Incidental Mutation 'R4827:Gng2'
ID 372523
Institutional Source Beutler Lab
Gene Symbol Gng2
Ensembl Gene ENSMUSG00000043004
Gene Name guanine nucleotide binding protein (G protein), gamma 2
Synonyms 1110003P13Rik
MMRRC Submission 042443-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.112) question?
Stock # R4827 (G1)
Quality Score 225
Status Validated
Chromosome 14
Chromosomal Location 19922627-20027695 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 19925898 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Lysine to Glutamic Acid at position 65 (K65E)
Ref Sequence ENSEMBL: ENSMUSP00000124153 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000055100] [ENSMUST00000159028] [ENSMUST00000159073] [ENSMUST00000160013] [ENSMUST00000161247] [ENSMUST00000162425]
AlphaFold P63213
Predicted Effect possibly damaging
Transcript: ENSMUST00000055100
AA Change: K65E

PolyPhen 2 Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000055256
Gene: ENSMUSG00000043004
AA Change: K65E

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000159028
AA Change: K65E

PolyPhen 2 Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000125141
Gene: ENSMUSG00000043004
AA Change: K65E

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000159073
AA Change: K65E

PolyPhen 2 Score 0.716 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000125000
Gene: ENSMUSG00000043004
AA Change: K65E

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000160013
AA Change: K65E

PolyPhen 2 Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000125697
Gene: ENSMUSG00000043004
AA Change: K65E

DomainStartEndE-ValueType
G_gamma 5 70 5.7e-29 SMART
GGL 9 70 4.3e-34 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000161247
AA Change: K65E

PolyPhen 2 Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000124725
Gene: ENSMUSG00000043004
AA Change: K65E

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000162425
AA Change: K65E

PolyPhen 2 Score 0.903 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000124153
Gene: ENSMUSG00000043004
AA Change: K65E

