Incidental Mutation 'R4291:Brpf3'
ID 371076
Institutional Source Beutler Lab
Gene Symbol Brpf3
Ensembl Gene ENSMUSG00000063952
Gene Name bromodomain and PHD finger containing, 3
Synonyms
MMRRC Submission 041081-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.459) question?
Stock # R4291 (G1)
Quality Score 225
Status Validated
Chromosome 17
Chromosomal Location 29020088-29057763 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 29042949 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Methionine at position 997 (V997M)
Ref Sequence ENSEMBL: ENSMUSP00000004985 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000004985]
AlphaFold B2KF05
Predicted Effect probably benign
Transcript: ENSMUST00000004985
AA Change: V997M

PolyPhen 2 Score 0.001 (Sensitivity: 0.99; Specificity: 0.15)
SMART Domains Protein: ENSMUSP00000004985
Gene: ENSMUSG00000063952
AA Change: V997M

DomainStartEndE-ValueType
Pfam:EPL1 48 194 8.4e-38 PFAM
PHD 214 260 7.07e-5 SMART
PHD 324 387 4.74e-6 SMART
low complexity region 405 436 N/A INTRINSIC
Blast:BROMO 491 534 7e-21 BLAST
low complexity region 558 577 N/A INTRINSIC
BROMO 586 694 4.93e-39 SMART
low complexity region 777 792 N/A INTRINSIC
low complexity region 813 823 N/A INTRINSIC
PWWP 1073 1156 2.07e-38 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000127007
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140587
Predicted Effect noncoding transcript
Transcript: ENSMUST00000140973
Predicted Effect noncoding transcript
Transcript: ENSMUST00000144022
Predicted Effect noncoding transcript
Transcript: ENSMUST00000156029
Meta Mutation Damage Score 0.0898 question?
Coding Region Coverage
  • 1x: 99.3%
  • 3x: 98.7%
  • 10x: 97.6%
  • 20x: 96.0%
Validation Efficiency 100% (62/62)
MGI Phenotype PHENOTYPE: Homozygous knockout does not result in any obvious neurological, behavioral, developmental, histological, hematological, survival or reproductive phenotype. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acad9 T C 3: 36,120,337 (GRCm39) F27S probably benign Het
AK157302 T A 13: 21,679,715 (GRCm39) D80E probably damaging Het
Amz2 T C 11: 109,324,881 (GRCm39) probably null Het
Angel1 A G 12: 86,767,057 (GRCm39) Y440H probably damaging Het
Ankrd34c T A 9: 89,611,817 (GRCm39) K175* probably null Het
Arid1b C A 17: 5,090,938 (GRCm39) S546R probably damaging Het
Atf6b T A 17: 34,871,648 (GRCm39) M428K probably benign Het
Cckar A G 5: 53,863,839 (GRCm39) S41P probably benign Het
Cd96 T A 16: 45,892,112 (GRCm39) Q292L probably damaging Het
Cdh18 C A 15: 22,714,637 (GRCm39) probably benign Het
Cfb T G 17: 35,080,114 (GRCm39) D122A possibly damaging Het
Copa G T 1: 171,919,964 (GRCm39) probably benign Het
Ctnna2 T A 6: 76,859,728 (GRCm39) K854N probably damaging Het
Cwh43 G A 5: 73,569,275 (GRCm39) V106M probably benign Het
Dact2 C T 17: 14,416,833 (GRCm39) E456K probably benign Het
Dnah8 T C 17: 30,967,533 (GRCm39) S2582P probably benign Het
Eef2 A G 10: 81,015,414 (GRCm39) T312A probably benign Het
Enpep T A 3: 129,063,966 (GRCm39) R934* probably null Het
Fam240b A T 13: 64,629,627 (GRCm39) M63K possibly damaging Het
Fhdc1 C A 3: 84,352,133 (GRCm39) V1031F probably benign Het
