Incidental Mutation 'R4422:Vmn2r86'
| ID |
371172 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Vmn2r86
|
| Ensembl Gene |
ENSMUSG00000092162 |
| Gene Name |
vomeronasal 2, receptor 86 |
| Synonyms |
EG625109 |
| MMRRC Submission |
041695-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.080)
|
| Stock # |
R4422 (G1)
|
| Quality Score |
47 |
|
Status
|
Validated
|
| Chromosome |
10 |
| Chromosomal Location |
130282068-130291763 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 130288845 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 219
(I219V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000126596
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000170257]
|
| AlphaFold |
G5E8Y4 |
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000170257
AA Change: I219V
PolyPhen 2
Score 0.874 (Sensitivity: 0.83; Specificity: 0.93)
|
| SMART Domains |
Protein: ENSMUSP00000126596
Gene: ENSMUSG00000092162
AA Change: I219V
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
|
Pfam:ANF_receptor
|
77 |
425 |
1.1e-25 |
PFAM |
|
Pfam:NCD3G
|
508 |
562 |
2.4e-19 |
PFAM |
|
Pfam:7tm_3
|
595 |
829 |
6.4e-55 |
PFAM |
|
| Meta Mutation Damage Score |
0.1795 |
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.6%
- 10x: 97.3%
- 20x: 95.3%
|
| Validation Efficiency |
96% (67/70) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 63 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adamts13 |
T |
C |
2: 26,895,412 (GRCm39) |
S1168P |
probably benign |
Het |
| Adgrf2 |
T |
C |
17: 43,024,046 (GRCm39) |
M142V |
probably benign |
Het |
| Akna |
G |
T |
4: 63,305,330 (GRCm39) |
Q479K |
possibly damaging |
Het |
| Arhgef9 |
T |
G |
X: 94,144,670 (GRCm39) |
I131L |
possibly damaging |
Het |
| AW551984 |
A |
T |
9: 39,511,373 (GRCm39) |
C111S |
probably null |
Het |
| Bak1 |
C |
A |
17: 27,240,298 (GRCm39) |
G130W |
probably damaging |
Het |
| Bank1 |
T |
A |
3: 135,788,972 (GRCm39) |
Q441L |
probably damaging |
Het |
| C030034I22Rik |
T |
C |
17: 69,725,153 (GRCm39) |
|
noncoding transcript |
Het |
| Capns2 |
T |
A |
8: 93,628,252 (GRCm39) |
I47N |
possibly damaging |
Het |
| Cct7 |
A |
G |
6: 85,444,127 (GRCm39) |
R355G |
probably damaging |
Het |
| Cd19 |
C |
T |
7: 126,012,578 (GRCm39) |
V272I |
probably benign |
Het |
| Cenpf |
A |
G |
1: 189,390,547 (GRCm39) |
L1095S |
probably damaging |
Het |
| Cep44 |
G |
A |
8: 56,991,652 (GRCm39) |
P317S |
probably benign |
Het |
| Chrm3 |
A |
T |
13: 9,928,591 (GRCm39) |
Y148* |
probably null |
Het |
| Chrnb3 |
T |
C |
8: 27,886,761 (GRCm39) |
V445A |
possibly damaging |
Het |
| Col4a4 |
T |
A |
1: 82,467,559 (GRCm39) |
M852L |
unknown |
Het |
| Dhx29 |
T |
C |
13: 113,083,781 (GRCm39) |
L612P |
probably damaging |
Het |
| Dlgap2 |
T |
C |
8: 14,793,463 (GRCm39) |
|
probably null |
Het |
| Dnah17 |
T |
C |
11: 117,972,799 (GRCm39) |
T2045A |
possibly damaging |
Het |
| Dync1li1 |
A |
G |
9: 114,538,377 (GRCm39) |
T245A |
probably damaging |
Het |
| Epha4 |
T |
C |
1: 77,488,354 (GRCm39) |
E42G |
probably damaging |
Het |
| Fam120b |
C |
A |
17: 15,622,445 (GRCm39) |
T141K |
probably damaging |
Het |
| Fhod1 |
T |
C |
8: 106,063,983 (GRCm39) |
|
probably benign |
Het |
| Gcnt2 |
T |
G |
13: 41,014,001 (GRCm39) |
Y57* |
probably null |
Het |
| Gm5409 |
C |
T |
6: 41,396,519 (GRCm39) |
|
noncoding transcript |
Het |
| Hip1r |
A |
G |
5: 124,135,069 (GRCm39) |
K402E |
possibly damaging |
Het |
| Hlcs |
G |
A |
16: 93,939,819 (GRCm39) |
P506L |
possibly damaging |
Het |
| Itih4 |
T |
A |
14: 30,611,821 (GRCm39) |
F142I |
probably damaging |
Het |
| Krt78 |
T |
C |
15: 101,856,375 (GRCm39) |
T479A |
probably benign |
Het |
| Lamb2 |
A |
G |
9: 108,360,754 (GRCm39) |
D518G |
probably damaging |
Het |
| Ldlr |
G |
A |
9: 21,649,248 (GRCm39) |
C341Y |
probably damaging |
Het |
| Lsr |
G |
T |
7: 30,665,422 (GRCm39) |
N177K |
probably benign |
Het |
| Macf1 |
G |
A |
4: 123,359,839 (GRCm39) |
S1815F |
probably damaging |
Het |
| Mms22l |
T |
C |
4: 24,503,008 (GRCm39) |
S95P |
probably damaging |
Het |
| Mon2 |
A |
G |
10: 122,878,887 (GRCm39) |
L218P |
probably damaging |
Het |
| Nlrp4f |
C |
T |
13: 65,332,776 (GRCm39) |
|
probably null |
Het |
| Nrde2 |
G |
A |
12: 100,112,286 (GRCm39) |
Q137* |
probably null |
Het |
| Or12e10 |
C |
A |
2: 87,640,989 (GRCm39) |
T275K |
probably damaging |
Het |
| Or51l14 |
G |
T |
7: 103,101,450 (GRCm39) |
R302L |
probably damaging |
Het |
| Or6z7 |
G |
T |
7: 6,484,037 (GRCm39) |
Y39* |
probably null |
Het |
| Phf24 |
G |
A |
4: 42,934,817 (GRCm39) |
C151Y |
probably damaging |
Het |
| Pik3r1 |
T |
G |
13: 101,830,892 (GRCm39) |
N3T |
probably benign |
Het |
| Plcb2 |
T |
C |
2: 118,542,484 (GRCm39) |
K821E |
probably benign |
Het |
| Ppat |
A |
G |
5: 77,063,061 (GRCm39) |
W517R |
probably damaging |
Het |
| Prelid2 |
T |
C |
18: 42,045,461 (GRCm39) |
T150A |
probably benign |
Het |
| Psg21 |
A |
G |
7: 18,381,257 (GRCm39) |
S429P |
probably damaging |
Het |
| Reg4 |
T |
C |
3: 98,140,360 (GRCm39) |
Y114H |
possibly damaging |
Het |
| Rsbn1l |
G |
T |
5: 21,101,544 (GRCm39) |
H665Q |
probably damaging |
Het |
| Rspo2 |
T |
C |
15: 43,033,150 (GRCm39) |
N24S |
probably benign |
Het |
| Ryr2 |
G |
T |
13: 11,731,952 (GRCm39) |
C2329* |
probably null |
Het |
| Skint2 |
T |
A |
4: 112,441,785 (GRCm39) |
|
probably benign |
Het |
| Spmap2l |
T |
C |
5: 77,202,383 (GRCm39) |
I268T |
possibly damaging |
Het |
| Syvn1 |
C |
T |
19: 6,099,951 (GRCm39) |
|
probably benign |
Het |
| Tmem53 |
T |
C |
4: 117,123,149 (GRCm39) |
Y37H |
probably damaging |
Het |
| Tmem59l |
G |
A |
8: 70,938,749 (GRCm39) |
R111W |
probably damaging |
Het |
| Tnks2 |
G |
A |
19: 36,823,053 (GRCm39) |
V107I |
probably damaging |
Het |
| Tpcn1 |
T |
C |
5: 120,680,583 (GRCm39) |
K549R |
probably damaging |
Het |
| Tubgcp4 |
T |
A |
2: 121,019,882 (GRCm39) |
L404* |
probably null |
Het |
| Vsig10 |
T |
C |
5: 117,462,986 (GRCm39) |
S71P |
probably benign |
Het |
| Wnk1 |
T |
C |
6: 119,930,856 (GRCm39) |
N896S |
probably benign |
Het |
| Zfp871 |
T |
A |
17: 32,993,808 (GRCm39) |
S437C |
probably benign |
Het |
| Zfp871 |
C |
A |
17: 32,993,807 (GRCm39) |
S456I |
probably benign |
Het |
| Zfp873 |
A |
G |
10: 81,896,708 (GRCm39) |
T480A |
probably benign |
Het |
|
| Other mutations in Vmn2r86 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01295:Vmn2r86
|
APN |
10 |
130,288,895 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01328:Vmn2r86
|
APN |
10 |
130,288,365 (GRCm39) |
missense |
possibly damaging |
0.78 |
|
IGL01377:Vmn2r86
|
APN |
10 |
130,288,855 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01548:Vmn2r86
|
APN |
10 |
130,282,151 (GRCm39) |
missense |
probably benign |
0.22 |
|
IGL01804:Vmn2r86
|
APN |
10 |
130,288,858 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01921:Vmn2r86
|
APN |
10 |
130,291,610 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL02406:Vmn2r86
|
APN |
10 |
130,284,508 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
IGL02625:Vmn2r86
|
APN |
10 |
130,288,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02960:Vmn2r86
|
APN |
10 |
130,289,636 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
IGL03104:Vmn2r86
|
APN |
10 |
130,282,501 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0408:Vmn2r86
|
UTSW |
10 |
130,282,723 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0437:Vmn2r86
|
UTSW |
10 |
130,282,412 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0577:Vmn2r86
|
UTSW |
10 |
130,288,444 (GRCm39) |
missense |
probably benign |
0.04 |
|
R0726:Vmn2r86
|
UTSW |
10 |
130,282,265 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0811:Vmn2r86
|
UTSW |
10 |
130,289,497 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0812:Vmn2r86
|
UTSW |
10 |
130,289,497 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1055:Vmn2r86
|
UTSW |
10 |
130,282,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1066:Vmn2r86
|
UTSW |
10 |
130,282,145 (GRCm39) |
missense |
probably benign |
0.01 |
|
R1199:Vmn2r86
|
UTSW |
10 |
130,284,443 (GRCm39) |
splice site |
probably benign |
|
|
R1332:Vmn2r86
|
UTSW |
10 |
130,282,739 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1568:Vmn2r86
|
UTSW |
10 |
130,289,010 (GRCm39) |
missense |
probably benign |
0.09 |
|
R1866:Vmn2r86
|
UTSW |
10 |
130,282,255 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1897:Vmn2r86
|
UTSW |
10 |
130,288,314 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2017:Vmn2r86
|
UTSW |
10 |
130,282,582 (GRCm39) |
missense |
probably benign |
0.39 |
|
R3162:Vmn2r86
|
UTSW |
10 |
130,291,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3162:Vmn2r86
|
UTSW |
10 |
130,291,673 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R3858:Vmn2r86
|
UTSW |
10 |
130,291,594 (GRCm39) |
missense |
probably benign |
|
|
R4049:Vmn2r86
|
UTSW |
10 |
130,282,966 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4378:Vmn2r86
|
UTSW |
10 |
130,288,469 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4411:Vmn2r86
|
UTSW |
10 |
130,288,469 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4413:Vmn2r86
|
UTSW |
10 |
130,288,469 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R4738:Vmn2r86
|
UTSW |
10 |
130,282,939 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4767:Vmn2r86
|
UTSW |
10 |
130,291,606 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4872:Vmn2r86
|
UTSW |
10 |
130,289,460 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4880:Vmn2r86
|
UTSW |
10 |
130,289,484 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5092:Vmn2r86
|
UTSW |
10 |
130,282,456 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5421:Vmn2r86
|
UTSW |
10 |
130,282,805 (GRCm39) |
missense |
probably benign |
0.41 |
|
R6007:Vmn2r86
|
UTSW |
10 |
130,289,535 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6330:Vmn2r86
|
UTSW |
10 |
130,282,396 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6355:Vmn2r86
|
UTSW |
10 |
130,291,763 (GRCm39) |
start codon destroyed |
probably damaging |
0.98 |
|
R6397:Vmn2r86
|
UTSW |
10 |
130,282,131 (GRCm39) |
nonsense |
probably null |
|
|
R6419:Vmn2r86
|
UTSW |
10 |
130,282,795 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6933:Vmn2r86
|
UTSW |
10 |
130,282,126 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6937:Vmn2r86
|
UTSW |
10 |
130,284,523 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6959:Vmn2r86
|
UTSW |
10 |
130,282,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7010:Vmn2r86
|
UTSW |
10 |
130,291,726 (GRCm39) |
missense |
probably benign |
|
|
R7549:Vmn2r86
|
UTSW |
10 |
130,282,697 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8179:Vmn2r86
|
UTSW |
10 |
130,288,953 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8257:Vmn2r86
|
UTSW |
10 |
130,288,279 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R8286:Vmn2r86
|
UTSW |
10 |
130,285,855 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8479:Vmn2r86
|
UTSW |
10 |
130,282,735 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8805:Vmn2r86
|
UTSW |
10 |
130,282,396 (GRCm39) |
missense |
probably benign |
0.05 |
|
R8960:Vmn2r86
|
UTSW |
10 |
130,289,672 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9021:Vmn2r86
|
UTSW |
10 |
130,282,934 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9120:Vmn2r86
|
UTSW |
10 |
130,289,677 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9137:Vmn2r86
|
UTSW |
10 |
130,282,409 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9311:Vmn2r86
|
UTSW |
10 |
130,288,440 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9312:Vmn2r86
|
UTSW |
10 |
130,288,406 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9433:Vmn2r86
|
UTSW |
10 |
130,282,567 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R9696:Vmn2r86
|
UTSW |
10 |
130,285,702 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
| Predicted Primers |
PCR Primer
(F):5'- GAGGTTGTGATCCAGATCCTC -3'
(R):5'- CAGGAGTTCTTAAAGGTGGGTAGC -3'
Sequencing Primer
(F):5'- GTTGTGATCCAGATCCTCCGAGC -3'
(R):5'- ATCTCATGTGGATGTTACATTTTCTC -3'
|
| Posted On |
2016-02-29 |
Incidental Mutation