Incidental Mutation 'R4839:Tpr'
ID |
371595 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Tpr
|
Ensembl Gene |
ENSMUSG00000006005 |
Gene Name |
translocated promoter region, nuclear basket protein |
Synonyms |
2610029M07Rik |
Accession Numbers |
|
Essential gene? |
Essential
(E-score: 1.000)
|
Stock # |
R4839 (G1)
|
Quality Score |
225 |
Status
|
Not validated
|
Chromosome |
1 |
Chromosomal Location |
150268589-150325686 bp(+) (GRCm39) |
Type of Mutation |
nonsense |
DNA Base Change (assembly) |
T to A
at 150324948 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Leucine to Stop codon
at position 2400
(L2400*)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000117616
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000006171]
[ENSMUST00000111901]
[ENSMUST00000111902]
[ENSMUST00000119161]
[ENSMUST00000124484]
[ENSMUST00000124973]
[ENSMUST00000162367]
[ENSMUST00000164600]
[ENSMUST00000161611]
|
AlphaFold |
F6ZDS4 |
Predicted Effect |
probably benign
Transcript: ENSMUST00000006171
|
SMART Domains |
Protein: ENSMUSP00000006171 Gene: ENSMUSG00000006014
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
SO
|
26 |
68 |
9.21e-18 |
SMART |
SO
|
69 |
108 |
4.21e-12 |
SMART |
low complexity region
|
110 |
124 |
N/A |
INTRINSIC |
HX
|
169 |
211 |
1.67e-7 |
SMART |
HX
|
213 |
256 |
3.76e-10 |
SMART |
Blast:HX
|
369 |
422 |
2e-27 |
BLAST |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000111901
|
SMART Domains |
Protein: ENSMUSP00000107532 Gene: ENSMUSG00000006014
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
SO
|
26 |
68 |
9.21e-18 |
SMART |
SO
|
69 |
108 |
4.21e-12 |
SMART |
low complexity region
|
110 |
124 |
N/A |
INTRINSIC |
low complexity region
|
141 |
151 |
N/A |
INTRINSIC |
low complexity region
|
189 |
221 |
N/A |
INTRINSIC |
low complexity region
|
241 |
535 |
N/A |
INTRINSIC |
low complexity region
|
570 |
623 |
N/A |
INTRINSIC |
HX
|
711 |
753 |
1.67e-7 |
SMART |
HX
|
755 |
798 |
3.76e-10 |
SMART |
Blast:HX
|
911 |
964 |
5e-27 |
BLAST |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000111902
|
SMART Domains |
Protein: ENSMUSP00000107533 Gene: ENSMUSG00000006014
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
SO
|
25 |
67 |
2.71e-15 |
SMART |
low complexity region
|
69 |
81 |
N/A |
INTRINSIC |
low complexity region
|
86 |
143 |
N/A |
INTRINSIC |
low complexity region
|
150 |
171 |
N/A |
INTRINSIC |
low complexity region
|
188 |
198 |
N/A |
INTRINSIC |
low complexity region
|
236 |
268 |
N/A |
INTRINSIC |
low complexity region
|
288 |
582 |
N/A |
INTRINSIC |
internal_repeat_1
|
588 |
614 |
2.72e-5 |
PROSPERO |
low complexity region
|
617 |
670 |
N/A |
INTRINSIC |
internal_repeat_1
|
680 |
706 |
2.72e-5 |
PROSPERO |
HX
|
758 |
800 |
1.67e-7 |
SMART |
HX
|
802 |
845 |
3.76e-10 |
SMART |
Blast:HX
|
958 |
1011 |
4e-27 |
BLAST |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000119161
AA Change: L2326*
|
SMART Domains |
Protein: ENSMUSP00000112606 Gene: ENSMUSG00000006005 AA Change: L2326*
Domain | Start | End | E-Value | Type |
coiled coil region
|
49 |
370 |
N/A |
INTRINSIC |
coiled coil region
|
423 |
515 |
N/A |
INTRINSIC |
low complexity region
|
518 |
534 |
N/A |
INTRINSIC |
coiled coil region
|
539 |
604 |
N/A |
INTRINSIC |
low complexity region
|
690 |
703 |
N/A |
INTRINSIC |
low complexity region
|
782 |
795 |
N/A |
INTRINSIC |
low complexity region
|
811 |
826 |
N/A |
INTRINSIC |
low complexity region
|
1003 |
1019 |
N/A |
INTRINSIC |
Pfam:TPR_MLP1_2
|
1036 |
1167 |
9.1e-33 |
