Incidental Mutation 'R4839:Magi1'
| ID |
371624 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Magi1
|
| Ensembl Gene |
ENSMUSG00000045095 |
| Gene Name |
membrane associated guanylate kinase, WW and PDZ domain containing 1 |
| Synonyms |
Baiap1, Gukmi1, AIP3, BAP1, WWP3 |
| Accession Numbers |
|
| Essential gene? |
Possibly essential
(E-score: 0.593)
|
| Stock # |
R4839 (G1)
|
| Quality Score |
173 |
|
Status
|
Not validated
|
| Chromosome |
6 |
| Chromosomal Location |
93652436-94260898 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 93671177 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Valine to Glutamic Acid
at position 796
(V796E)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000091283
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000055224]
[ENSMUST00000089317]
[ENSMUST00000093769]
[ENSMUST00000203519]
[ENSMUST00000203688]
[ENSMUST00000204347]
[ENSMUST00000204532]
|
| AlphaFold |
Q6RHR9 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000055224
|
| SMART Domains |
Protein: ENSMUSP00000062085
Gene: ENSMUSG00000045095
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
|
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
|
WW
|
301 |
333 |
9.65e-11 |
SMART |
|
WW
|
348 |
380 |
2.88e-9 |
SMART |
|
low complexity region
|
390 |
402 |
N/A |
INTRINSIC |
|
low complexity region
|
410 |
428 |
N/A |
INTRINSIC |
|
PDZ
|
460 |
536 |
3.71e-18 |
SMART |
|
PDZ
|
631 |
703 |
4.68e-15 |
SMART |
|
low complexity region
|
707 |
714 |
N/A |
INTRINSIC |
|
low complexity region
|
720 |
733 |
N/A |
INTRINSIC |
|
PDZ
|
800 |
876 |
4.64e-19 |
SMART |
|
low complexity region
|
920 |
942 |
N/A |
INTRINSIC |
|
PDB:1UEW|A
|
945 |
977 |
2e-6 |
PDB |
|
PDZ
|
1043 |
1117 |
1.26e-20 |
SMART |
|
low complexity region
|
1152 |
1164 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000089317
|
| SMART Domains |
Protein: ENSMUSP00000086730
Gene: ENSMUSG00000045095
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
4e-7 |
SMART |
|
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
|
WW
|
301 |
333 |
5.8e-13 |
SMART |
|
WW
|
360 |
392 |
1.7e-11 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
|
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
|
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
|
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
|
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
|
PDZ
|
999 |
1074 |
6.1e-25 |
SMART |
|
PDZ
|
1140 |
1214 |
6.1e-23 |
SMART |
|
low complexity region
|
1347 |
1357 |
N/A |
INTRINSIC |
|
low complexity region
|
1366 |
1423 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000093769
AA Change: V796E
PolyPhen 2
Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
|
| SMART Domains |
Protein: ENSMUSP00000091283
Gene: ENSMUSG00000045095
AA Change: V796E
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
10 |
15 |
N/A |
INTRINSIC |
|
WW
|
74 |
106 |
9.65e-11 |
SMART |
|
WW
|
133 |
165 |
2.88e-9 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
|
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
|
low complexity region
|
492 |
499 |
N/A |
INTRINSIC |
|
low complexity region
|
505 |
518 |
N/A |
INTRINSIC |
|
PDZ
|
613 |
689 |
4.64e-19 |
SMART |
|
low complexity region
|
733 |
755 |
N/A |
INTRINSIC |
|
PDZ
|
771 |
858 |
2.3e-23 |
SMART |
|
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
low complexity region
|
1131 |
1141 |
N/A |
