Incidental Mutation 'R4846:Nek11'
ID 372172
Institutional Source Beutler Lab
Gene Symbol Nek11
Ensembl Gene ENSMUSG00000035032
Gene Name NIMA (never in mitosis gene a)-related expressed kinase 11
Synonyms 4932416N14Rik
MMRRC Submission 042459-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R4846 (G1)
Quality Score 225
Status Validated
Chromosome 9
Chromosomal Location 105039355-105272723 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 105040362 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Aspartic acid at position 566 (E566D)
Ref Sequence ENSEMBL: ENSMUSP00000038611 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000038648] [ENSMUST00000177029]
AlphaFold Q8C0Q4
Predicted Effect probably damaging
Transcript: ENSMUST00000038648
AA Change: E566D

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000038611
Gene: ENSMUSG00000035032
AA Change: E566D

DomainStartEndE-ValueType
S_TKc 30 288 3.87e-80 SMART
coiled coil region 348 384 N/A INTRINSIC
low complexity region 408 423 N/A INTRINSIC
low complexity region 450 466 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000177029
SMART Domains Protein: ENSMUSP00000135837
Gene: ENSMUSG00000035032

DomainStartEndE-ValueType
SCOP:d1h8fa_ 11 80 1e-6 SMART
Blast:S_TKc 30 70 1e-11 BLAST
Predicted Effect noncoding transcript
Transcript: ENSMUST00000192953
Meta Mutation Damage Score 0.1186 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.4%
  • 10x: 96.6%
  • 20x: 93.4%
Validation Efficiency 100% (60/60)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the never in mitosis gene A family of kinases. The encoded protein localizes to the nucleoli, and may function with NEK2A in the S-phase checkpoint. The encoded protein appears to play roles in DNA replication and response to genotoxic stress. Alternatively spliced transcript variants have been described.[provided by RefSeq, Mar 2009]
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
9930012K11Rik T A 14: 70,393,392 (GRCm39) H299L probably damaging Het
Abcb4 C T 5: 8,985,180 (GRCm39) A687V probably benign Het
Abtb3 A G 10: 85,465,130 (GRCm39) T657A probably damaging Het
Adam20 A G 8: 41,248,048 (GRCm39) T53A probably benign Het
Afg1l G A 10: 42,330,490 (GRCm39) T59I probably benign Het
AI837181 A G 19: 5,476,329 (GRCm39) Q164R probably benign Het
Anapc15 T A 7: 101,546,974 (GRCm39) I12N probably benign Het
Ankrd55 A C 13: 112,499,988 (GRCm39) E278D probably benign Het
Axin2 A G 11: 108,833,125 (GRCm39) T437A probably benign Het
BC051665 T C 13: 60,931,895 (GRCm39) D168G probably damaging Het
Cd200 C T 16: 45,212,664 (GRCm39) R261H probably benign Het
Clk1 G A 1: 58,460,261 (GRCm39) S123L probably benign Het
Csrnp2 A T 15: 100,382,571 (GRCm39) D156E probably damaging Het
Ctss C T 3: 95,452,695 (GRCm39) Q159* probably null Het
Dennd2b C A 7: 109,156,043 (GRCm39) E236* probably null Het
Dip2a A G 10: 76,157,327 (GRCm39) S93P probably damaging Het
Dnase1l1 C T X: 73,320,644 (GRCm39) probably null Het
Dync1h1 C A 12: 110,624,560 (GRCm39) T3700N probably damaging Het
Ephb6 G A 6: 41,593,743 (GRCm39) R542Q probably benign Het
Fmo3 T C 1: 162,781,880 (GRCm39) D491G possibly damaging Het
Galnt14 A T 17: 73,843,888 (GRCm39) M140K probably benign Het
Ghsr T C 3: 27,425,986 (GRCm39) V14A probably benign Het
Gm17546 C A 15: 95,727,843 (GRCm39) probably benign Het
Gprc5c G T 11: 114,755,093 (GRCm39) V257L possibly damaging Het
Hc A G 2: 34,909,682 (GRCm39) V866A probably benign Het
Hoxb6 G A 11: 96,190,348 (GRCm39) G116R probably damaging Het
Hykk A G 9: 54,827,890 (GRCm39) Y43C probably damaging Het
Jade2 T C 11: 51,711,975 (GRCm39) T495A probably benign Het
Kansl1 A T 11: 104,233,798 (GRCm39) V755E possibly damaging Het
Lrp2 T A 2: 69,309,457 (GRCm39) D2814V probably damaging Het
Mbd5 T A 2: 49,147,009 (GRCm39) N406K probably damaging Het
Met A T 6: 17,491,928 (GRCm39) D230V probably damaging Het
Mrgprx2 A T 7: 48,132,584 (GRCm39) V78D probably damaging Het
Mrpl20 A G 4: 155,892,993 (GRCm39) T112A possibly damaging Het
Nostrin T C 2: 69,005,923 (GRCm39) S235P probably damaging Het
Npas4 C A 19: 5,036,805 (GRCm39) S453I probably benign Het
Pnkp C T 7: 44,511,827 (GRCm39) S113L probably damaging Het
Psg18 A T 7: 18,084,711 (GRCm39) Y128* probably null Het
Ptges3l A T 11: 101,310,010 (GRCm39) probably benign Het
Pus1 T C 5: 110,927,796 (GRCm39) probably benign Het
Raf1 T A 6: 115,621,544 (GRCm39) S12C possibly damaging Het
Rps6-ps2 T G 8: 89,533,206 (GRCm39) noncoding transcript Het
Slc5a4b A G 10: 75,898,073 (GRCm39) L547P probably damaging Het
Socs3 A G 11: 117,858,654 (GRCm39) S135P probably benign Het
Spata31d1e T C 13: 59,890,047 (GRCm39) D591G probably benign Het
Stra6l G A 4: 45,873,682 (GRCm39) V281M possibly damaging Het
Suco G A 1: 161,661,977 (GRCm39) T818I possibly damaging Het
Syde1 A T 10: 78,424,731 (GRCm39) V367D probably damaging Het
Tet3 A T 6: 83,353,865 (GRCm39) L932* probably null Het
Trpm7 G A 2: 126,655,105 (GRCm39) L1278F possibly damaging Het
Vmn1r168 A T 7: 23,240,490 (GRCm39) T116S probably damaging Het
Wfdc6b A G 2: 164,459,214 (GRCm39) Q92R possibly damaging Het
Other mutations in Nek11
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01348:Nek11 APN 9 105,270,112 (GRCm39) missense probably damaging 1.00
IGL01369:Nek11 APN 9 105,177,259 (GRCm39) critical splice donor site probably null
IGL01958:Nek11 APN 9 105,177,502 (GRCm39) missense probably benign 0.06
IGL03099:Nek11 APN 9 105,164,852 (GRCm39) missense probably benign 0.02
IGL03256:Nek11 APN 9 105,121,613 (GRCm39) missense probably damaging 1.00
IGL03400:Nek11 APN 9 105,082,065 (GRCm39) missense probably benign 0.01
R0051:Nek11 UTSW 9 105,095,738 (GRCm39) splice site probably benign
R0051:Nek11 UTSW 9 105,095,738 (GRCm39) splice site probably benign
R0194:Nek11 UTSW 9 105,270,151 (GRCm39) missense probably benign 0.05
R0942:Nek11 UTSW 9 105,172,570 (GRCm39) splice site probably null
R1226:Nek11 UTSW 9 105,270,091 (GRCm39) missense probably damaging 1.00
R1503:Nek11 UTSW 9 105,040,403 (GRCm39) missense probably damaging 1.00
R1709:Nek11 UTSW 9 105,225,260 (GRCm39) missense probably damaging 1.00
R1958:Nek11 UTSW 9 105,170,916 (GRCm39) missense probably benign 0.00
R2128:Nek11 UTSW 9 105,177,560 (GRCm39) missense probably benign 0.01
R3754:Nek11 UTSW 9 105,191,917 (GRCm39) missense probably damaging 1.00
R4027:Nek11 UTSW 9 105,121,589 (GRCm39) nonsense probably null
R4594:Nek11 UTSW 9 105,270,046 (GRCm39) critical splice donor site probably null
R4650:Nek11 UTSW 9 105,225,279 (GRCm39) missense possibly damaging 0.79
R4724:Nek11 UTSW 9 105,270,169 (GRCm39) missense possibly damaging 0.89
R4903:Nek11 UTSW 9 105,191,921 (GRCm39) missense possibly damaging 0.63
R4908:Nek11 UTSW 9 105,175,488 (GRCm39) missense probably benign 0.00
R4912:Nek11 UTSW 9 105,164,857 (GRCm39) missense probably benign 0.01
R4930:Nek11 UTSW 9 105,177,265 (GRCm39) missense probably damaging 1.00
R5827:Nek11 UTSW 9 105,191,944 (GRCm39) missense probably damaging 1.00
R5860:Nek11 UTSW 9 105,270,160 (GRCm39) missense probably benign 0.01
R6030:Nek11 UTSW 9 105,082,087 (GRCm39) critical splice acceptor site probably null
R6030:Nek11 UTSW 9 105,082,087 (GRCm39) critical splice acceptor site probably null
R6154:Nek11 UTSW 9 105,200,368 (GRCm39) makesense probably null
R6915:Nek11 UTSW 9 105,270,256 (GRCm39) unclassified probably benign
R7197:Nek11 UTSW 9 105,121,614 (GRCm39) missense probably damaging 1.00
R8059:Nek11 UTSW 9 105,040,173 (GRCm39) makesense probably null
R8140:Nek11 UTSW 9 105,270,156 (GRCm39) missense probably damaging 0.99
R8357:Nek11 UTSW 9 105,225,191 (GRCm39) missense probably damaging 1.00
R8457:Nek11 UTSW 9 105,225,191 (GRCm39) missense probably damaging 1.00
R8536:Nek11 UTSW 9 105,175,538 (GRCm39) missense probably benign 0.04
R8752:Nek11 UTSW 9 105,225,207 (GRCm39) missense probably benign 0.00
R8885:Nek11 UTSW 9 105,172,571 (GRCm39) critical splice donor site probably null
R9098:Nek11 UTSW 9 105,170,856 (GRCm39) missense probably benign 0.32
R9616:Nek11 UTSW 9 105,082,011 (GRCm39) missense probably damaging 1.00
Z1176:Nek11 UTSW 9 105,170,868 (GRCm39) missense probably benign 0.28
Predicted Primers PCR Primer
(F):5'- AAATGAGTGCCCTTGACCGG -3'
(R):5'- GGGTGAGATTCTGCACCTTAG -3'

Sequencing Primer
(F):5'- TGACCGGCTTCTTCTGGGC -3'
(R):5'- GAGATTCTGCACCTTAGGGTCATC -3'
Posted On 2016-03-01