PFAM |
coiled coil region
|
1215 |
1421 |
N/A |
INTRINSIC |
coiled coil region
|
1473 |
1629 |
N/A |
INTRINSIC |
internal_repeat_3
|
1630 |
1691 |
1.48e-5 |
PROSPERO |
low complexity region
|
1695 |
1717 |
N/A |
INTRINSIC |
low complexity region
|
1761 |
1777 |
N/A |
INTRINSIC |
internal_repeat_5
|
1814 |
1827 |
5.58e-5 |
PROSPERO |
internal_repeat_3
|
1819 |
1881 |
1.48e-5 |
PROSPERO |
internal_repeat_4
|
1875 |
1895 |
5.58e-5 |
PROSPERO |
internal_repeat_1
|
1893 |
1919 |
2.03e-6 |
PROSPERO |
low complexity region
|
1920 |
1933 |
N/A |
INTRINSIC |
low complexity region
|
1942 |
1981 |
N/A |
INTRINSIC |
low complexity region
|
1989 |
2014 |
N/A |
INTRINSIC |
internal_repeat_4
|
2017 |
2036 |
5.58e-5 |
PROSPERO |
low complexity region
|
2059 |
2078 |
N/A |
INTRINSIC |
internal_repeat_2
|
2084 |
2135 |
3.95e-6 |
PROSPERO |
internal_repeat_5
|
2127 |
2140 |
5.58e-5 |
PROSPERO |
internal_repeat_1
|
2154 |
2179 |
2.03e-6 |
PROSPERO |
internal_repeat_2
|
2156 |
2212 |
3.95e-6 |
PROSPERO |
low complexity region
|
2239 |
2251 |
N/A |
INTRINSIC |
low complexity region
|
2263 |
2277 |
N/A |
INTRINSIC |
low complexity region
|
2292 |
2314 |
N/A |
INTRINSIC |
low complexity region
|
2346 |
2357 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000124484
AA Change: L113*
|
SMART Domains |
Protein: ENSMUSP00000121991 Gene: ENSMUSG00000006005 AA Change: L113*
Domain | Start | End | E-Value | Type |
low complexity region
|
26 |
38 |
N/A |
INTRINSIC |
low complexity region
|
50 |
64 |
N/A |
INTRINSIC |
low complexity region
|
79 |
101 |
N/A |
INTRINSIC |
low complexity region
|
133 |
144 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably null
Transcript: ENSMUST00000124973
AA Change: L2400*
|
SMART Domains |
Protein: ENSMUSP00000117616 Gene: ENSMUSG00000006005 AA Change: L2400*
Domain | Start | End | E-Value | Type |
low complexity region
|
3 |
14 |
N/A |
INTRINSIC |
low complexity region
|
24 |
77 |
N/A |
INTRINSIC |
coiled coil region
|
123 |
444 |
N/A |
INTRINSIC |
coiled coil region
|
497 |
589 |
N/A |
INTRINSIC |
low complexity region
|
592 |
608 |
N/A |
INTRINSIC |
coiled coil region
|
613 |
678 |
N/A |
INTRINSIC |
low complexity region
|
764 |
777 |
N/A |
INTRINSIC |
low complexity region
|
856 |
869 |
N/A |
INTRINSIC |
low complexity region
|
885 |
900 |
N/A |
INTRINSIC |
low complexity region
|
1077 |
1093 |
N/A |
INTRINSIC |
Pfam:TPR_MLP1_2
|
1112 |
1240 |
5.1e-37 |
PFAM |
coiled coil region
|
1289 |
1495 |
N/A |
INTRINSIC |
low complexity region
|
1682 |
1698 |
N/A |
INTRINSIC |
internal_repeat_5
|
1703 |
1750 |
8.04e-5 |
PROSPERO |
internal_repeat_3
|
1704 |
1765 |
1.07e-5 |
PROSPERO |
low complexity region
|
1769 |
1791 |
N/A |
INTRINSIC |
low complexity region
|
1835 |
1851 |
N/A |
INTRINSIC |
internal_repeat_5
|
1857 |
1900 |
8.04e-5 |
PROSPERO |
internal_repeat_6
|
1887 |
1911 |
8.04e-5 |
PROSPERO |
internal_repeat_3
|
1893 |
1955 |
1.07e-5 |
PROSPERO |
internal_repeat_4
|
1949 |
1969 |
4.1e-5 |
PROSPERO |
internal_repeat_1
|
1967 |
1993 |
1.42e-6 |
PROSPERO |
low complexity region
|
1994 |
2007 |
N/A |
INTRINSIC |
low complexity region
|
2016 |
2055 |
N/A |
INTRINSIC |
low complexity region
|
2063 |
2088 |
N/A |
INTRINSIC |
internal_repeat_4
|
2091 |
2110 |
4.1e-5 |
PROSPERO |
internal_repeat_6
|
2108 |
2132 |
8.04e-5 |
PROSPERO |
low complexity region
|
2133 |
2152 |
N/A |
INTRINSIC |
internal_repeat_2
|
2158 |
2209 |
2.78e-6 |
PROSPERO |
internal_repeat_1
|
2228 |
2253 |
1.42e-6 |
PROSPERO |
internal_repeat_2
|
2230 |
2286 |
2.78e-6 |
PROSPERO |
low complexity region
|
2313 |
2325 |
N/A |
INTRINSIC |
low complexity region
|
2337 |
2351 |
N/A |
INTRINSIC |
low complexity region
|
2366 |
2388 |
N/A |
INTRINSIC |
low complexity region
|
2420 |
2431 |
N/A |
INTRINSIC |
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000130779
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000152967
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000128417
|
Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000138718
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000162367
|
SMART Domains |
Protein: ENSMUSP00000125551 Gene: ENSMUSG00000006014
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
SO
|
26 |
68 |
9.21e-18 |
SMART |
SO
|
69 |
108 |
4.21e-12 |
SMART |
low complexity region
|
110 |
124 |
N/A |
INTRINSIC |
HX
|
169 |
211 |
1.67e-7 |
SMART |
HX
|
213 |
256 |
3.76e-10 |
SMART |
Blast:HX
|
369 |
422 |
2e-27 |
BLAST |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000164600
|
SMART Domains |
Protein: ENSMUSP00000128943 Gene: ENSMUSG00000006014
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
SO
|
26 |
68 |
9.21e-18 |
SMART |
SO
|
69 |
108 |
2.77e-12 |
SMART |
low complexity region
|
110 |
122 |
N/A |
INTRINSIC |
low complexity region
|
127 |
184 |
N/A |
INTRINSIC |
low complexity region
|
191 |
212 |
N/A |
INTRINSIC |
low complexity region
|
229 |
239 |
N/A |
INTRINSIC |
internal_repeat_3
|
244 |
271 |
7.42e-5 |
PROSPERO |
low complexity region
|
277 |
309 |
N/A |
INTRINSIC |
Pfam:Cornifin
|
404 |
497 |
2.4e-14 |
PFAM |
Pfam:Cornifin
|
468 |
584 |
3.2e-15 |
PFAM |
Pfam:Cornifin
|
550 |
648 |
3.3e-16 |
PFAM |
Pfam:Cornifin
|
625 |
722 |
2.1e-15 |
PFAM |
Pfam:Cornifin
|
647 |
743 |
7.8e-16 |
PFAM |
Pfam:Cornifin
|
706 |
822 |
1.4e-12 |
PFAM |
low complexity region
|
826 |
879 |
N/A |
INTRINSIC |
internal_repeat_2
|
889 |
915 |
1.24e-5 |
PROSPERO |
HX
|
967 |
1009 |
1.67e-7 |
SMART |
HX
|
1011 |
1054 |
3.76e-10 |
SMART |
Blast:HX
|
1167 |
1220 |
6e-27 |
BLAST |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000161611
|
SMART Domains |
Protein: ENSMUSP00000125677 Gene: ENSMUSG00000006014
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
24 |
N/A |
INTRINSIC |
SO
|
26 |
68 |
9.21e-18 |
SMART |
SO
|
69 |
108 |
2.77e-12 |
SMART |
low complexity region
|
110 |
122 |
N/A |
INTRINSIC |
low complexity region
|
127 |
184 |
N/A |
INTRINSIC |
low complexity region
|
191 |
212 |
N/A |
INTRINSIC |
low complexity region
|
229 |
239 |
N/A |
INTRINSIC |
internal_repeat_3
|
244 |
271 |
7.42e-5 |
PROSPERO |
low complexity region
|
277 |
309 |
N/A |
INTRINSIC |
Pfam:Cornifin
|
578 |
691 |
2.2e-9 |
PFAM |
internal_repeat_3
|
796 |
825 |
7.42e-5 |
PROSPERO |
internal_repeat_2
|
797 |
823 |
1.24e-5 |
PROSPERO |
low complexity region
|
826 |
879 |
N/A |
INTRINSIC |
internal_repeat_2
|
889 |
915 |
1.24e-5 |
PROSPERO |
HX
|
967 |
1009 |
1.67e-7 |
SMART |
HX
|
1011 |
1054 |
3.76e-10 |
SMART |
Blast:HX
|
1167 |
1220 |
6e-27 |
BLAST |
|
Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.8%
|
Validation Efficiency |
|
MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]
|
Allele List at MGI |
All alleles(28) : Targeted, other(2) Gene trapped(26) |
Other mutations in this stock |
Total: 93 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
1700010I14Rik |
T |
A |
17: 9,226,845 (GRCm39) |
S467T |
probably benign |
Het |
2310030G06Rik |
A |
T |
9: 50,652,023 (GRCm39) |
Y68* |
probably null |
Het |
Abat |
T |
G |
16: 8,401,512 (GRCm39) |
|
probably benign |
Het |
Abca2 |
C |
T |
2: 25,330,921 (GRCm39) |
S1203F |
probably damaging |
Het |
Adam22 |
G |
A |
5: 8,186,813 (GRCm39) |
P436L |
probably damaging |
Het |
Ak3 |
A |
C |
19: 29,025,132 (GRCm39) |
L33R |
probably damaging |
Het |
Arhgap11a |
A |
T |
2: 113,672,374 (GRCm39) |
I198K |
probably damaging |
Het |
Arl14epl |
A |
T |
18: 47,065,544 (GRCm39) |
K103M |
possibly damaging |
Het |
Atg16l1 |
T |
A |
1: 87,693,896 (GRCm39) |
N65K |
probably damaging |
Het |
Btnl2 |
G |
A |
17: 34,584,260 (GRCm39) |
W394* |
probably null |
Het |
Cacna1e |
C |
A |
1: 154,296,804 (GRCm39) |
R1687L |
probably damaging |
Het |
Cacna1g |
G |
T |
11: 94,350,433 (GRCm39) |
R471S |
probably benign |
Het |
Cdh13 |
A |
T |
8: 119,578,587 (GRCm39) |
R205* |
probably null |
Het |
Cdkl3 |
A |
T |
11: 51,895,861 (GRCm39) |
Y36F |
probably damaging |
Het |
Cep290 |
T |
A |
10: 100,344,648 (GRCm39) |
N488K |
probably damaging |
Het |
Cep350 |
A |
T |
1: 155,804,240 (GRCm39) |
C948S |
probably benign |
Het |
Cep70 |
A |
G |
9: 99,178,138 (GRCm39) |
K446R |
probably benign |
Het |
Cfap70 |
T |
C |
14: 20,475,597 (GRCm39) |
T375A |
probably damaging |
Het |
Cfhr1 |
A |
G |
1: 139,487,871 (GRCm39) |
L9S |
probably damaging |
Het |
Chrm4 |
T |
A |
2: 91,757,952 (GRCm39) |
M120K |
probably damaging |
Het |
Col1a1 |
A |
G |
11: 94,840,921 (GRCm39) |
|
probably null |
Het |
Col3a1 |
T |
C |
1: 45,362,963 (GRCm39) |
|
probably null |
Het |
Csrnp3 |
A |
T |
2: 65,852,375 (GRCm39) |
R256* |
probably null |
Het |
Dbf4 |
T |
A |
5: 8,458,263 (GRCm39) |
K190* |
probably null |
Het |
Dnah10 |
A |
T |
5: 124,850,196 (GRCm39) |
I1573F |
probably damaging |
Het |
Dock8 |
A |
G |
19: 25,146,858 (GRCm39) |
I1446V |
probably benign |
Het |
Dst |
G |
T |
1: 34,229,943 (GRCm39) |
R2187M |
probably damaging |
Het |
Ece2 |
C |
T |
16: 20,449,918 (GRCm39) |
R257C |
probably damaging |
Het |
Espn |
A |
G |
4: 152,222,961 (GRCm39) |
Y306H |
probably damaging |
Het |
Fkbpl |
G |
A |
17: 34,864,839 (GRCm39) |
M202I |
probably benign |
Het |
Fn1 |
A |
G |
1: 71,681,242 (GRCm39) |
L362P |
probably damaging |
Het |
Ganc |
A |
C |
2: 120,290,304 (GRCm39) |
R880S |
probably benign |
Het |
Gucy1b2 |
A |
T |
14: 62,685,695 (GRCm39) |
L90Q |
probably damaging |
Het |
Hcn1 |
T |
A |
13: 118,062,246 (GRCm39) |
I504N |
unknown |
Het |
Hdac2 |
C |
A |
10: 36,873,462 (GRCm39) |
T352K |
probably benign |
Het |
Hip1 |
T |
C |
5: 135,455,172 (GRCm39) |
|
probably null |
Het |
Hspa13 |
G |
A |
16: 75,562,169 (GRCm39) |
S10L |
probably damaging |
Het |
Ipo5 |
T |
C |
14: 121,157,450 (GRCm39) |
I96T |
probably benign |
Het |
Isl1 |
T |
C |
13: 116,438,220 (GRCm39) |
Y264C |
probably damaging |
Het |
Izumo1 |
T |
C |
7: 45,275,657 (GRCm39) |
I322T |
probably benign |
Het |
Kars1 |
A |
C |
8: 112,729,158 (GRCm39) |
V183G |
possibly damaging |
Het |
Lrrc15 |
C |
A |
16: 30,093,086 (GRCm39) |
M84I |
probably benign |
Het |
Magi1 |
A |
T |
6: 93,671,177 (GRCm39) |
V796E |
probably damaging |
Het |
Matn4 |
G |
T |
2: 164,242,896 (GRCm39) |
D67E |
probably benign |
Het |
Mertk |
A |
G |
2: 128,624,496 (GRCm39) |
M636V |
probably damaging |
Het |
Mettl27 |
C |
A |
5: 134,963,266 (GRCm39) |
P126T |
probably damaging |
Het |
Mfrp |
T |
A |
9: 44,013,432 (GRCm39) |
H52Q |
possibly damaging |
Het |
Mrgprb8 |
T |
G |
7: 48,038,656 (GRCm39) |
I109R |
probably benign |
Het |
Mroh2a |
G |
A |
1: 88,165,666 (GRCm39) |
G512S |
probably damaging |
Het |
Ncoa7 |
T |
A |
10: 30,598,655 (GRCm39) |
R89S |
possibly damaging |
Het |
Nfkb2 |
G |
T |
19: 46,296,006 (GRCm39) |
E170D |
probably benign |
Het |
Nin |
G |
T |
12: 70,137,325 (GRCm39) |
H84N |
possibly damaging |
Het |
Nwd2 |
A |
T |
5: 63,962,893 (GRCm39) |
I826F |
possibly damaging |
Het |
Or10d1 |
A |
G |
9: 39,484,441 (GRCm39) |
M38T |
probably benign |
Het |
Or14c43 |
T |
C |
7: 86,115,117 (GRCm39) |
F166S |
probably damaging |
Het |
Or1j11 |
G |
A |
2: 36,312,012 (GRCm39) |
V201I |
probably benign |
Het |
Or4l15 |
C |
T |
14: 50,197,646 (GRCm39) |
M294I |
probably benign |
Het |
Or52a5b |
T |
C |
7: 103,416,961 (GRCm39) |
I214M |
possibly damaging |
Het |
Or5k3 |
A |
G |
16: 58,969,393 (GRCm39) |
Y60C |
probably damaging |
Het |
Or5p73 |
T |
C |
7: 108,064,938 (GRCm39) |
S136P |
probably benign |
Het |
Otof |
C |
T |
5: 30,576,748 (GRCm39) |
R168H |
probably damaging |
Het |
Pcdha6 |
T |
C |
18: 37,101,485 (GRCm39) |
V226A |
possibly damaging |
Het |
Pggt1b |
T |
C |
18: 46,391,166 (GRCm39) |
I200V |
possibly damaging |
Het |
Ppat |
G |
A |
5: 77,098,811 (GRCm39) |
Q41* |
probably null |
Het |
Ppfibp2 |
A |
T |
7: 107,342,192 (GRCm39) |
H27L |
probably damaging |
Het |
Rbm27 |
T |
A |
18: 42,460,510 (GRCm39) |
I775N |
probably damaging |
Het |
Rnf40 |
C |
T |
7: 127,191,812 (GRCm39) |
R349* |
probably null |
Het |
Rtp3 |
A |
T |
9: 110,818,544 (GRCm39) |
W46R |
probably damaging |
Het |
Sass6 |
C |
T |
3: 116,403,949 (GRCm39) |
R196W |
probably damaging |
Het |
Sel1l |
A |
T |
12: 91,799,932 (GRCm39) |
D131E |
probably benign |
Het |
Slain2 |
T |
C |
5: 73,106,066 (GRCm39) |
S234P |
probably damaging |
Het |
Slc47a1 |
C |
T |
11: 61,264,176 (GRCm39) |
|
probably null |
Het |
Sp140 |
CAGAAGAAG |
CAGAAG |
1: 85,538,529 (GRCm39) |
|
probably benign |
Het |
Spata31e2 |
T |
C |
1: 26,724,440 (GRCm39) |
T247A |
probably benign |
Het |
Spef2 |
A |
T |
15: 9,713,264 (GRCm39) |
Y369* |
probably null |
Het |
Spred2 |
T |
A |
11: 19,948,233 (GRCm39) |
M76K |
possibly damaging |
Het |
Svs5 |
T |
A |
2: 164,078,806 (GRCm39) |
D367V |
probably benign |
Het |
Tasor2 |
G |
A |
13: 3,634,807 (GRCm39) |
P667S |
probably damaging |
Het |
Tefm |
A |
T |
11: 80,027,947 (GRCm39) |
D270E |
probably benign |
Het |
Tfcp2l1 |
C |
A |
1: 118,597,194 (GRCm39) |
P425H |
probably benign |
Het |
Thbd |
A |
T |
2: 148,248,591 (GRCm39) |
C426S |
probably damaging |
Het |
Timm10b |
T |
A |
7: 105,333,219 (GRCm39) |
D968E |
probably damaging |
Het |
Tle2 |
C |
T |
10: 81,413,518 (GRCm39) |
T119I |
probably damaging |
Het |
Tnik |
T |
A |
3: 28,650,224 (GRCm39) |
Y446N |
possibly damaging |
Het |
Trrap |
T |
C |
5: 144,782,402 (GRCm39) |
F3328S |
probably damaging |
Het |
Vldlr |
G |
A |
19: 27,215,465 (GRCm39) |
C154Y |
probably damaging |
Het |
Vmn1r79 |
T |
G |
7: 11,910,361 (GRCm39) |
M81R |
probably benign |
Het |
Vps13d |
T |
C |
4: 144,812,000 (GRCm39) |
T3305A |
possibly damaging |
Het |
Wdr62 |
T |
C |
7: 29,970,111 (GRCm39) |
E232G |
probably damaging |
Het |
Wdr62 |
T |
A |
7: 29,940,890 (GRCm39) |
I843F |
probably benign |
Het |
Zfp747l1 |
T |
C |
7: 126,984,179 (GRCm39) |
S308G |
probably benign |
Het |
Zfp873 |
T |
A |
10: 81,896,353 (GRCm39) |
H361Q |
probably damaging |
Het |
Zfp949 |
A |
C |
9: 88,452,047 (GRCm39) |
H539P |
probably damaging |
Het |
|
Other mutations in Tpr |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00327:Tpr
|
APN |
1 |
150,299,447 (GRCm39) |
splice site |
probably benign |
|
IGL00424:Tpr
|
APN |
1 |
150,274,346 (GRCm39) |
splice site |
probably benign |
|
IGL01095:Tpr
|
APN |
1 |
150,285,891 (GRCm39) |
missense |
possibly damaging |
0.95 |
IGL01347:Tpr
|
APN |
1 |
150,302,738 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01519:Tpr
|
APN |
1 |
150,306,919 (GRCm39) |
missense |
probably benign |
0.01 |
IGL01768:Tpr
|
APN |
1 |
150,320,199 (GRCm39) |
missense |
possibly damaging |
0.85 |
IGL01939:Tpr
|
APN |
1 |
150,289,496 (GRCm39) |
missense |
possibly damaging |
0.82 |
IGL01988:Tpr
|
APN |
1 |
150,302,750 (GRCm39) |
splice site |
probably null |
|
IGL02065:Tpr
|
APN |
1 |
150,289,525 (GRCm39) |
missense |
probably benign |
0.13 |
IGL02110:Tpr
|
APN |
1 |
150,311,493 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL02311:Tpr
|
APN |
1 |
150,274,404 (GRCm39) |
missense |
probably damaging |
0.97 |
IGL02454:Tpr
|
APN |
1 |
150,306,943 (GRCm39) |
missense |
probably benign |
0.00 |
IGL02569:Tpr
|
APN |
1 |
150,301,382 (GRCm39) |
unclassified |
probably benign |
|
IGL03168:Tpr
|
APN |
1 |
150,284,508 (GRCm39) |
missense |
probably benign |
0.04 |
IGL03193:Tpr
|
APN |
1 |
150,315,831 (GRCm39) |
missense |
possibly damaging |
0.85 |
IGL03333:Tpr
|
APN |
1 |
150,302,718 (GRCm39) |
missense |
probably benign |
0.04 |
gridiron
|
UTSW |
1 |
150,299,267 (GRCm39) |
missense |
probably damaging |
1.00 |
Pouch
|
UTSW |
1 |
150,309,523 (GRCm39) |
missense |
probably damaging |
1.00 |
punt
|
UTSW |
1 |
150,293,790 (GRCm39) |
missense |
probably benign |
0.02 |
Turf
|
UTSW |
1 |
150,317,996 (GRCm39) |
critical splice donor site |
probably null |
|
F6893:Tpr
|
UTSW |
1 |
150,269,313 (GRCm39) |
missense |
possibly damaging |
0.84 |
PIT4305001:Tpr
|
UTSW |
1 |
150,315,888 (GRCm39) |
missense |
possibly damaging |
0.85 |
PIT4469001:Tpr
|
UTSW |
1 |
150,279,707 (GRCm39) |
missense |
probably benign |
0.41 |
R0085:Tpr
|
UTSW |
1 |
150,293,164 (GRCm39) |
missense |
possibly damaging |
0.95 |
R0101:Tpr
|
UTSW |
1 |
150,285,053 (GRCm39) |
splice site |
probably benign |
|
R0116:Tpr
|
UTSW |
1 |
150,285,898 (GRCm39) |
missense |
probably damaging |
0.98 |
R0136:Tpr
|
UTSW |
1 |
150,306,346 (GRCm39) |
missense |
probably benign |
0.01 |
R0207:Tpr
|
UTSW |
1 |
150,293,178 (GRCm39) |
missense |
possibly damaging |
0.74 |
R0219:Tpr
|
UTSW |
1 |
150,319,009 (GRCm39) |
splice site |
probably null |
|
R0380:Tpr
|
UTSW |
1 |
150,288,698 (GRCm39) |
missense |
probably benign |
0.27 |
R0403:Tpr
|
UTSW |
1 |
150,283,165 (GRCm39) |
splice site |
probably benign |
|
R0469:Tpr
|
UTSW |
1 |
150,299,418 (GRCm39) |
frame shift |
probably null |
|
R0480:Tpr
|
UTSW |
1 |
150,303,992 (GRCm39) |
missense |
possibly damaging |
0.83 |
R0514:Tpr
|
UTSW |
1 |
150,278,024 (GRCm39) |
missense |
possibly damaging |
0.55 |
R0563:Tpr
|
UTSW |
1 |
150,284,609 (GRCm39) |
missense |
probably benign |
0.13 |
R0631:Tpr
|
UTSW |
1 |
150,298,282 (GRCm39) |
missense |
probably damaging |
0.98 |
R0685:Tpr
|
UTSW |
1 |
150,309,476 (GRCm39) |
missense |
possibly damaging |
0.69 |
R0730:Tpr
|
UTSW |
1 |
150,269,158 (GRCm39) |
utr 5 prime |
probably benign |
|
R0739:Tpr
|
UTSW |
1 |
150,283,248 (GRCm39) |
missense |
possibly damaging |
0.94 |
R0780:Tpr
|
UTSW |
1 |
150,307,092 (GRCm39) |
missense |
probably benign |
0.00 |
R1018:Tpr
|
UTSW |
1 |
150,317,934 (GRCm39) |
missense |
possibly damaging |
0.53 |
R1084:Tpr
|
UTSW |
1 |
150,317,912 (GRCm39) |
missense |
probably benign |
0.18 |
R1532:Tpr
|
UTSW |
1 |
150,293,751 (GRCm39) |
missense |
probably damaging |
0.99 |
R1551:Tpr
|
UTSW |
1 |
150,312,552 (GRCm39) |
missense |
probably benign |
0.00 |
R1608:Tpr
|
UTSW |
1 |
150,302,644 (GRCm39) |
missense |
probably damaging |
0.96 |
R1759:Tpr
|
UTSW |
1 |
150,305,275 (GRCm39) |
missense |
probably benign |
0.19 |
R1817:Tpr
|
UTSW |
1 |
150,295,654 (GRCm39) |
missense |
probably damaging |
0.98 |
R1932:Tpr
|
UTSW |
1 |
150,297,414 (GRCm39) |
missense |
probably benign |
0.00 |
R1978:Tpr
|
UTSW |
1 |
150,295,658 (GRCm39) |
missense |
possibly damaging |
0.65 |
R2031:Tpr
|
UTSW |
1 |
150,317,870 (GRCm39) |
missense |
probably benign |
|
R2176:Tpr
|
UTSW |
1 |
150,295,691 (GRCm39) |
missense |
possibly damaging |
0.56 |
R2235:Tpr
|
UTSW |
1 |
150,317,843 (GRCm39) |
missense |
probably benign |
0.33 |
R2339:Tpr
|
UTSW |
1 |
150,289,525 (GRCm39) |
missense |
probably benign |
0.01 |
R2367:Tpr
|
UTSW |
1 |
150,309,479 (GRCm39) |
missense |
probably damaging |
0.99 |
R2507:Tpr
|
UTSW |
1 |
150,268,695 (GRCm39) |
start codon destroyed |
probably null |
|
R3931:Tpr
|
UTSW |
1 |
150,311,655 (GRCm39) |
missense |
probably damaging |
1.00 |
R4320:Tpr
|
UTSW |
1 |
150,299,325 (GRCm39) |
missense |
possibly damaging |
0.96 |
R4439:Tpr
|
UTSW |
1 |
150,279,712 (GRCm39) |
missense |
probably benign |
0.01 |
R4568:Tpr
|
UTSW |
1 |
150,268,710 (GRCm39) |
unclassified |
probably benign |
|
R4644:Tpr
|
UTSW |
1 |
150,299,250 (GRCm39) |
missense |
probably benign |
0.01 |
R4665:Tpr
|
UTSW |
1 |
150,320,150 (GRCm39) |
missense |
probably damaging |
0.97 |
R4672:Tpr
|
UTSW |
1 |
150,299,318 (GRCm39) |
missense |
probably benign |
0.45 |
R4673:Tpr
|
UTSW |
1 |
150,299,318 (GRCm39) |
missense |
probably benign |
0.45 |
R4735:Tpr
|
UTSW |
1 |
150,317,947 (GRCm39) |
missense |
possibly damaging |
0.91 |
R4767:Tpr
|
UTSW |
1 |
150,306,280 (GRCm39) |
intron |
probably benign |
|
R4772:Tpr
|
UTSW |
1 |
150,288,864 (GRCm39) |
missense |
possibly damaging |
0.46 |
R4815:Tpr
|
UTSW |
1 |
150,274,359 (GRCm39) |
missense |
probably benign |
0.01 |
R4844:Tpr
|
UTSW |
1 |
150,321,630 (GRCm39) |
missense |
possibly damaging |
0.86 |
R4925:Tpr
|
UTSW |
1 |
150,308,316 (GRCm39) |
missense |
probably benign |
0.00 |
R4967:Tpr
|
UTSW |
1 |
150,285,810 (GRCm39) |
missense |
probably damaging |
0.99 |
R5017:Tpr
|
UTSW |
1 |
150,274,388 (GRCm39) |
missense |
probably benign |
0.00 |
R5096:Tpr
|
UTSW |
1 |
150,321,953 (GRCm39) |
missense |
probably damaging |
0.99 |
R5353:Tpr
|
UTSW |
1 |
150,321,675 (GRCm39) |
missense |
probably damaging |
1.00 |
R5354:Tpr
|
UTSW |
1 |
150,321,675 (GRCm39) |
missense |
probably damaging |
1.00 |
R5484:Tpr
|
UTSW |
1 |
150,302,639 (GRCm39) |
missense |
probably benign |
0.33 |
R5601:Tpr
|
UTSW |
1 |
150,311,604 (GRCm39) |
missense |
possibly damaging |
0.75 |
R5642:Tpr
|
UTSW |
1 |
150,299,569 (GRCm39) |
missense |
probably damaging |
0.99 |
R5779:Tpr
|
UTSW |
1 |
150,299,292 (GRCm39) |
missense |
probably damaging |
1.00 |
R5787:Tpr
|
UTSW |
1 |
150,271,037 (GRCm39) |
missense |
probably benign |
0.01 |
R5892:Tpr
|
UTSW |
1 |
150,283,151 (GRCm39) |
missense |
probably benign |
0.44 |
R5915:Tpr
|
UTSW |
1 |
150,301,400 (GRCm39) |
missense |
probably benign |
0.15 |
R5928:Tpr
|
UTSW |
1 |
150,303,878 (GRCm39) |
missense |
probably benign |
0.30 |
R6146:Tpr
|
UTSW |
1 |
150,298,913 (GRCm39) |
missense |
possibly damaging |
0.83 |
R6154:Tpr
|
UTSW |
1 |
150,299,567 (GRCm39) |
missense |
probably benign |
0.00 |
R6234:Tpr
|
UTSW |
1 |
150,293,790 (GRCm39) |
missense |
probably benign |
0.02 |
R6263:Tpr
|
UTSW |
1 |
150,317,996 (GRCm39) |
critical splice donor site |
probably null |
|
R6318:Tpr
|
UTSW |
1 |
150,321,639 (GRCm39) |
missense |
possibly damaging |
0.93 |
R6550:Tpr
|
UTSW |
1 |
150,299,728 (GRCm39) |
missense |
probably damaging |
1.00 |
R6592:Tpr
|
UTSW |
1 |
150,287,656 (GRCm39) |
missense |
possibly damaging |
0.83 |
R6704:Tpr
|
UTSW |
1 |
150,282,259 (GRCm39) |
missense |
possibly damaging |
0.80 |
R6716:Tpr
|
UTSW |
1 |
150,290,516 (GRCm39) |
missense |
probably damaging |
1.00 |
R6836:Tpr
|
UTSW |
1 |
150,312,424 (GRCm39) |
splice site |
probably null |
|
R6886:Tpr
|
UTSW |
1 |
150,299,716 (GRCm39) |
missense |
probably benign |
0.00 |
R6894:Tpr
|
UTSW |
1 |
150,312,598 (GRCm39) |
missense |
probably benign |
0.28 |
R6928:Tpr
|
UTSW |
1 |
150,284,536 (GRCm39) |
missense |
possibly damaging |
0.83 |
R7011:Tpr
|
UTSW |
1 |
150,309,523 (GRCm39) |
missense |
probably damaging |
1.00 |
R7034:Tpr
|
UTSW |
1 |
150,299,358 (GRCm39) |
missense |
probably benign |
0.02 |
R7036:Tpr
|
UTSW |
1 |
150,299,358 (GRCm39) |
missense |
probably benign |
0.02 |
R7183:Tpr
|
UTSW |
1 |
150,282,302 (GRCm39) |
missense |
probably damaging |
1.00 |
R7221:Tpr
|
UTSW |
1 |
150,321,929 (GRCm39) |
missense |
possibly damaging |
0.96 |
R7223:Tpr
|
UTSW |
1 |
150,315,007 (GRCm39) |
missense |
possibly damaging |
0.53 |
R7294:Tpr
|
UTSW |
1 |
150,279,638 (GRCm39) |
missense |
probably damaging |
1.00 |
R7343:Tpr
|
UTSW |
1 |
150,269,245 (GRCm39) |
missense |
unknown |
|
R7361:Tpr
|
UTSW |
1 |
150,323,372 (GRCm39) |
missense |
possibly damaging |
0.73 |
R7405:Tpr
|
UTSW |
1 |
150,317,878 (GRCm39) |
missense |
probably benign |
0.02 |
R7637:Tpr
|
UTSW |
1 |
150,299,267 (GRCm39) |
missense |
probably damaging |
1.00 |
R7720:Tpr
|
UTSW |
1 |
150,305,283 (GRCm39) |
missense |
possibly damaging |
0.49 |
R7721:Tpr
|
UTSW |
1 |
150,320,180 (GRCm39) |
missense |
probably benign |
|
R7751:Tpr
|
UTSW |
1 |
150,295,646 (GRCm39) |
missense |
probably benign |
0.17 |
R7804:Tpr
|
UTSW |
1 |
150,308,310 (GRCm39) |
missense |
probably damaging |
0.99 |
R7878:Tpr
|
UTSW |
1 |
150,299,411 (GRCm39) |
missense |
possibly damaging |
0.67 |
R7973:Tpr
|
UTSW |
1 |
150,279,638 (GRCm39) |
missense |
probably damaging |
1.00 |
R8013:Tpr
|
UTSW |
1 |
150,274,359 (GRCm39) |
missense |
probably benign |
|
R8220:Tpr
|
UTSW |
1 |
150,308,164 (GRCm39) |
missense |
probably benign |
0.05 |
R8274:Tpr
|
UTSW |
1 |
150,299,230 (GRCm39) |
splice site |
probably benign |
|
R8428:Tpr
|
UTSW |
1 |
150,290,564 (GRCm39) |
missense |
probably damaging |
1.00 |
R8482:Tpr
|
UTSW |
1 |
150,309,451 (GRCm39) |
missense |
probably damaging |
1.00 |
R8699:Tpr
|
UTSW |
1 |
150,293,772 (GRCm39) |
missense |
probably damaging |
0.99 |
R8859:Tpr
|
UTSW |
1 |
150,284,597 (GRCm39) |
missense |
possibly damaging |
0.90 |
R9119:Tpr
|
UTSW |
1 |
150,279,753 (GRCm39) |
missense |
probably damaging |
0.99 |
R9326:Tpr
|
UTSW |
1 |
150,301,407 (GRCm39) |
missense |
possibly damaging |
0.86 |
R9618:Tpr
|
UTSW |
1 |
150,321,979 (GRCm39) |
missense |
possibly damaging |
0.70 |
R9680:Tpr
|
UTSW |
1 |
150,314,887 (GRCm39) |
missense |
probably benign |
0.32 |
R9776:Tpr
|
UTSW |
1 |
150,324,939 (GRCm39) |
missense |
probably benign |
0.00 |
X0021:Tpr
|
UTSW |
1 |
150,270,958 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1177:Tpr
|
UTSW |
1 |
150,303,986 (GRCm39) |
missense |
probably damaging |
0.99 |
|
Predicted Primers |
PCR Primer
(F):5'- GGCCATGGTATGTAAGAGGC -3'
(R):5'- CTAAAAGAAGCTTTCTGGCTAAGTG -3'
Sequencing Primer
(F):5'- AGCTTCCTTTGCTCTTAAAGTAGAC -3'
(R):5'- TGGCTAAGTGTCACACGATC -3'
|
Posted On |
2016-03-01 |