Incidental Mutation 'R4859:Kndc1'
| ID |
372325 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Kndc1
|
| Ensembl Gene |
ENSMUSG00000066129 |
| Gene Name |
kinase non-catalytic C-lobe domain (KIND) containing 1 |
| Synonyms |
B830014K08Rik, VKIND, very-kind, 2410012C07Rik |
| MMRRC Submission |
042470-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R4859 (G1)
|
| Quality Score |
225 |
|
Status
|
Validated
|
| Chromosome |
7 |
| Chromosomal Location |
139474612-139521450 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 139501821 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Serine to Proline
at position 953
(S953P)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000050586
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000053445]
|
| AlphaFold |
Q0KK55 |
| Predicted Effect |
probably benign
Transcript: ENSMUST00000053445
AA Change: S953P
PolyPhen 2
Score 0.027 (Sensitivity: 0.95; Specificity: 0.81)
|
| SMART Domains |
Protein: ENSMUSP00000050586
Gene: ENSMUSG00000066129
AA Change: S953P
| Domain | Start | End | E-Value | Type |
|---|
|
KIND
|
37 |
217 |
4.66e-65 |
SMART |
|
Blast:KIND
|
381 |
454 |
2e-10 |
BLAST |
|
KIND
|
456 |
620 |
1.22e-50 |
SMART |
|
low complexity region
|
658 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
755 |
771 |
N/A |
INTRINSIC |
|
low complexity region
|
792 |
801 |
N/A |
INTRINSIC |
|
low complexity region
|
949 |
965 |
N/A |
INTRINSIC |
|
coiled coil region
|
1121 |
1151 |
N/A |
INTRINSIC |
|
Pfam:RasGEF_N
|
1242 |
1341 |
2.2e-17 |
PFAM |
|
Pfam:RasGEF
|
1464 |
1672 |
3.8e-22 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000151421
AA Change: S953P
PolyPhen 2
Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)
|
| SMART Domains |
Protein: ENSMUSP00000116435
Gene: ENSMUSG00000066129
AA Change: S953P
| Domain | Start | End | E-Value | Type |
|---|
|
KIND
|
37 |
217 |
4.66e-65 |
SMART |
|
Blast:KIND
|
381 |
454 |
2e-10 |
BLAST |
|
KIND
|
456 |
620 |
1.22e-50 |
SMART |
|
low complexity region
|
658 |
670 |
N/A |
INTRINSIC |
|
low complexity region
|
755 |
771 |
N/A |
INTRINSIC |
|
low complexity region
|
792 |
801 |
N/A |
INTRINSIC |
|
low complexity region
|
949 |
965 |
N/A |
INTRINSIC |
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000154782
|
| Predicted Effect |
noncoding transcript
Transcript: ENSMUST00000156941
|
| Meta Mutation Damage Score |
0.1031 |
| Coding Region Coverage |
- 1x: 98.9%
- 3x: 98.1%
- 10x: 95.5%
- 20x: 89.5%
|
| Validation Efficiency |
100% (112/112) |
| MGI Phenotype |
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a Ras guanine nucleotide exchange factor that appears to negatively regulate dendritic growth in the brain. Knockdown of this gene in senescent umbilical vein endothelial cells partially reversed the senescence, showing that this gene could potentially be targeted by anti-aging therapies. [provided by RefSeq, Dec 2016]
PHENOTYPE: Mice homozygous for a knock-out allele are viable and overtly normal. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 86 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adam25 |
T |
A |
8: 41,207,580 (GRCm39) |
V282E |
probably benign |
Het |
| Adam26b |
T |
C |
8: 43,973,296 (GRCm39) |
T569A |
possibly damaging |
Het |
| Adam6a |
A |
G |
12: 113,509,609 (GRCm39) |
N661D |
probably damaging |