Gm6124 A T 7: 38,872,195 (GRCm39) noncoding transcript Het
Gsn G A 2: 35,180,432 (GRCm39) V147I probably benign Het
Gucy1a1 A T 3: 82,002,066 (GRCm39) F671Y possibly damaging Het
Hectd3 A G 4: 116,852,889 (GRCm39) E97G probably damaging Het
Kcnv1 G A 15: 44,977,840 (GRCm39) T66M probably damaging Het
Krba1 C T 6: 48,392,599 (GRCm39) P802S possibly damaging Het
Lca5l C T 16: 95,979,974 (GRCm39) S52N probably damaging Het
Lmf1 T C 17: 25,873,455 (GRCm39) L320P probably damaging Het
Map3k4 G T 17: 12,474,147 (GRCm39) Q845K probably benign Het
Mapkapk3 T C 9: 107,136,131 (GRCm39) probably benign Het
Mccc1 A G 3: 36,044,217 (GRCm39) V203A probably damaging Het
Mcm9 C A 10: 53,423,668 (GRCm39) M677I probably benign Het
Mkrn2 A G 6: 115,594,395 (GRCm39) T369A possibly damaging Het
Mthfr C A 4: 148,139,949 (GRCm39) N623K probably damaging Het
Myh2 T C 11: 67,071,985 (GRCm39) V571A probably benign Het
Nom1 G A 5: 29,651,370 (GRCm39) probably null Het
Nucb1 T A 7: 45,144,704 (GRCm39) D283V probably damaging Het
Or12e8 G A 2: 87,188,419 (GRCm39) M210I probably benign Het
Or14c46 A T 7: 85,918,968 (GRCm39) F10I probably damaging Het
Or2v2 T A 11: 49,004,254 (GRCm39) I100L probably benign Het
Pcdhb1 A C 18: 37,398,470 (GRCm39) L140F probably damaging Het
Ptgs2 G A 1: 149,976,002 (GRCm39) A10T probably benign Het
Rfx3 C T 19: 27,777,632 (GRCm39) R497Q probably damaging Het
Rps6kb1 A T 11: 86,410,702 (GRCm39) probably benign Het
Slc22a21 T C 11: 53,860,329 (GRCm39) D34G probably damaging Het
Spata13 T A 14: 60,947,004 (GRCm39) M684K probably damaging Het
Tet3 T C 6: 83,350,181 (GRCm39) T961A probably damaging Het
Ttc27 T C 17: 75,163,474 (GRCm39) L694P probably damaging Het
Vmn1r238 G A 18: 3,123,214 (GRCm39) Q67* probably null Het
Vmn2r101 A T 17: 19,832,303 (GRCm39) R766S probably damaging Het
Vwf A T 6: 125,619,285 (GRCm39) Y1321F probably damaging Het
Wfdc1 C A 8: 120,406,194 (GRCm39) P103Q probably damaging Het
Zfp488 C A 14: 33,692,851 (GRCm39) C104F possibly damaging Het
Other mutations in Brpf3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00906:Brpf3 APN 17 29,055,674 (GRCm39) utr 3 prime probably benign
IGL01397:Brpf3 APN 17 29,036,606 (GRCm39) missense probably benign 0.22
IGL01608:Brpf3 APN 17 29,040,491 (GRCm39) missense probably benign 0.00
IGL02073:Brpf3 APN 17 29,026,370 (GRCm39) missense probably benign
IGL02540:Brpf3 APN 17 29,047,328 (GRCm39) missense probably damaging 1.00
IGL02838:Brpf3 APN 17 29,054,758 (GRCm39) missense probably benign 0.19
IGL02888:Brpf3 APN 17 29,047,365 (GRCm39) missense probably damaging 1.00
IGL02969:Brpf3 APN 17 29,040,279 (GRCm39) missense probably benign 0.05
IGL03036:Brpf3 APN 17 29,043,022 (GRCm39) missense possibly damaging 0.89
IGL03084:Brpf3 APN 17 29,054,751 (GRCm39) missense probably damaging 0.98
R0448:Brpf3 UTSW 17 29,025,010 (GRCm39) missense probably benign 0.10
R0898:Brpf3 UTSW 17 29,025,964 (GRCm39) missense possibly damaging 0.65
R1268:Brpf3 UTSW 17 29,055,530 (GRCm39) missense probably damaging 0.98
R1639:Brpf3 UTSW 17 29,043,042 (GRCm39) critical splice donor site probably null
R1754:Brpf3 UTSW 17 29,040,297 (GRCm39) missense probably benign 0.00
R1867:Brpf3 UTSW 17 29,026,342 (GRCm39) missense probably benign
