm39) Y199C probably damaging Het
Fgd3 A G 13: 49,443,126 (GRCm39) S149P probably benign Het
Gabra4 T C 5: 71,781,325 (GRCm39) E362G probably damaging Het
Galnt14 T C 17: 73,819,116 (GRCm39) I325V probably damaging Het
Gas2l3 CACTCGTCATACT CACT 10: 89,266,820 (GRCm39) probably benign Het
Gm10088 G T 16: 18,847,081 (GRCm39) noncoding transcript Het
Grik5 T C 7: 24,714,922 (GRCm39) N691D probably damaging Het
Grm1 C G 10: 10,658,438 (GRCm39) D351H probably damaging Het
Grm8 T C 6: 27,761,295 (GRCm39) S310G possibly damaging Het
Gtf2h2 A G 13: 100,617,510 (GRCm39) probably null Het
Hhex G T 19: 37,428,103 (GRCm39) L49F probably damaging Het
Hkdc1 T A 10: 62,247,304 (GRCm39) R159S probably benign Het
Iqcm A G 8: 76,615,281 (GRCm39) Y454C probably damaging Het
Kcnh8 G A 17: 53,212,248 (GRCm39) probably null Het
Mtmr3 A T 11: 4,448,046 (GRCm39) N297K probably benign Het
Nek8 G A 11: 78,058,629 (GRCm39) T557I probably benign Het
Nlrp9c A C 7: 26,077,602 (GRCm39) probably null Het
Nmrk1 T A 19: 18,617,273 (GRCm39) D48E probably benign Het
Npepps G A 11: 97,131,759 (GRCm39) T365I probably damaging Het
Obscn G A 11: 58,922,417 (GRCm39) T5921M possibly damaging Het
Or8b44 C A 9: 38,410,620 (GRCm39) Y218* probably null Het
Or8c9 A G 9: 38,241,690 (GRCm39) E269G probably benign Het
Otud7b C T 3: 96,043,918 (GRCm39) A23V probably damaging Het
Pcdhga9 G A 18: 37,871,601 (GRCm39) A477T possibly damaging Het
Plekha7 A T 7: 115,744,173 (GRCm39) I663N probably damaging Het
Plscr1l1 A G 9: 92,236,683 (GRCm39) D190G probably damaging Het
Polk A T 13: 96,620,003 (GRCm39) S732R possibly damaging Het
Ppfia2 A G 10: 106,751,551 (GRCm39) I1166V probably benign Het
Ppp2r5a C T 1: 191,088,589 (GRCm39) probably benign Het
Prkaa2 T C 4: 104,897,011 (GRCm39) K401E probably damaging Het
Ptpn23 A G 9: 110,218,204 (GRCm39) Y611H possibly damaging Het
Rab31 C T 17: 66,028,998 (GRCm39) probably null Het
Rad51ap2 T A 12: 11,507,406 (GRCm39) C443S probably damaging Het
Ralgapa1 A G 12: 55,841,778 (GRCm39) probably null Het
Rev3l T C 10: 39,699,721 (GRCm39) L1406P probably benign Het
Rnaset2b T A 17: 7,259,167 (GRCm39) D48E probably benign Het
Rnf13 G T 3: 57,703,693 (GRCm39) M105I probably damaging Het
Rnf150 T C 8: 83,716,991 (GRCm39) V166A possibly damaging Het
Rps6kc1 C A 1: 190,541,160 (GRCm39) R381L probably damaging Het
Rspo2 C T 15: 43,033,216 (GRCm39) R2H probably benign Het
Septin8 A G 11: 53,425,416 (GRCm39) D103G probably damaging Het
Sirt4 A G 5: 115,618,508 (GRCm39) W189R probably damaging Het
Slco6d1 T C 1: 98,350,979 (GRCm39) V110A possibly damaging Het
Sncaip C A 18: 53,040,271 (GRCm39) Q822K possibly damaging Het
Spg11 A C 2: 121,890,277 (GRCm39) F2070V probably damaging Het
Sptb A T 12: 76,669,971 (GRCm39) Y452* probably null Het
Srsf4 C T 4: 131,627,413 (GRCm39) probably benign Het
Tead1 C A 7: 112,441,073 (GRCm39) probably null Het
Tmem156 G T 5: 65,248,790 (GRCm39) probably benign Het
Tmem169 A G 1: 72,337,311 (GRCm39) D82G probably benign Het
Tmem260 A G 14: 48,709,930 (GRCm39) E51G probably damaging Het
Trim36 G T 18: 46,305,536 (GRCm39) N470K probably benign Het
Trps1 T A 15: 50,685,692 (GRCm39) T158S probably benign Het
Ube2c A G 2: 164,614,482 (GRCm39) *180W probably null Het
Ube2i T C 17: 25,484,121 (GRCm39) D45G probably benign Het
Uggt2 A C 14: 119,250,933 (GRCm39) L1188R probably damaging Het
Uroc1 T C 6: 90,340,135 (GRCm39) I680T probably damaging Het
Vmn2r2 T A 3: 64,044,883 (GRCm39) M88L probably damaging Het
Zfp248 G A 6: 118,406,807 (GRCm39) R261C possibly damaging Het
Zfp418 G T 7: 7,185,846 (GRCm39) R603L possibly damaging Het
Zmpste24 T A 4: 120,918,251 (GRCm39) Y457F probably damaging Het
Other mutations in Larp4b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01746:Larp4b APN 13 9,208,160 (GRCm39) missense probably damaging 0.99
IGL02519:Larp4b APN 13 9,208,616 (GRCm39) missense probably benign 0.04
IGL02609:Larp4b APN 13 9,220,716 (GRCm39) missense probably damaging 1.00
R0116:Larp4b UTSW 13 9,220,724 (GRCm39) missense probably damaging 1.00
R0390:Larp4b UTSW 13 9,208,143 (GRCm39) splice site probably null
R0585:Larp4b UTSW 13 9,220,737 (GRCm39) missense probably benign 0.08
R0585:Larp4b UTSW 13 9,197,529 (GRCm39) missense probably damaging 1.00
R0751:Larp4b UTSW 13 9,216,345 (GRCm39) splice site probably benign
R1184:Larp4b UTSW 13 9,216,345 (GRCm39) splice site probably benign
R1202:Larp4b UTSW 13 9,216,362 (GRCm39) missense possibly damaging 0.84
R1525:Larp4b UTSW 13 9,195,486 (GRCm39) missense probably damaging 1.00
R1599:Larp4b UTSW 13 9,172,186 (GRCm39) missense probably damaging 1.00
R1637:Larp4b UTSW 13 9,201,133 (GRCm39) missense probably benign 0.12
R1833:Larp4b UTSW 13 9,201,235 (GRCm39) missense possibly damaging 0.89
R1852:Larp4b UTSW 13 9,187,339 (GRCm39) critical splice donor site probably null
R1962:Larp4b UTSW 13 9,186,878 (GRCm39) missense probably benign
R2359:Larp4b UTSW 13 9,208,199 (GRCm39) missense probably damaging 0.97
R2973:Larp4b UTSW 13 9,216,347 (GRCm39) splice site probably benign
R3803:Larp4b UTSW 13 9,208,590 (GRCm39) missense probably benign 0.03
R4828:Larp4b UTSW 13 9,220,934 (GRCm39) missense probably damaging 1.00
R5135:Larp4b UTSW 13 9,220,773 (GRCm39) missense probably damaging 1.00
R5250:Larp4b UTSW 13 9,221,013 (GRCm39) utr 3 prime probably benign
R5259:Larp4b UTSW 13 9,208,220 (GRCm39) missense probably damaging 0.98
R5379:Larp4b UTSW 13 9,186,945 (GRCm39) missense probably benign 0.17
R5436:Larp4b UTSW 13 9,218,936 (GRCm39) missense possibly damaging 0.93
R5616:Larp4b UTSW 13 9,208,695 (GRCm39) missense probably damaging 0.98
R5774:Larp4b UTSW 13 9,220,679 (GRCm39) splice site probably null
R5818:Larp4b UTSW 13 9,208,596 (GRCm39) missense probably benign
R6007:Larp4b UTSW 13 9,218,793 (GRCm39) missense probably benign 0.13
R6248:Larp4b UTSW 13 9,208,738 (GRCm39) missense probably benign 0.01
R6452:Larp4b UTSW 13 9,197,503 (GRCm39) missense probably damaging 0.98
R6501:Larp4b UTSW 13 9,218,829 (GRCm39) missense probably damaging 1.00
R7324:Larp4b UTSW 13 9,208,616 (GRCm39) missense probably benign 0.04
R7689:Larp4b UTSW 13 9,186,834 (GRCm39) missense probably damaging 1.00
R7737:Larp4b UTSW 13 9,220,679 (GRCm39) splice site probably null
R7955:Larp4b UTSW 13 9,186,816 (GRCm39) missense probably benign 0.00
R8877:Larp4b UTSW 13 9,193,835 (GRCm39) missense probably benign 0.04
R8975:Larp4b UTSW 13 9,195,537 (GRCm39) missense probably damaging 1.00
R9147:Larp4b UTSW 13 9,186,819 (GRCm39) missense possibly damaging 0.51
R9191:Larp4b UTSW 13 9,220,830 (GRCm39) missense probably benign 0.32
R9361:Larp4b UTSW 13 9,199,937 (GRCm39) missense probably damaging 1.00
RF017:Larp4b UTSW 13 9,173,946 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- CAATGGATGCCAGCAGTGAG -3'
(R):5'- CCAGGAGAGGATTCAAGACTAC -3'

Sequencing Primer
(F):5'- CTCCTCAGAGAAGGCTTTGG -3'
(R):5'- GACTACTTGGCTCCACACG -3'
Posted On 2016-02-04