Incidental Mutation 'R4822:Myh3'
| ID |
371232 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Myh3
|
| Ensembl Gene |
ENSMUSG00000020908 |
| Gene Name |
myosin, heavy polypeptide 3, skeletal muscle, embryonic |
| Synonyms |
Myhse, Myhs-e, MyHC-emb |
| MMRRC Submission |
042438-MU
|
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.593)
|
| Stock # |
R4822 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
11 |
| Chromosomal Location |
66969126-66993117 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 66979836 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Threonine
at position 592
(S592T)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000131883
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000007301]
[ENSMUST00000108689]
[ENSMUST00000165221]
|
| AlphaFold |
P13541 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000007301
AA Change: S592T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000007301
Gene: ENSMUSG00000020908
AA Change: S592T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
76 |
1.1e-14 |
PFAM |
|
MYSc
|
80 |
780 |
N/A |
SMART |
|
IQ
|
781 |
803 |
1.65e-2 |
SMART |
|
IQ
|
807 |
829 |
2.25e2 |
SMART |
|
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
939 |
N/A |
INTRINSIC |
|
low complexity region
|
1020 |
1028 |
N/A |
INTRINSIC |
|
Pfam:Myosin_tail_1
|
1069 |
1927 |
N/A |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000108689
AA Change: S592T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000104329
Gene: ENSMUSG00000020908
AA Change: S592T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
76 |
1.1e-14 |
PFAM |
|
MYSc
|
80 |
780 |
N/A |
SMART |
|
IQ
|
781 |
803 |
1.65e-2 |
SMART |
|
IQ
|
807 |
829 |
2.25e2 |
SMART |
|
low complexity region
|
844 |
856 |
N/A |
INTRINSIC |
|
low complexity region
|
925 |
939 |
N/A |
INTRINSIC |
|
low complexity region
|
1020 |
1028 |
N/A |
INTRINSIC |
|
Pfam:Myosin_tail_1
|
1069 |
1927 |
N/A |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000165221
AA Change: S592T
PolyPhen 2
Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
|
| SMART Domains |
Protein: ENSMUSP00000131883
Gene: ENSMUSG00000020908
AA Change: S592T
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Myosin_N
|
35 |
74 |
2.2e-13 |
PFAM |
|
MYSc
|
80 |
780 |
N/A |
SMART |
|
IQ
|
781 |
803 |
1.65e-2 |
SMART |
|
IQ
|
807 |
829 |
2.25e2 |
SMART |
|
Pfam:Myosin_tail_1
|
844 |
1925 |
2.1e-164 |
PFAM |
|
| Meta Mutation Damage Score |
0.0692 |
| Coding Region Coverage |
- 1x: 99.1%
- 3x: 98.4%
- 10x: 96.7%
- 20x: 93.7%
|
| Validation Efficiency |
98% (101/103) |
| MGI Phenotype |
FUNCTION: Myosin is a major contractile protein which converts chemical energy into mechanical energy through the hydrolysis of ATP. Myosin is a hexameric protein composed of a pair of myosin heavy chains (MYH) and two pairs of nonidentical light chains. This gene is a member of the MYH family and encodes a protein with an IQ domain and a myosin head-like domain. [provided by RefSeq, Sep 2015]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 92 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 9930012K11Rik |
C |
T |
14: 70,393,907 (GRCm39) |
V243I |
probably benign |
Het |
| Acadvl |
C |
T |
11: 69,902,010 (GRCm39) |
G485S |
probably benign |
Het |
| Acap3 |
T |
A |
4: 155,986,908 (GRCm39) |
|
probably benign |
Het |
| Adamts19 |
A |
G |
18: 59,023,356 (GRCm39) |
I250M |
probably damaging |
Het |
| Amacr |
T |
A |
15: 10,983,496 (GRCm39) |
I102N |
probably damaging |
Het |
| Apob |
A |
G |
12: 8,065,741 (GRCm39) |
T4237A |
probably benign |
Het |
| Bbs10 |
A |
G |
10: 111,136,995 (GRCm39) |
K703E |
probably benign |
Het |
| Bicd1 |
A |
T |
6: 149,420,752 (GRCm39) |
|
probably benign |
Het |
| Caskin2 |
T |
A |
11: 115,698,125 (GRCm39) |
E49V |
probably damaging |
Het |
| Cemip |
T |
A |
7: 83,622,449 (GRCm39) |
I577F |
probably benign |
Het |
| Chrnb1 |
T |
C |
11: 69,686,501 (GRCm39) |
S40G |
possibly damaging |
Het |
| Ctif |
C |
T |
18: 75,654,632 (GRCm39) |
C298Y |
probably benign |
Het |
| Cul9 |
A |
C |
17: 46,840,977 (GRCm39) |
H764Q |
probably benign |
Het |
| Cwf19l2 |
T |
A |
9: 3,458,839 (GRCm39) |
C763S |
probably damaging |
Het |
| Dhx57 |
A |
T |
17: 80,549,596 (GRCm39) |
|
probably null |
Het |
| Dnaaf10 |
T |
A |
11: 17,177,165 (GRCm39) |
N174K |
probably damaging |
Het |
| Dnhd1 |
G |
A |
7: 105,353,171 (GRCm39) |
D2775N |
probably benign |
Het |
| Enpp1 |
A |
T |
10: 24,537,833 (GRCm39) |
M384K |
possibly damaging |
Het |
| Fat2 |
T |
C |
11: 55,202,144 (GRCm39) |
N310S |
probably benign |
Het |
| Fbxw7 |
A |
T |
3: 84,874,814 (GRCm39) |
Y232F |
possibly damaging |
Het |
| Fcamr |
T |
A |
1: 130,740,423 (GRCm39) |
S281T |
possibly damaging |
Het |
| Gm10762 |
C |
T |
2: 128,809,106 (GRCm39) |
W81* |
probably null |
Het |
| Gm5592 |
A |
G |
7: 40,805,314 (GRCm39) |
|
probably benign |
Het |
| Gm5745 |
T |
C |
9: 73,082,980 (GRCm39) |
|
noncoding transcript |
Het |
| Gm6185 |
G |
C |
1: 161,040,824 (GRCm39) |
|
noncoding transcript |
Het |
| Hid1 |
T |
A |
11: 115,246,125 (GRCm39) |
N382Y |
probably damaging |
Het |
| Hoxa10 |
A |
T |
6: 52,209,569 (GRCm39) |
F68I |
probably damaging |
Het |
| Ift88 |
T |
A |
14: 57,679,326 (GRCm39) |
|
probably null |
Het |
| Ighg2b |
A |
T |
12: 113,270,011 (GRCm39) |
*336R |
probably null |
Het |
| Ighv7-2 |
A |
C |
12: 113,875,892 (GRCm39) |
L37R |
probably damaging |
Het |
| Kcnd3 |
C |
T |
3: 105,566,082 (GRCm39) |
A421V |
probably damaging |
Het |
| Kcnn3 |
G |
C |
3: 89,574,596 (GRCm39) |
V703L |
possibly damaging |
Het |
| Kiz |
C |
A |
2: 146,732,989 (GRCm39) |
S388R |
probably damaging |
Het |
| Klhl20 |
G |
A |
1: 160,921,333 (GRCm39) |
Q41* |
probably null |
Het |
| Krt31 |
T |
C |
11: 99,938,610 (GRCm39) |
I328V |
possibly damaging |
Het |
| Lama4 |
A |
T |
10: 38,909,049 (GRCm39) |
I330L |
probably benign |
Het |
| Lipo2 |
A |
T |
19: 33,723,151 (GRCm39) |
S213T |
probably benign |
Het |
| Lrsam1 |
A |
T |
2: 32,816,804 (GRCm39) |
I723N |
probably damaging |
Het |
| Man2b2 |
G |
A |
5: 36,972,865 (GRCm39) |
R550W |
probably damaging |
Het |
| Map4k5 |
A |
T |
12: 69,888,758 (GRCm39) |
L224* |
probably null |
Het |
| Mast3 |
A |
G |
8: 71,233,010 (GRCm39) |
S1101P |
probably damaging |
Het |
| Mertk |
A |
G |
2: 128,643,225 (GRCm39) |
S875G |
probably benign |
Het |
| Mmel1 |
A |
G |
4: 154,972,354 (GRCm39) |
M302V |
probably benign |
Het |
| Mrgpra3 |
T |
A |
7: 47,239,716 (GRCm39) |
H70L |
possibly damaging |
Het |
| Nbeal2 |
T |
C |
9: 110,465,383 (GRCm39) |
I451V |
possibly damaging |
Het |
| Nup155 |
T |
A |
15: 8,158,010 (GRCm39) |
V489D |
possibly damaging |
Het |
| Obscn |
T |
A |
11: 58,913,159 (GRCm39) |
T6300S |
probably benign |
Het |
| Oprm1 |
A |
G |
10: 6,779,036 (GRCm39) |
I146V |
probably damaging |
Het |
| Or1ad1 |
T |
A |
11: 50,875,910 (GRCm39) |
C127* |
probably null |
Het |
| Or1j4 |
A |
G |
2: 36,740,888 (GRCm39) |
M277V |
probably benign |
Het |
| Or4k44 |
G |
T |
2: 111,367,797 (GRCm39) |
T279K |
probably damaging |
Het |
| Or5ae1 |
A |
C |
7: 84,565,634 (GRCm39) |
I216L |
possibly damaging |
Het |
| Otub1 |
A |
T |
19: 7,181,794 (GRCm39) |
D27E |
probably damaging |
Het |
| Pik3ca |
T |
C |
3: 32,492,131 (GRCm39) |
V243A |
probably benign |
Het |
| Pla2g12b |
G |
A |
10: 59,252,336 (GRCm39) |
|
probably null |
Het |
| Plekha8 |
A |
G |
6: 54,601,546 (GRCm39) |
D321G |
probably damaging |
Het |
| Pprc1 |
T |
C |
19: 46,059,795 (GRCm39) |
|
probably benign |
Het |
| Prkdc |
A |
G |
16: 15,468,576 (GRCm39) |
D129G |
possibly damaging |
Het |
| Rbms3 |
C |
T |
9: 116,773,441 (GRCm39) |
|
probably benign |
Het |
| Rictor |
T |
A |
15: 6,821,161 (GRCm39) |
V1495D |
probably benign |
Het |
| Rpl31-ps21 |
T |
C |
5: 21,324,507 (GRCm39) |
|
noncoding transcript |
Het |
| Ryr3 |
A |
T |
2: 112,483,090 (GRCm39) |
I4219N |
probably damaging |
Het |
| Sbf2 |
G |
A |
7: 109,977,146 (GRCm39) |
|
probably benign |
Het |
| Scn10a |
C |
T |
9: 119,467,738 (GRCm39) |
A801T |
probably damaging |
Het |
| Scn9a |
T |
A |
2: 66,314,093 (GRCm39) |
Y1866F |
possibly damaging |
Het |
| Sec1 |
A |
C |
7: 45,328,727 (GRCm39) |
Y107D |
probably damaging |
Het |
| Sema6d |
C |
T |
2: 124,504,214 (GRCm39) |
T619M |
possibly damaging |
Het |
| Sh2b3 |
C |
A |
5: 121,966,618 (GRCm39) |
|
probably benign |
Het |
| Slc2a4 |
A |
G |
11: 69,837,413 (GRCm39) |
V44A |
probably damaging |
Het |
| Slc5a12 |
T |
C |
2: 110,452,085 (GRCm39) |
I326T |
possibly damaging |
Het |
| Smarca5 |
T |
C |
8: 81,435,309 (GRCm39) |
|
probably null |
Het |
| Smarcd2 |
A |
G |
11: 106,157,357 (GRCm39) |
|
probably null |
Het |
| Snrpa1 |
A |
T |
7: 65,719,321 (GRCm39) |
|
probably benign |
Het |
| Sptbn5 |
T |
G |
2: 119,898,449 (GRCm39) |
K470Q |
probably benign |
Het |
| Stard9 |
T |
G |
2: 120,526,422 (GRCm39) |
V893G |
possibly damaging |
Het |
| Stx8 |
T |
G |
11: 67,864,099 (GRCm39) |
V53G |
possibly damaging |
Het |
| Sv2c |
A |
T |
13: 96,122,457 (GRCm39) |
W440R |
probably damaging |
Het |
| Tcstv2a |
A |
T |
13: 120,725,686 (GRCm39) |
T117S |
probably damaging |
Het |
| Tmem181a |
A |
T |
17: 6,330,940 (GRCm39) |
I67F |
probably benign |
Het |
| Tmprss7 |
C |
T |
16: 45,483,679 (GRCm39) |
C565Y |
probably damaging |
Het |
| Trafd1 |
A |
T |
5: 121,516,561 (GRCm39) |
L109H |
probably damaging |
Het |
| Trpv4 |
A |
G |
5: 114,768,083 (GRCm39) |
I422T |
possibly damaging |
Het |
| Usp24 |
T |
A |
4: 106,273,244 (GRCm39) |
Y2210N |
probably damaging |
Het |
| Vmn1r236 |
A |
T |
17: 21,507,202 (GRCm39) |
N107Y |
probably damaging |
Het |
| Vmn2r13 |
A |
T |
5: 109,321,938 (GRCm39) |
I253K |
probably damaging |
Het |
| Vmn2r2 |
T |
A |
3: 64,041,960 (GRCm39) |
I252F |
probably damaging |
Het |
| Vsig8 |
A |
G |
1: 172,387,205 (GRCm39) |
D27G |
probably damaging |
Het |
| Wiz |
A |
T |
17: 32,575,411 (GRCm39) |
Y908* |
probably null |
Het |
| Wnk1 |
A |
T |
6: 119,939,399 (GRCm39) |
S1113T |
probably benign |
Het |
| Zdhhc1 |
CGGGGG |
CGGGGGG |
8: 106,210,376 (GRCm39) |
|
probably null |
Het |
| Zfp691 |
G |
T |
4: 119,027,764 (GRCm39) |
T156K |
probably damaging |
Het |
| Zfp791 |
A |
T |
8: 85,837,035 (GRCm39) |
D276E |
probably benign |
Het |
|
| Other mutations in Myh3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00850:Myh3
|
APN |
11 |
66,981,681 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01989:Myh3
|
APN |
11 |
66,977,481 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02097:Myh3
|
APN |
11 |
66,973,750 (GRCm39) |
missense |
probably benign |
|
|
IGL02197:Myh3
|
APN |
11 |
66,989,409 (GRCm39) |
missense |
probably benign |
0.05 |
|
IGL02458:Myh3
|
APN |
11 |
66,987,766 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
IGL02526:Myh3
|
APN |
11 |
66,978,371 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02559:Myh3
|
APN |
11 |
66,991,921 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
IGL02600:Myh3
|
APN |
11 |
66,974,227 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02866:Myh3
|
APN |
11 |
66,979,849 (GRCm39) |
missense |
probably benign |
0.08 |
|
IGL02943:Myh3
|
APN |
11 |
66,981,891 (GRCm39) |
missense |
probably benign |
0.02 |
|
IGL03087:Myh3
|
APN |
11 |
66,981,798 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03131:Myh3
|
APN |
11 |
66,981,935 (GRCm39) |
splice site |
probably benign |
|
|
bud
|
UTSW |
11 |
66,986,833 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R0049:Myh3
|
UTSW |
11 |
66,990,498 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0157:Myh3
|
UTSW |
11 |
66,973,735 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0266:Myh3
|
UTSW |
11 |
66,984,498 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R0352:Myh3
|
UTSW |
11 |
66,981,254 (GRCm39) |
missense |
possibly damaging |
0.79 |
|
R0391:Myh3
|
UTSW |
11 |
66,987,333 (GRCm39) |
splice site |
probably benign |
|
|
R0926:Myh3
|
UTSW |
11 |
66,981,340 (GRCm39) |
splice site |
probably null |
|
|
R1243:Myh3
|
UTSW |
11 |
66,981,279 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R1344:Myh3
|
UTSW |
11 |
66,983,158 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1414:Myh3
|
UTSW |
11 |
66,989,491 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1442:Myh3
|
UTSW |
11 |
66,978,103 (GRCm39) |
missense |
possibly damaging |
0.77 |
|
R1470:Myh3
|
UTSW |
11 |
66,988,885 (GRCm39) |
splice site |
probably benign |
|
|
R1480:Myh3
|
UTSW |
11 |
66,984,371 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R1598:Myh3
|
UTSW |
11 |
66,983,997 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1620:Myh3
|
UTSW |
11 |
66,979,562 (GRCm39) |
splice site |
probably benign |
|
|
R1682:Myh3
|
UTSW |
11 |
66,979,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1759:Myh3
|
UTSW |
11 |
66,987,717 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R1772:Myh3
|
UTSW |
11 |
66,990,220 (GRCm39) |
missense |
probably benign |
0.32 |
|
R1868:Myh3
|
UTSW |
11 |
66,975,852 (GRCm39) |
missense |
probably benign |
0.34 |
|
R1874:Myh3
|
UTSW |
11 |
66,984,005 (GRCm39) |
missense |
probably benign |
0.03 |
|
R1885:Myh3
|
UTSW |
11 |
66,977,453 (GRCm39) |
missense |
probably benign |
0.23 |
|
R1923:Myh3
|
UTSW |
11 |
66,970,828 (GRCm39) |
missense |
probably benign |
0.00 |
|
R2145:Myh3
|
UTSW |
11 |
66,981,882 (GRCm39) |
missense |
probably benign |
|
|
R3973:Myh3
|
UTSW |
11 |
66,987,262 (GRCm39) |
nonsense |
probably null |
|
|
R4410:Myh3
|
UTSW |
11 |
66,975,858 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R4583:Myh3
|
UTSW |
11 |
66,987,279 (GRCm39) |
nonsense |
probably null |
|
|
R4650:Myh3
|
UTSW |
11 |
66,977,270 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4836:Myh3
|
UTSW |
11 |
66,987,765 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4898:Myh3
|
UTSW |
11 |
66,990,233 (GRCm39) |
missense |
probably benign |
0.05 |
|
R4946:Myh3
|
UTSW |
11 |
66,984,364 (GRCm39) |
missense |
probably benign |
|
|
R5506:Myh3
|
UTSW |
11 |
66,974,915 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5534:Myh3
|
UTSW |
11 |
66,987,870 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5733:Myh3
|
UTSW |
11 |
66,979,445 (GRCm39) |
missense |
probably benign |
0.24 |
|
R5889:Myh3
|
UTSW |
11 |
66,977,201 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6056:Myh3
|
UTSW |
11 |
66,978,371 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6223:Myh3
|
UTSW |
11 |
66,988,843 (GRCm39) |
missense |
probably benign |
|
|
R6228:Myh3
|
UTSW |
11 |
66,978,312 (GRCm39) |
missense |
probably benign |
0.17 |
|
R6341:Myh3
|
UTSW |
11 |
66,973,822 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6434:Myh3
|
UTSW |
11 |
66,973,193 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6533:Myh3
|
UTSW |
11 |
66,981,245 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R6812:Myh3
|
UTSW |
11 |
66,977,228 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7336:Myh3
|
UTSW |
11 |
66,981,847 (GRCm39) |
missense |
probably benign |
0.13 |
|
R7354:Myh3
|
UTSW |
11 |
66,987,708 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7498:Myh3
|
UTSW |
11 |
66,987,874 (GRCm39) |
missense |
possibly damaging |
0.96 |
|
R7532:Myh3
|
UTSW |
11 |
66,981,921 (GRCm39) |
missense |
probably benign |
|
|
R7841:Myh3
|
UTSW |
11 |
66,989,518 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7878:Myh3
|
UTSW |
11 |
66,978,077 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8169:Myh3
|
UTSW |
11 |
66,979,856 (GRCm39) |
missense |
probably benign |
0.06 |
|
R8194:Myh3
|
UTSW |
11 |
66,982,828 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8215:Myh3
|
UTSW |
11 |
66,992,005 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8240:Myh3
|
UTSW |
11 |
66,983,196 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8255:Myh3
|
UTSW |
11 |
66,985,848 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8310:Myh3
|
UTSW |
11 |
66,986,833 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9103:Myh3
|
UTSW |
11 |
66,989,451 (GRCm39) |
missense |
probably benign |
0.01 |
|
R9249:Myh3
|
UTSW |
11 |
66,975,855 (GRCm39) |
missense |
probably benign |
0.12 |
|
R9307:Myh3
|
UTSW |
11 |
66,984,397 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R9430:Myh3
|
UTSW |
11 |
66,982,726 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9529:Myh3
|
UTSW |
11 |
66,979,556 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9558:Myh3
|
UTSW |
11 |
66,983,316 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9565:Myh3
|
UTSW |
11 |
66,983,187 (GRCm39) |
nonsense |
probably null |
|
|
R9691:Myh3
|
UTSW |
11 |
66,991,921 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9790:Myh3
|
UTSW |
11 |
66,992,005 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9791:Myh3
|
UTSW |
11 |
66,992,005 (GRCm39) |
missense |
probably damaging |
0.99 |
|
RF009:Myh3
|
UTSW |
11 |
66,977,183 (GRCm39) |
frame shift |
probably null |
|
|
RF009:Myh3
|
UTSW |
11 |
66,977,182 (GRCm39) |
frame shift |
probably null |
|
|
RF009:Myh3
|
UTSW |
11 |
66,977,181 (GRCm39) |
frame shift |
probably null |
|
|
RF010:Myh3
|
UTSW |
11 |
66,977,185 (GRCm39) |
frame shift |
probably null |
|
|
RF010:Myh3
|
UTSW |
11 |
66,977,182 (GRCm39) |
frame shift |
probably null |
|
|
RF013:Myh3
|
UTSW |
11 |
66,977,182 (GRCm39) |
frame shift |
probably null |
|
|
RF015:Myh3
|
UTSW |
11 |
66,977,182 (GRCm39) |
frame shift |
probably null |
|
|
X0060:Myh3
|
UTSW |
11 |
66,985,824 (GRCm39) |
missense |
probably benign |
0.00 |
|
X0062:Myh3
|
UTSW |
11 |
66,979,942 (GRCm39) |
missense |
probably benign |
0.03 |
|
Z1176:Myh3
|
UTSW |
11 |
66,973,241 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
| Predicted Primers |
PCR Primer
(F):5'- TGCCTTCAATCCAGCCGATG -3'
(R):5'- ATGTATCGAGACTTTTGCATGCTG -3'
Sequencing Primer
(F):5'- GATGGGCATCTTCTCCATCCTGG -3'
(R):5'- AGACTTTTGCATGCTGTGGGAAAG -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation