Incidental Mutation 'R4845:Iqcm'
ID 372113
Institutional Source Beutler Lab
Gene Symbol Iqcm
Ensembl Gene ENSMUSG00000031620
Gene Name IQ motif containing M
Synonyms 1700007B14Rik
MMRRC Submission 042458-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R4845 (G1)
Quality Score 225
Status Not validated
Chromosome 8
Chromosomal Location 76175322-76711131 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 76472980 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Arginine to Isoleucine at position 273 (R273I)
Ref Sequence ENSEMBL: ENSMUSP00000148495 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000034033] [ENSMUST00000121983] [ENSMUST00000212704]
AlphaFold Q149I8
Predicted Effect probably damaging
Transcript: ENSMUST00000034033
AA Change: R273I

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000034033
Gene: ENSMUSG00000031620
AA Change: R273I

DomainStartEndE-ValueType
IQ 281 303 2.54e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000121983
AA Change: R273I

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000112901
Gene: ENSMUSG00000031620
AA Change: R273I

DomainStartEndE-ValueType
IQ 281 303 2.54e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000212704
AA Change: R273I

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.7%
  • 20x: 93.6%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 57 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcg1 C T 17: 31,333,057 (GRCm39) S600F possibly damaging Het
Arhgap21 T A 2: 20,885,998 (GRCm39) N393I probably damaging Het
Atp5pf T A 16: 84,628,365 (GRCm39) I6F possibly damaging Het
B4galt6 A G 18: 20,821,517 (GRCm39) L337S probably benign Het
C8b G T 4: 104,649,009 (GRCm39) V308F possibly damaging Het
Cables1 A G 18: 12,077,545 (GRCm39) R558G probably damaging Het
Chmp2b T A 16: 65,347,862 (GRCm39) Q38L probably damaging Het
Clca3b A T 3: 144,531,031 (GRCm39) I773K probably benign Het
Cnmd T C 14: 79,899,448 (GRCm39) T2A probably benign Het
Crb1 C T 1: 139,170,772 (GRCm39) D812N probably benign Het
Dnah7c T A 1: 46,832,692 (GRCm39) D3901E probably damaging Het
Dst T C 1: 34,232,208 (GRCm39) V3445A probably benign Het
Epn1 T A 7: 5,096,908 (GRCm39) I230N possibly damaging Het
Exoc6b G T 6: 84,812,119 (GRCm39) D627E probably benign Het
Exosc1 T C 19: 41,919,797 (GRCm39) K74E possibly damaging Het
Extl3 T C 14: 65,315,024 (GRCm39) T53A probably benign Het
Fam227a C T 15: 79,533,912 (GRCm39) R17H probably damaging Het
Faxc G T 4: 21,993,358 (GRCm39) W334L probably damaging Het
Gabrr3 T C 16: 59,246,833 (GRCm39) I94T probably damaging Het
Ifi203 A T 1: 173,754,595 (GRCm39) M298K probably benign Het
Igkv4-78 A T 6: 69,037,207 (GRCm39) M1K probably null Het
Itga1 G T 13: 115,110,708 (GRCm39) S961* probably null Het
Jmy T A 13: 93,576,246 (GRCm39) M886L possibly damaging Het
Lrp2 T C 2: 69,339,585 (GRCm39) T1109A possibly damaging Het
Mastl A G 2: 23,030,010 (GRCm39) S239P probably benign Het
Mettl14 T A 3: 123,165,004 (GRCm39) E112V probably damaging Het
Mfng C T 15: 78,648,588 (GRCm39) R163H probably benign Het
Musk A G 4: 58,296,679 (GRCm39) D93G probably damaging Het
Myoc C T 1: 162,475,034 (GRCm39) T195M possibly damaging Het
Ncapg2 A G 12: 116,404,208 (GRCm39) D893G probably damaging Het
Nrap C T 19: 56,339,902 (GRCm39) V908M probably benign Het
Or4a79 T C 2: 89,552,120 (GRCm39) I112V probably benign Het
Or52n5 T C 7: 104,588,570 (GRCm39) V279A possibly damaging Het
Or5g9 T A 2: 85,551,836 (GRCm39) L29* probably null Het
Orc4 T C 2: 48,799,478 (GRCm39) N333S probably benign Het
Otx1 C A 11: 21,947,037 (GRCm39) A91S probably damaging Het
Pcdhb8 G A 18: 37,489,771 (GRCm39) G483D probably benign Het
Pclo A T 5: 14,729,132 (GRCm39) probably benign Het
Ppm1k A T 6: 57,499,753 (GRCm39) Y174* probably null Het
Ptprq A T 10: 107,489,393 (GRCm39) S911T probably benign Het
Rp1 C A 1: 4,419,451 (GRCm39) A554S probably benign Het
Sema3f T C 9: 107,562,700 (GRCm39) Y427C probably damaging Het
Slc12a1 A T 2: 125,030,146 (GRCm39) I573F probably damaging Het
Slc17a1 A T 13: 24,060,601 (GRCm39) Y201F probably damaging Het
Slc4a7 A T 14: 14,733,803 (GRCm38) H71L probably damaging Het
Spata6l G T 19: 28,905,148 (GRCm39) D305E probably benign Het
St13 G C 15: 81,283,786 (GRCm39) R4G probably benign Het
Tab1 C T 15: 80,036,964 (GRCm39) R217W probably damaging Het
Taf6 T A 5: 138,180,909 (GRCm39) Y224F possibly damaging Het
Tmc5 C G 7: 118,241,604 (GRCm39) F432L probably damaging Het
Trbc1 A T 6: 41,516,169 (GRCm39) probably benign Het
Trbv21 A G 6: 41,179,879 (GRCm39) N65S probably benign Het
Trim15 G A 17: 37,177,875 (GRCm39) P40L probably benign Het
Txnip T C 3: 96,466,916 (GRCm39) S197P probably benign Het
Vmn1r167 T A 7: 23,204,158 (GRCm39) Q286L probably benign Het
Wnt9a A G 11: 59,222,067 (GRCm39) I322V probably benign Het
Zfp879 T C 11: 50,724,672 (GRCm39) E128G probably damaging Het
Other mutations in Iqcm
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01895:Iqcm APN 8 76,615,188 (GRCm39) missense probably damaging 1.00
IGL02835:Iqcm APN 8 76,281,511 (GRCm39) utr 5 prime probably benign
R0056:Iqcm UTSW 8 76,480,014 (GRCm39) missense probably benign
R2146:Iqcm UTSW 8 76,615,241 (GRCm39) missense probably damaging 1.00
R2910:Iqcm UTSW 8 76,441,404 (GRCm39) missense probably benign
R3801:Iqcm UTSW 8 76,396,021 (GRCm39) missense possibly damaging 0.59
R3804:Iqcm UTSW 8 76,396,021 (GRCm39) missense possibly damaging 0.59
R3834:Iqcm UTSW 8 76,304,380 (GRCm39) missense possibly damaging 0.93
R3897:Iqcm UTSW 8 76,480,028 (GRCm39) missense probably damaging 1.00
R4447:Iqcm UTSW 8 76,356,394 (GRCm39) missense probably damaging 0.97
R4448:Iqcm UTSW 8 76,356,394 (GRCm39) missense probably damaging 0.97
R4450:Iqcm UTSW 8 76,356,394 (GRCm39) missense probably damaging 0.97
R4687:Iqcm UTSW 8 76,489,617 (GRCm39) missense probably damaging 1.00
R4810:Iqcm UTSW 8 76,615,281 (GRCm39) missense probably damaging 1.00
R4856:Iqcm UTSW 8 76,615,228 (GRCm39) missense possibly damaging 0.95
R4886:Iqcm UTSW 8 76,615,228 (GRCm39) missense possibly damaging 0.95
R5063:Iqcm UTSW 8 76,472,914 (GRCm39) missense probably damaging 1.00
R5460:Iqcm UTSW 8 76,441,417 (GRCm39) missense probably benign
R6403:Iqcm UTSW 8 76,304,624 (GRCm39) critical splice donor site probably null
R6667:Iqcm UTSW 8 76,479,980 (GRCm39) missense probably damaging 1.00
R7187:Iqcm UTSW 8 76,480,044 (GRCm39) missense probably benign 0.22
R7263:Iqcm UTSW 8 76,489,701 (GRCm39) missense probably benign
R7701:Iqcm UTSW 8 76,281,539 (GRCm39) missense probably benign 0.02
R7916:Iqcm UTSW 8 76,304,578 (GRCm39) missense probably benign
R7938:Iqcm UTSW 8 76,304,596 (GRCm39) missense probably benign
R7974:Iqcm UTSW 8 76,281,520 (GRCm39) start codon destroyed probably null 0.66
R8039:Iqcm UTSW 8 76,489,733 (GRCm39) missense probably damaging 1.00
R8311:Iqcm UTSW 8 76,480,118 (GRCm39) splice site probably benign
R8703:Iqcm UTSW 8 76,615,271 (GRCm39) missense probably damaging 1.00
R9175:Iqcm UTSW 8 76,710,867 (GRCm39) missense possibly damaging 0.84
R9475:Iqcm UTSW 8 76,480,083 (GRCm39) missense probably damaging 1.00
RF002:Iqcm UTSW 8 76,304,527 (GRCm39) missense probably benign 0.01
X0018:Iqcm UTSW 8 76,710,840 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CTGGCCTCAATCCTTACTACTGAAG -3'
(R):5'- AGCAAGTTCCAGGACAGTCAA -3'

Sequencing Primer
(F):5'- CAATCCTTACTACTGAAGTGTGTGTG -3'
(R):5'- TTCCAGGACAGTCAAGGACTACATG -3'
Posted On 2016-03-01