DomainStartEndE-ValueType
G_gamma 5 70 5.6e-29 SMART
GGL 9 70 4.2e-34 SMART
Predicted Effect noncoding transcript
Transcript: ENSMUST00000224546
Meta Mutation Damage Score 0.4402 question?
Coding Region Coverage
  • 1x: 99.1%
  • 3x: 98.5%
  • 10x: 96.8%
  • 20x: 94.0%
Validation Efficiency 96% (67/70)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit reduced vomeronasal basal neurons, reduced posterior glomerular layer of the accessory olfactory bulb and decreased aggression towards male mice. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 67 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adck1 A G 12: 88,413,489 (GRCm39) R274G probably benign Het
Agbl5 T G 5: 31,053,158 (GRCm39) S83R probably damaging Het
Ankib1 A G 5: 3,751,907 (GRCm39) I711T probably damaging Het
Arnt T A 3: 95,397,224 (GRCm39) probably null Het
Atad2 C G 15: 57,971,744 (GRCm39) V702L probably benign Het
B4galnt4 A G 7: 140,648,392 (GRCm39) E636G probably benign Het
Btbd2 A G 10: 80,482,223 (GRCm39) I244T probably damaging Het
Cenpc1 A T 5: 86,182,290 (GRCm39) N531K possibly damaging Het
Ces3b T A 8: 105,813,527 (GRCm39) M266K probably benign Het
Cfap54 A T 10: 92,737,937 (GRCm39) probably benign Het
Coq8a A G 1: 179,994,903 (GRCm39) V590A possibly damaging Het
Drc7 A G 8: 95,798,267 (GRCm39) Y504C probably damaging Het
Elovl4 T C 9: 83,688,091 (GRCm39) M1V probably null Het
Exd1 C T 2: 119,350,807 (GRCm39) A485T probably benign Het
Fads2 A G 19: 10,059,958 (GRCm39) F239L probably benign Het
Gcc2 A T 10: 58,121,953 (GRCm39) probably null Het
Ggact C T 14: 123,128,987 (GRCm39) R76H probably benign Het
Gm17535 T A 9: 3,035,786 (GRCm39) L218H probably benign Het
Gm3739 A T 14: 18,506,218 (GRCm39) F13I probably damaging Het
Gnmt A G 17: 47,038,245 (GRCm39) Y94H possibly damaging Het
Gzme C A 14: 56,356,755 (GRCm39) R69M probably null Het
Hdc G A 2: 126,436,233 (GRCm39) P546L probably benign Het
Ibtk C A 9: 85,610,607 (GRCm39) V326F probably benign Het
Inpp5b G T 4: 124,637,643 (GRCm39) probably benign Het
Kcnh7 A T 2: 62,546,564 (GRCm39) C1006S probably benign Het
Kcnk18 A T 19: 59,208,362 (GRCm39) N66I probably damaging Het
Lpar6 T A 14: 73,476,190 (GRCm39) N50K probably damaging Het
Lrba G T 3: 86,267,457 (GRCm39) D1716Y possibly damaging Het
Ltf T A 9: 110,856,445 (GRCm39) probably benign Het
Map3k6 A G 4: 132,976,160 (GRCm39) T794A possibly damaging Het
Mcm8 A G 2: 132,665,174 (GRCm39) T217A probably damaging Het
Meaf6 A G 4: 124,996,713 (GRCm39) E141G probably damaging Het
Mmp13 A G 9: 7,278,880 (GRCm39) T324A possibly damaging Het
Mplkipl1 C T 19: 61,164,364 (GRCm39) G24R unknown Het
Msl2 T G 9: 100,979,350 (GRCm39) F575V probably benign Het
Ncoa4-ps C T 12: 119,225,529 (GRCm39) noncoding transcript Het
Nlrp2 A T 7: 5,331,950 (GRCm39) W149R possibly damaging Het
Ntng1 C A 3: 110,042,727 (GRCm39) C33F probably damaging Het
Nxn A G 11: 76,152,418 (GRCm39) Y359H probably benign Het
Olfml2a A C 2: 38,850,033 (GRCm39) D583A probably damaging Het
Or12j5 A C 7: 140,083,583 (GRCm39) L263R probably damaging Het
Or1e32 A T 11: 73,705,547 (GRCm39) Y120* probably null Het
Or2t48 A G 11: 58,420,422 (GRCm39) I130T probably damaging Het
Or4b1b A T 2: 90,112,547 (GRCm39) I124N probably damaging Het
Or51ac3 A T 7: 103,213,752 (GRCm39) S245T probably damaging Het
Pcdha4 T C 18: 37,086,251 (GRCm39) S145P probably damaging Het
Pcsk2 A T 2: 143,643,099 (GRCm39) K459* probably null Het
Pirb C T 7: 3,720,602 (GRCm39) G299S probably benign Het
Plch2 A G 4: 155,075,570 (GRCm39) F653S probably damaging Het
Plpp3 T C 4: 105,088,167 (GRCm39) I296T probably benign Het
Polr2b A G 5: 77,490,398 (GRCm39) E846G probably benign Het
Ptpro A T 6: 137,419,708 (GRCm39) N157Y probably damaging Het
Ralgapa1 A G 12: 55,723,222 (GRCm39) L1815P probably damaging Het
Sap18 A G 14: 58,036,020 (GRCm39) N69D probably damaging Het
Sncg C A 14: 34,095,284 (GRCm39) V74F probably damaging Het
Spata31e2 T C 1: 26,724,923 (GRCm39) K86E possibly damaging Het
Spmip4 A C 6: 50,572,836 (GRCm39) S26A possibly damaging Het
Tmem186 A T 16: 8,453,681 (GRCm39) Y193* probably null Het
Trrap A G 5: 144,737,758 (GRCm39) S1045G probably benign Het
Tti2 T G 8: 31,640,998 (GRCm39) S41A probably benign Het
Unc13c T C 9: 73,838,568 (GRCm39) E761G probably damaging Het
Vamp2 T A 11: 68,980,637 (GRCm39) D68E probably benign Het
Vmn1r200 A T 13: 22,579,265 (GRCm39) M14L probably benign Het
Vps35 T A 8: 86,000,186 (GRCm39) D480V possibly damaging Het
Zfp462 T C 4: 55,012,213 (GRCm39) L1393P probably damaging Het
Zfp512 G A 5: 31,630,158 (GRCm39) M274I probably benign Het
Znfx1 C G 2: 166,886,151 (GRCm39) G803A possibly damaging Het
Other mutations in Gng2
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0883:Gng2 UTSW 14 19,941,363 (GRCm39) missense probably benign 0.04
R4615:Gng2 UTSW 14 19,941,395 (GRCm39) missense possibly damaging 0.86
R5460:Gng2 UTSW 14 19,941,426 (GRCm39) missense probably benign 0.42
R5840:Gng2 UTSW 14 19,925,882 (GRCm39) missense probably damaging 0.97
R8711:Gng2 UTSW 14 19,941,438 (GRCm39) start codon destroyed probably null
R9096:Gng2 UTSW 14 19,941,471 (GRCm39) critical splice acceptor site probably null
R9303:Gng2 UTSW 14 19,925,961 (GRCm39) missense probably damaging 0.96
R9305:Gng2 UTSW 14 19,925,961 (GRCm39) missense probably damaging 0.96
Predicted Primers PCR Primer
(F):5'- TTTAAACATGCACAGCCCGG -3'
(R):5'- ACTTAGGTCCTCTGGCTTAGC -3'

Sequencing Primer
(F):5'- GAGTGTCCAGGATGGTTCTCC -3'
(R):5'- TTAGCCTGATGAGCTCCAAG -3'
Posted On 2016-03-01