R1954:Brpf3 UTSW 17 29,025,533 (GRCm39) missense probably benign
R2000:Brpf3 UTSW 17 29,040,531 (GRCm39) missense probably benign 0.20
R2064:Brpf3 UTSW 17 29,040,338 (GRCm39) missense probably benign
R2209:Brpf3 UTSW 17 29,047,394 (GRCm39) missense probably damaging 0.98
R2413:Brpf3 UTSW 17 29,024,924 (GRCm39) start gained probably benign
R3977:Brpf3 UTSW 17 29,026,016 (GRCm39) missense possibly damaging 0.49
R4067:Brpf3 UTSW 17 29,040,233 (GRCm39) missense probably benign
R4369:Brpf3 UTSW 17 29,055,594 (GRCm39) missense probably damaging 1.00
R4371:Brpf3 UTSW 17 29,055,594 (GRCm39) missense probably damaging 1.00
R4741:Brpf3 UTSW 17 29,036,758 (GRCm39) missense possibly damaging 0.50
R4773:Brpf3 UTSW 17 29,040,233 (GRCm39) missense probably benign 0.00
R4824:Brpf3 UTSW 17 29,025,460 (GRCm39) missense probably benign
R5360:Brpf3 UTSW 17 29,029,536 (GRCm39) missense probably benign
R5923:Brpf3 UTSW 17 29,025,610 (GRCm39) missense possibly damaging 0.90
R6181:Brpf3 UTSW 17 29,029,555 (GRCm39) missense probably damaging 1.00
R6278:Brpf3 UTSW 17 29,040,258 (GRCm39) missense probably benign 0.00
R6702:Brpf3 UTSW 17 29,029,633 (GRCm39) missense probably benign 0.01
R6884:Brpf3 UTSW 17 29,050,324 (GRCm39) missense probably benign 0.03
R6920:Brpf3 UTSW 17 29,042,970 (GRCm39) missense probably benign 0.34
R6976:Brpf3 UTSW 17 29,054,751 (GRCm39) missense probably damaging 0.98
R7099:Brpf3 UTSW 17 29,025,611 (GRCm39) missense probably benign 0.06
R7108:Brpf3 UTSW 17 29,036,099 (GRCm39) missense probably benign 0.01
R7193:Brpf3 UTSW 17 29,055,665 (GRCm39) makesense probably null
R7316:Brpf3 UTSW 17 29,033,660 (GRCm39) missense probably damaging 1.00
R7326:Brpf3 UTSW 17 29,025,267 (GRCm39) missense probably benign 0.00
R7403:Brpf3 UTSW 17 29,040,330 (GRCm39) missense probably benign
R7666:Brpf3 UTSW 17 29,029,546 (GRCm39) missense possibly damaging 0.83
R7686:Brpf3 UTSW 17 29,025,908 (GRCm39) missense probably damaging 0.98
R7691:Brpf3 UTSW 17 29,025,805 (GRCm39) missense probably damaging 1.00
R8054:Brpf3 UTSW 17 29,055,571 (GRCm39) missense probably damaging 1.00
R8165:Brpf3 UTSW 17 29,025,248 (GRCm39) missense probably benign 0.01
R8200:Brpf3 UTSW 17 29,025,248 (GRCm39) missense probably benign 0.01
R8698:Brpf3 UTSW 17 29,037,436 (GRCm39) missense probably damaging 0.99
R8722:Brpf3 UTSW 17 29,029,510 (GRCm39) missense probably benign 0.42
R8738:Brpf3 UTSW 17 29,040,214 (GRCm39) missense probably benign
R9044:Brpf3 UTSW 17 29,025,871 (GRCm39) missense possibly damaging 0.90
R9250:Brpf3 UTSW 17 29,054,788 (GRCm39) missense probably damaging 1.00
R9349:Brpf3 UTSW 17 29,040,276 (GRCm39) missense probably benign 0.00
R9496:Brpf3 UTSW 17 29,040,453 (GRCm39) missense probably benign
R9564:Brpf3 UTSW 17 29,026,152 (GRCm39) missense probably benign
R9649:Brpf3 UTSW 17 29,037,597 (GRCm39) missense probably benign
R9720:Brpf3 UTSW 17 29,026,330 (GRCm39) missense probably benign 0.13
Z1177:Brpf3 UTSW 17 29,040,452 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- TAGTTTCCCTCCGTGGTCAG -3'
(R):5'- CGACCTGTCACTGAATGGAG -3'

Sequencing Primer
(F):5'- GGAGGTACAGTCTGCTCACTAG -3'
(R):5'- CCTGTCACTGAATGGAGAACGAAG -3'
Posted On 2016-02-16