INTRINSIC |
|
low complexity region
|
1150 |
1207 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000203519
|
| SMART Domains |
Protein: ENSMUSP00000145244
Gene: ENSMUSG00000045095
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
8.04e-5 |
SMART |
|
GuKc
|
111 |
295 |
2.55e-49 |
SMART |
|
WW
|
301 |
333 |
9.65e-11 |
SMART |
|
WW
|
360 |
392 |
2.88e-9 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
3.71e-18 |
SMART |
|
PDZ
|
643 |
715 |
4.68e-15 |
SMART |
|
low complexity region
|
719 |
726 |
N/A |
INTRINSIC |
|
low complexity region
|
732 |
745 |
N/A |
INTRINSIC |
|
PDZ
|
812 |
888 |
4.64e-19 |
SMART |
|
low complexity region
|
932 |
954 |
N/A |
INTRINSIC |
|
PDB:1UEW|A
|
957 |
989 |
2e-6 |
PDB |
|
PDZ
|
1055 |
1115 |
1.13e-8 |
SMART |
|
| Predicted Effect |
possibly damaging
Transcript: ENSMUST00000203688
AA Change: V796E
PolyPhen 2
Score 0.885 (Sensitivity: 0.82; Specificity: 0.94)
|
| SMART Domains |
Protein: ENSMUSP00000145515
Gene: ENSMUSG00000045095
AA Change: V796E
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MAGI_u1
|
1 |
34 |
2.9e-17 |
PFAM |
|
WW
|
74 |
106 |
9.65e-11 |
SMART |
|
WW
|
133 |
165 |
2.88e-9 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
3.71e-18 |
SMART |
|
PDZ
|
416 |
488 |
4.68e-15 |
SMART |
|
low complexity region
|
506 |
519 |
N/A |
INTRINSIC |
|
PDZ
|
614 |
690 |
4.64e-19 |
SMART |
|
low complexity region
|
734 |
756 |
N/A |
INTRINSIC |
|
PDZ
|
772 |
858 |
1.74e-23 |
SMART |
|
PDZ
|
924 |
998 |
1.26e-20 |
SMART |
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000204347
AA Change: V1024E
PolyPhen 2
Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000144881
Gene: ENSMUSG00000045095
AA Change: V1024E
| Domain | Start | End | E-Value | Type |
|---|
|
PDZ
|
26 |
105 |
4e-7 |
SMART |
|
GuKc
|
111 |
295 |
1.3e-51 |
SMART |
|
WW
|
301 |
333 |
5.8e-13 |
SMART |
|
WW
|
360 |
392 |
1.7e-11 |
SMART |
|
low complexity region
|
402 |
414 |
N/A |
INTRINSIC |
|
low complexity region
|
422 |
440 |
N/A |
INTRINSIC |
|
PDZ
|
472 |
548 |
1.9e-20 |
SMART |
|
PDZ
|
643 |
715 |
2.3e-17 |
SMART |
|
low complexity region
|
733 |
746 |
N/A |
INTRINSIC |
|
PDZ
|
841 |
917 |
2.4e-21 |
SMART |
|
low complexity region
|
961 |
983 |
N/A |
INTRINSIC |
|
PDZ
|
999 |
1086 |
1.1e-25 |
SMART |
|
PDZ
|
1152 |
1226 |
6.1e-23 |
SMART |
|
low complexity region
|
1261 |
1273 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000204532
|
| SMART Domains |
Protein: ENSMUSP00000144769
Gene: ENSMUSG00000045095
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:MAGI_u1
|
1 |
34 |
1.8e-14 |
PFAM |
|
WW
|
74 |
106 |
5.8e-13 |
SMART |
|
WW
|
133 |
165 |
1.7e-11 |
SMART |
|
low complexity region
|
175 |
187 |
N/A |
INTRINSIC |
|
low complexity region
|
195 |
213 |
N/A |
INTRINSIC |
|
PDZ
|
245 |
321 |
1.9e-20 |
SMART |
|
PDZ
|
416 |
488 |
7.3e-17 |
SMART |
|
| Coding Region Coverage |
- 1x: 99.2%
- 3x: 98.5%
- 10x: 96.8%
- 20x: 93.8%
|
| Validation Efficiency |
|
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a member of the membrane-associated guanylate kinase homologue (MAGUK) family. MAGUK proteins participate in the assembly of multiprotein complexes on the inner surface of the plasma membrane at regions of cell-cell contact. The product of this gene may play a role as scaffolding protein at cell-cell junctions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
|
| Allele List at MGI |
All alleles(165) : Targeted(2) Gene trapped(163)
|
| Other mutations in this stock |
Total: 93 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 1700010I14Rik |
T |
A |
17: 9,226,845 (GRCm39) |
S467T |
probably benign |
Het |
| 2310030G06Rik |
A |
T |
9: 50,652,023 (GRCm39) |
Y68* |
probably null |
Het |
| Abat |
T |
G |
16: 8,401,512 (GRCm39) |
|
probably benign |
Het |
| Abca2 |
C |
T |
2: 25,330,921 (GRCm39) |
S1203F |
probably damaging |
Het |
| Adam22 |
G |
A |
5: 8,186,813 (GRCm39) |
P436L |
probably damaging |
Het |
| Ak3 |
A |
C |
19: 29,025,132 (GRCm39) |
L33R |
probably damaging |
Het |
| Arhgap11a |
A |
T |
2: 113,672,374 (GRCm39) |
I198K |
probably damaging |
Het |
| Arl14epl |
A |
T |
18: 47,065,544 (GRCm39) |
K103M |
possibly damaging |
Het |
| Atg16l1 |
T |
A |
1: 87,693,896 (GRCm39) |
N65K |
probably damaging |
Het |
| Btnl2 |
G |
A |
17: 34,584,260 (GRCm39) |
W394* |
probably null |
Het |
| Cacna1e |
C |
A |
1: 154,296,804 (GRCm39) |
R1687L |
probably damaging |
Het |
| Cacna1g |
G |
T |
11: 94,350,433 (GRCm39) |
R471S |
probably benign |
Het |
| Cdh13 |
A |
T |
8: 119,578,587 (GRCm39) |
R205* |
probably null |
Het |
| Cdkl3 |
A |
T |
11: 51,895,861 (GRCm39) |
Y36F |
probably damaging |
Het |
| Cep290 |
T |
A |
10: 100,344,648 (GRCm39) |
N488K |
probably damaging |
Het |
| Cep350 |
A |
T |
1: 155,804,240 (GRCm39) |
C948S |
probably benign |
Het |
| Cep70 |
A |
G |
9: 99,178,138 (GRCm39) |
K446R |
probably benign |
Het |
| Cfap70 |
T |
C |
14: 20,475,597 (GRCm39) |
T375A |
probably damaging |
Het |
| Cfhr1 |
A |
G |
1: 139,487,871 (GRCm39) |
L9S |
probably damaging |
Het |
| Chrm4 |
T |
A |
2: 91,757,952 (GRCm39) |
M120K |
probably damaging |
Het |
| Col1a1 |
A |
G |
11: 94,840,921 (GRCm39) |
|
probably null |
Het |
| Col3a1 |
T |
C |
1: 45,362,963 (GRCm39) |
|
probably null |
Het |
| Csrnp3 |
A |
T |
2: 65,852,375 (GRCm39) |
R256* |
probably null |
Het |
| Dbf4 |
T |
A |
5: 8,458,263 (GRCm39) |
K190* |
probably null |
Het |
| Dnah10 |
A |
T |
5: 124,850,196 (GRCm39) |
I1573F |
probably damaging |
Het |
| Dock8 |
A |
G |
19: 25,146,858 (GRCm39) |
I1446V |
probably benign |
Het |
| Dst |
G |
T |
1: 34,229,943 (GRCm39) |
R2187M |
probably damaging |
Het |
| Ece2 |
C |
T |
16: 20,449,918 (GRCm39) |
R257C |
probably damaging |
Het |
| Espn |
A |
G |
4: 152,222,961 (GRCm39) |
Y306H |
probably damaging |
Het |
| Fkbpl |
G |
A |
17: 34,864,839 (GRCm39) |
M202I |
probably benign |
Het |
| Fn1 |
A |
G |
1: 71,681,242 (GRCm39) |
L362P |
probably damaging |
Het |
| Ganc |
A |
C |
2: 120,290,304 (GRCm39) |
R880S |
probably benign |
Het |
| Gucy1b2 |
A |
T |
14: 62,685,695 (GRCm39) |
L90Q |
probably damaging |
Het |
| Hcn1 |
T |
A |
13: 118,062,246 (GRCm39) |
I504N |
unknown |
Het |
| Hdac2 |
C |
A |
10: 36,873,462 (GRCm39) |
T352K |
probably benign |
Het |
| Hip1 |
T |
C |
5: 135,455,172 (GRCm39) |
|
probably null |
Het |
| Hspa13 |
G |
A |
16: 75,562,169 (GRCm39) |
S10L |
probably damaging |
Het |
| Ipo5 |
T |
C |
14: 121,157,450 (GRCm39) |
I96T |
probably benign |
Het |
| Isl1 |
T |
C |
13: 116,438,220 (GRCm39) |
Y264C |
probably damaging |
Het |
| Izumo1 |
T |
C |
7: 45,275,657 (GRCm39) |
I322T |
probably benign |
Het |
| Kars1 |
A |
C |
8: 112,729,158 (GRCm39) |
V183G |
possibly damaging |
Het |
| Lrrc15 |
C |
A |
16: 30,093,086 (GRCm39) |
M84I |
probably benign |
Het |
| Matn4 |
G |
T |
2: 164,242,896 (GRCm39) |
D67E |