Het |
| Adck1 |
G |
A |
12: 88,407,865 (GRCm39) |
A199T |
probably benign |
Het |
| Adhfe1 |
A |
G |
1: 9,628,438 (GRCm39) |
Y270C |
probably damaging |
Het |
| Aldh16a1 |
C |
T |
7: 44,796,731 (GRCm39) |
R256H |
probably benign |
Het |
| Ap5z1 |
T |
C |
5: 142,459,748 (GRCm39) |
M466T |
possibly damaging |
Het |
| Aspm |
C |
T |
1: 139,397,131 (GRCm39) |
L908F |
probably damaging |
Het |
| Atp8b2 |
T |
A |
3: 89,853,287 (GRCm39) |
T743S |
probably benign |
Het |
| Bag2 |
G |
T |
1: 33,786,022 (GRCm39) |
T100K |
probably damaging |
Het |
| Camk2a |
A |
G |
18: 61,076,246 (GRCm39) |
|
probably benign |
Het |
| Ccdc158 |
A |
G |
5: 92,781,262 (GRCm39) |
Y848H |
probably damaging |
Het |
| Ccp110 |
T |
G |
7: 118,324,653 (GRCm39) |
V725G |
possibly damaging |
Het |
| Cdh6 |
A |
G |
15: 13,051,418 (GRCm39) |
V405A |
probably benign |
Het |
| Ces2g |
T |
C |
8: 105,694,094 (GRCm39) |
|
probably null |
Het |
| Cfap157 |
A |
G |
2: 32,667,554 (GRCm39) |
F510L |
probably benign |
Het |
| Chd3 |
A |
T |
11: 69,250,722 (GRCm39) |
M669K |
possibly damaging |
Het |
| Cnot10 |
C |
T |
9: 114,456,532 (GRCm39) |
A168T |
probably damaging |
Het |
| Crybg1 |
A |
G |
10: 43,868,565 (GRCm39) |
V1371A |
probably damaging |
Het |
| Dars2 |
A |
G |
1: 160,872,560 (GRCm39) |
L547P |
probably damaging |
Het |
| Dis3 |
A |
G |
14: 99,325,226 (GRCm39) |
C483R |
probably damaging |
Het |
| Dnah7b |
T |
A |
1: 46,395,762 (GRCm39) |
L3888Q |
probably damaging |
Het |
| Dpysl2 |
A |
T |
14: 67,066,888 (GRCm39) |
Y182N |
probably damaging |
Het |
| Eif4g1 |
T |
A |
16: 20,500,923 (GRCm39) |
F509L |
probably benign |
Het |
| Evc |
T |
C |
5: 37,458,253 (GRCm39) |
T85A |
probably damaging |
Het |
| Farsb |
T |
C |
1: 78,444,609 (GRCm39) |
T283A |
probably benign |
Het |
| Fem1al |
G |
T |
11: 29,775,178 (GRCm39) |
A93E |
probably damaging |
Het |
| Fgf14 |
C |
A |
14: 124,429,845 (GRCm39) |
R30L |
possibly damaging |
Het |
| Gbe1 |
T |
C |
16: 70,275,289 (GRCm39) |
L363P |
probably damaging |
Het |
| Gcg |
A |
G |
2: 62,307,189 (GRCm39) |
V124A |
probably damaging |
Het |
| Glb1l |
A |
G |
1: 75,176,963 (GRCm39) |
|
probably benign |
Het |
| Gm5431 |
T |
C |
11: 48,780,409 (GRCm39) |
E449G |
probably damaging |
Het |
| Gon4l |
T |
C |
3: 88,802,655 (GRCm39) |
S1089P |
probably benign |
Het |
| Hgd |
T |
C |
16: 37,409,111 (GRCm39) |
L25P |
probably damaging |
Het |
| Hnf1a |
T |
C |
5: 115,093,311 (GRCm39) |
H318R |
possibly damaging |
Het |
| Hsd17b7 |
A |
C |
1: 169,794,826 (GRCm39) |
V71G |
possibly damaging |
Het |
| Hydin |
T |
C |
8: 111,233,126 (GRCm39) |
S1742P |
possibly damaging |
Het |
| Insyn2b |
A |
G |
11: 34,353,154 (GRCm39) |
S399G |
probably benign |
Het |
| Kank2 |
T |
C |
9: 21,691,078 (GRCm39) |
E552G |
probably benign |
Het |
| Kcnq4 |
C |
A |
4: 120,573,810 (GRCm39) |
R217L |
probably damaging |
Het |
| Klrg2 |
T |
C |
6: 38,604,540 (GRCm39) |
*201W |
probably null |
Het |
| Lama2 |
TTTGCGCATT |
TTT |
10: 26,919,639 (GRCm39) |
|
probably null |
Het |
| Lonp1 |
A |
G |
17: 56,933,587 (GRCm39) |
V96A |
probably benign |
Het |
| Mgat4e |
T |
C |
1: 134,469,478 (GRCm39) |
K189E |
possibly damaging |
Het |
| Msantd5f8 |
A |
G |
4: 73,805,457 (GRCm39) |
S351P |
probably damaging |
Het |
| Msh2 |
G |
A |
17: 88,026,187 (GRCm39) |
V722I |
possibly damaging |
Het |
| Mtcl3 |
A |
C |
10: 29,026,390 (GRCm39) |
M491L |
probably benign |
Het |
| N4bp2 |
T |
C |
5: 65,982,641 (GRCm39) |
Y1632H |
probably damaging |
Het |
| Nlrc4 |
T |
G |
17: 74,743,032 (GRCm39) |
K862T |
probably damaging |
Het |
| Notch4 |
A |
T |
17: 34,806,154 (GRCm39) |
Q1750L |
probably damaging |
Het |
| Obscn |
C |
T |
11: 58,972,849 (GRCm39) |
V2066I |
possibly damaging |
Het |
| Or2v2 |
T |
C |
11: 49,003,993 (GRCm39) |
K187E |
probably damaging |
Het |
| Or4c15 |
T |
A |
2: 88,760,627 (GRCm39) |
I11L |
probably benign |
Het |
| Or4f14b |
A |
T |
2: 111,775,156 (GRCm39) |
I215N |
probably damaging |
Het |
| Or52d13 |
A |
T |
7: 103,110,243 (GRCm39) |
Y57* |
probably null |
Het |
| Or5m8 |
T |
C |
2: 85,823,075 (GRCm39) |
S305P |
probably damaging |
Het |
| Pde7a |
T |
A |
3: 19,295,655 (GRCm39) |
|
probably benign |
Het |
| Pign |
A |
T |
1: 105,575,892 (GRCm39) |
Y249* |
probably null |
Het |
| Ppp1r17 |
A |
T |
6: 56,003,449 (GRCm39) |
E87D |
probably damaging |
Het |
| Prss3 |
T |
A |
6: 41,350,857 (GRCm39) |
Q211L |
probably damaging |
Het |
| Rapgef6 |
A |
G |
11: 54,526,989 (GRCm39) |
E413G |
probably benign |
Het |
| Rnf150 |
A |
G |
8: 83,590,712 (GRCm39) |
H25R |
probably damaging |
Het |
| Scamp2 |
T |
C |
9: 57,488,934 (GRCm39) |
|
probably null |
Het |
| Scap |
T |
A |
9: 110,203,410 (GRCm39) |
|
probably benign |
Het |
| Sdc2 |
A |
C |
15: 33,032,602 (GRCm39) |
K175N |
probably damaging |
Het |
| Serpinb6d |
T |
A |
13: 33,851,547 (GRCm39) |
|
probably null |
Het |
| Sh3tc2 |
A |
G |
18: 62,146,164 (GRCm39) |
N1181S |
probably benign |
Het |
| Slc44a2 |
T |
C |
9: 21,259,441 (GRCm39) |
I46T |
probably damaging |
Het |
| Slfn8 |
A |
G |
11: 82,908,540 (GRCm39) |
M1T |
probably null |
Het |
| Slitrk6 |
T |
C |
14: 110,989,315 (GRCm39) |
T131A |
probably damaging |
Het |
| Spata1 |
C |
G |
3: 146,175,529 (GRCm39) |
D326H |
probably damaging |
Het |
| Tbck |
T |
G |
3: 132,507,288 (GRCm39) |
S753R |
probably benign |
Het |
| Tdp1 |
A |
G |
12: 99,876,070 (GRCm39) |
I340M |
probably benign |
Het |
| Tmprss6 |
T |
A |
15: 78,330,877 (GRCm39) |
Y50F |
probably damaging |
Het |
| Trank1 |
T |
A |
9: 111,194,078 (GRCm39) |
S701T |
probably benign |
Het |
| Trbv17 |
A |
T |
6: 41,140,223 (GRCm39) |
N26I |
probably benign |
Het |
| Trip12 |
A |
T |
1: 84,771,531 (GRCm39) |
S248T |
probably damaging |
Het |
| Vmn2r53 |
T |
G |
7: 12,335,330 (GRCm39) |
Q110P |
probably damaging |
Het |
| Vmn2r75 |
A |
G |
7: 85,797,611 (GRCm39) |
V734A |
probably benign |
Het |
| Wfdc11 |
A |
T |
2: 164,507,415 (GRCm39) |
M14K |
probably null |
Het |
| Xcr1 |
T |
A |
9: 123,685,712 (GRCm39) |
M17L |
probably benign |
Het |
| Zbtb40 |
A |
G |
4: 136,716,070 (GRCm39) |
I965T |
probably damaging |
Het |
| Zfp760 |
A |
T |
17: 21,942,511 (GRCm39) |
H562L |
probably damaging |
Het |
| Zfp760 |
A |
T |
17: 21,942,516 (GRCm39) |
R564* |
probably null |
Het |
| Znf41-ps |
T |
A |
4: 145,555,283 (GRCm39) |
|
noncoding transcript |
Het |
| Zyg11a |
A |
T |
4: 108,067,387 (GRCm39) |
I41N |
probably damaging |
Het |
|
| Other mutations in Kndc1 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00340:Kndc1
|
APN |
7 |
139,481,904 (GRCm39) |
splice site |
probably benign |
|
|
IGL01061:Kndc1
|
APN |
7 |
139,502,610 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL01099:Kndc1
|
APN |
7 |
139,500,700 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01522:Kndc1
|
APN |
7 |
139,493,888 (GRCm39) |
splice site |
probably benign |
|
|
IGL01767:Kndc1
|
APN |
7 |
139,509,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01884:Kndc1
|
APN |
7 |
139,494,110 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01932:Kndc1
|
APN |
7 |
139,503,705 (GRCm39) |
missense |
probably damaging |
0.98 |
|
IGL02133:Kndc1
|
APN |
7 |
139,500,683 (GRCm39) |
missense |
probably benign |
0.19 |
|
IGL02411:Kndc1
|
APN |
7 |
139,501,829 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL02472:Kndc1
|
APN |
7 |
139,490,817 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02537:Kndc1
|
APN |
7 |
139,490,326 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL02708:Kndc1
|
APN |
7 |
139,481,097 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03115:Kndc1
|
APN |
7 |
139,501,425 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL03160:Kndc1
|
APN |
7 |
139,500,605 (GRCm39) |
nonsense |
probably null |
|
|
IGL03138:Kndc1
|
UTSW |
7 |
139,519,791 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
PIT4142001:Kndc1
|
UTSW |
7 |
139,503,692 (GRCm39) |
frame shift |
probably null |
|
|
PIT4696001:Kndc1
|
UTSW |
7 |
139,512,830 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0349:Kndc1
|
UTSW |
7 |
139,490,220 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0384:Kndc1
|
UTSW |
7 |
139,490,515 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R0415:Kndc1
|
UTSW |
7 |
139,510,037 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0421:Kndc1
|
UTSW |
7 |
139,488,912 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0487:Kndc1
|
UTSW |
7 |
139,493,939 (GRCm39) |
missense |
probably null |
0.19 |
|
R0530:Kndc1
|
UTSW |
7 |
139,481,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0905:Kndc1
|
UTSW |
7 |
139,503,651 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R1434:Kndc1
|
UTSW |
7 |
139,502,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1608:Kndc1
|
UTSW |
7 |
139,507,321 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R1644:Kndc1
|
UTSW |
7 |
139,510,669 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1835:Kndc1
|
UTSW |
7 |
139,507,624 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2012:Kndc1
|
UTSW |
7 |
139,501,196 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2102:Kndc1
|
UTSW |
7 |
139,510,674 (GRCm39) |
missense |
probably benign |
0.02 |
|
R2103:Kndc1
|
UTSW |
7 |
139,501,150 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2128:Kndc1
|
UTSW |
7 |
139,510,025 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2516:Kndc1
|
UTSW |
7 |
139,501,738 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3030:Kndc1
|
UTSW |
7 |
139,481,123 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3617:Kndc1
|
UTSW |
7 |
139,481,976 (GRCm39) |
splice site |
probably benign |
|
|
R3747:Kndc1
|
UTSW |
7 |
139,507,817 (GRCm39) |
critical splice donor site |
probably null |
|
|
R3848:Kndc1
|
UTSW |
7 |
139,488,893 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4028:Kndc1
|
UTSW |
7 |
139,509,941 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R4043:Kndc1
|
UTSW |
7 |
139,504,044 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4044:Kndc1
|
UTSW |
7 |
139,504,044 (GRCm39) |
missense |
probably benign |
0.06 |
|
R4095:Kndc1
|
UTSW |
7 |
139,516,938 (GRCm39) |
missense |
possibly damaging |
0.49 |
|
R4289:Kndc1
|
UTSW |
7 |
139,490,798 (GRCm39) |
missense |
probably benign |
0.01 |
|
R4478:Kndc1
|
UTSW |
7 |
139,500,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4514:Kndc1
|
UTSW |
7 |
139,490,202 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4540:Kndc1
|
UTSW |
7 |
139,501,343 (GRCm39) |
nonsense |
probably null |
|
|
R4584:Kndc1
|
UTSW |
7 |
139,481,159 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4693:Kndc1
|
UTSW |
7 |
139,501,695 (GRCm39) |
missense |
probably benign |
0.02 |
|
R4705:Kndc1
|
UTSW |
7 |
139,510,036 (GRCm39) |
missense |
possibly damaging |
0.81 |
|
R4773:Kndc1
|
UTSW |
7 |
139,503,946 (GRCm39) |
nonsense |
probably null |
|
|
R5004:Kndc1
|
UTSW |
7 |
139,512,792 (GRCm39) |
nonsense |
probably null |
|
|
R5037:Kndc1
|
UTSW |
7 |
139,490,371 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5322:Kndc1
|
UTSW |
7 |
139,516,722 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5428:Kndc1
|
UTSW |
7 |
139,488,878 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5503:Kndc1
|
UTSW |
7 |
139,511,802 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5506:Kndc1
|
UTSW |
7 |
139,507,804 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5525:Kndc1
|
UTSW |
7 |
139,504,026 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5888:Kndc1
|
UTSW |
7 |
139,475,133 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5942:Kndc1
|
UTSW |
7 |
139,516,792 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5979:Kndc1
|
UTSW |
7 |
139,519,740 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5990:Kndc1
|
UTSW |
7 |
139,507,333 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6038:Kndc1
|
UTSW |
7 |
139,503,691 (GRCm39) |
frame shift |
probably null |
|
|
R6076:Kndc1
|
UTSW |
7 |
139,481,954 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6118:Kndc1
|
UTSW |
7 |
139,503,717 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6151:Kndc1
|
UTSW |
7 |
139,501,129 (GRCm39) |
missense |
probably benign |
0.04 |
|
R6276:Kndc1
|
UTSW |
7 |
139,500,979 (GRCm39) |
missense |
probably benign |
|
|
R6367:Kndc1
|
UTSW |
7 |
139,493,422 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6726:Kndc1
|
UTSW |
7 |
139,502,667 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6745:Kndc1
|
UTSW |
7 |
139,500,892 (GRCm39) |
missense |
probably benign |
0.02 |
|
R6886:Kndc1
|
UTSW |
7 |
139,493,485 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6912:Kndc1
|
UTSW |
7 |
139,490,194 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7070:Kndc1
|
UTSW |
7 |
139,501,744 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7123:Kndc1
|
UTSW |
7 |
139,516,749 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7158:Kndc1
|
UTSW |
7 |
139,511,773 (GRCm39) |
missense |
possibly damaging |
0.48 |
|
R7248:Kndc1
|
UTSW |
7 |
139,500,699 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7437:Kndc1
|
UTSW |
7 |
139,488,959 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7564:Kndc1
|
UTSW |
7 |
139,500,612 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7570:Kndc1
|
UTSW |
7 |
139,503,691 (GRCm39) |
frame shift |
probably null |
|
|
R7625:Kndc1
|
UTSW |
7 |
139,517,930 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R7629:Kndc1
|
UTSW |
7 |
139,475,176 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7726:Kndc1
|
UTSW |
7 |
139,519,751 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R7840:Kndc1
|
UTSW |
7 |
139,503,731 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7859:Kndc1
|
UTSW |
7 |
139,500,880 (GRCm39) |
missense |
possibly damaging |
0.57 |
|
R7934:Kndc1
|
UTSW |
7 |
139,501,402 (GRCm39) |
missense |
probably benign |
0.02 |
|
R8011:Kndc1
|
UTSW |
7 |
139,490,536 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R8062:Kndc1
|
UTSW |
7 |
139,498,760 (GRCm39) |
missense |
probably benign |
0.01 |
|
R8134:Kndc1
|
UTSW |
7 |
139,481,285 (GRCm39) |
splice site |
probably null |
|
|
R8197:Kndc1
|
UTSW |
7 |
139,493,447 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8350:Kndc1
|
UTSW |
7 |
139,503,960 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8399:Kndc1
|
UTSW |
7 |
139,493,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8400:Kndc1
|
UTSW |
7 |
139,493,434 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8447:Kndc1
|
UTSW |
7 |
139,481,121 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8534:Kndc1
|
UTSW |
7 |
139,503,669 (GRCm39) |
missense |
probably benign |
0.27 |
|
R8735:Kndc1
|
UTSW |
7 |
139,490,130 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8816:Kndc1
|
UTSW |
7 |
139,517,909 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R8883:Kndc1
|
UTSW |
7 |
139,507,708 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8899:Kndc1
|
UTSW |
7 |
139,507,708 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8961:Kndc1
|
UTSW |
7 |
139,507,708 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R8961:Kndc1
|
UTSW |
7 |
139,503,976 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R9002:Kndc1
|
UTSW |
7 |
139,507,708 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9010:Kndc1
|
UTSW |
7 |
139,507,708 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9065:Kndc1
|
UTSW |
7 |
139,507,708 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9066:Kndc1
|
UTSW |
7 |
139,507,708 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9223:Kndc1
|
UTSW |
7 |
139,501,357 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9230:Kndc1
|
UTSW |
7 |
139,500,600 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9291:Kndc1
|
UTSW |
7 |
139,475,140 (GRCm39) |
missense |
possibly damaging |
0.55 |
|
R9441:Kndc1
|
UTSW |
7 |
139,501,392 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R9476:Kndc1
|
UTSW |
7 |
139,510,031 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9510:Kndc1
|
UTSW |
7 |
139,510,031 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9518:Kndc1
|
UTSW |
7 |
139,519,827 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9758:Kndc1
|
UTSW |
7 |
139,500,620 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
Z1177:Kndc1
|
UTSW |
7 |
139,501,828 (GRCm39) |
missense |
possibly damaging |
0.63 |
|
Z1186:Kndc1
|
UTSW |
7 |
139,490,729 (GRCm39) |
missense |
probably damaging |
0.98 |
|
| Predicted Primers |
PCR Primer
(F):5'- TCCCGTGTGTAACCTGACTG -3'
(R):5'- CAGAGCTATGGAAATGCTGTTG -3'
Sequencing Primer
(F):5'- GTGTGTAACCTGACTGACCTATC -3'
(R):5'- TGAGTTCAAGGTCAGTCACAGCTC -3'
|
| Posted On |
2016-03-01 |
Incidental Mutation