probably benign |
Het |
| Mertk |
A |
G |
2: 128,624,496 (GRCm39) |
M636V |
probably damaging |
Het |
| Mettl27 |
C |
A |
5: 134,963,266 (GRCm39) |
P126T |
probably damaging |
Het |
| Mfrp |
T |
A |
9: 44,013,432 (GRCm39) |
H52Q |
possibly damaging |
Het |
| Mrgprb8 |
T |
G |
7: 48,038,656 (GRCm39) |
I109R |
probably benign |
Het |
| Mroh2a |
G |
A |
1: 88,165,666 (GRCm39) |
G512S |
probably damaging |
Het |
| Ncoa7 |
T |
A |
10: 30,598,655 (GRCm39) |
R89S |
possibly damaging |
Het |
| Nfkb2 |
G |
T |
19: 46,296,006 (GRCm39) |
E170D |
probably benign |
Het |
| Nin |
G |
T |
12: 70,137,325 (GRCm39) |
H84N |
possibly damaging |
Het |
| Nwd2 |
A |
T |
5: 63,962,893 (GRCm39) |
I826F |
possibly damaging |
Het |
| Or10d1 |
A |
G |
9: 39,484,441 (GRCm39) |
M38T |
probably benign |
Het |
| Or14c43 |
T |
C |
7: 86,115,117 (GRCm39) |
F166S |
probably damaging |
Het |
| Or1j11 |
G |
A |
2: 36,312,012 (GRCm39) |
V201I |
probably benign |
Het |
| Or4l15 |
C |
T |
14: 50,197,646 (GRCm39) |
M294I |
probably benign |
Het |
| Or52a5b |
T |
C |
7: 103,416,961 (GRCm39) |
I214M |
possibly damaging |
Het |
| Or5k3 |
A |
G |
16: 58,969,393 (GRCm39) |
Y60C |
probably damaging |
Het |
| Or5p73 |
T |
C |
7: 108,064,938 (GRCm39) |
S136P |
probably benign |
Het |
| Otof |
C |
T |
5: 30,576,748 (GRCm39) |
R168H |
probably damaging |
Het |
| Pcdha6 |
T |
C |
18: 37,101,485 (GRCm39) |
V226A |
possibly damaging |
Het |
| Pggt1b |
T |
C |
18: 46,391,166 (GRCm39) |
I200V |
possibly damaging |
Het |
| Ppat |
G |
A |
5: 77,098,811 (GRCm39) |
Q41* |
probably null |
Het |
| Ppfibp2 |
A |
T |
7: 107,342,192 (GRCm39) |
H27L |
probably damaging |
Het |
| Rbm27 |
T |
A |
18: 42,460,510 (GRCm39) |
I775N |
probably damaging |
Het |
| Rnf40 |
C |
T |
7: 127,191,812 (GRCm39) |
R349* |
probably null |
Het |
| Rtp3 |
A |
T |
9: 110,818,544 (GRCm39) |
W46R |
probably damaging |
Het |
| Sass6 |
C |
T |
3: 116,403,949 (GRCm39) |
R196W |
probably damaging |
Het |
| Sel1l |
A |
T |
12: 91,799,932 (GRCm39) |
D131E |
probably benign |
Het |
| Slain2 |
T |
C |
5: 73,106,066 (GRCm39) |
S234P |
probably damaging |
Het |
| Slc47a1 |
C |
T |
11: 61,264,176 (GRCm39) |
|
probably null |
Het |
| Sp140 |
CAGAAGAAG |
CAGAAG |
1: 85,538,529 (GRCm39) |
|
probably benign |
Het |
| Spata31e2 |
T |
C |
1: 26,724,440 (GRCm39) |
T247A |
probably benign |
Het |
| Spef2 |
A |
T |
15: 9,713,264 (GRCm39) |
Y369* |
probably null |
Het |
| Spred2 |
T |
A |
11: 19,948,233 (GRCm39) |
M76K |
possibly damaging |
Het |
| Svs5 |
T |
A |
2: 164,078,806 (GRCm39) |
D367V |
probably benign |
Het |
| Tasor2 |
G |
A |
13: 3,634,807 (GRCm39) |
P667S |
probably damaging |
Het |
| Tefm |
A |
T |
11: 80,027,947 (GRCm39) |
D270E |
probably benign |
Het |
| Tfcp2l1 |
C |
A |
1: 118,597,194 (GRCm39) |
P425H |
probably benign |
Het |
| Thbd |
A |
T |
2: 148,248,591 (GRCm39) |
C426S |
probably damaging |
Het |
| Timm10b |
T |
A |
7: 105,333,219 (GRCm39) |
D968E |
probably damaging |
Het |
| Tle2 |
C |
T |
10: 81,413,518 (GRCm39) |
T119I |
probably damaging |
Het |
| Tnik |
T |
A |
3: 28,650,224 (GRCm39) |
Y446N |
possibly damaging |
Het |
| Tpr |
T |
A |
1: 150,324,948 (GRCm39) |
L2400* |
probably null |
Het |
| Trrap |
T |
C |
5: 144,782,402 (GRCm39) |
F3328S |
probably damaging |
Het |
| Vldlr |
G |
A |
19: 27,215,465 (GRCm39) |
C154Y |
probably damaging |
Het |
| Vmn1r79 |
T |
G |
7: 11,910,361 (GRCm39) |
M81R |
probably benign |
Het |
| Vps13d |
T |
C |
4: 144,812,000 (GRCm39) |
T3305A |
possibly damaging |
Het |
| Wdr62 |
T |
C |
7: 29,970,111 (GRCm39) |
E232G |
probably damaging |
Het |
| Wdr62 |
T |
A |
7: 29,940,890 (GRCm39) |
I843F |
probably benign |
Het |
| Zfp747l1 |
T |
C |
7: 126,984,179 (GRCm39) |
S308G |
probably benign |
Het |
| Zfp873 |
T |
A |
10: 81,896,353 (GRCm39) |
H361Q |
probably damaging |
Het |
| Zfp949 |
A |
C |
9: 88,452,047 (GRCm39) |
H539P |
probably damaging |
Het |
|
| Other mutations in Magi1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01376:Magi1
|
APN |
6 |
94,260,074 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
IGL01457:Magi1
|
APN |
6 |
93,724,205 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL01642:Magi1
|
APN |
6 |
93,663,605 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
IGL01724:Magi1
|
APN |
6 |
93,769,381 (GRCm39) |
splice site |
probably null |
|
|
IGL01967:Magi1
|
APN |
6 |
93,685,115 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01984:Magi1
|
APN |
6 |
93,685,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02074:Magi1
|
APN |
6 |
93,722,579 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02098:Magi1
|
APN |
6 |
93,655,768 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02225:Magi1
|
APN |
6 |
93,671,007 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02522:Magi1
|
APN |
6 |
93,655,617 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
IGL02659:Magi1
|
APN |
6 |
93,762,591 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL02900:Magi1
|
APN |
6 |
93,663,854 (GRCm39) |
missense |
probably damaging |
1.00 |
|
P0007:Magi1
|
UTSW |
6 |
93,722,969 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0149:Magi1
|
UTSW |
6 |
93,724,226 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0512:Magi1
|
UTSW |
6 |
93,671,045 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1487:Magi1
|
UTSW |
6 |
93,685,060 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1497:Magi1
|
UTSW |
6 |
93,724,310 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1502:Magi1
|
UTSW |
6 |
93,671,151 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1824:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R2042:Magi1
|
UTSW |
6 |
93,732,026 (GRCm39) |
missense |
probably benign |
|
|
R2132:Magi1
|
UTSW |
6 |
93,674,255 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2331:Magi1
|
UTSW |
6 |
93,662,543 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2418:Magi1
|
UTSW |
6 |
93,722,891 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3076:Magi1
|
UTSW |
6 |
93,734,668 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R3551:Magi1
|
UTSW |
6 |
93,676,610 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4005:Magi1
|
UTSW |
6 |
93,678,299 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4455:Magi1
|
UTSW |
6 |
93,762,438 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4670:Magi1
|
UTSW |
6 |
93,663,624 (GRCm39) |
splice site |
probably null |
|
|
R4671:Magi1
|
UTSW |
6 |
93,657,768 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5132:Magi1
|
UTSW |
6 |
93,660,072 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R5147:Magi1
|
UTSW |
6 |
93,724,248 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5525:Magi1
|
UTSW |
6 |
93,769,354 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R5724:Magi1
|
UTSW |
6 |
93,722,682 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5724:Magi1
|
UTSW |
6 |
93,657,852 (GRCm39) |
missense |
probably benign |
0.03 |
|
R5846:Magi1
|
UTSW |
6 |
93,662,584 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5896:Magi1
|
UTSW |
6 |
93,685,180 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5912:Magi1
|
UTSW |
6 |
93,685,126 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6112:Magi1
|
UTSW |
6 |
93,722,571 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6115:Magi1
|
UTSW |
6 |
93,685,051 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R6351:Magi1
|
UTSW |
6 |
93,920,210 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R6355:Magi1
|
UTSW |
6 |
94,260,177 (GRCm39) |
missense |
probably benign |
0.06 |
|
R6457:Magi1
|
UTSW |
6 |
93,676,620 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6464:Magi1
|
UTSW |
6 |
93,676,770 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6613:Magi1
|
UTSW |
6 |
93,722,654 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6661:Magi1
|
UTSW |
6 |
93,920,289 (GRCm39) |
missense |
probably benign |
0.08 |
|
R6755:Magi1
|
UTSW |
6 |
93,685,158 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6909:Magi1
|
UTSW |
6 |
93,674,301 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7180:Magi1
|
UTSW |
6 |
93,792,731 (GRCm39) |
missense |
probably benign |
0.10 |
|
R7224:Magi1
|
UTSW |
6 |
93,660,070 (GRCm39) |
missense |
probably benign |
0.34 |
|
R7447:Magi1
|
UTSW |
6 |
93,722,562 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
R7517:Magi1
|
UTSW |
6 |
93,685,189 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7537:Magi1
|
UTSW |
6 |
93,685,091 (GRCm39) |
nonsense |
probably null |
|
|
R7549:Magi1
|
UTSW |
6 |
93,685,095 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7566:Magi1
|
UTSW |
6 |
93,655,308 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7805:Magi1
|
UTSW |
6 |
93,659,927 (GRCm39) |
missense |
probably benign |
|
|
R8022:Magi1
|
UTSW |
6 |
93,674,346 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8290:Magi1
|
UTSW |
6 |
94,260,066 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8519:Magi1
|
UTSW |
6 |
93,681,330 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R8762:Magi1
|
UTSW |
6 |
93,792,789 (GRCm39) |
nonsense |
probably null |
|
|
R8894:Magi1
|
UTSW |
6 |
93,663,586 (GRCm39) |
missense |
probably benign |
0.12 |
|
R8974:Magi1
|
UTSW |
6 |
93,674,223 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9225:Magi1
|
UTSW |
6 |
93,762,511 (GRCm39) |
missense |
possibly damaging |
0.64 |
|
R9277:Magi1
|
UTSW |
6 |
93,920,234 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R9300:Magi1
|
UTSW |
6 |
93,724,209 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9393:Magi1
|
UTSW |
6 |
93,659,890 (GRCm39) |
missense |
probably benign |
0.27 |
|
R9402:Magi1
|
UTSW |
6 |
94,260,278 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9432:Magi1
|
UTSW |
6 |
93,660,058 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9567:Magi1
|
UTSW |
6 |
93,659,931 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9567:Magi1
|
UTSW |
6 |
93,655,431 (GRCm39) |
missense |
probably damaging |
1.00 |
|
| Predicted Primers |
PCR Primer
(F):5'- ATGATGCGGAGAGTCACTGTG -3'
(R):5'- ACGTTGAACTGTAGACTCGGAG -3'
Sequencing Primer
(F):5'- AGAGTCACTGTGTTGCCCG -3'
(R):5'- CCCTTCACTATATTCCCACATAA -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation